AiPD: Autoinhibited Protein Database

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

263-334 (Predicted disordered autoinhibitory region) PR

263-334 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q8CEE7-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
rs3397196165	38	G>E	No	EVA
rs3388874903	46	A>T	No	EVA
rs3388879444	48	T>I	No	EVA
rs3388867346	58	L>R	No	EVA
rs3388855054	70	R>G	No	EVA
rs3388871119	70	R>Q	No	EVA
rs3388872647	71	D>G	No	EVA
rs3388876873	72	M>R	No	EVA
rs47860906	77	V>A	No	EVA
rs3388874936	92	R>C	No	EVA
rs3388876814	92	R>H	No	EVA
rs221887335	95	R>H	No	EVA
rs3412028328	109	R>G	No	EVA
rs50534020	111	V>I	No	EVA
rs244704193	112	I>F	No	EVA
rs3388854996	148	L>M	No	EVA
rs3396807198	183	D>E	No	EVA
rs49818861	185	E>D	No	EVA
rs3397349391	185	E>I	No	EVA
rs3397349391	185	E>K	No	EVA
rs3388874892	186	D>G	No	EVA
rs3388863457	211	T>A	No	EVA
rs3388876877	227	A>V	No	EVA
rs3397751699	247	A>S	No	EVA
rs6240813	282	N>S	No	EVA
rs3388859058	311	T>M	No	EVA
rs3388859023	318	G>D	No	EVA

Type	Name	Position	InterPro Accession
conserved_site	Short-chain dehydrogenase/reductase, conserved site	187 - 215	IPR020904

		Description
EC Number	1.1.1.300	With NAD(+) or NADP(+) as acceptor
Subcellular Localization	Mitochondrion inner membrane ; Peripheral membrane protein	Localized on the outer side of the inner mitochondrial membrane
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
mitochondrial inner membrane	The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae.
mitochondrion	A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.

Name	Definition
NADP-retinol dehydrogenase activity	Catalysis of the reaction: all-trans-retinol + NADP+ = all-trans-retinal + NADPH + H+.

Name	Definition
eye photoreceptor cell development	Development of a photoreceptor, a sensory cell in the eye that reacts to the presence of light. They usually contain a pigment that undergoes a chemical change when light is absorbed, thus stimulating a nerve.
response to high light intensity	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a high light intensity stimulus.
retina layer formation	The process in which the vertebrate retina is organized into three laminae: the outer nuclear layer (ONL), which contains photoreceptor nuclei; the inner nuclear layer (INL), which contains amacrine, bipolar and horizontal cells; and the retinal ganglion cell (RGC) layer. Between the inner and outer nuclear layers, the outer plexiform layer (OPL) contains connections between the photoreceptors and bipolar and horizontal cells. The inner plexiform layer (IPL) is positioned between the INL and the ganglion cell layer and contains the dendrites of RGCs and processes of bipolar and amacrine cells. Spanning all layers of the retina are the radially oriented Mueller glia.
retinal metabolic process	The chemical reactions and pathways involving retinal, a compound that plays an important role in the visual process in most vertebrates. In the retina, retinal combines with opsins to form visual pigments. Retinal is one of the forms of vitamin A.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q9VLU5	Wwox	WW domain-containing oxidoreductase	Drosophila melanogaster (Fruit fly)	PR
P16152	CBR1	Carbonyl reductase [NADPH] 1	Homo sapiens (Human)	PR
O75828	CBR3	Carbonyl reductase [NADPH] 3	Homo sapiens (Human)	PR
A6NN90	C2orf81	Uncharacterized protein C2orf81	Homo sapiens (Human)	PR
Q9HBH5	RDH14	Retinol dehydrogenase 14	Homo sapiens (Human)	PR
Q9NZC7	WWOX	WW domain-containing oxidoreductase	Homo sapiens (Human)	PR
Q91WL8	Wwox	WW domain-containing oxidoreductase	Mus musculus (Mouse)	PR
Q9ERI6	Rdh14	Retinol dehydrogenase 14	Mus musculus (Mouse)	PR
Q9DAQ4		Uncharacterized protein C2orf81 homolog	Mus musculus (Mouse)	PR
Q6AXP4		Uncharacterized protein C2orf81 homolog	Rattus norvegicus (Rat)	PR
A2RVM0	TIC32	Short-chain dehydrogenase TIC 32, chloroplastic	Arabidopsis thaliana (Mouse-ear cress)	PR
Q803A8	wwox	WW domain-containing oxidoreductase	Danio rerio (Zebrafish) (Brachydanio rerio)	PR