AiPD: Autoinhibited Protein Database

P16152

Gene name	CBR1
Protein name	Carbonyl reductase [NADPH] 1
Names	GP150, GPL115, Galactoglycoprotein, GALGP, Leukocyte sialoglycoprotein, Sialophorin, 15-hydroxyprostaglandin dehydrogenase [NADP(+)], 20-beta-hydroxysteroid dehydrogenase, Alcohol dehydrogenase [NAD(P)+] CBR1, NADPH-dependent carbonyl reductase 1, Prostaglandin 9-ketoreductase, PG-9-KR, Prostaglandin-E(2) 9-reductase, Short chain dehydrogenase/reductase family 21C member 1
Species	Homo sapiens (Human)
KEGG Pathway	hsa:873
EC number	1.1.1.71: With NAD(+) or NADP(+) as acceptor
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

116-201 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

116-201 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

7 structures for P16152

Entry ID	Method	Resolution	Chain	Position	Source
1WMA	X-ray	124 A	A	2-277	PDB
2PFG	X-ray	154 A	A	2-277	PDB
3BHI	X-ray	227 A	A	2-277	PDB
3BHJ	X-ray	177 A	A	2-277	PDB
3BHM	X-ray	180 A	A	2-277	PDB
4Z3D	X-ray	180 A	A/B/C/D	2-277	PDB
AF-P16152-F1	Predicted				AlphaFoldDB

263 variants for P16152

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
CA320272603 rs897824559	2	S>A		No	ClinGen TOPMed
rs1441384240 CA409882182	3	S>C		No	ClinGen gnomAD
CA409882178 rs1441384240	3	S>F		No	ClinGen gnomAD
rs369228069 CA10015263	4	G>S		No	ClinGen ExAC gnomAD
rs371089618 CA10015264	5	I>T		No	ClinGen ESP ExAC TOPMed gnomAD
rs1223191674 CA409882239	6	H>D		No	ClinGen TOPMed gnomAD
rs1240399629 CA409882253	6	H>R		No	ClinGen TOPMed
CA10015265 rs143215551	7	V>I		No	ClinGen ESP ExAC TOPMed gnomAD
rs566688474 CA320272609	8	A>G		No	ClinGen Ensembl
rs1318266119 CA409882276	8	A>S		No	ClinGen gnomAD
rs745692534 CA10015266	9	L>P		No	ClinGen ExAC gnomAD
CA409882363 rs1429068762	11	T>I		No	ClinGen TOPMed gnomAD
TCGA novel	12	G>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1255330242 CA409882399	13	G>S		No	ClinGen gnomAD
rs763746901 CA10015270	14	N>I		No	ClinGen ExAC gnomAD
CA320272624 rs1023456554	16	G>S		No	ClinGen TOPMed gnomAD
CA10015272 rs763329185	16	G>V		No	ClinGen ExAC TOPMed gnomAD
CA10015273 rs766929443	18	G>S		No	ClinGen ExAC TOPMed gnomAD
rs759895472 CA10015275	19	L>F		No	ClinGen ExAC gnomAD
CA10015274 rs751812271	19	L>V		No	ClinGen ExAC gnomAD
rs1327638590 CA409882571	19	L>W		No	ClinGen gnomAD
CA409882613 rs1441381936	21	I>F		No	ClinGen gnomAD
rs146570341 CA10015276	23	R>C		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA409882721 rs1374801279	23	R>H		No	ClinGen gnomAD
rs752970795 CA409882763	24	D>H		No	ClinGen ExAC gnomAD
rs752970795 CA10015277	24	D>Y		No	ClinGen ExAC gnomAD
CA409882824 rs1272100463	25	L>V		No	ClinGen gnomAD
rs1215228855 CA409882888	26	C>Y		No	ClinGen gnomAD
CA409883006 rs1190579111	28	L>P		No	ClinGen TOPMed
CA10015280 rs753977576	29	F>Y		No	ClinGen ExAC TOPMed gnomAD
CA409883071 rs1471173349	30	S>L		No	ClinGen gnomAD
CA10015282 rs757086930	31	G>V		No	ClinGen ExAC TOPMed gnomAD
rs745656182 CA10015284	32	D>N		No	ClinGen ExAC gnomAD
CA10015286 rs779831065	37	A>T		No	ClinGen ExAC gnomAD
CA409883355 rs1356237695	37	A>V		No	ClinGen gnomAD
rs775955102 CA10015289	38	R>Q		No	ClinGen ExAC gnomAD
rs768453981 CA10015288	38	R>W		No	ClinGen ExAC
CA10015290 rs761398228	40	V>M		No	ClinGen ExAC TOPMed gnomAD
CA409883589 rs1195611627	42	R>G		No	ClinGen gnomAD
CA409883599 rs1286647577	42	R>Q		No	ClinGen gnomAD
CA10015293 rs759878913	43	G>S		No	ClinGen ExAC TOPMed gnomAD
rs767914019 CA10015294	45	A>E		No	ClinGen ExAC gnomAD
CA409883830 rs1475577154	46	A>V		No	ClinGen gnomAD
rs200223739 CA10015295	47	V>I		No	ClinGen ExAC TOPMed gnomAD
rs1371575719 CA409883904	48	Q>*		No	ClinGen gnomAD
TCGA novel	48	Q>P	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs760841760 CA10015296	49	Q>R		No	ClinGen ExAC TOPMed gnomAD
rs1421450227 CA409884041	51	Q>*		No	ClinGen gnomAD
CA409884115 rs1432771382	52	A>V		No	ClinGen TOPMed gnomAD
rs367857649 CA10015299	53	E>K		No	ClinGen ESP ExAC TOPMed gnomAD
rs1315732436 CA409884219	54	G>D		No	ClinGen gnomAD
CA10015300 rs778704295	54	G>S		No	ClinGen ExAC TOPMed gnomAD
rs1325522379 CA409884245	55	L>P		No	ClinGen gnomAD
TCGA novel	56	S>G	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA409884278 rs1418542265	56	S>N		No	ClinGen TOPMed
rs758236840 CA10015302	57	P>L		No	ClinGen ExAC gnomAD
CA320272676 rs951888249	58	R>H		No	ClinGen Ensembl
CA409884375 rs1280254619	59	F>C		No	ClinGen gnomAD
CA409884361 rs1419813148	59	F>L		No	ClinGen TOPMed gnomAD
rs1419813148 CA409884364	59	F>V		No	ClinGen TOPMed gnomAD
rs779953785 CA10015303	60	H>P		No	ClinGen ExAC gnomAD
CA409884400 rs779953785	60	H>R		No	ClinGen ExAC gnomAD
rs1213148153 CA409884389	60	H>Y		No	ClinGen gnomAD
CA409884450 rs1159873364	61	Q>E		No	ClinGen gnomAD
CA409884503 rs41540715	61	Q>H		No	ClinGen ExAC TOPMed gnomAD
rs746822383 CA10015304	61	Q>P		No	ClinGen ExAC gnomAD
rs1374578653 CA409884506	62	L>V		No	ClinGen gnomAD
CA10015306 rs555028304	63	D>N		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs370920023 CA320272686	64	I>F		No	ClinGen gnomAD
CA409884585 rs9979814	64	I>M		No	ClinGen ExAC TOPMed gnomAD
CA320272684 rs370920023	64	I>V		No	ClinGen gnomAD
rs769401188 CA10015309	65	D>E		No	ClinGen ExAC TOPMed gnomAD
rs543800905 CA10015311	69	S>N		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
TCGA novel	69	S>P	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1349189945 CA409884841	71	R>H		No	ClinGen gnomAD
rs775778302 CA409884856	72	A>P		No	ClinGen ExAC
rs775778302 CA10015313	72	A>T		No	ClinGen ExAC
CA409884888 rs1259025375	72	A>V		No	ClinGen TOPMed gnomAD
CA409884892 rs558896125	73	L>M		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA409884900 rs558896125	73	L>V		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs117272030 CA10015317	74	R>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA10015318 rs559267091	75	D>N		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA409884985 rs1455517132	75	D>V		No	ClinGen gnomAD
CA10015319 rs142778878	76	F>L		No	ClinGen ESP ExAC TOPMed gnomAD
TCGA novel	77	L>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA409885030 rs766432246	77	L>V		No	ClinGen ExAC gnomAD
TCGA novel	78	R>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA409885058 rs1467343109	78	R>G		No	ClinGen Ensembl
CA409885065 rs1048322369 COSM3405382	78	R>H	Variant assessed as Somatic; 0.0 impact. central_nervous_system [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA TOPMed gnomAD
rs1048322369 CA320272706	78	R>L		No	ClinGen TOPMed gnomAD
CA10015323 rs754868460	79	K>R		No	ClinGen ExAC gnomAD
rs1305498936 CA409885156	81	Y>*		No	ClinGen TOPMed gnomAD
CA10015327 rs777221378	81	Y>C		No	ClinGen ExAC TOPMed gnomAD
rs529825233 CA10015326	81	Y>D		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA10015330 rs151043730	82	G>A		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA10015331 rs151043730	82	G>E		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs200695117 CA10015328	82	G>R		No	ClinGen ExAC TOPMed gnomAD
CA10015329 rs200695117	82	G>W		No	ClinGen ExAC TOPMed gnomAD
CA409885189 rs1439950229	83	G>V		No	ClinGen TOPMed
CA409885231 rs1332918930	85	D>E		No	ClinGen gnomAD
rs1003256032 CA320272721	85	D>V		No	ClinGen TOPMed
CA409885246 rs1305707920	86	V>A		No	ClinGen TOPMed
rs1213360369 CA409885253	87	L>Q		No	ClinGen gnomAD
rs1213360369 CA409885257	87	L>R		No	ClinGen gnomAD
CA320272723 VAR_059053 rs1143663	88	V>I	reduced affinity for NADPH and reduced activity towards daunorubicin and prostaglandin E2 [UniProt]	No	ClinGen UniProt TOPMed dbSNP gnomAD
rs776688059 CA10015333	89	N>S		No	ClinGen ExAC gnomAD
rs762056579 CA10015334	90	N>K		No	ClinGen ExAC gnomAD
CA320272726 rs1030669258	90	N>S		No	ClinGen TOPMed
CA320272729 rs1000335693	91	A>T		No	ClinGen Ensembl
rs1296409952 CA409885351	91	A>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
rs773365505 CA10015337	92	G>A		No	ClinGen ExAC gnomAD
TCGA novel	92	G>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs773365505 CA10015336	92	G>V		No	ClinGen ExAC gnomAD
CA409885434 rs1474667551	94	A>P		No	ClinGen TOPMed gnomAD
CA409885430 rs1474667551	94	A>T		No	ClinGen TOPMed gnomAD
rs1395588502 CA409885471	95	F>L		No	ClinGen TOPMed gnomAD
CA10015340 rs754702330	96	K>N		No	ClinGen ExAC gnomAD
rs751602193 CA10015339	96	K>R		No	ClinGen ExAC gnomAD
CA409885513 rs767383110	97	V>F		No	ClinGen ExAC TOPMed gnomAD
CA10015341 rs767383110	97	V>L		No	ClinGen ExAC TOPMed gnomAD
rs141259214 CA10015373	98	A>V		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1170972649 CA409885748 COSM1030475	100	P>S	endometrium [Cosmic]	No	ClinGen cosmic curated gnomAD
rs1393836095 CA409885896	105	I>S		No	ClinGen gnomAD
CA10015374 rs778116397	107	A>V		No	ClinGen ExAC
rs774437766 CA10015377	109	V>L		No	ClinGen ExAC TOPMed gnomAD
rs200192508 CA409886075	110	T>M		No	ClinGen ExAC TOPMed
CA10015378 rs200192508	110	T>R		No	ClinGen ExAC TOPMed
CA409886108 rs1415376106	112	K>E		No	ClinGen TOPMed
rs557204729 CA320272930	112	K>I		No	ClinGen gnomAD
rs772044820 CA10015379	113	T>A		No	ClinGen ExAC gnomAD
CA409886174 rs1437037247	114	N>D		No	ClinGen gnomAD
rs150365005 CA10015380	114	N>K	Variant assessed as Somatic; 0.0001386 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
rs760444957 CA10015381	115	F>L		No	ClinGen ExAC gnomAD
CA10015382 rs763917846	116	F>I		No	ClinGen ExAC gnomAD
CA409886235 rs763917846	116	F>L		No	ClinGen ExAC gnomAD
rs753663954 CA10015383	116	F>S		No	ClinGen ExAC gnomAD
CA10015385 rs761407628	119	R>*		No	ClinGen ExAC gnomAD
rs759028268 CA320272942	119	R>Q		No	ClinGen TOPMed gnomAD
rs764885114 CA10015387	121	V>G		No	ClinGen ExAC gnomAD
CA10015388 rs375784875	122	C>R		No	ClinGen ESP ExAC TOPMed gnomAD
TCGA novel	123	T>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA10015389 rs757911931	126	L>F		No	ClinGen ExAC TOPMed gnomAD
rs781715120 CA10015390	129	I>T		No	ClinGen ExAC gnomAD
CA10015391 rs753192675	130	K>I		No	ClinGen ExAC TOPMed gnomAD
rs1346053730 CA409886685	131	P>L		No	ClinGen gnomAD
CA10015393 VAR_031706 rs41557318	131	P>S		No	ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
CA409886701 rs1459050066	132	Q>*		No	ClinGen gnomAD
CA320272954 rs747156853	133	G>R		No	ClinGen Ensembl
rs1286291461 CA409892476	134	R>T		No	ClinGen TOPMed
CA10015472 rs760237383	137	N>D		No	ClinGen ExAC gnomAD
CA320273330 rs1031038422	137	N>S		No	ClinGen Ensembl
rs770198762 COSM478554 CA10015473	138	V>I	kidney [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
rs770198762 CA409892576	138	V>L		No	ClinGen ExAC TOPMed gnomAD
rs1173180839 CA409892629	140	S>G		No	ClinGen gnomAD
rs763204071 CA10015475	141	I>T	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA10015474 rs773828531	141	I>V		No	ClinGen ExAC TOPMed gnomAD
rs751952306 CA10015477	142	M>I		No	ClinGen ExAC
rs766768951 CA10015476	142	M>V		No	ClinGen ExAC TOPMed gnomAD
COSM1030477 CA10015479 rs370632546	144	V>I	Variant assessed as Somatic; 0.0 impact. large_intestine endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated 1000Genomes ESP ExAC NCI-TCGA TOPMed gnomAD
CA409892748 rs752649052	145	R>S		No	ClinGen ExAC TOPMed gnomAD
CA409892764 rs1389111479	146	A>D		No	ClinGen gnomAD
CA409892759 rs199962768	146	A>P		No	ClinGen 1000Genomes ExAC gnomAD
CA10015481 rs199962768	146	A>T		No	ClinGen 1000Genomes ExAC gnomAD
rs763917680 CA10015482	147	L>V		No	ClinGen ExAC gnomAD
TCGA novel	149	S>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1568957942 CA409892935	151	S>N		No	ClinGen Ensembl
CA10015486 rs757294585	152	P>L		No	ClinGen ExAC gnomAD
COSM1196207 rs1030203718 CA320273350	152	P>S	lung [Cosmic]	No	ClinGen cosmic curated TOPMed
CA10015488 rs745672468	153	E>G		No	ClinGen ExAC TOPMed gnomAD
CA10015489 rs758058719	154	L>M		No	ClinGen ExAC gnomAD
CA320273361 rs746489070	158	F>C		No	ClinGen Ensembl
CA10015493 rs773560089	159	R>C		No	ClinGen ExAC TOPMed gnomAD
COSM1030478 CA10015495 rs146559297	159	R>H	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated 1000Genomes ESP ExAC NCI-TCGA TOPMed gnomAD
CA10015494 rs146559297	159	R>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs774636988 CA10015497	166	E>D		No	ClinGen ExAC gnomAD
CA320273369 rs976993481	166	E>G		No	ClinGen Ensembl
rs557925178 CA10015499	169	V>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs557925178 CA409893371	169	V>M		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA320273377 rs922499873	170	G>A		No	ClinGen Ensembl
rs775837893 CA10015500	171	L>F		No	ClinGen ExAC gnomAD
CA10015501 rs760643033	172	M>V		No	ClinGen ExAC gnomAD
rs1046874551 CA320273386	174	K>R		No	ClinGen Ensembl
rs764197380 CA10015502	175	F>L		No	ClinGen ExAC gnomAD
rs1458662102 CA409893453	175	F>S		No	ClinGen TOPMed gnomAD
CA409893461 rs1437133285	176	V>G		No	ClinGen gnomAD
CA10015503 rs753889721	176	V>M		No	ClinGen ExAC gnomAD
rs757208303 CA10015504	178	D>N		No	ClinGen ExAC TOPMed gnomAD
CA10015505 rs765270229	178	D>V		No	ClinGen ExAC TOPMed gnomAD
CA409893483 rs1288650046	180	K>E		No	ClinGen gnomAD
rs1318349126 CA409893495	181	K>R		No	ClinGen gnomAD
rs533864137 CA10015509	182	G>E		No	ClinGen 1000Genomes ExAC gnomAD
rs555473871 CA320273401	183	V>L		No	ClinGen 1000Genomes TOPMed gnomAD
rs555473871 CA320273399	183	V>M		No	ClinGen 1000Genomes TOPMed gnomAD
CA10015511 rs780703439	187	E>G		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	188	G>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs763436504 CA320273407	189	W>*		No	ClinGen Ensembl
CA409893625 rs1252861298	190	P>L		No	ClinGen gnomAD
CA409893624 rs1252861298	190	P>R		No	ClinGen gnomAD
CA409893653 rs1473712205	192	S>N		No	ClinGen gnomAD
CA10015514 rs199906618	193	A>T		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1246144650 CA409893678	193	A>V		No	ClinGen TOPMed
CA10015517 rs752113715	195	G>E		No	ClinGen ExAC gnomAD
rs146758729 CA10015516 RCV000894661	195	G>R		No	ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs1601323647 CA409893727	196	V>G		No	ClinGen Ensembl
rs1408734538 CA409893715	196	V>L		No	ClinGen gnomAD
CA409893717 rs1408734538	196	V>M		No	ClinGen gnomAD
rs201334038 CA10015518	197	T>M		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA10015520 rs546119820	198	K>M		No	ClinGen 1000Genomes ExAC gnomAD
TCGA novel	199	I>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs765253793 CA10015522	201	V>I		No	ClinGen ExAC TOPMed gnomAD
CA409893807 rs765253793	201	V>L		No	ClinGen ExAC TOPMed gnomAD
rs762808256 CA10015524	203	V>F		No	ClinGen ExAC TOPMed gnomAD
rs762808256 CA10015525	203	V>I	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA409893899 rs1340099289	206	R>K		No	ClinGen gnomAD
CA409893940 rs1040147297	207	I>M		No	ClinGen TOPMed gnomAD
CA10015528 rs754600918	209	A>S		No	ClinGen ExAC gnomAD
CA10015527 rs754600918	209	A>T		No	ClinGen ExAC gnomAD
rs779368600 CA10015531	211	K>Q		No	ClinGen ExAC
rs746336766 CA10015532	213	S>N		No	ClinGen ExAC gnomAD
rs772480635 CA10015533	217	K>R		No	ClinGen ExAC gnomAD
CA409894364 rs1388206717	218	G>E		No	ClinGen gnomAD
rs1371878931 CA409894396	219	D>E		No	ClinGen gnomAD
TCGA novel	219	D>G	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA409894373 rs1168612130	219	D>H		No	ClinGen gnomAD
rs1429227352 CA409894400	220	K>E		No	ClinGen TOPMed
rs1412397891 CA409894421	221	I>V		No	ClinGen gnomAD
rs1286354289 CA409894582	227	C>S		No	ClinGen gnomAD
CA10015537 rs374414411	229	G>A		No	ClinGen ESP ExAC gnomAD
CA320273442 rs964388540	231	V>M		No	ClinGen Ensembl
CA320273444 rs573227330	232	R>K		No	ClinGen Ensembl
CA409894816 rs1275357410	233	T>I		No	ClinGen gnomAD
rs762932134 CA10015541	235	M>T		No	ClinGen ExAC TOPMed gnomAD
rs1189297937 CA409894883	235	M>V		No	ClinGen TOPMed
CA320273450 rs867128163	236	A>V		No	ClinGen gnomAD
rs754001791 CA320273454	238	P>R		No	ClinGen Ensembl
rs1203728473 CA409895035	240	A>S		No	ClinGen TOPMed
CA409895111 rs1448728879	244	P>S		No	ClinGen gnomAD
CA409895125 rs1189215235	245	E>K		No	ClinGen TOPMed gnomAD
rs1476785218 CA409895153	246	E>*		No	ClinGen gnomAD
rs1476785218 CA409895151	246	E>K		No	ClinGen gnomAD
rs759316194 CA10015544	247	G>D		No	ClinGen ExAC TOPMed gnomAD
rs141295222 CA10015545	248	A>T		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA10015546 rs752394402	248	A>V		No	ClinGen ExAC TOPMed gnomAD
rs148205009 CA10015547	250	T>N		No	ClinGen ESP ExAC TOPMed gnomAD
TCGA novel	251	P>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs146879523 CA409895327	253	Y>C		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs146879523 CA10015549	253	Y>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA409895381 rs1231206647	255	A>V		No	ClinGen gnomAD
CA10015551 rs780496525	256	L>P		No	ClinGen ExAC TOPMed gnomAD
CA10015552 rs747389864	258	P>S	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA409895481 rs1464320802	260	D>V		No	ClinGen gnomAD
CA10015554 rs781536281	261	A>T		No	ClinGen ExAC gnomAD
TCGA novel	262	E>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs143175086 CA320273484	262	E>D		No	ClinGen 1000Genomes ESP ExAC gnomAD
rs748338970 CA10015555	262	E>V		No	ClinGen ExAC TOPMed gnomAD
CA320273485 rs867646435	263	G>S		No	ClinGen TOPMed gnomAD
CA320273486 rs1046674820	267	Q>H		No	ClinGen TOPMed gnomAD
rs762942037 CA10015559	272	K>R		No	ClinGen ExAC gnomAD
rs770896302 CA10015560	274	V>I		No	ClinGen ExAC TOPMed gnomAD
CA10015561 rs147519087	275	E>K		No	ClinGen ESP ExAC TOPMed gnomAD
CA409895912 rs1321771130	276	Q>*		No	ClinGen gnomAD
rs759352463 CA10015562	276	Q>R		No	ClinGen ExAC gnomAD
CA10015563 rs767338903	277	W>C		No	ClinGen ExAC TOPMed gnomAD

No associated diseases with P16152

1 regional properties for P16152

Type	Name	Position	InterPro Accession
conserved_site	Short-chain dehydrogenase/reductase, conserved site	181 - 209	IPR020904

Functions

		Description
EC Number	1.1.1.71	With NAD(+) or NADP(+) as acceptor
Subcellular Localization	Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

3 GO annotations of cellular component

Name	Definition
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
extracellular exosome	A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
extracellular vesicle	Any vesicle that is part of the extracellular region.

8 GO annotations of molecular function

Name	Definition
15-hydroxyprostaglandin dehydrogenase (NADP+) activity	Catalysis of the reaction: NADP(+) + prostaglandin E(1) = 15-dehydro-prostaglandin E1 + H(+) + NADPH.
15-hydroxyprostaglandin-D dehydrogenase (NADP+) activity	Catalysis of the reaction: NADP+ + (5Z,13E)-(15S)-9-alpha,15-dihydroxy-11-oxoprosta-5,13-dienoate = NADPH + H+ + (5Z,13E)-9-alpha-hydroxy-11,15-dioxoprosta-5,13-dienoate.
alcohol dehydrogenase (NADP+) activity	Catalysis of the reaction: an alcohol + NADP+ = an aldehyde + NADPH + H+.
carbonyl reductase (NADPH) activity	Catalysis of the reaction: R-CHOH-R' + NADP+ = R-CO-R' + NADPH + H+.
oxidoreductase activity	Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced.
oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor	Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces a quinone or a similar acceptor molecule.
oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP.
prostaglandin-E2 9-reductase activity	Catalysis of the reaction: (5Z,13E)-(15S)-9-alpha,11-alpha,15-trihydroxyprosta-5,13-dienoate + NADP+ = (5Z,13E)-(15S)-11-alpha,15-dihydroxy-9-oxoprosta-5,13-dienoate + NADPH.

6 GO annotations of biological process

Name	Definition
cyclooxygenase pathway	The chemical reactions and pathways by which prostaglandins are formed from arachidonic acid, and in which prostaglandin-endoperoxide synthase (cyclooxygenase) catalyzes the committed step in the conversion of arachidonic acid to the prostaglandin-endoperoxides PGG2 and PGH2.
epithelial cell differentiation	The process in which a relatively unspecialized cell acquires specialized features of an epithelial cell, any of the cells making up an epithelium.
glucocorticoid metabolic process	The chemical reactions and pathways involving glucocorticoids, hormonal C21 corticosteroids synthesized from cholesterol. Glucocorticoids act primarily on carbohydrate and protein metabolism, and have anti-inflammatory effects.
positive regulation of reactive oxygen species metabolic process	Any process that activates or increases the frequency, rate or extent of reactive oxygen species metabolic process.
vitamin K metabolic process	The chemical reactions and pathways involving any of the forms of vitamin K, quinone-derived vitamins which are involved in the synthesis of blood-clotting factors in mammals. Vitamin K substances share a methylated naphthoquinone ring structure and vary in the aliphatic side chains attached to the molecule.
xenobiotic metabolic process	The chemical reactions and pathways involving a xenobiotic compound, a compound foreign to the organim exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical.

13 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q9VLU5	Wwox	WW domain-containing oxidoreductase	Drosophila melanogaster (Fruit fly)	PR
A6NN90	C2orf81	Uncharacterized protein C2orf81	Homo sapiens (Human)	PR
Q9HBH5	RDH14	Retinol dehydrogenase 14	Homo sapiens (Human)	PR
Q9NZC7	WWOX	WW domain-containing oxidoreductase	Homo sapiens (Human)	PR
O75828	CBR3	Carbonyl reductase [NADPH] 3	Homo sapiens (Human)	PR
Q91WL8	Wwox	WW domain-containing oxidoreductase	Mus musculus (Mouse)	PR
Q8CEE7	Rdh13	Retinol dehydrogenase 13	Mus musculus (Mouse)	PR
Q9ERI6	Rdh14	Retinol dehydrogenase 14	Mus musculus (Mouse)	PR
Q9DAQ4		Uncharacterized protein C2orf81 homolog	Mus musculus (Mouse)	PR
Q28960	CBR1	Carbonyl reductase [NADPH] 1	Sus scrofa (Pig)	PR
Q6AXP4		Uncharacterized protein C2orf81 homolog	Rattus norvegicus (Rat)	PR
A2RVM0	TIC32	Short-chain dehydrogenase TIC 32, chloroplastic	Arabidopsis thaliana (Mouse-ear cress)	PR
Q803A8	wwox	WW domain-containing oxidoreductase	Danio rerio (Zebrafish) (Brachydanio rerio)	PR

10	20	30	40	50	60
MSSGIHVALV	TGGNKGIGLA	IVRDLCRLFS	GDVVLTARDV	TRGQAAVQQL	QAEGLSPRFH
70	80	90	100	110	120
QLDIDDLQSI	RALRDFLRKE	YGGLDVLVNN	AGIAFKVADP	TPFHIQAEVT	MKTNFFGTRD
130	140	150	160	170	180
VCTELLPLIK	PQGRVVNVSS	IMSVRALKSC	SPELQQKFRS	ETITEEELVG	LMNKFVEDTK
190	200	210	220	230	240
KGVHQKEGWP	SSAYGVTKIG	VTVLSRIHAR	KLSEQRKGDK	ILLNACCPGW	VRTDMAGPKA
250	260	270
TKSPEEGAET	PVYLALLPPD	AEGPHGQFVS	EKRVEQW