Q9D4V0

PR
Gene name
Etnk1 (Eki1)
Protein name
Ethanolamine kinase 1
Names
EKI 1
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:75320
EC number
2.7.1.82: Phosphotransferases with an alcohol group as acceptor
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-54 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q9D4V0

Entry ID Method Resolution Chain Position Source
AF-Q9D4V0-F1 Predicted AlphaFoldDB

9 variants for Q9D4V0

Variant ID(s) Position Change Description Diseaes Association Provenance
rs3397525402 16 K>Q No EVA
rs3397441353 194 P>L No EVA
rs3397275202 196 L>H No EVA
rs3397368036 196 L>I No EVA
rs3397496604 198 Q>R No EVA
rs3388865645 240 D>G No EVA
rs3388868297 267 D>N No EVA
rs3388868297 267 D>Y No EVA
rs3388871904 337 D>V No EVA

No associated diseases with Q9D4V0

3 regional properties for Q9D4V0

Type Name Position InterPro Accession
domain B3 DNA binding domain 5 - 92 IPR003340-1
domain B3 DNA binding domain 162 - 259 IPR003340-2
domain B3 DNA binding domain 284 - 386 IPR003340-3

Functions

Description
EC Number 2.7.1.82 Phosphotransferases with an alcohol group as acceptor
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

2 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
ethanolamine kinase activity Catalysis of the reaction: ATP + ethanolamine = ADP + 2 H(+) + phosphoethanolamine.

2 GO annotations of biological process

Name Definition
phosphatidylethanolamine biosynthetic process The chemical reactions and pathways resulting in the formation of phosphatidylethanolamine, any of a class of glycerophospholipids in which a phosphatidyl group is esterified to the hydroxyl group of ethanolamine.
phosphorylation The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide.

9 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P20485 CKI1 Choline kinase Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PR
P54352 eas Ethanolamine kinase Drosophila melanogaster (Fruit fly) PR
P35790 CHKA Choline kinase alpha Homo sapiens (Human) PR
Q9HBU6 ETNK1 Ethanolamine kinase 1 Homo sapiens (Human) PR
A7MCT6 Etnk2 Ethanolamine kinase 2 Mus musculus (Mouse) PR
O54804 Chka Choline kinase alpha Mus musculus (Mouse) PR
D3ZRW8 Etnk2 Ethanolamine kinase 2 Rattus norvegicus (Rat) PR
Q01134 Chka Choline kinase alpha Rattus norvegicus (Rat) PR
Q8L518 At1g74320 Probable choline kinase 2 Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MANYIHVPPG SPEVPKLDVT VQDQEEQRCR DGALSLLRHL RPHWDPREVT LQLFTDGITN
70 80 90 100 110 120
KLIACYVGDT MEDVVLVRIY GNKTELLVDR DEEVKSFRVL QAHGCAPQLY CTFNNGLCYE
130 140 150 160 170 180
FIQGEALDPQ HVCNPAIFRL IARQLAKIHA IHAHNGWIPK SNLWLKMGKY FSLIPTGFAD
190 200 210 220 230 240
ENINKRFLSE IPSPQLLQEE MTWMKELLSS LGSPVVLCHN DLLCKNIIYN EKQGDVQFID
250 260 270 280 290 300
YEYSGYNYLA YDIGNHFNEF AGVSDVDYSL YPDRELQGQW LRSYLEAYKE YKGFGSDVTE
310 320 330 340 350 360
KEVETLFIQV NQFALASHFF WGLWALIQAK YSTIEFDFLG YAVVRFNQYF KMKPEVTALK
MPE