AiPD: Autoinhibited Protein Database

Gene name	Etnk2 (Tuc1)
Protein name	Ethanolamine kinase 2
Names	EKI 2, Ethanolamine kinase-like protein
Species	Mus musculus (Mouse)
KEGG Pathway	mmu:214253
EC number	2.7.1.82: Phosphotransferases with an alcohol group as acceptor
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

1-72 (Predicted disordered autoinhibitory region) PR

1-72 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
AF-A7MCT6-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
rs3390662306	43	P>S	No	EVA
rs3390575671	54	S>G	No	EVA
rs3388499155	65	G>A	No	EVA
rs3390654356	89	D>E	No	EVA
rs3388497572	127	V>I	No	EVA
rs3388499296	142	L>F	No	EVA
rs3390654363	166	R>Q	No	EVA
rs3388498047	177	E>K	No	EVA
rs3388497555	202	Y>F	No	EVA
rs3388498102	205	L>P	No	EVA
rs3388500748	227	E>D	No	EVA
rs3388500747	236	S>T	No	EVA
rs3390648081	239	D>G	No	EVA
rs3388501224	285	N>T	No	EVA
rs3390575687	292	V>E	No	EVA
rs3388499188	317	G>E	No	EVA
rs3388501483	325	V>M	No	EVA
rs3388497608	326	E>V	No	EVA
rs3388497828	334	K>E	No	EVA
rs3390575600	336	A>S	No	EVA
rs3388497352	355	T>I	No	EVA
rs3388499169	370	Q>*	No	EVA
rs3388499287	378	V>M	No	EVA

Type	Name	Position	InterPro Accession
domain	Damage-control phosphatase ARMT1-like, metal-binding domain	49 - 356	IPR002791

		Description
EC Number	2.7.1.82	Phosphotransferases with an alcohol group as acceptor
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

Name	Definition
ATP binding	Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
ethanolamine kinase activity	Catalysis of the reaction: ATP + ethanolamine = ADP + 2 H(+) + phosphoethanolamine.

Name	Definition
in utero embryonic development	The process whose specific outcome is the progression of the embryo in the uterus over time, from formation of the zygote in the oviduct, to birth. An example of this process is found in Mus musculus.
multicellular organism growth	The increase in size or mass of an entire multicellular organism, as opposed to cell growth.
phosphatidylethanolamine biosynthetic process	The chemical reactions and pathways resulting in the formation of phosphatidylethanolamine, any of a class of glycerophospholipids in which a phosphatidyl group is esterified to the hydroxyl group of ethanolamine.
phosphorylation	The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide.
placenta development	The process whose specific outcome is the progression of the placenta over time, from its formation to the mature structure. The placenta is an organ of metabolic interchange between fetus and mother, partly of embryonic origin and partly of maternal origin.
post-embryonic development	The process whose specific outcome is the progression of the organism over time, from the completion of embryonic development to the mature structure. See embryonic development.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
P20485	CKI1	Choline kinase	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)	PR
P54352	eas	Ethanolamine kinase	Drosophila melanogaster (Fruit fly)	PR
Q9HBU6	ETNK1	Ethanolamine kinase 1	Homo sapiens (Human)	PR
P35790	CHKA	Choline kinase alpha	Homo sapiens (Human)	PR
Q9D4V0	Etnk1	Ethanolamine kinase 1	Mus musculus (Mouse)	PR
O54804	Chka	Choline kinase alpha	Mus musculus (Mouse)	PR
Q01134	Chka	Choline kinase alpha	Rattus norvegicus (Rat)	PR
D3ZRW8	Etnk2	Ethanolamine kinase 2	Rattus norvegicus (Rat)	PR
Q8L518	At1g74320	Probable choline kinase 2	Arabidopsis thaliana (Mouse-ear cress)	PR