AiPD: Autoinhibited Protein Database

Gene name	Chka (Chk)
Protein name	Choline kinase alpha
Names	CK, CHETK-alpha, Ethanolamine kinase, EK
Species	Mus musculus (Mouse)
KEGG Pathway	mmu:12660
EC number	2.7.1.32: Phosphotransferases with an alcohol group as acceptor
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

1-93 (Predicted disordered autoinhibitory region) PR

1-93 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
AF-O54804-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
rs216994478	51	T>N	No	EVA
rs864276473	64	L>P	No	EVA
rs3389529761	165	N>Y	No	EVA
rs3389509459	187	S>P	No	EVA
rs3409272626	192	L>V	No	EVA
rs36262694	193	F>Y	No	EVA
rs3389515650	202	E>K	No	EVA
rs3389493711	207	S>C	No	EVA
rs3389509408	219	D>A	No	EVA
rs3389509408	219	D>V	No	EVA
rs3411715012	225	A>S	No	EVA
rs3408835176	226	E>G	No	EVA
rs3412960061	274	L>I	No	EVA
rs3389472123	287	S>L	No	EVA
rs3389518269	301	N>I	No	EVA
rs214046561	316	N>S	No	EVA
rs235305459	321	K>E	No	EVA
rs217141100	361	N>S	No	EVA
rs3389472060	387	E>K	No	EVA
rs3389514783	440	R>G	No	EVA

Type	Name	Position	InterPro Accession
domain	Calcium uniporter protein, C-terminal	156 - 315	IPR006769

		Description
EC Number	2.7.1.32	Phosphotransferases with an alcohol group as acceptor
Subcellular Localization	Cytoplasm, cytosol ;
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
lipid droplet	An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins.

Name	Definition
ATP binding	Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
choline binding	Binding to choline, the amine 2-hydroxy-N,N,N-trimethylethanaminium.
choline kinase activity	Catalysis of the reaction: ATP + choline = ADP + choline phosphate + 2 H(+).
cholinesterase activity	Catalysis of the reaction: an acylcholine + H2O = choline + a carboxylic acid anion.
ethanolamine kinase activity	Catalysis of the reaction: ATP + ethanolamine = ADP + 2 H(+) + phosphoethanolamine.
identical protein binding	Binding to an identical protein or proteins.
protein homodimerization activity	Binding to an identical protein to form a homodimer.
protein tyrosine kinase activity	Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate.

Name	Definition
CDP-choline pathway	The phosphatidylcholine biosynthetic process that begins with the phosphorylation of choline and ends with the combination of CDP-choline with diacylglycerol to form phosphatidylcholine.
cellular response to glucose starvation	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of glucose.
choline metabolic process	The chemical reactions and pathways involving choline (2-hydroxyethyltrimethylammonium), an amino alcohol that occurs widely in living organisms as a constituent of certain types of phospholipids and in the neurotransmitter acetylcholine.
ethanolamine metabolic process	The chemical reactions and pathways involving ethanolamine (2-aminoethanol), an important water-soluble base of phospholipid (phosphatidylethanolamine).
lipid droplet disassembly	The disaggregation of a lipid particle into its constituent components.
phosphatidylcholine biosynthetic process	The chemical reactions and pathways resulting in the formation of phosphatidylcholines, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of choline.
phosphatidylethanolamine biosynthetic process	The chemical reactions and pathways resulting in the formation of phosphatidylethanolamine, any of a class of glycerophospholipids in which a phosphatidyl group is esterified to the hydroxyl group of ethanolamine.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
P20485	CKI1	Choline kinase	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)	PR
P54352	eas	Ethanolamine kinase	Drosophila melanogaster (Fruit fly)	PR
P35790	CHKA	Choline kinase alpha	Homo sapiens (Human)	PR
Q9D4V0	Etnk1	Ethanolamine kinase 1	Mus musculus (Mouse)	PR
A7MCT6	Etnk2	Ethanolamine kinase 2	Mus musculus (Mouse)	PR
D3ZRW8	Etnk2	Ethanolamine kinase 2	Rattus norvegicus (Rat)	PR
Q01134	Chka	Choline kinase alpha	Rattus norvegicus (Rat)	PR
Q8L518	At1g74320	Probable choline kinase 2	Arabidopsis thaliana (Mouse-ear cress)	PR