Q01134

PR
Gene name
Chka (Chk, Ckr)
Protein name
Choline kinase alpha
Names
CK, CHETK-alpha, Ethanolamine kinase, EK
Species
Rattus norvegicus (Rat)
KEGG Pathway
rno:29194
EC number
2.7.1.32: Phosphotransferases with an alcohol group as acceptor
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-98 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q01134

Entry ID Method Resolution Chain Position Source
AF-Q01134-F1 Predicted AlphaFoldDB

No variants for Q01134

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q01134

No associated diseases with Q01134

No regional properties for Q01134

Type Name Position InterPro Accession
No domain, repeats, and functional sites for Q01134

Functions

Description
EC Number 2.7.1.32 Phosphotransferases with an alcohol group as acceptor
Subcellular Localization
  • Cytoplasm, cytosol
  • ;
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
lipid droplet An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins.

8 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
choline binding Binding to choline, the amine 2-hydroxy-N,N,N-trimethylethanaminium.
choline kinase activity Catalysis of the reaction: ATP + choline = ADP + choline phosphate + 2 H(+).
cholinesterase activity Catalysis of the reaction: an acylcholine + H2O = choline + a carboxylic acid anion.
ethanolamine kinase activity Catalysis of the reaction: ATP + ethanolamine = ADP + 2 H(+) + phosphoethanolamine.
identical protein binding Binding to an identical protein or proteins.
protein homodimerization activity Binding to an identical protein to form a homodimer.
protein tyrosine kinase activity Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate.

9 GO annotations of biological process

Name Definition
CDP-choline pathway The phosphatidylcholine biosynthetic process that begins with the phosphorylation of choline and ends with the combination of CDP-choline with diacylglycerol to form phosphatidylcholine.
cellular response to glucose starvation Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of glucose.
choline metabolic process The chemical reactions and pathways involving choline (2-hydroxyethyltrimethylammonium), an amino alcohol that occurs widely in living organisms as a constituent of certain types of phospholipids and in the neurotransmitter acetylcholine.
ethanolamine metabolic process The chemical reactions and pathways involving ethanolamine (2-aminoethanol), an important water-soluble base of phospholipid (phosphatidylethanolamine).
lipid droplet disassembly The disaggregation of a lipid particle into its constituent components.
phosphatidylcholine biosynthetic process The chemical reactions and pathways resulting in the formation of phosphatidylcholines, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of choline.
phosphatidylethanolamine biosynthetic process The chemical reactions and pathways resulting in the formation of phosphatidylethanolamine, any of a class of glycerophospholipids in which a phosphatidyl group is esterified to the hydroxyl group of ethanolamine.
response to 3-methylcholanthrene Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a 3-methylcholanthrene stimulus.
response to toxic substance Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a toxic stimulus.

8 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P20485 CKI1 Choline kinase Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PR
P54352 eas Ethanolamine kinase Drosophila melanogaster (Fruit fly) PR
P35790 CHKA Choline kinase alpha Homo sapiens (Human) PR
A7MCT6 Etnk2 Ethanolamine kinase 2 Mus musculus (Mouse) PR
Q9D4V0 Etnk1 Ethanolamine kinase 1 Mus musculus (Mouse) PR
O54804 Chka Choline kinase alpha Mus musculus (Mouse) PR
D3ZRW8 Etnk2 Ethanolamine kinase 2 Rattus norvegicus (Rat) PR
Q8L518 At1g74320 Probable choline kinase 2 Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MKTKFCTGGE AEPSPLGLLL SCGGSAAPTP GVGQQRDAAG ELESKQLGGR SQPLALPPPP
70 80 90 100 110 120
PPPLPLPPPP SPPLADEQPE PRTRRRAYLW CKEFLPGAWR GLREDQFHIS VIRGGLSNML
130 140 150 160 170 180
FQCSLPDSIA SVGDEPRKVL LRLYGAILKM RSCNKEGSEQ AQNENEFQGA EAMVLESVMF
190 200 210 220 230 240
AILAERSLGP KLYGIFPQGR LEQFIPSRRL DTEELCLPDI SAEIAEKMAT FHGMKMPFNK
250 260 270 280 290 300
EPKWLFGTME KYLNQVLRLK FSREARVQQL HKFLSYNLPL ELENLRSLLQ YTRSPVVFCH
310 320 330 340 350 360
NDCQEGNILL LEGQENSEKQ KLMLIDFEYS SYNYRGFDIG NHFCEWMYDY TYEKYPFFRA
370 380 390 400 410 420
NIQKYPTRKQ QLHFISSYLT TFQNDFESLS SEEQSATKED MLLEVNRFAL ASHFLWGLWS
430 440 450
IVQAKISSIE FGYMEYAQAR FDAYFDQKRK LGV