Q8L518
Gene name |
At1g74320 (F1O17.1) |
Protein name |
Probable choline kinase 2 |
Names |
|
Species |
Arabidopsis thaliana (Mouse-ear cress) |
KEGG Pathway |
ath:AT1G74320 |
EC number |
2.7.1.32: Phosphotransferases with an alcohol group as acceptor |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q8L518
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q8L518-F1 | Predicted | AlphaFoldDB |
33 variants for Q8L518
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| tmp_1_27941207_A_T | 6 | T>S | No | 1000Genomes | |
| tmp_1_27941284_G_C | 31 | E>D | No | 1000Genomes | |
| tmp_1_27941289_A_G | 33 | E>G | No | 1000Genomes | |
| ENSVATH13807230 | 45 | P>A | No | 1000Genomes | |
| ENSVATH05143847 | 106 | G>D | No | 1000Genomes | |
| tmp_1_27941746_G_A | 134 | G>S | No | 1000Genomes | |
| tmp_1_27941772_G_T | 142 | E>D | No | 1000Genomes | |
| ENSVATH13807234 | 150 | G>S | No | 1000Genomes | |
| ENSVATH13807235 | 158 | D>A | No | 1000Genomes | |
| tmp_1_27941828_G_A | 161 | R>Q | No | 1000Genomes | |
| tmp_1_27941970_A_C | 165 | T>P | No | 1000Genomes | |
| ENSVATH05143851 | 176 | A>T | No | 1000Genomes | |
| ENSVATH01535165 | 177 | K>T | No | 1000Genomes | |
| ENSVATH00142548 | 182 | D>G | No | 1000Genomes | |
| ENSVATH01535166 | 190 | M>L | No | 1000Genomes | |
| ENSVATH00142549 | 202 | I>F | No | 1000Genomes | |
| tmp_1_27942123_A_T | 216 | M>L | No | 1000Genomes | |
| ENSVATH00142552 | 282 | D>G | No | 1000Genomes | |
| ENSVATH13807247 | 284 | K>N | No | 1000Genomes | |
| ENSVATH05143857 | 284 | K>T | No | 1000Genomes | |
| ENSVATH05143858 | 288 | T>A | No | 1000Genomes | |
| ENSVATH00142553 | 288 | T>N | No | 1000Genomes | |
| ENSVATH00142553 | 288 | T>S | No | 1000Genomes | |
| ENSVATH05143859 | 290 | V>I | No | 1000Genomes | |
| tmp_1_27942644_C_G | 293 | L>V | No | 1000Genomes | |
| tmp_1_27942660_A_G | 298 | E>G | No | 1000Genomes | |
| tmp_1_27942687_T_C | 307 | I>T | No | 1000Genomes | |
| tmp_1_27942797_A_G | 316 | E>G | No | 1000Genomes | |
| ENSVATH14478674 | 336 | Y>* | No | 1000Genomes | |
| tmp_1_27942871_C_T | 341 | P>S | No | 1000Genomes | |
| ENSVATH01535176 | 345 | A>E | No | 1000Genomes | |
| tmp_1_27942896_A_G | 349 | H>R | No | 1000Genomes | |
| tmp_1_27942899_A_T | 350 | K>M | No | 1000Genomes |
No associated diseases with Q8L518
No regional properties for Q8L518
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for Q8L518 | |||
Functions
| Description | ||
|---|---|---|
| EC Number | 2.7.1.32 | Phosphotransferases with an alcohol group as acceptor |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| choline kinase activity | Catalysis of the reaction: ATP + choline = ADP + choline phosphate + 2 H(+). |
| ethanolamine kinase activity | Catalysis of the reaction: ATP + ethanolamine = ADP + 2 H(+) + phosphoethanolamine. |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| phosphatidylcholine biosynthetic process | The chemical reactions and pathways resulting in the formation of phosphatidylcholines, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of choline. |
| phosphatidylethanolamine biosynthetic process | The chemical reactions and pathways resulting in the formation of phosphatidylethanolamine, any of a class of glycerophospholipids in which a phosphatidyl group is esterified to the hydroxyl group of ethanolamine. |
| phosphorylation | The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide. |
9 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P20485 | CKI1 | Choline kinase | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| P54352 | eas | Ethanolamine kinase | Drosophila melanogaster (Fruit fly) | PR |
| Q9HBU6 | ETNK1 | Ethanolamine kinase 1 | Homo sapiens (Human) | PR |
| P35790 | CHKA | Choline kinase alpha | Homo sapiens (Human) | PR |
| Q9D4V0 | Etnk1 | Ethanolamine kinase 1 | Mus musculus (Mouse) | PR |
| A7MCT6 | Etnk2 | Ethanolamine kinase 2 | Mus musculus (Mouse) | PR |
| O54804 | Chka | Choline kinase alpha | Mus musculus (Mouse) | PR |
| D3ZRW8 | Etnk2 | Ethanolamine kinase 2 | Rattus norvegicus (Rat) | PR |
| Q01134 | Chka | Choline kinase alpha | Rattus norvegicus (Rat) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MTMGGTEKNV | ENKQYRLPRE | VKEALQAIAS | EWEDVIDSKA | LQVIPLKGAM | TNEVFQIKWP |
| 70 | 80 | 90 | 100 | 110 | 120 |
| TREKGPSRKV | LVRIYGEGVE | IFFDREDEIR | TFEFMSKHGH | GPLLLGRFGN | GRIEEFLHAR |
| 130 | 140 | 150 | 160 | 170 | 180 |
| TLSACDLRDP | EISGRIATRM | KEFHGLEMPG | AKKALLWDRL | RNWLTACKRL | ASPEEAKSFR |
| 190 | 200 | 210 | 220 | 230 | 240 |
| LDVMEMEINM | LEKSLFDNDE | NIGFCHNDLQ | YGNIMMDEET | KAITIIDYEY | SCYNPVAYDI |
| 250 | 260 | 270 | 280 | 290 | 300 |
| ANHFCEMAAD | YHTETPHIMD | YSKYPGVEER | QRFLKTYMSY | SDEKPSDTMV | KKLLEDVEKY |
| 310 | 320 | 330 | 340 | ||
| TLASHLIWGL | WGIISEHVNE | IDFDYMEYAR | QRFEQYWLTK | PRLLAASEHK |