P20485

PR
Gene name
CKI1
Protein name
Choline kinase
Names
ATP:choline phosphotransferase
Species
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
KEGG Pathway
sce:YLR133W
EC number
2.7.1.32: Phosphotransferases with an alcohol group as acceptor
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-130 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P20485

Entry ID Method Resolution Chain Position Source
AF-P20485-F1 Predicted AlphaFoldDB

10 variants for P20485

Variant ID(s) Position Change Description Diseaes Association Provenance
s12-408648 68 G>D No SGRP
s12-408710 89 V>I No SGRP
s12-408720 92 S>N No SGRP
s12-409271 276 K>E No SGRP
s12-409340 299 F>I No SGRP
s12-409418 325 I>V No SGRP
s12-409568 375 D>N No SGRP
s12-409601 386 Q>E No SGRP
s12-410007 521 E>G No SGRP
s12-410181 579 T>S No SGRP

No associated diseases with P20485

5 regional properties for P20485

Type Name Position InterPro Accession
domain WHEP-TRS domain 61 - 120 IPR000738
domain Aminoacyl-tRNA synthetase, class II (G/ P/ S/T) 294 - 588 IPR002314
domain Anticodon-binding 611 - 703 IPR004154
domain Aminoacyl-tRNA synthetase, class II 293 - 609 IPR006195
domain Glycyl-tRNA synthetase-like core domain 122 - 466 IPR033731

Functions

Description
EC Number 2.7.1.32 Phosphotransferases with an alcohol group as acceptor
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

3 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
choline kinase activity Catalysis of the reaction: ATP + choline = ADP + choline phosphate + 2 H(+).
ethanolamine kinase activity Catalysis of the reaction: ATP + ethanolamine = ADP + 2 H(+) + phosphoethanolamine.

3 GO annotations of biological process

Name Definition
phosphatidylcholine biosynthetic process The chemical reactions and pathways resulting in the formation of phosphatidylcholines, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of choline.
phosphatidylethanolamine biosynthetic process The chemical reactions and pathways resulting in the formation of phosphatidylethanolamine, any of a class of glycerophospholipids in which a phosphatidyl group is esterified to the hydroxyl group of ethanolamine.
phosphorylation The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide.

9 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P54352 eas Ethanolamine kinase Drosophila melanogaster (Fruit fly) PR
Q9HBU6 ETNK1 Ethanolamine kinase 1 Homo sapiens (Human) PR
P35790 CHKA Choline kinase alpha Homo sapiens (Human) PR
A7MCT6 Etnk2 Ethanolamine kinase 2 Mus musculus (Mouse) PR
Q9D4V0 Etnk1 Ethanolamine kinase 1 Mus musculus (Mouse) PR
O54804 Chka Choline kinase alpha Mus musculus (Mouse) PR
D3ZRW8 Etnk2 Ethanolamine kinase 2 Rattus norvegicus (Rat) PR
Q01134 Chka Choline kinase alpha Rattus norvegicus (Rat) PR
Q8L518 At1g74320 Probable choline kinase 2 Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MVQESRPGSV RSYSVGYQAR SRSSSQRRHS LTRQRSSQRL IRTISIESDV SNITDDDDLR
70 80 90 100 110 120
AVNEGVAGVQ LDVSETANKG PRRASATDVT DSLGSTSSEY IEIPFVKETL DASLPSDYLK
130 140 150 160 170 180
QDILNLIQSL KISKWYNNKK IQPVAQDMNL VKISGAMTNA IFKVEYPKLP SLLLRIYGPN
190 200 210 220 230 240
IDNIIDREYE LQILARLSLK NIGPSLYGCF VNGRFEQFLE NSKTLTKDDI RNWKNSQRIA
250 260 270 280 290 300
RRMKELHVGV PLLSSERKNG SACWQKINQW LRTIEKVDQW VGDPKNIENS LLCENWSKFM
310 320 330 340 350 360
DIVDRYHKWL ISQEQGIEQV NKNLIFCHND AQYGNLLFTA PVMNTPSLYT APSSTSLTSQ
370 380 390 400 410 420
SSSLFPSSSN VIVDDIINPP KQEQSQDSKL VVIDFEYAGA NPAAYDLANH LSEWMYDYNN
430 440 450 460 470 480
AKAPHQCHAD RYPDKEQVLN FLYSYVSHLR GGAKEPIDEE VQRLYKSIIQ WRPTVQLFWS
490 500 510 520 530 540
LWAILQSGKL EKKEASTAIT REEIGPNGKK YIIKTEPESP EEDFVENDDE PEAGVSIDTF
550 560 570 580
DYMAYGRDKI AVFWGDLIGL GIITEEECKN FSSFKFLDTS YL