Q96JG8

PR
Gene name
MAGED4B
Protein name
Melanoma-associated antigen D4
Names
MAGE-D4 antigen, MAGE-E1 antigen
Species
Homo sapiens (Human)
KEGG Pathway
hsa:81557
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-51 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q96JG8

Entry ID Method Resolution Chain Position Source
AF-Q96JG8-F1 Predicted AlphaFoldDB

29 variants for Q96JG8

Variant ID(s) Position Change Description Diseaes Association Provenance
CA413221815
rs1557383696
 122 A>T No ClinGen
Ensembl
rs1557375845
CA413219722
 122 A>T No ClinGen
Ensembl
CA413216954
rs1557375844
 408 R>G No ClinGen
Ensembl
CA413223790
rs1557383697
 408 R>G No ClinGen
Ensembl
rs1557383702
CA413224560
 511 V>I No ClinGen
Ensembl
rs1557375840
CA413215765
 511 V>I No ClinGen
Ensembl
rs1557383710
CA413225369
 598 N>K No ClinGen
gnomAD
rs1557383711
CA413225373
 599 R>Q No ClinGen
gnomAD
CA413225559
rs1602010009
 623 M>T No ClinGen
Ensembl
rs1602010018
CA413225573
 625 E>V No ClinGen
Ensembl
rs1557383714
CA413225589
 627 H>R No ClinGen
gnomAD
rs1602010031
CA413225605
 629 R>S No ClinGen
Ensembl
CA413225700
rs1557383717
 642 A>V No ClinGen
gnomAD
rs1557383720
CA413225722
 646 R>Q No ClinGen
gnomAD
CA413225830
rs1557383721
 661 E>K No ClinGen
gnomAD
rs1557383728
CA413226039
 689 R>H No ClinGen
gnomAD
CA10417762
rs782042156
 700 V>I No ClinGen
ExAC
gnomAD
CA413226146
rs868946464
 705 N>S No ClinGen
gnomAD
rs782149392
CA10417763
 709 S>G No ClinGen
ExAC
gnomAD
rs782394547
CA10417764
 712 V>I No ClinGen
ExAC
gnomAD
CA413226226
rs1557383736
 717 S>R No ClinGen
gnomAD
rs1557383740
CA413226247
 721 T>P No ClinGen
gnomAD
rs781992579
CA10417765
 723 R>Q No ClinGen
ExAC
gnomAD
CA413226261
rs1557383742
 723 R>W No ClinGen
gnomAD
CA10417766
rs782089484
 728 A>G No ClinGen
ExAC
gnomAD
rs782724575
CA10417767
 732 A>G No ClinGen
ExAC
gnomAD
rs1557383747
CA413226316
 732 A>T No ClinGen
gnomAD
rs781932311
CA10417768
 733 S>G No ClinGen
ExAC
gnomAD
rs782779782
CA10417787
 741 R>H No ClinGen
ExAC
gnomAD

No associated diseases with Q96JG8

1 regional properties for Q96JG8

Type Name Position InterPro Accession
domain MAGE homology domain 413 - 611 IPR002190

Functions

Description
EC Number
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

No GO annotations of molecular function

Name Definition
No GO annotations for molecular function

1 GO annotations of biological process

Name Definition
negative regulation of transcription by RNA polymerase II Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.

20 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
A6QLI5 MAGED4 Melanoma-associated antigen D4 Bos taurus (Bovine) PR
P43356 MAGEA2B Melanoma-associated antigen 2 Homo sapiens (Human) PR
Q96JG8 MAGED4B Melanoma-associated antigen D4 Homo sapiens (Human) PR
O15479 MAGEB2 Melanoma-associated antigen B2 Homo sapiens (Human) PR
Q96MG7 NSMCE3 Non-structural maintenance of chromosomes element 3 homolog Homo sapiens (Human) PR
Q8TD90 MAGEE2 Melanoma-associated antigen E2 Homo sapiens (Human) PR
O15480 MAGEB3 Melanoma-associated antigen B3 Homo sapiens (Human) PR
P43365 MAGEA12 Melanoma-associated antigen 12 Homo sapiens (Human) PR
P43361 MAGEA8 Melanoma-associated antigen 8 Homo sapiens (Human) PR
P43364 MAGEA11 Melanoma-associated antigen 11 Homo sapiens (Human) PR
P43355 MAGEA1 Melanoma-associated antigen 1 Homo sapiens (Human) PR
P43358 MAGEA4 Melanoma-associated antigen 4 Homo sapiens (Human) PR
P43357 MAGEA3 Melanoma-associated antigen 3 Homo sapiens (Human) PR
P43360 MAGEA6 Melanoma-associated antigen 6 Homo sapiens (Human) PR
P43363 MAGEA10 Melanoma-associated antigen 10 Homo sapiens (Human) PR
Q9UNF1 MAGED2 Melanoma-associated antigen D2 Homo sapiens (Human) PR
Q9Y5V3 MAGED1 Melanoma-associated antigen D1 Homo sapiens (Human) PR
Q9BZ81 MAGEB5 Melanoma-associated antigen B5 Homo sapiens (Human) PR
Q9HAY2 MAGEF1 Melanoma-associated antigen F1 Homo sapiens (Human) PR
Q9QYH6 Maged1 Melanoma-associated antigen D1 Mus musculus (Mouse) PR
10 20 30 40 50 60
MAEGSFSVQS ESYSVEDMDE GSDEVGEEEM VEGNDYEEFG AFGGYGTLTS FDIHILRAFG
70 80 90 100 110 120
SLGPGLRILS NEPWELENPV LAQTLVEALQ LDPETLANET AARAANVARA AASNRAARAA
130 140 150 160 170 180
AAAARTAFSQ VVASHRVATP QVSGEDTQPT TYAAEAQGPT PEPPLASPQT SQMLVTSKMA
190 200 210 220 230 240
APEAPATSAQ SQTGSPAQEA ATEGPSSACA FSQAPCAREV DANRPSTAFL GQNDVFDFTQ
250 260 270 280 290 300
PAGVSGMAFP RPKRPAPAQE AATEGPSAAS GVPQTGPGRE VAATRPKTTK SGKALAKTRW
310 320 330 340 350 360
VEPQNVVAAA AAKAKMATSI PEPEGAAAAT AQHSAEPWAR MGGKRTKKSK HLDDEYESSE
370 380 390 400 410 420
EERETPAVPP TWRASQPSLT VRAQLAPRPP MAPRSQIPSR HVLCLPPRNV TLLQERANKL
430 440 450 460 470 480
VKYLMIKDYK KIPIKRADML KDVIREYDEH FPEIIERATY TLEKKFGIHL KEIDKEEHLY
490 500 510 520 530 540
ILVCTRDSSA RLLGKTKDTP RLSLLLVILG VIFMNGNRAS EAVLWEALRK MGLRPGVRHP
550 560 570 580 590 600
FLGDLRKLIT DDFVKQKYLE YKKIPNSNPP EYEFLWGLRA RHETSKMRVL RFIAQNQNRD
610 620 630 640 650 660
PREWKAHFLE AVDDAFKTMD VDMAEEHARA QMRAQMNIGD EALIGRWSWD DIQVELLTWD
670 680 690 700 710 720
EDGDFGDAWA RIPFAFWARY HQYILNSNRA NRRATWRAGV SSGTNGGAST SVLDGPSTSS
730 740
TIRTRNAARA GASFFSWIQH R