P43357
PR
Gene name |
MAGEA3 |
Protein name |
Melanoma-associated antigen 3 |
Names |
Antigen MZ2-D, Cancer/testis antigen 1.3, CT1.3, MAGE-3 antigen |
Species |
Homo sapiens (Human) |
KEGG Pathway |
hsa:4102 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
4 structures for P43357
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 1QEW | X-ray | 220 A | C | 271-279 | PDB |
| 4V0P | X-ray | 207 A | A | 104-314 | PDB |
| 5BRZ | X-ray | 262 A | C | 168-176 | PDB |
| AF-P43357-F1 | Predicted | AlphaFoldDB |
366 variants for P43357
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
|
rs1556825929 CA10544563 |
2 | P>S | No |
ClinGen TOPMed |
|
|
CA415061327 rs1556825941 |
8 | Q>H | No |
ClinGen gnomAD |
|
|
rs35123853 CA415061385 |
10 | C>Y | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
| TCGA novel | 12 | P>A | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA415061462 rs1556825947 |
13 | E>V | No |
ClinGen gnomAD |
|
|
CA415061488 rs1556825950 |
14 | E>K | No |
ClinGen gnomAD |
|
|
CA415061531 rs782264103 |
16 | L>F | No |
ClinGen 1000Genomes gnomAD |
|
| TCGA novel | 17 | E>Q | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
| TCGA novel | 18 | A>T | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs1478258146 CA415061596 |
19 | R>G | No |
ClinGen TOPMed gnomAD |
|
|
CA10544562 rs1556825956 |
19 | R>Q | No |
ClinGen gnomAD |
|
| TCGA novel | 21 | E>K | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs782489065 CA415061652 |
21 | E>Q | No |
ClinGen ExAC gnomAD |
|
|
CA415061689 rs1556825959 |
22 | A>G | No |
ClinGen gnomAD |
|
|
CA415061710 rs1569458710 |
24 | G>C | No |
ClinGen Ensembl |
|
|
CA415061751 rs1426131243 |
26 | V>L | No |
ClinGen TOPMed |
|
|
CA415061777 rs1556825964 |
27 | G>D | No |
ClinGen gnomAD |
|
|
rs782605651 CA10544561 |
28 | A>V | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1556825973 CA415061802 |
29 | Q>* | No |
ClinGen gnomAD |
|
|
rs782454114 CA415061820 |
31 | P>A | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA415061821 rs782454114 |
31 | P>S | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs782454114 CA415061819 |
31 | P>T | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1436053705 CA415061829 |
32 | A>S | No |
ClinGen TOPMed |
|
|
CA415061899 rs1556825979 CA415061901 |
35 | E>D | No |
ClinGen gnomAD |
|
|
rs782679870 CA415061910 |
36 | Q>E | No |
ClinGen ExAC gnomAD |
|
|
rs782282148 CA415061919 |
36 | Q>R | No |
ClinGen ExAC gnomAD |
|
|
rs1556825990 CA415061935 |
37 | E>Q | No |
ClinGen gnomAD |
|
|
rs1556825992 CA415061960 |
38 | A>T | No |
ClinGen gnomAD |
|
|
rs1602852368 CA415062017 |
41 | S>Y | No |
ClinGen Ensembl |
|
|
CA415062028 rs1556826007 |
42 | S>T | No |
ClinGen gnomAD |
|
|
CA415062060 rs1272002095 |
43 | S>F | No |
ClinGen TOPMed |
|
|
rs1556826021 CA415062128 |
46 | V>A | No |
ClinGen Ensembl |
|
|
CA415062120 rs1319547122 |
46 | V>I | No |
ClinGen TOPMed |
|
|
CA415062143 rs1569458742 |
47 | E>K | No |
ClinGen Ensembl |
|
|
CA415062172 rs1355489850 |
48 | V>G | No |
ClinGen TOPMed |
|
|
rs1556826028 CA10544556 |
48 | V>L | No |
ClinGen TOPMed |
|
|
rs1556826046 CA415062233 |
51 | G>E | No |
ClinGen gnomAD |
|
|
CA415062257 rs1556826051 |
52 | E>D | No |
ClinGen gnomAD |
|
|
rs782415871 CA337178863 |
53 | V>L | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs782415871 CA10544549 |
53 | V>M | No |
ClinGen ExAC TOPMed gnomAD |
|
| TCGA novel | 56 | A>S | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA415062348 rs1402923812 |
56 | A>V | No |
ClinGen TOPMed |
|
|
CA415062383 rs1556826067 |
57 | E>D | No |
ClinGen gnomAD |
|
|
CA415062362 rs1475020079 |
57 | E>K | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA TOPMed gnomAD |
|
rs782113261 CA415062377 |
57 | E>V | No |
ClinGen ExAC gnomAD |
|
|
rs144481382 CA10544547 |
60 | D>H | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
rs144481382 CA415062417 |
60 | D>N | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
rs1556826075 CA415062450 |
62 | P>L | No |
ClinGen gnomAD |
|
|
CA337178901 rs1556826083 |
63 | Q>H | No |
ClinGen gnomAD |
|
|
rs781911633 CA415062481 |
64 | S>N | No |
ClinGen ExAC gnomAD |
|
|
rs1556826086 CA10544541 |
66 | Q>R | No |
ClinGen TOPMed |
|
|
rs1556826094 CA415062527 |
68 | A>G | No |
ClinGen TOPMed |
|
|
CA337178938 rs1556826088 |
68 | A>S | No |
ClinGen TOPMed |
|
|
CA415062532 rs1556826098 |
69 | S>P | No |
ClinGen gnomAD |
|
|
CA415062540 rs1458882797 |
70 | S>R | No |
ClinGen TOPMed |
|
|
rs782533858 CA415062563 |
71 | L>P | No |
ClinGen ExAC gnomAD |
|
|
CA415062580 rs782667045 |
72 | P>L | No |
ClinGen ExAC gnomAD |
|
|
rs781830379 CA415062588 |
73 | T>N | No |
ClinGen ExAC gnomAD |
|
|
rs1271064035 CA415062598 |
74 | T>A | No |
ClinGen TOPMed |
|
| TCGA novel | 75 | M>I | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA415062606 rs376199306 |
75 | M>L | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs1556826133 CA415062614 |
75 | M>T | No |
ClinGen TOPMed gnomAD |
|
|
CA415062608 rs376199306 |
75 | M>V | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA415062631 rs1321992954 |
76 | N>S | No |
ClinGen TOPMed |
|
|
CA10544536 rs782179243 |
77 | Y>C | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA TOPMed gnomAD |
|
rs1556826135 CA415062641 |
77 | Y>H | No |
ClinGen gnomAD |
|
|
rs1221634514 CA415062678 |
78 | P>R | No |
ClinGen TOPMed |
|
|
rs782420250 CA10544535 |
78 | P>S | No |
ClinGen ExAC gnomAD |
|
|
rs1309096110 CA415062738 |
80 | W>C | No |
ClinGen TOPMed |
|
|
CA415062763 rs782664023 |
81 | S>N | No |
ClinGen ExAC gnomAD |
|
|
rs1448194730 CA415062769 |
81 | S>R | No |
ClinGen TOPMed gnomAD |
|
|
rs371118717 CA415062823 |
83 | S>C | No |
ClinGen ESP ExAC gnomAD |
|
|
rs371118717 CA415062821 |
83 | S>F | No |
ClinGen ESP ExAC gnomAD |
|
|
CA415062849 rs782081925 |
84 | Y>C | No |
ClinGen ExAC gnomAD |
|
|
rs1379524477 CA415062837 |
84 | Y>D | No |
ClinGen TOPMed |
|
|
CA415062852 rs782081925 |
84 | Y>F | No |
ClinGen ExAC gnomAD |
|
|
CA10544534 rs782328621 |
86 | D>G | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs782328621 CA337179002 |
86 | D>V | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1556826182 CA415063018 |
90 | Q>K | No |
ClinGen gnomAD |
|
| TCGA novel | 91 | E>* | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA10544530 rs782041540 |
94 | G>E | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA TOPMed |
|
rs782802426 CA415063230 |
95 | P>L | No |
ClinGen ExAC gnomAD |
|
| TCGA novel | 96 | S>N | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA415063292 rs782089346 |
98 | F>S | No |
ClinGen ExAC gnomAD |
|
|
CA415063306 rs782715078 |
99 | P>S | Variant assessed as Somatic; impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA gnomAD |
|
CA415063302 rs782715078 |
99 | P>T | Variant assessed as Somatic; impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA gnomAD |
|
rs781797577 CA415063320 |
100 | D>N | No |
ClinGen ExAC gnomAD |
|
|
CA10544525 rs1556826208 |
102 | E>G | No |
ClinGen TOPMed |
|
|
CA415063368 rs1556826207 |
102 | E>Q | Variant assessed as Somatic; impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA gnomAD |
|
CA337179050 rs1556826223 |
104 | E>D | No |
ClinGen TOPMed |
|
|
CA415063394 rs782091871 |
104 | E>K | No |
ClinGen 1000Genomes ExAC TOPMed |
|
|
CA10544523 rs782091871 |
104 | E>Q | No |
ClinGen 1000Genomes ExAC TOPMed |
|
| TCGA novel | 106 | Q>H | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs376254989 CA415063494 |
108 | A>G | No |
ClinGen ESP ExAC gnomAD |
|
|
rs782224756 CA10544517 |
109 | L>I | No |
ClinGen ExAC gnomAD |
|
|
CA10544516 rs782483422 |
110 | S>N | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs782578721 CA415063580 |
110 | S>R | No |
ClinGen ExAC gnomAD |
|
|
rs1556826230 CA415063558 |
110 | S>R | No |
ClinGen gnomAD |
|
|
CA337179098 rs782483422 |
110 | S>T | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1556826235 CA415063630 |
112 | K>E | No |
ClinGen gnomAD |
|
|
CA337179109 rs142634954 |
113 | V>L | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA519163440 rs1248162986 |
115 | E>* | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA415063729 rs782270510 |
115 | E>G | No |
ClinGen ExAC gnomAD |
|
|
CA10544511 RCV000900798 rs1248162986 |
115 | E>K | No |
ClinGen ClinVar ESP ExAC TOPMed dbSNP gnomAD |
|
|
rs1248162986 CA519163439 |
115 | E>Q | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs1556826263 CA415063797 |
118 | H>P | No |
ClinGen gnomAD |
|
|
rs1556826261 CA415063796 |
118 | H>Y | Variant assessed as Somatic; impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA gnomAD |
|
rs782382036 CA415063805 |
119 | F>I | No |
ClinGen ExAC gnomAD |
|
|
rs782382036 CA415063807 |
119 | F>L | No |
ClinGen ExAC gnomAD |
|
|
rs782056374 CA415063882 |
122 | L>F | No |
ClinGen ExAC gnomAD |
|
| TCGA novel | 122 | L>R | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs782700886 CA415063897 |
123 | K>Q | No |
ClinGen ExAC gnomAD |
|
|
rs1569458897 CA415063918 |
124 | Y>C | No |
ClinGen Ensembl |
|
|
COSM1117176 CA10544507 rs782026359 |
125 | R>* | Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic] | No |
ClinGen cosmic curated ExAC NCI-TCGA gnomAD |
|
rs782026359 CA337179219 |
125 | R>G | No |
ClinGen ExAC gnomAD |
|
|
CA10544505 rs140660790 |
125 | R>Q | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA337179268 rs1556826293 |
126 | A>D | No |
ClinGen TOPMed gnomAD |
|
|
CA10544503 rs1556826293 |
126 | A>V | No |
ClinGen TOPMed gnomAD |
|
|
CA415063942 rs1301683493 |
127 | R>K | No |
ClinGen TOPMed gnomAD |
|
|
CA415063954 rs782474244 |
128 | E>Q | No |
ClinGen ExAC gnomAD |
|
|
CA10544502 rs370292729 |
129 | P>L | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD |
|
CA337179283 rs370292729 |
129 | P>R | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs1386626430 CA415063965 |
129 | P>S | No |
ClinGen TOPMed |
|
|
CA10544500 rs782497930 |
130 | V>F | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA337179310 rs782497930 |
130 | V>I | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1428918230 CA415063985 |
131 | T>P | No |
ClinGen TOPMed |
|
| TCGA novel | 134 | E>D | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA415064047 rs1556826320 |
135 | M>I | No |
ClinGen gnomAD |
|
|
rs1359938410 CA415064038 |
135 | M>V | No |
ClinGen TOPMed |
|
|
CA10544497 rs782317072 |
137 | G>E | No |
ClinGen ExAC gnomAD |
|
|
rs1556826327 CA415064080 |
138 | S>T | No |
ClinGen gnomAD |
|
|
rs1556826333 CA337179334 |
139 | V>I | No |
ClinGen gnomAD |
|
|
rs782278365 COSM457002 CA10544494 |
140 | V>I | Variant assessed as Somatic; 0.0 impact. breast [NCI-TCGA, Cosmic] | No |
ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD |
|
CA337179348 rs782278365 |
140 | V>L | No |
ClinGen ExAC TOPMed gnomAD |
|
|
COSM1466420 CA10544491 rs150014878 |
141 | G>R | large_intestine [Cosmic] | No |
ClinGen cosmic curated 1000Genomes ESP ExAC TOPMed gnomAD |
|
CA415064126 rs1172778460 |
142 | N>D | No |
ClinGen TOPMed |
|
|
rs1556826362 CA10544488 CA415064148 |
143 | W>C | No |
ClinGen gnomAD |
|
|
CA10544489 rs145228268 |
143 | W>L | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA415064138 rs1556826352 |
143 | W>R | No |
ClinGen gnomAD |
|
|
CA10544490 rs145228268 |
143 | W>S | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA415064157 rs782730060 |
144 | Q>P | No |
ClinGen ExAC gnomAD |
|
|
rs1556826367 CA10544486 |
145 | Y>D | No |
ClinGen gnomAD |
|
|
rs782657742 CA415064170 COSM755845 |
146 | F>L | lung [Cosmic] | No |
ClinGen cosmic curated TOPMed gnomAD |
|
rs1556826380 COSM755845 CA10544483 |
146 | F>L | lung Variant assessed as Somatic; 0.0 impact. [Cosmic, NCI-TCGA] | No |
ClinGen cosmic curated NCI-TCGA TOPMed |
|
rs1556826383 CA415064183 |
147 | F>L | No |
ClinGen gnomAD |
|
|
CA415064190 rs782051609 |
147 | F>Y | No |
ClinGen ExAC gnomAD |
|
|
rs782712845 CA415064208 |
148 | P>L | Variant assessed as Somatic; impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA gnomAD |
|
rs1556826393 CA415064220 |
149 | V>A | Variant assessed as Somatic; impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA gnomAD |
|
CA415064214 rs781881814 |
149 | V>M | No |
ClinGen ExAC gnomAD |
|
|
rs1485362196 CA415064240 |
151 | F>L | No |
ClinGen TOPMed |
|
| TCGA novel | 152 | S>G | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs7056365 VAR_053493 CA10544480 |
152 | S>I | No |
ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD |
|
|
CA10544479 rs1556826402 |
152 | S>R | No |
ClinGen TOPMed |
|
|
rs1556826413 CA10544478 |
153 | K>E | No |
ClinGen TOPMed |
|
|
CA10544477 rs373650973 |
154 | A>P | No |
ClinGen ESP TOPMed gnomAD |
|
|
CA415064282 rs373650973 |
154 | A>S | No |
ClinGen ESP TOPMed gnomAD |
|
|
CA415064280 rs373650973 |
154 | A>T | No |
ClinGen ESP TOPMed gnomAD |
|
|
CA415064296 rs1556826426 |
155 | S>C | No |
ClinGen gnomAD |
|
|
rs782460836 CA519163721 |
156 | S>C | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs782460836 CA10544475 RCV000893782 |
156 | S>G | No |
ClinGen ClinVar ExAC TOPMed dbSNP gnomAD |
|
|
CA10544474 rs782764980 RCV000897126 |
156 | S>N | No |
ClinGen ClinVar 1000Genomes ExAC TOPMed dbSNP gnomAD |
|
|
rs1212998540 CA415064307 |
156 | S>R | No |
ClinGen TOPMed gnomAD |
|
|
CA415064317 rs1340187332 |
157 | S>Y | No |
ClinGen TOPMed gnomAD |
|
|
rs1298872460 CA415064339 |
159 | Q>L | No |
ClinGen TOPMed gnomAD |
|
|
rs1298872460 CA415064337 |
159 | Q>P | No |
ClinGen TOPMed gnomAD |
|
|
rs782694559 CA337179518 |
164 | I>F | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA10544472 rs782694559 |
164 | I>V | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs782244390 CA415064371 |
165 | E>A | No |
ClinGen ExAC gnomAD |
|
|
CA10544471 rs1556826458 |
165 | E>K | No |
ClinGen gnomAD |
|
|
CA415064376 rs781822580 |
166 | L>M | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA415064377 rs781822580 |
166 | L>V | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA10544469 rs782594164 |
167 | M>I | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1168114187 CA415064382 |
167 | M>L | No |
ClinGen TOPMed gnomAD |
|
|
rs1168114187 CA415064383 |
167 | M>V | No |
ClinGen TOPMed gnomAD |
|
|
rs782233501 CA415064422 |
169 | V>A | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA415064423 rs782233501 |
169 | V>G | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1556826479 CA415064418 |
169 | V>M | No |
ClinGen gnomAD |
|
|
CA415064435 rs1556826490 |
170 | D>V | No |
ClinGen gnomAD |
|
|
rs1556826499 CA10544466 |
173 | G>S | No |
ClinGen TOPMed gnomAD |
|
|
rs782147006 CA415064485 |
173 | G>V | No |
ClinGen ExAC gnomAD |
|
|
CA415064502 rs782412538 |
174 | H>L | No |
ClinGen ExAC gnomAD |
|
|
rs781981002 CA415064506 |
174 | H>Q | No |
ClinGen ExAC TOPMed |
|
|
CA10544465 rs1556826506 |
174 | H>Y | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA TOPMed |
|
rs1200348365 CA415064514 |
175 | L>M | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
rs1200348365 COSM1466419 CA10544464 |
175 | L>V | large_intestine [Cosmic] | No |
ClinGen cosmic curated 1000Genomes ESP ExAC TOPMed gnomAD |
|
CA10544462 rs1556826532 |
178 | F>L | No |
ClinGen TOPMed gnomAD |
|
|
rs375835600 CA10544461 |
179 | A>V | No |
ClinGen ESP ExAC gnomAD |
|
|
rs782075446 CA415064645 |
180 | T>A | No |
ClinGen ExAC gnomAD |
|
|
CA415064653 rs1258115634 |
180 | T>I | No |
ClinGen TOPMed |
|
|
CA415064671 rs1556826546 |
181 | C>S | No |
ClinGen gnomAD |
|
|
rs782802387 CA415064703 |
183 | G>A | No |
ClinGen ExAC gnomAD |
|
|
CA415064701 rs782802387 |
183 | G>D | No |
ClinGen ExAC gnomAD |
|
|
CA10544458 rs1556826552 |
183 | G>S | No |
ClinGen TOPMed gnomAD |
|
|
rs781902716 CA415064726 |
184 | L>F | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA10544457 rs781902716 |
184 | L>V | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
rs1556826567 CA415064750 |
185 | S>C | No |
ClinGen TOPMed |
|
|
CA415064744 rs1556826565 |
185 | S>P | No |
ClinGen gnomAD |
|
|
CA415064770 rs781824026 |
186 | Y>C | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA415064761 rs1220719013 |
186 | Y>H | No |
ClinGen TOPMed |
|
|
rs1556826582 COSM1715827 CA10544455 |
187 | D>N | Variant assessed as Somatic; 0.0 impact. skin [NCI-TCGA, Cosmic] | No |
ClinGen cosmic curated NCI-TCGA TOPMed gnomAD |
|
CA415028117 rs1556826586 |
188 | G>S | No |
ClinGen gnomAD |
|
|
rs1569459068 CA415028131 |
190 | L>Q | No |
ClinGen Ensembl |
|
|
rs1556826592 CA10544453 |
191 | G>C | No |
ClinGen TOPMed gnomAD |
|
|
CA337159296 rs1556826592 |
191 | G>R | No |
ClinGen TOPMed gnomAD |
|
|
rs782405934 CA415028148 |
192 | D>N | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA415028167 rs782678450 |
193 | N>S | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs782243919 CA415028187 |
194 | Q>H | No |
ClinGen ExAC gnomAD |
|
|
rs782388710 CA337159308 |
195 | I>L | No |
ClinGen ExAC gnomAD |
|
|
CA415028195 rs1172316168 |
195 | I>T | No |
ClinGen TOPMed |
|
|
CA415028227 rs781944468 |
198 | K>Q | No |
ClinGen ExAC gnomAD |
|
|
CA415028235 rs145852745 |
198 | K>R | No |
ClinGen 1000Genomes ESP ExAC gnomAD |
|
|
CA415028247 rs1367348655 |
199 | A>E | No |
ClinGen TOPMed |
|
|
CA10544446 rs1459578488 |
199 | A>T | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
rs1367348655 CA415028244 |
199 | A>V | No |
ClinGen TOPMed |
|
|
CA415028261 rs1556826635 |
200 | G>A | No |
ClinGen gnomAD |
|
|
CA415028251 rs782024175 |
200 | G>R | No |
ClinGen ExAC gnomAD |
|
|
rs1556826637 CA10544444 |
201 | L>F | No |
ClinGen ExAC gnomAD |
|
|
rs1175992732 CA415028320 |
205 | V>A | No |
ClinGen TOPMed |
|
|
rs1258965349 CA10544441 |
205 | V>I | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen 1000Genomes ESP ExAC NCI-TCGA TOPMed gnomAD |
|
rs1258965349 CA415028316 |
205 | V>L | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
CA415028338 rs1556826664 |
207 | A>D | No |
ClinGen TOPMed |
|
|
rs782082209 CA10544437 |
209 | I>V | No |
ClinGen ExAC gnomAD |
|
|
rs782793391 CA415028374 |
210 | A>E | No |
ClinGen ExAC gnomAD |
|
|
rs150714849 CA10544435 |
210 | A>S | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs150714849 CA337159475 COSM1117172 |
210 | A>T | Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic] | No |
ClinGen cosmic curated ESP ExAC NCI-TCGA TOPMed gnomAD |
|
rs782793391 CA415028379 |
210 | A>V | No |
ClinGen ExAC gnomAD |
|
|
CA10544434 rs1333026174 |
211 | R>K | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA10544433 rs1556826697 |
212 | E>Q | No |
ClinGen TOPMed |
|
|
rs1245694960 CA415028418 |
213 | G>V | No |
ClinGen TOPMed |
|
|
rs868907159 CA415028425 |
214 | D>N | No |
ClinGen Ensembl |
|
|
CA415028442 rs137998711 |
215 | C>S | No |
ClinGen ESP ExAC gnomAD |
|
|
CA415028451 rs782646104 |
216 | A>V | No |
ClinGen ExAC gnomAD |
|
|
CA415028457 rs782281854 |
217 | P>L | No |
ClinGen ExAC gnomAD |
|
|
rs782281854 CA415028456 |
217 | P>R | No |
ClinGen ExAC gnomAD |
|
|
rs368156903 CA415028454 |
217 | P>S | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs1569459122 CA415028468 |
219 | E>* | Variant assessed as Somatic; impact. [NCI-TCGA] | No |
ClinGen Ensembl NCI-TCGA |
| TCGA novel | 220 | K>N | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA415028505 rs1304704216 |
223 | E>D | No |
ClinGen TOPMed |
|
|
rs1445987379 CA415028512 |
224 | E>D | No |
ClinGen TOPMed |
|
|
CA415028523 rs782441448 |
226 | S>T | No |
ClinGen ExAC gnomAD |
|
|
CA415028530 rs781988021 |
227 | V>A | No |
ClinGen ExAC gnomAD |
|
| TCGA novel | 228 | L>S | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs1556826774 CA10544430 |
229 | E>Q | No |
ClinGen TOPMed |
|
| TCGA novel | 229 | E>V | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA337159545 CA337159554 rs201532747 |
230 | V>L | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA10544429 rs201532747 |
230 | V>M | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA415028551 rs782051087 |
231 | F>L | No |
ClinGen ExAC |
|
|
CA415028559 rs1556826797 |
232 | E>Q | No |
ClinGen gnomAD |
|
|
CA415028571 rs782250868 |
233 | G>E | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
rs149483923 CA415028568 |
233 | G>W | No |
ClinGen ESP ExAC gnomAD |
|
|
rs782156750 CA415028580 |
235 | E>* | No |
ClinGen ExAC gnomAD |
|
|
CA415028583 rs782758488 |
235 | E>V | No |
ClinGen ExAC gnomAD |
|
|
CA337159579 rs781867592 |
236 | D>E | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA10544426 rs1556826819 |
236 | D>G | No |
ClinGen TOPMed |
|
| TCGA novel | 236 | D>Y | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs782468131 CA415028590 |
237 | S>G | No |
ClinGen ExAC gnomAD |
|
|
rs1556826838 CA415028597 |
238 | I>L | No |
ClinGen gnomAD |
|
|
CA415028599 rs1556826838 |
238 | I>V | No |
ClinGen gnomAD |
|
|
CA10544423 rs1239145925 CA519163686 |
239 | L>F | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA10544424 rs1556826840 |
239 | L>V | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA TOPMed |
|
CA415028606 rs782554920 CA415028605 |
240 | G>R | No |
ClinGen ExAC gnomAD |
|
|
rs1556826867 CA10544420 |
242 | P>S | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA TOPMed gnomAD |
|
CA337159638 rs1556826867 |
242 | P>T | No |
ClinGen TOPMed gnomAD |
|
|
rs1556826871 CA415028625 |
243 | K>R | No |
ClinGen gnomAD |
|
|
CA10544419 rs782681690 |
245 | L>V | No |
ClinGen ExAC gnomAD |
|
|
rs782517657 CA415028647 |
247 | T>A | No |
ClinGen ExAC gnomAD |
|
|
rs1358494889 CA519163712 |
249 | H>D | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
CA10544416 rs1358494889 |
249 | H>Y | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
rs1259074679 CA415028667 |
250 | F>C | No |
ClinGen TOPMed |
|
|
CA10544415 rs782271747 |
250 | F>L | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA337159703 rs376647411 COSM755846 |
251 | V>L | lung [Cosmic] | No |
ClinGen cosmic curated 1000Genomes ESP ExAC TOPMed gnomAD |
|
CA10544414 rs376647411 |
251 | V>M | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
rs1556826914 CA10544413 |
252 | Q>R | No |
ClinGen TOPMed |
|
|
CA415028681 rs1556826925 |
253 | E>G | No |
ClinGen gnomAD |
|
|
CA10544412 rs1556826927 |
254 | N>D | No |
ClinGen TOPMed |
|
|
rs1556826927 CA337159749 |
254 | N>H | No |
ClinGen TOPMed |
|
|
rs1556826932 CA415028686 |
254 | N>S | No |
ClinGen gnomAD |
|
|
rs1438530084 CA415028695 |
255 | Y>F | No |
ClinGen TOPMed |
|
|
CA10544410 rs1556826939 |
257 | E>Q | No |
ClinGen TOPMed |
|
|
CA415028715 rs782723696 |
258 | Y>C | No |
ClinGen ExAC gnomAD |
|
|
rs782707643 CA415028723 |
259 | R>L | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs782707643 CA415028721 |
259 | R>Q | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA TOPMed gnomAD |
|
rs782045437 CA415028720 |
259 | R>W | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA415028725 rs782117916 |
260 | Q>E | No |
ClinGen ExAC gnomAD |
|
|
rs782797722 CA415028730 |
260 | Q>H | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA10544409 rs782491242 |
261 | V>G | No |
ClinGen ExAC gnomAD |
|
|
CA415028732 rs781824205 |
261 | V>I | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA415028737 rs782534869 |
262 | P>H | No |
ClinGen ExAC |
|
|
rs782534869 CA415028738 |
262 | P>L | Variant assessed as Somatic; impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA |
|
rs1160976495 CA415028740 |
263 | G>D | No |
ClinGen TOPMed gnomAD |
|
|
rs782603431 CA10544405 |
263 | G>S | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA415028748 rs782220564 |
264 | S>N | No |
ClinGen ExAC gnomAD |
|
| TCGA novel | 264 | S>R | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA415028746 rs782220564 |
264 | S>T | No |
ClinGen ExAC gnomAD |
|
| TCGA novel | 265 | D>H | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA10544401 rs371872627 |
266 | P>A | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
| TCGA novel | 266 | P>L | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA10544400 rs781930988 |
266 | P>L | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA415028756 rs371872627 |
266 | P>S | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA415028757 rs371872627 |
266 | P>T | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA415028759 rs374730078 |
267 | A>P | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA415028758 rs374730078 |
267 | A>T | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs782087165 CA337159896 |
268 | C>F | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs782087165 CA10544399 |
268 | C>Y | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA415028771 rs782068507 |
269 | Y>C | No |
ClinGen ExAC gnomAD |
|
|
CA415028768 rs781793265 |
269 | Y>H | No |
ClinGen ExAC gnomAD |
|
|
rs12846936 CA415028782 |
270 | E>D | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA415028790 rs139885560 |
271 | F>L | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
CA415028785 rs782084893 |
271 | F>L | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
CA10544395 rs1556827058 |
273 | W>C | No |
ClinGen gnomAD |
|
| TCGA novel | 274 | G>V | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs1343970879 CA415028808 |
274 | G>V | No |
ClinGen TOPMed |
|
|
rs1234932431 CA415028812 |
275 | P>Q | No |
ClinGen TOPMed |
|
|
rs781819175 CA415028815 |
276 | R>G | No |
ClinGen ExAC gnomAD |
|
|
rs1556827076 CA415028817 |
276 | R>K | No |
ClinGen gnomAD |
|
|
rs1556827081 CA415028821 |
276 | R>S | No |
ClinGen gnomAD |
|
|
rs782491828 CA337159911 |
278 | L>F | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA10544393 rs782491828 |
278 | L>I | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA415028832 rs151030550 |
279 | V>A | No |
ClinGen 1000Genomes ESP ExAC gnomAD |
|
|
rs151030550 CA415028833 |
279 | V>D | No |
ClinGen 1000Genomes ESP ExAC gnomAD |
|
|
CA10544391 rs1361909824 COSM611535 |
279 | V>I | lung [Cosmic] | No |
ClinGen cosmic curated 1000Genomes ESP ExAC TOPMed gnomAD |
|
CA519163826 rs1361909824 |
279 | V>L | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
CA415028839 rs1556827106 |
280 | E>V | No |
ClinGen gnomAD |
|
|
rs1556827109 CA415028849 |
282 | S>G | No |
ClinGen gnomAD |
|
|
rs782640650 CA415028851 |
282 | S>N | No |
ClinGen ExAC gnomAD |
|
|
CA415028860 rs372708723 |
283 | Y>C | No |
ClinGen ESP ExAC gnomAD |
|
| TCGA novel | 283 | Y>N | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs781976450 CA415028865 |
284 | V>L | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs781976450 CA415028864 |
284 | V>M | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA415028876 rs1556827139 |
285 | K>N | No |
ClinGen gnomAD |
|
|
CA415028880 rs141015573 |
286 | V>L | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA337159928 rs1556827146 |
287 | L>M | No |
ClinGen gnomAD |
|
|
rs782165571 CA415028894 |
288 | H>Q | No |
ClinGen ExAC gnomAD |
|
|
rs1413294554 CA415028903 |
290 | M>L | No |
ClinGen TOPMed |
|
|
TCGA novel rs1401909115 CA415028913 |
291 | V>L | Variant assessed as Somatic; impact. [NCI-TCGA] | No |
ClinGen TOPMed NCI-TCGA |
|
CA337159965 rs1556827154 |
293 | I>L | No |
ClinGen gnomAD |
|
|
rs149795670 CA415028930 |
294 | S>G | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA415028942 rs782733244 |
296 | G>E | No |
ClinGen ExAC gnomAD |
|
|
rs782733244 CA415028944 |
296 | G>V | No |
ClinGen ExAC gnomAD |
|
|
rs1421845987 CA415028946 |
297 | P>A | No |
ClinGen TOPMed gnomAD |
|
|
rs782440006 CA415028948 |
297 | P>L | No |
ClinGen ExAC gnomAD |
|
|
rs1421845987 CA415028947 |
297 | P>S | No |
ClinGen TOPMed gnomAD |
|
|
CA337160027 rs1556827170 |
298 | H>D | No |
ClinGen TOPMed |
|
|
CA337160021 rs1556827170 |
298 | H>N | No |
ClinGen TOPMed |
|
|
CA519163854 rs1478156944 |
298 | H>P | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
rs1556827178 CA337160028 |
298 | H>Q | No |
ClinGen gnomAD |
|
|
rs1478156944 CA10544379 |
298 | H>R | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
CA10544377 rs1556827180 |
299 | I>V | No |
ClinGen TOPMed |
|
|
CA415028965 rs782528948 |
301 | Y>C | No |
ClinGen ExAC gnomAD |
|
|
CA10544376 rs782604854 |
302 | P>L | No |
ClinGen ExAC gnomAD |
|
|
CA337160047 rs782604854 |
302 | P>Q | No |
ClinGen ExAC gnomAD |
|
|
rs1556827186 CA415028971 |
302 | P>S | No |
ClinGen gnomAD |
|
|
CA337160056 rs1556827190 |
303 | P>A | No |
ClinGen TOPMed gnomAD |
|
|
rs1202032617 CA10544374 |
303 | P>L | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen 1000Genomes ExAC NCI-TCGA TOPMed gnomAD |
|
rs1556827190 CA337160057 |
303 | P>S | No |
ClinGen TOPMed gnomAD |
|
|
CA415028979 rs782580627 |
305 | H>Y | No |
ClinGen ExAC gnomAD |
|
|
rs782274286 CA415028984 |
306 | E>K | No |
ClinGen ExAC gnomAD |
|
|
CA10544369 rs782418549 CA337160119 |
307 | W>R | No |
ClinGen ExAC TOPMed gnomAD |
|
|
RCV000958044 CA10544367 rs1290943393 |
308 | V>A | No |
ClinGen ClinVar ExAC TOPMed dbSNP gnomAD |
|
|
CA415028995 rs1556827209 |
308 | V>I | No |
ClinGen gnomAD |
|
|
CA337160139 CA10544365 RCV000958043 rs782339504 |
309 | L>F | No |
ClinGen ClinVar ExAC TOPMed dbSNP gnomAD |
|
|
rs782264205 CA415029001 |
309 | L>S | No |
ClinGen ExAC TOPMed |
|
|
CA337160143 rs1556827244 CA10544363 |
311 | E>D | No |
ClinGen TOPMed |
|
|
rs781963365 CA415029011 |
311 | E>Q | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs782046696 CA10544364 |
311 | E>V | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA415029017 rs1466365767 |
312 | G>R | No |
ClinGen TOPMed |
No associated diseases with P43357
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| endoplasmic reticulum | The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| caspase binding | Binding to a caspase family protein. |
| histone deacetylase binding | Binding to histone deacetylase. |
5 GO annotations of biological process
| Name | Definition |
|---|---|
| negative regulation of autophagy | Any process that stops, prevents, or reduces the frequency, rate or extent of autophagy. Autophagy is the process in which cells digest parts of their own cytoplasm. |
| negative regulation of cysteine-type endopeptidase activity involved in apoptotic process | Any process that stops, prevents, or reduces the frequency, rate or extent of a cysteine-type endopeptidase activity involved in the apoptotic process. |
| negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway | Any process that stops, prevents or reduces the frequency, rate or extent of an endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway. |
| negative regulation of protein processing | Any process that decreases the rate, frequency or extent of protein maturation by peptide bond cleavage. |
| negative regulation of transcription by RNA polymerase II | Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II. |
17 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P43356 | MAGEA2B | Melanoma-associated antigen 2 | Homo sapiens (Human) | PR |
| O15479 | MAGEB2 | Melanoma-associated antigen B2 | Homo sapiens (Human) | PR |
| O15480 | MAGEB3 | Melanoma-associated antigen B3 | Homo sapiens (Human) | PR |
| P43355 | MAGEA1 | Melanoma-associated antigen 1 | Homo sapiens (Human) | PR |
| P43358 | MAGEA4 | Melanoma-associated antigen 4 | Homo sapiens (Human) | PR |
| P43360 | MAGEA6 | Melanoma-associated antigen 6 | Homo sapiens (Human) | PR |
| P43361 | MAGEA8 | Melanoma-associated antigen 8 | Homo sapiens (Human) | PR |
| P43363 | MAGEA10 | Melanoma-associated antigen 10 | Homo sapiens (Human) | PR |
| P43365 | MAGEA12 | Melanoma-associated antigen 12 | Homo sapiens (Human) | PR |
| Q8TD90 | MAGEE2 | Melanoma-associated antigen E2 | Homo sapiens (Human) | PR |
| Q96MG7 | NSMCE3 | Non-structural maintenance of chromosomes element 3 homolog | Homo sapiens (Human) | PR |
| Q9BZ81 | MAGEB5 | Melanoma-associated antigen B5 | Homo sapiens (Human) | PR |
| Q9HAY2 | MAGEF1 | Melanoma-associated antigen F1 | Homo sapiens (Human) | PR |
| P43364 | MAGEA11 | Melanoma-associated antigen 11 | Homo sapiens (Human) | PR |
| Q9UNF1 | MAGED2 | Melanoma-associated antigen D2 | Homo sapiens (Human) | PR |
| Q9Y5V3 | MAGED1 | Melanoma-associated antigen D1 | Homo sapiens (Human) | PR |
| Q96JG8 | MAGED4B | Melanoma-associated antigen D4 | Homo sapiens (Human) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MPLEQRSQHC | KPEEGLEARG | EALGLVGAQA | PATEEQEAAS | SSSTLVEVTL | GEVPAAESPD |
| 70 | 80 | 90 | 100 | 110 | 120 |
| PPQSPQGASS | LPTTMNYPLW | SQSYEDSSNQ | EEEGPSTFPD | LESEFQAALS | RKVAELVHFL |
| 130 | 140 | 150 | 160 | 170 | 180 |
| LLKYRAREPV | TKAEMLGSVV | GNWQYFFPVI | FSKASSSLQL | VFGIELMEVD | PIGHLYIFAT |
| 190 | 200 | 210 | 220 | 230 | 240 |
| CLGLSYDGLL | GDNQIMPKAG | LLIIVLAIIA | REGDCAPEEK | IWEELSVLEV | FEGREDSILG |
| 250 | 260 | 270 | 280 | 290 | 300 |
| DPKKLLTQHF | VQENYLEYRQ | VPGSDPACYE | FLWGPRALVE | TSYVKVLHHM | VKISGGPHIS |
| 310 | |||||
| YPPLHEWVLR | EGEE |