P43356
Gene name |
MAGEA2B (MAGE2, MAGEA2) |
Protein name |
Melanoma-associated antigen 2 |
Names |
Cancer/testis antigen 1.2, CT1.2, MAGE-2 antigen |
Species |
Homo sapiens (Human) |
KEGG Pathway |
hsa:4101 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for P43356
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P43356-F1 | Predicted | AlphaFoldDB |
4 variants for P43356
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
|
rs200459473 CA337160732 |
247 | M>I | No |
ClinGen Ensembl |
|
|
CA337173120 rs1556835648 |
247 | M>I | No |
ClinGen gnomAD |
|
|
CA337160728 rs202231943 |
247 | M>T | No |
ClinGen Ensembl |
|
|
CA337173122 rs1556835652 |
247 | M>T | No |
ClinGen gnomAD |
No associated diseases with P43356
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
| PML body | A class of nuclear body; they react against SP100 auto-antibodies (PML, promyelocytic leukemia); cells typically contain 10-30 PML bodies per nucleus; alterations in the localization of PML bodies occurs after viral infection. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| DNA-binding transcription factor binding | Binding to a DNA-binding transcription factor, a protein that interacts with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription. |
| histone deacetylase binding | Binding to histone deacetylase. |
| ubiquitin protein ligase binding | Binding to a ubiquitin protein ligase enzyme, any of the E3 proteins. |
7 GO annotations of biological process
| Name | Definition |
|---|---|
| cellular senescence | A cell aging process stimulated in response to cellular stress, whereby normal cells lose the ability to divide through irreversible cell cycle arrest. |
| negative regulation of protein acetylation | Any process that stops, prevents or reduces the frequency, rate or extent of protein acetylation. |
| negative regulation of protein sumoylation | Any process that stops, prevents, or reduces the frequency, rate or extent of the addition of SUMO groups to a protein. |
| negative regulation of transcription by RNA polymerase II | Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II. |
| positive regulation of ubiquitin-protein transferase activity | Any process that activates, maintains or increases the rate of ubiquitin transferase activity. |
| protein catabolic process | The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds. |
| signal transduction by p53 class mediator | An intracellular signaling process that is induced by the cell cycle regulator phosphoprotein p53 or an equivalent protein. |
17 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| O15479 | MAGEB2 | Melanoma-associated antigen B2 | Homo sapiens (Human) | PR |
| O15480 | MAGEB3 | Melanoma-associated antigen B3 | Homo sapiens (Human) | PR |
| P43355 | MAGEA1 | Melanoma-associated antigen 1 | Homo sapiens (Human) | PR |
| P43357 | MAGEA3 | Melanoma-associated antigen 3 | Homo sapiens (Human) | PR |
| P43358 | MAGEA4 | Melanoma-associated antigen 4 | Homo sapiens (Human) | PR |
| P43360 | MAGEA6 | Melanoma-associated antigen 6 | Homo sapiens (Human) | PR |
| P43361 | MAGEA8 | Melanoma-associated antigen 8 | Homo sapiens (Human) | PR |
| P43363 | MAGEA10 | Melanoma-associated antigen 10 | Homo sapiens (Human) | PR |
| P43364 | MAGEA11 | Melanoma-associated antigen 11 | Homo sapiens (Human) | PR |
| P43365 | MAGEA12 | Melanoma-associated antigen 12 | Homo sapiens (Human) | PR |
| Q8TD90 | MAGEE2 | Melanoma-associated antigen E2 | Homo sapiens (Human) | PR |
| Q96JG8 | MAGED4B | Melanoma-associated antigen D4 | Homo sapiens (Human) | PR |
| Q96MG7 | NSMCE3 | Non-structural maintenance of chromosomes element 3 homolog | Homo sapiens (Human) | PR |
| Q9BZ81 | MAGEB5 | Melanoma-associated antigen B5 | Homo sapiens (Human) | PR |
| Q9HAY2 | MAGEF1 | Melanoma-associated antigen F1 | Homo sapiens (Human) | PR |
| Q9UNF1 | MAGED2 | Melanoma-associated antigen D2 | Homo sapiens (Human) | PR |
| Q9Y5V3 | MAGED1 | Melanoma-associated antigen D1 | Homo sapiens (Human) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MPLEQRSQHC | KPEEGLEARG | EALGLVGAQA | PATEEQQTAS | SSSTLVEVTL | GEVPAADSPS |
| 70 | 80 | 90 | 100 | 110 | 120 |
| PPHSPQGASS | FSTTINYTLW | RQSDEGSSNQ | EEEGPRMFPD | LESEFQAAIS | RKMVELVHFL |
| 130 | 140 | 150 | 160 | 170 | 180 |
| LLKYRAREPV | TKAEMLESVL | RNCQDFFPVI | FSKASEYLQL | VFGIEVVEVV | PISHLYILVT |
| 190 | 200 | 210 | 220 | 230 | 240 |
| CLGLSYDGLL | GDNQVMPKTG | LLIIVLAIIA | IEGDCAPEEK | IWEELSMLEV | FEGREDSVFA |
| 250 | 260 | 270 | 280 | 290 | 300 |
| HPRKLLMQDL | VQENYLEYRQ | VPGSDPACYE | FLWGPRALIE | TSYVKVLHHT | LKIGGEPHIS |
| 310 | |||||
| YPPLHERALR | EGEE |