Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

Autoinhibited structure

Activated structure

3 structures for P43355

Entry ID Method Resolution Chain Position Source
1W72 X-ray 215 A C/F 161-169 PDB
3BO8 X-ray 180 A C 161-169 PDB
AF-P43355-F1 Predicted AlphaFoldDB

170 variants for P43355

Variant ID(s) Position Change Description Diseaes Association Provenance
CA415290646
rs1389171390
6 R>K No ClinGen
TOPMed
gnomAD
rs781891821
CA10546058
7 S>R No ClinGen
ExAC
TOPMed
gnomAD
TCGA novel 12 P>S Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
CA415290682
rs1556944064
12 P>T No ClinGen
gnomAD
rs781874892
CA10546055
13 E>K No ClinGen
ExAC
gnomAD
CA415290701
rs1444089551
14 E>D No ClinGen
TOPMed
CA10546054
rs782796633
15 A>D No ClinGen
1000Genomes
ExAC
gnomAD
CA415290734
rs1556944071
20 Q>K No ClinGen
gnomAD
TCGA novel 22 A>D Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
CA10546052
rs781934369
27 C>Y No ClinGen
ExAC
gnomAD
TCGA novel 28 V>E Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
rs1191077612
CA415290805
31 A>T No ClinGen
TOPMed
rs2008160
VAR_004283
CA10546050
32 T>A No ClinGen
UniProt
1000Genomes
ESP
ExAC
TOPMed
dbSNP
gnomAD
TCGA novel 32 T>I Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
rs781981187
CA10546049
33 S>A No ClinGen
ExAC
gnomAD
rs1203743166
CA415290827
34 S>F No ClinGen
TOPMed
gnomAD
TCGA novel 35 S>F Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
CA10546046
rs151247964
37 P>L No ClinGen
1000Genomes
ESP
ExAC
TOPMed
gnomAD
rs1266852633
CA415290860
40 L>P No ClinGen
TOPMed
gnomAD
rs1266852633
CA415290861
40 L>R No ClinGen
TOPMed
gnomAD
rs782207325
CA10546044
41 G>D No ClinGen
ExAC
TOPMed
gnomAD
rs782306002
CA10546045
41 G>S No ClinGen
ExAC
gnomAD
rs782098342
CA10546043
45 E>D No ClinGen
1000Genomes
ExAC
TOPMed
gnomAD
CA337641252
rs782559268
46 V>L No ClinGen
ExAC
TOPMed
gnomAD
CA10546042
rs782559268
46 V>M No ClinGen
ExAC
TOPMed
gnomAD
CA10546040
rs782643679
48 T>P No ClinGen
ExAC
gnomAD
rs1365830109
CA415290902
49 A>S No ClinGen
TOPMed
CA10546038
rs781985915
50 G>E No ClinGen
1000Genomes
ExAC
TOPMed
gnomAD
CA10546039
rs782483613
50 G>R No ClinGen
ExAC
TOPMed
gnomAD
TCGA novel 51 S>* Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
rs1392532041
CA415290911
51 S>P No ClinGen
TOPMed
gnomAD
CA10546036
rs111525045
53 D>H No ClinGen
1000Genomes
ESP
ExAC
TOPMed
gnomAD
rs1556944096
CA415290928
53 D>V No ClinGen
gnomAD
CA415290942
rs1383519941
55 P>L No ClinGen
TOPMed
CA415290947
rs1170562291
56 Q>R No ClinGen
TOPMed
rs781905272
CA10546035
57 S>G No ClinGen
ExAC
gnomAD
CA10546034
rs782761428
58 P>L No ClinGen
ExAC
TOPMed
gnomAD
CA337641261
rs144650259
61 A>G No ClinGen
ESP
gnomAD
VAR_053491
rs2233044
COSM1466466
CA10546032
63 A>T large_intestine [Cosmic] No ClinGen
cosmic curated
UniProt
1000Genomes
ESP
ExAC
TOPMed
dbSNP
gnomAD
CA10546030
rs782043198
65 P>L Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] No ClinGen
ExAC
NCI-TCGA
TOPMed
gnomAD
rs782733251
CA10546031
65 P>S No ClinGen
ExAC
gnomAD
TCGA novel 66 T>N Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
rs781929533
CA10546029
67 T>I No ClinGen
ExAC
gnomAD
rs782414241
CA10546028
68 I>T No ClinGen
ExAC
gnomAD
rs782303860
CA10546027
69 N>S No ClinGen
ExAC
TOPMed
gnomAD
COSM1117249
CA337641272
rs781993726
72 R>* Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic] No ClinGen
cosmic curated
ExAC
NCI-TCGA
TOPMed
gnomAD
VAR_011737
rs2008144
CA10546025
72 R>Q No ClinGen
UniProt
1000Genomes
ESP
ExAC
TOPMed
dbSNP
gnomAD
CA10546024
rs782211531
75 Q>* No ClinGen
ExAC
gnomAD
rs940562569
CA337641276
76 P>A No ClinGen
Ensembl
rs1556944112
CA415291063
77 S>G No ClinGen
gnomAD
CA10546023
rs782627136
77 S>I No ClinGen
ExAC
TOPMed
gnomAD
rs143755053
CA415291069
78 E>K No ClinGen
ESP
TOPMed
TCGA novel 80 S>A Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
CA415291105
rs1225102165
83 R>C No ClinGen
TOPMed
gnomAD
rs782432961
CA10546020
83 R>H No ClinGen
ExAC
TOPMed
gnomAD
rs1556944117
CA415291125
86 E>A No ClinGen
gnomAD
rs782207286
CA10546019
87 G>E No ClinGen
1000Genomes
ExAC
gnomAD
CA415291130
rs1556944118
87 G>R No ClinGen
gnomAD
rs782683172
CA10546018
88 P>L Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] No ClinGen
ExAC
NCI-TCGA
gnomAD
rs1283658297
CA415291141
89 S>N No ClinGen
TOPMed
rs781872243
CA10546016
90 T>I No ClinGen
ExAC
gnomAD
rs1404608153
CA415291157
92 C>S No ClinGen
TOPMed
rs782726763
CA10546015
93 I>F No ClinGen
ExAC
gnomAD
rs782491782
CA10546014
COSM1466465
96 S>P large_intestine [Cosmic] No ClinGen
cosmic curated
ExAC
gnomAD
CA415291184
rs1602751635
97 L>V No ClinGen
Ensembl
rs1556944129
CA415291193
98 F>Y No ClinGen
gnomAD
rs1363932326
CA415291199
99 R>* No ClinGen
TOPMed
gnomAD
rs1556944132
CA415291200
99 R>Q No ClinGen
gnomAD
CA10546013
rs61737513
100 A>V No ClinGen
1000Genomes
ESP
ExAC
TOPMed
gnomAD
CA415291231
rs1556944136
104 K>R No ClinGen
gnomAD
TCGA novel 108 D>A Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
rs1556944143
CA415291306
115 L>R No ClinGen
gnomAD
CA10546012
rs373351745
118 R>Q No ClinGen
ESP
ExAC
TOPMed
gnomAD
TCGA novel 123 V>I Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
CA415291407
rs1556944145
130 E>D No ClinGen
gnomAD
rs146942997
CA10546008
134 K>N No ClinGen
1000Genomes
ESP
ExAC
TOPMed
gnomAD
TCGA novel 136 Y>C Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
rs781959861
CA10546007
137 K>N No ClinGen
ExAC
gnomAD
CA415291493
rs1569525184
142 E>* No ClinGen
Ensembl
rs1556944151
CA415291514
145 G>S No ClinGen
gnomAD
rs782053099
CA10546005
148 S>F Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] No ClinGen
ExAC
NCI-TCGA
TOPMed
gnomAD
TCGA novel 150 S>P Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
rs1271618549
CA415291565
152 Q>R No ClinGen
TOPMed
TCGA novel 156 G>V Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
CA337641297
rs782245100
158 D>E No ClinGen
ExAC
TOPMed
gnomAD
CA415291610
rs782650488
159 V>L No ClinGen
ExAC
TOPMed
gnomAD
CA10546001
rs782650488
159 V>M No ClinGen
ExAC
TOPMed
gnomAD
CA415291627
rs1556944158
161 E>A No ClinGen
gnomAD
TCGA novel 161 E>D Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
CA415291641
rs1556944160
163 D>A No ClinGen
gnomAD
rs782661974
CA10546000
163 D>E No ClinGen
1000Genomes
ExAC
TOPMed
gnomAD
rs1556944159
CA415291639
163 D>H No ClinGen
gnomAD
rs1010428087
CA337641299
164 P>A No ClinGen
Ensembl
rs782563036
CA10545999
165 T>A No ClinGen
ExAC
gnomAD
rs782563036
CA10545998
165 T>P No ClinGen
ExAC
gnomAD
CA415291653
rs1290477231
166 G>S No ClinGen
TOPMed
gnomAD
TCGA novel 168 S>F Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
TCGA novel 169 Y>C Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
CA10545995
rs782682055
176 G>C No ClinGen
ExAC
TOPMed
gnomAD
rs782682055
CA337641308
176 G>R No ClinGen
ExAC
TOPMed
gnomAD
CA415291743
rs1556944169
177 L>I No ClinGen
gnomAD
rs144596051
CA415291758
178 S>F No ClinGen
ESP
TOPMed
rs782519489
CA10545994
179 Y>C No ClinGen
ExAC
gnomAD
rs782734083
CA10545992
184 G>A No ClinGen
ExAC
CA10545991
rs782105925
185 D>A No ClinGen
ExAC
gnomAD
rs1556944175
CA415291892
190 P>L No ClinGen
gnomAD
rs781792706
CA10545990
197 I>V No ClinGen
ExAC
gnomAD
rs1556944178
CA415291965
198 V>I No ClinGen
gnomAD
TCGA novel 201 M>I Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
CA10545989
rs782728367
204 M>V No ClinGen
ExAC
gnomAD
CA415292062
rs1556944186
206 G>D No ClinGen
gnomAD
TCGA novel 210 P>S Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
rs782555287
CA415292213
219 S>G No ClinGen
1000Genomes
rs781984291
CA10545987
221 M>T No ClinGen
ExAC
TOPMed
gnomAD
rs782169023
CA415292257
222 E>G No ClinGen
1000Genomes
CA337641326
rs1034431294
222 E>K Variant assessed as Somatic; impact. [NCI-TCGA] No ClinGen
NCI-TCGA
TOPMed
rs952057687
CA337641329
223 V>M No ClinGen
Ensembl
rs1470295473
CA415292277
224 Y>F No ClinGen
TOPMed
rs782381592
CA10545986
225 D>V No ClinGen
ExAC
TOPMed
gnomAD
rs373257494
CA10545984
229 H>N No ClinGen
ESP
ExAC
TOPMed
gnomAD
CA10545983
rs782306135
229 H>Q No ClinGen
ExAC
TOPMed
gnomAD
CA415292371
rs1263687818
231 A>T No ClinGen
TOPMed
gnomAD
CA415292406
rs1556944207
234 E>* No ClinGen
gnomAD
CA10545981
rs369289180
238 L>P No ClinGen
ESP
ExAC
TOPMed
gnomAD
CA415292546
rs1556944213
245 Q>R No ClinGen
gnomAD
rs782441595
CA10545980
247 K>E No ClinGen
ExAC
rs1269766512
CA415292567
247 K>M No ClinGen
TOPMed
CA415292569
rs1556944216
247 K>N No ClinGen
gnomAD
TCGA novel 249 L>Q Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
CA337641338
rs962244158
252 R>L No ClinGen
gnomAD
CA415292650
rs962244158
252 R>Q No ClinGen
gnomAD
CA10545979
rs202173682
254 V>G No ClinGen
ExAC
gnomAD
rs782477850
CA10545978
255 P>A No ClinGen
ExAC
rs781843123
CA10545976
255 P>L No ClinGen
ExAC
gnomAD
rs782477850
CA10545977
255 P>T No ClinGen
ExAC
rs782457391
CA10545974
256 D>G No ClinGen
ExAC
rs781888492
CA10545973
257 S>R No ClinGen
ExAC
CA10545972
rs142315436
258 D>A No ClinGen
ESP
ExAC
TOPMed
gnomAD
rs1450308862
CA415292739
260 A>P No ClinGen
TOPMed
gnomAD
rs1450308862
CA415292738
260 A>T No ClinGen
TOPMed
gnomAD
rs781817941
CA10545970
260 A>V No ClinGen
ExAC
gnomAD
CA10545969
rs376229047
261 R>C Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] No ClinGen
ESP
ExAC
NCI-TCGA
TOPMed
gnomAD
CA10545968
rs782046671
264 F>I No ClinGen
ExAC
gnomAD
TCGA novel 268 P>T Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
TCGA novel 269 R>S Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
rs782464959
CA337641360
272 A>G No ClinGen
1000Genomes
ExAC
TOPMed
gnomAD
rs782788272
CA337641358
272 A>S No ClinGen
ExAC
TOPMed
gnomAD
CA10545966
rs782788272
272 A>T Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] No ClinGen
ExAC
NCI-TCGA
TOPMed
gnomAD
rs782464959
CA10545965
272 A>V No ClinGen
1000Genomes
ExAC
TOPMed
gnomAD
TCGA novel 274 T>P Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
COSM1466458
rs781992458
CA337641363
278 K>E large_intestine [Cosmic] No ClinGen
cosmic curated
ExAC
gnomAD
rs781992458
CA10545964
278 K>Q No ClinGen
ExAC
gnomAD
VAR_036581 278 K>T a breast cancer sample; somatic mutation [UniProt] No UniProt
CA415292982
rs782202233
280 L>F No ClinGen
Ensembl
rs1156384241
CA415293011
282 Y>F No ClinGen
TOPMed
TCGA novel 283 V>A Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
rs1556944244
CA415293019
283 V>M No ClinGen
gnomAD
rs1182968785
CA415293049
285 K>E No ClinGen
TOPMed
TCGA novel 285 K>R Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
TCGA novel 286 V>A Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
rs1459904286
CA415293081
288 A>P No ClinGen
TOPMed
TCGA novel 289 R>I Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
CA10545961
rs782387656
290 V>A No ClinGen
ExAC
TOPMed
gnomAD
CA415293118
COSM3235161
rs1216226226
291 R>C Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic] No ClinGen
cosmic curated
NCI-TCGA
TOPMed
gnomAD
CA10545960
rs369028108
296 S>T No ClinGen
ESP
ExAC
TOPMed
gnomAD
rs61737511
CA10545958
298 R>C No ClinGen
1000Genomes
ESP
ExAC
TOPMed
gnomAD
rs61737511
CA10545957
298 R>G No ClinGen
1000Genomes
ESP
ExAC
TOPMed
gnomAD
CA10545956
rs376635182
298 R>H No ClinGen
ESP
ExAC
TOPMed
gnomAD
CA415293202
rs376635182
298 R>L No ClinGen
ESP
ExAC
TOPMed
gnomAD
rs1556944256
CA415293347
308 G>E Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] No ClinGen
NCI-TCGA
gnomAD

No associated diseases with P43355

2 regional properties for P43355

Type Name Position InterPro Accession
domain MAGE homology domain 102 - 301 IPR002190
domain Melanoma associated antigen, N-terminal 3 - 89 IPR021072

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

1 GO annotations of molecular function

Name Definition
histone deacetylase binding Binding to histone deacetylase.

2 GO annotations of biological process

Name Definition
negative regulation of Notch signaling pathway Any process that stops, prevents, or reduces the frequency, rate or extent of the Notch signaling pathway.
negative regulation of transcription by RNA polymerase II Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.

17 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P43356 MAGEA2B Melanoma-associated antigen 2 Homo sapiens (Human) PR
O15479 MAGEB2 Melanoma-associated antigen B2 Homo sapiens (Human) PR
O15480 MAGEB3 Melanoma-associated antigen B3 Homo sapiens (Human) PR
P43357 MAGEA3 Melanoma-associated antigen 3 Homo sapiens (Human) PR
P43358 MAGEA4 Melanoma-associated antigen 4 Homo sapiens (Human) PR
P43360 MAGEA6 Melanoma-associated antigen 6 Homo sapiens (Human) PR
P43361 MAGEA8 Melanoma-associated antigen 8 Homo sapiens (Human) PR
P43363 MAGEA10 Melanoma-associated antigen 10 Homo sapiens (Human) PR
P43365 MAGEA12 Melanoma-associated antigen 12 Homo sapiens (Human) PR
Q8TD90 MAGEE2 Melanoma-associated antigen E2 Homo sapiens (Human) PR
Q96MG7 NSMCE3 Non-structural maintenance of chromosomes element 3 homolog Homo sapiens (Human) PR
Q9BZ81 MAGEB5 Melanoma-associated antigen B5 Homo sapiens (Human) PR
Q9HAY2 MAGEF1 Melanoma-associated antigen F1 Homo sapiens (Human) PR
P43364 MAGEA11 Melanoma-associated antigen 11 Homo sapiens (Human) PR
Q9UNF1 MAGED2 Melanoma-associated antigen D2 Homo sapiens (Human) PR
Q9Y5V3 MAGED1 Melanoma-associated antigen D1 Homo sapiens (Human) PR
Q96JG8 MAGED4B Melanoma-associated antigen D4 Homo sapiens (Human) PR
10 20 30 40 50 60
MSLEQRSLHC KPEEALEAQQ EALGLVCVQA ATSSSSPLVL GTLEEVPTAG STDPPQSPQG
70 80 90 100 110 120
ASAFPTTINF TRQRQPSEGS SSREEEGPST SCILESLFRA VITKKVADLV GFLLLKYRAR
130 140 150 160 170 180
EPVTKAEMLE SVIKNYKHCF PEIFGKASES LQLVFGIDVK EADPTGHSYV LVTCLGLSYD
190 200 210 220 230 240
GLLGDNQIMP KTGFLIIVLV MIAMEGGHAP EEEIWEELSV MEVYDGREHS AYGEPRKLLT
250 260 270 280 290 300
QDLVQEKYLE YRQVPDSDPA RYEFLWGPRA LAETSYVKVL EYVIKVSARV RFFFPSLREA
ALREEEEGV