Q9QYH6
PR
Gene name |
Maged1 (Nrage) |
Protein name |
Melanoma-associated antigen D1 |
Names |
Dlxin-1, MAGE-D1 antigen, Neurotrophin receptor-interacting MAGE homolog |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:94275 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q9QYH6
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q9QYH6-F1 | Predicted | AlphaFoldDB |
35 variants for Q9QYH6
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3411191578 | 12 | R>C | No | EVA | |
| rs3411356421 | 38 | E>G | No | EVA | |
| rs13469003 | 47 | A>V | No | EVA | |
| rs3411304520 | 64 | A>S | No | EVA | |
| rs230379675 | 109 | Q>H | No | EVA | |
| rs13469004 | 124 | P>S | No | EVA | |
| rs3389572783 | 128 | S>C | No | EVA | |
| rs3389525458 | 132 | Q>E | No | EVA | |
| rs3389572797 | 142 | K>R | No | EVA | |
| rs3410342007 | 178 | K>* | No | EVA | |
| rs3411413359 | 181 | K>* | No | EVA | |
| rs3411765085 | 181 | K>N | No | EVA | |
| rs29071763 | 233 | V>M | No | EVA | |
| rs3389569765 | 284 | P>H | No | EVA | |
| rs3389577465 | 294 | T>I | No | EVA | |
| rs3389564510 | 314 | P>L | No | EVA | |
| rs3389534737 | 352 | I>F | No | EVA | |
| rs3389567695 | 372 | Q>H | No | EVA | |
| rs3389548736 | 402 | Q>R | No | EVA | |
| rs3389561831 | 407 | W>R | No | EVA | |
| rs3389516005 | 473 | N>S | No | EVA | |
| rs3389566896 | 559 | L>P | No | EVA | |
| rs3410774463 | 607 | E>A | No | EVA | |
| rs3389566872 | 647 | F>I | No | EVA | |
| rs3389515965 | 663 | F>Y | No | EVA | |
| rs13469002 | 668 | D>G | No | EVA | |
| rs3411356459 | 675 | D>A | No | EVA | |
| rs3389547417 | 703 | S>I | No | EVA | |
| rs864283972 | 706 | D>Y | No | EVA | |
| rs3389566893 | 722 | D>N | No | EVA | |
| rs3411034420 | 739 | A>T | No | EVA | |
| rs3411765141 | 754 | P>Q | No | EVA | |
| rs3409739131 | 756 | G>S | No | EVA | |
| rs3408693830 | 759 | T>A | No | EVA | |
| rs242592045 | 760 | A>T | No | EVA |
No associated diseases with Q9QYH6
1 regional properties for Q9QYH6
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | MAGE homology domain | 468 - 666 | IPR002190 |
Functions
5 GO annotations of cellular component
| Name | Definition |
|---|---|
| chromatin | The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome. |
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
| protein-containing complex | A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| identical protein binding | Binding to an identical protein or proteins. |
| transcription coactivator activity | A transcription coregulator activity that activates or increases the transcription of specific gene sets via binding to a DNA-bound DNA-binding transcription factor, either on its own or as part of a complex. Coactivators often act by altering chromatin structure and modifications. For example, one class of transcription coactivators modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators. A fourth class of coactivator activity is the bridging of a DNA-binding transcription factor to the general (basal) transcription machinery. The Mediator complex, which bridges sequence-specific DNA binding transcription factors and RNA polymerase, is also a transcription coactivator. |
12 GO annotations of biological process
| Name | Definition |
|---|---|
| circadian regulation of gene expression | Any process that modulates the frequency, rate or extent of gene expression such that an expression pattern recurs with a regularity of approximately 24 hours. |
| negative regulation of DNA-templated transcription | Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription. |
| negative regulation of epithelial cell proliferation | Any process that stops, prevents or reduces the rate or extent of epithelial cell proliferation. |
| negative regulation of protein localization to nucleus | Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to nucleus. |
| negative regulation of transcription by RNA polymerase II | Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II. |
| positive regulation of apoptotic signaling pathway | Any process that activates or increases the frequency, rate or extent of apoptotic signaling pathway. |
| positive regulation of branching involved in ureteric bud morphogenesis | Any process that increases the rate, frequency or extent of branching involved in ureteric bud morphogenesis, the process in which the branching structure of the ureteric bud is generated and organized. The ureteric bud is an epithelial tube that grows out from the metanephric duct. The bud elongates and branches to give rise to the ureter and kidney collecting tubules. |
| positive regulation of DNA-templated transcription | Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription. |
| positive regulation of MAP kinase activity | Any process that activates or increases the frequency, rate or extent of MAP kinase activity. |
| protein localization to nucleus | A process in which a protein transports or maintains the localization of another protein to the nucleus. |
| regulation of circadian rhythm | Any process that modulates the frequency, rate or extent of a circadian rhythm. A circadian rhythm is a biological process in an organism that recurs with a regularity of approximately 24 hours. |
| regulation of transcription by RNA polymerase II | Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II. |
7 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q96JG8 | MAGED4B | Melanoma-associated antigen D4 | Homo sapiens (Human) | PR |
| Q9UNF1 | MAGED2 | Melanoma-associated antigen D2 | Homo sapiens (Human) | PR |
| Q9Y5V3 | MAGED1 | Melanoma-associated antigen D1 | Homo sapiens (Human) | PR |
| P25233 | Ndn | Necdin | Mus musculus (Mouse) | PR |
| Q9CPR8 | Nsmce3 | Non-structural maintenance of chromosomes element 3 homolog | Mus musculus (Mouse) | PR |
| Q6ITT4 | MAGED1 | Melanoma-associated antigen D1 | Sus scrofa (Pig) | PR |
| Q9ES73 | Maged1 | Melanoma-associated antigen D1 | Rattus norvegicus (Rat) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MAQKPDGGAG | LRGFQAEASV | EDSALLVQTL | MEAIQISEAP | PTSQATAAAS | GPNASPQSSQ |
| 70 | 80 | 90 | 100 | 110 | 120 |
| PPTANEKADT | EVSAAAARPK | TGFKAQNATT | KGPNDYSQAR | NAKEMPKNQS | KAAFKSQNGT |
| 130 | 140 | 150 | 160 | 170 | 180 |
| PKGPHAASDF | SQAAPTGKSA | KKSEMAFKGQ | NSTKAGPGTT | YNFPQSPSAN | EMTNNQPKTA |
| 190 | 200 | 210 | 220 | 230 | 240 |
| KAWNDTTKVP | GADAQTQNVN | QAKMADVGTS | AGISEADGAA | AQTSADGSQT | QNVESRTIIR |
| 250 | 260 | 270 | 280 | 290 | 300 |
| GKRTRKVNNL | NVEENNSGDQ | RRASLASGNW | RSAPVPVTTQ | QNPPGAPPNV | VWQTPLAWQN |
| 310 | 320 | 330 | 340 | 350 | 360 |
| PSGWQNQTAR | QTPPAARQSP | PARQTPSAWQ | NPVAWQNPVI | WPNPVIWQNP | VIWPNPIVWP |
| 370 | 380 | 390 | 400 | 410 | 420 |
| GPIVWPNPMA | WQSTPGWQSP | PSWQAPPSWQ | SPQDWQGPPD | WQVPPDWSMP | PDWSFPSDWP |
| 430 | 440 | 450 | 460 | 470 | 480 |
| FPPDWIPADW | PIPPDWQNLR | PSPNLRSSSN | SRASQNQGPP | QPRDVALLQE | RANKLVKYLM |
| 490 | 500 | 510 | 520 | 530 | 540 |
| LKDYTKVPIK | RSEMLRDIIR | EYTDVYPEII | ERACFVLEKK | FGIQLKEIDK | EEHLYILIST |
| 550 | 560 | 570 | 580 | 590 | 600 |
| PESLAGILGT | TKDTPKLGLL | LVILGIIFMN | GNRATEAVLW | EALRKMGLRP | GVRHPLLGDL |
| 610 | 620 | 630 | 640 | 650 | 660 |
| RKLLTYEFVK | QKYLDYRRVP | NSNPPEYEFL | WGLRSYHETS | KMKVLRFIAE | VQKRDPRDWT |
| 670 | 680 | 690 | 700 | 710 | 720 |
| AQFMEAADEA | LDALDAAAAE | AEARAEARNR | MGIGDEAVSG | PWSWDDIEFE | LLTWDEEGDF |
| 730 | 740 | 750 | 760 | 770 | |
| GDPWSRIPFT | FWARYHQNAR | SRFPQAFTGP | IIGPSGTATA | NFAANFGAIG | FFWVE |