Q6ITT4
Gene name |
MAGED1 |
Protein name |
Melanoma-associated antigen D1 |
Names |
MAGE-D1 antigen |
Species |
Sus scrofa (Pig) |
KEGG Pathway |
ssc:414852 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q6ITT4
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q6ITT4-F1 | Predicted | AlphaFoldDB |
10 variants for Q6ITT4
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs80965199 | 354 | V>G | No | EVA | |
| rs80835827 | 378 | L>R | No | EVA | |
| rs80786691 | 530 | F>L | No | EVA | |
| rs80792244 | 573 | L>W | No | EVA | |
| rs341303055 | 673 | M>V | No | EVA | |
| rs80942772 | 674 | E>V | No | EVA | |
| rs80860794 | 719 | E>D | No | EVA | |
| rs80811689 | 761 | I>M | No | EVA | |
| rs80885212 | 775 | F>L | No | EVA | |
| rs80791568 | 778 | I>M | No | EVA |
No associated diseases with Q6ITT4
1 regional properties for Q6ITT4
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | MAGE homology domain | 477 - 675 | IPR002190 |
Functions
5 GO annotations of cellular component
| Name | Definition |
|---|---|
| chromatin | The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome. |
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
| protein-containing complex | A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| identical protein binding | Binding to an identical protein or proteins. |
4 GO annotations of biological process
| Name | Definition |
|---|---|
| circadian regulation of gene expression | Any process that modulates the frequency, rate or extent of gene expression such that an expression pattern recurs with a regularity of approximately 24 hours. |
| negative regulation of epithelial cell proliferation | Any process that stops, prevents or reduces the rate or extent of epithelial cell proliferation. |
| negative regulation of transcription by RNA polymerase II | Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II. |
| regulation of apoptotic process | Any process that modulates the occurrence or rate of cell death by apoptotic process. |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MAQKMDCGAG | LLGFQAEASV | EDSTLLMQTL | MEAIQISEAP | PTNQATAAAS | GPNASPQSSQ |
| 70 | 80 | 90 | 100 | 110 | 120 |
| PPSANEVADI | QALAAATKPK | TAFKAQNATT | KGPNAAYDFS | QALNAKEIPS | TPPTVAFKAP |
| 130 | 140 | 150 | 160 | 170 | 180 |
| NAPSKGPNAA | YDFSQAATTS | ELTAKPEMAF | KAQNATTKVG | PNATYNFSPS | LNANEMVNTQ |
| 190 | 200 | 210 | 220 | 230 | 240 |
| PKTAFKAWND | TTKAPTAETQ | TQNINQAKMA | TSQADIEADP | GPGICESDGA | AAQTSADGSQ |
| 250 | 260 | 270 | 280 | 290 | 300 |
| AQNLESRTII | RGKRTRKINN | LNVEESSSGD | QRRAPLAPGT | WRSAPVPITT | QSPPGAPPNV |
| 310 | 320 | 330 | 340 | 350 | 360 |
| LWQTPLAWQN | PSGWQNQPAR | QTPPARQSPP | ARQTPPAWQN | PVAWQNPVIW | PNPVIWQNPV |
| 370 | 380 | 390 | 400 | 410 | 420 |
| IWPNPIVWPG | PVVWPNPLAW | QNPPGWQTPP | GWQTPPGWQG | PPDWQGPPDW | PLPPDWPLPP |
| 430 | 440 | 450 | 460 | 470 | 480 |
| DWPLPTDWPL | PPDWIPTDWP | VPPDWQNLRP | SPNLRPSPNS | RASQNLGASQ | PRDVALLQER |
| 490 | 500 | 510 | 520 | 530 | 540 |
| ANKLVKYLML | KDYTKVPIKR | SEMLRDIIRE | YTDVYPEIIE | RACFVLEKKF | GIQLKEIDKE |
| 550 | 560 | 570 | 580 | 590 | 600 |
| EHLYILISTP | ESLAGILGTT | KDTPKLGLLL | VILGVIFMNG | NRASEAVLWE | ALRKMGLRPG |
| 610 | 620 | 630 | 640 | 650 | 660 |
| VRHPLLGDLR | KLLTYEFVKQ | KYLDYRRVPN | SNPPEYEFLW | GLRSYHETSK | MKVLRFIAEV |
| 670 | 680 | 690 | 700 | 710 | 720 |
| QKRDPRDWTA | QFMEAADEAL | DALDAAAAEA | EARAEARTRM | GIGDEAVSGP | WSWDDIEFEL |
| 730 | 740 | 750 | 760 | 770 | 780 |
| LTWDEEGDFG | DPWSRIPFTF | WARYHQNARS | RFPQTFAGPI | IGPGGTASAN | FAANFGAIGF |
| FWVE |