P25233
PR
Gene name |
Ndn |
Protein name |
Necdin |
Names |
|
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:17984 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for P25233
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P25233-F1 | Predicted | AlphaFoldDB |
12 variants for P25233
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3398148201 | 9 | S>R | No | EVA | |
| rs261911330 | 17 | V>A | No | EVA | |
| rs3397977484 | 21 | E>Q | No | EVA | |
| rs3388912854 | 45 | P>A | No | EVA | |
| rs243567932 | 56 | Q>P | No | EVA | |
| rs3388918439 | 277 | M>T | No | EVA | |
| rs3388915710 | 292 | Q>K | No | EVA | |
| rs3388913029 | 297 | R>* | No | EVA | |
| rs3388907100 | 297 | R>Q | No | EVA | |
| rs3397843162 | 315 | A>G | No | EVA | |
| rs3397977482 | 318 | P>S | No | EVA | |
| rs3388903042 | 320 | S>N | No | EVA |
No associated diseases with P25233
1 regional properties for P25233
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | MAGE homology domain | 102 - 301 | IPR002190 |
Functions
8 GO annotations of cellular component
| Name | Definition |
|---|---|
| cell projection | A prolongation or process extending from a cell, e.g. a flagellum or axon. |
| centrosome | A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle. |
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| nuclear matrix | The dense fibrillar network lying on the inner side of the nuclear membrane. |
| nucleoplasm | That part of the nuclear content other than the chromosomes or the nucleolus. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
| protein-containing complex | A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together. |
4 GO annotations of molecular function
| Name | Definition |
|---|---|
| DNA-binding transcription activator activity, RNA polymerase II-specific | A DNA-binding transcription factor activity that activates or increases transcription of specific gene sets transcribed by RNA polymerase II. |
| gamma-tubulin binding | Binding to the microtubule constituent protein gamma-tubulin. |
| promoter-specific chromatin binding | Binding to a section of chromatin that is associated with gene promoter sequences of DNA. |
| RNA polymerase II cis-regulatory region sequence-specific DNA binding | Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by RNA polymerase II. |
21 GO annotations of biological process
| Name | Definition |
|---|---|
| axon extension | Long distance growth of a single axon process involved in cellular development. |
| axonal fasciculation | The collection of axons into a bundle of rods, known as a fascicle. |
| axonogenesis | De novo generation of a long process of a neuron, including the terminal branched region. Refers to the morphogenesis or creation of shape or form of the developing axon, which carries efferent (outgoing) action potentials from the cell body towards target cells. |
| central nervous system development | The process whose specific outcome is the progression of the central nervous system over time, from its formation to the mature structure. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain and spinal cord. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord. |
| genomic imprinting | The establishment of epigenetic modifications (imprints) during gametogenesis, leading to an asymmetry in the heterochromatin between the maternal and paternal alleles, and differential expression of the corresponding alleles. This asymmetry results from the different epigenetic pathways acting in maternal and paternal gametes. |
| glial cell migration | The orderly movement of a glial cell, non-neuronal cells that provide support and nutrition, maintain homeostasis, form myelin, and participate in signal transmission in the nervous system. |
| multicellular organismal homeostasis | Any process involved in the maintenance of an internal steady state at the level of the multicellular organism. |
| negative regulation of cell population proliferation | Any process that stops, prevents or reduces the rate or extent of cell proliferation. |
| negative regulation of DNA-binding transcription factor activity | Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of a transcription factor, any factor involved in the initiation or regulation of transcription. |
| negative regulation of transcription by RNA polymerase II | Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II. |
| neuron development | The process whose specific outcome is the progression of a neuron over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. |
| neuron differentiation | The process in which a relatively unspecialized cell acquires specialized features of a neuron. |
| neuron migration | The characteristic movement of an immature neuron from germinal zones to specific positions where they will reside as they mature. |
| neurotrophin TRK receptor signaling pathway | The series of molecular signals initiated by neurotrophin binding to its receptor on the surface of a target cell where the receptor possesses tyrosine kinase activity, and ending with the regulation of a downstream cellular process, e.g. transcription. |
| positive regulation of protein deacetylation | Any process that increases the rate, frequency, or extent of protein deacetylation, the removal of an acetyl group from a protein amino acid. An acetyl group is CH3CO-, derived from acetic |
| positive regulation of transcription by RNA polymerase II | Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter. |
| post-embryonic development | The process whose specific outcome is the progression of the organism over time, from the completion of embryonic development to the mature structure. See embryonic development. |
| regulation of DNA-templated transcription | Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. |
| respiratory gaseous exchange by respiratory system | The process of gaseous exchange between an organism and its environment. In plants, microorganisms, and many small animals, air or water makes direct contact with the organism's cells or tissue fluids, and the processes of diffusion supply the organism with dioxygen (O2) and remove carbon dioxide (CO2). In larger animals the efficiency of gaseous exchange is improved by specialized respiratory organs, such as lungs and gills, which are ventilated by breathing mechanisms. |
| respiratory system process | A process carried out by the organs or tissues of the respiratory system. The respiratory system is an organ system responsible for respiratory gaseous exchange. |
| sensory perception of pain | The series of events required for an organism to receive a painful stimulus, convert it to a molecular signal, and recognize and characterize the signal. Pain is medically defined as the physical sensation of discomfort or distress caused by injury or illness, so can hence be described as a harmful stimulus which signals current (or impending) tissue damage. Pain may come from extremes of temperature, mechanical damage, electricity or from noxious chemical substances. This is a neurological process. |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSEQSKDLSD | PNFAAEVPDC | EMQDSDAVPV | GIPPPASLAA | NLAGPPCAPE | GPMAAQQASP |
| 70 | 80 | 90 | 100 | 110 | 120 |
| PPEERIEDVD | PKILQQAAEE | GRAHQPQSPA | RPIPAPPAPA | QLVQKAHELM | WYVLVKDQKR |
| 130 | 140 | 150 | 160 | 170 | 180 |
| MVLWFPDMVK | EVMGSYKKWC | RSILRRTSVI | LARVFGLHLR | LTNLHTMEFA | LVKALSPEEL |
| 190 | 200 | 210 | 220 | 230 | 240 |
| DRVALNNRMP | MTGLLLMILS | LIYVKGRGAR | EGAVWNVLRI | LGLRPWKKHS | TFGDVRKIIT |
| 250 | 260 | 270 | 280 | 290 | 300 |
| EEFVQQNYLK | YQRVPHIEPP | EYEFFWGSRA | NREITKMQIM | EFLARVFKKD | PQAWPSRYRE |
| 310 | 320 | ||||
| ALEQARALRE | ANLAAQAPRS | SVSED |