Q8VZ95
Gene name |
PVA11 (VAP27, VAP27-1, At3g60600, T4C21.10) |
Protein name |
Vesicle-associated protein 1-1 |
Names |
Plant VAP homolog 11, AtPVA11, VAMP-associated protein 1-1, Vesicle-associated protein 27-1 |
Species |
Arabidopsis thaliana (Mouse-ear cress) |
KEGG Pathway |
ath:AT3G60600 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q8VZ95
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q8VZ95-F1 | Predicted | AlphaFoldDB |
9 variants for Q8VZ95
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| ENSVATH12853723 | 17 | M>L | No | 1000Genomes | |
| ENSVATH00429647 | 23 | L>I | No | 1000Genomes | |
| tmp_3_22401090_T_C | 95 | S>P | No | 1000Genomes | |
| ENSVATH06349871 | 130 | H>N | No | 1000Genomes | |
| ENSVATH02531031 | 190 | N>I | No | 1000Genomes | |
| ENSVATH06349879 | 203 | E>K | No | 1000Genomes | |
| ENSVATH12853740 | 212 | N>T | No | 1000Genomes | |
| tmp_3_22402326_A_G | 230 | Q>R | No | 1000Genomes | |
| ENSVATH14461197 | 234 | I>L | No | 1000Genomes |
No associated diseases with Q8VZ95
1 regional properties for Q8VZ95
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Major sperm protein (MSP) domain | 22 - 142 | IPR000535 |
Functions
7 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| endoplasmic reticulum | The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). |
| endoplasmic reticulum membrane | The lipid bilayer surrounding the endoplasmic reticulum. |
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
| protein storage vacuole | A storage vacuole that contains a lytic vacuole; identified in plants. |
| protein storage vacuole membrane | The lipid bilayer surrounding a protein storage vacuole. |
No GO annotations of molecular function
| Name | Definition |
|---|---|
| No GO annotations for molecular function |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| endoplasmic reticulum membrane organization | A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an endoplasmic reticulum membrane. |
| endoplasmic reticulum-plasma membrane tethering | The attachment of an endoplasmic reticulum membrane to the plasma membrane via molecular tethers. |
| intracellular transport | The directed movement of substances within a cell. |
10 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q2T9W7 | MOSPD1 | Motile sperm domain-containing protein 1 | Bos taurus (Bovine) | PR |
| A2VDZ9 | VAPB | Vesicle-associated membrane protein-associated protein B | Bos taurus (Bovine) | PR |
| O95292 | VAPB | Vesicle-associated membrane protein-associated protein B/C | Homo sapiens (Human) | PR |
| Q8VEL0 | Mospd1 | Motile sperm domain-containing protein 1 | Mus musculus (Mouse) | PR |
| Q9QY76 | Vapb | Vesicle-associated membrane protein-associated protein B | Mus musculus (Mouse) | PR |
| Q5RJS6 | Mospd1 | Motile sperm domain-containing protein 1 | Rattus norvegicus (Rat) | PR |
| Q9Z269 | Vapb | Vesicle-associated membrane protein-associated protein B | Rattus norvegicus (Rat) | PR |
| Q1ECE0 | PVA41 | Vesicle-associated protein 4-1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q8LPQ7 | PVA43 | Vesicle-associated protein 4-3 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q8VYN2 | PVA42 | Vesicle-associated protein 4-2 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSNIDLIGMS | NRDLIGMSNS | ELLTVEPLDL | QFPFELKKQI | SCSLYLTNKT | DNNVAFKVKT |
| 70 | 80 | 90 | 100 | 110 | 120 |
| TNPKKYCVRP | NTGVVLPRST | CEVLVTMQAQ | KEAPSDMQCK | DKFLLQGVIA | SPGVTAKEVT |
| 130 | 140 | 150 | 160 | 170 | 180 |
| PEMFSKEAGH | RVEETKLRVT | YVAPPRPPSP | VHEGSEEGSS | PRASVSDNGH | GSEFSFERFI |
| 190 | 200 | 210 | 220 | 230 | 240 |
| VDNKAGHQEN | TSEARALITK | LTEEKQSAIQ | LNNRLQRELD | QLRRESKKSQ | SGGIPFMYVL |
| 250 | |||||
| LVGLIGLILG | YIMKRT |