Q8LPQ7
Gene name |
PVA43 (At4g05060, C17L7.8, T32N4.12) |
Protein name |
Vesicle-associated protein 4-3 |
Names |
Plant VAP homolog 4-3, AtPVA43, VAMP-associated protein 4-3 |
Species |
Arabidopsis thaliana (Mouse-ear cress) |
KEGG Pathway |
ath:AT4G05060 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q8LPQ7
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q8LPQ7-F1 | Predicted | AlphaFoldDB |
30 variants for Q8LPQ7
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| ENSVATH00465825 | 6 | D>E | No | 1000Genomes | |
| ENSVATH02665834 | 13 | R>G | No | 1000Genomes | |
| ENSVATH02665833 | 20 | L>F | No | 1000Genomes | |
| ENSVATH06479948 | 30 | P>T | No | 1000Genomes | |
| ENSVATH02665830 | 32 | A>P | No | 1000Genomes | |
| ENSVATH02665830 | 32 | A>S | No | 1000Genomes | |
| ENSVATH02665829 | 34 | S>L | No | 1000Genomes | |
| ENSVATH06479946 | 34 | S>T | No | 1000Genomes | |
| ENSVATH06479945 | 44 | S>F | No | 1000Genomes | |
| tmp_4_2591841_A_T | 54 | Y>N | No | 1000Genomes | |
| tmp_4_2591831_T_G | 57 | Q>P | No | 1000Genomes | |
| ENSVATH02665826 | 76 | H>Q | No | 1000Genomes | |
| tmp_4_2591768_T_G | 78 | Q>P | No | 1000Genomes | |
| ENSVATH10765116 | 108 | L>I | No | 1000Genomes | |
| ENSVATH13946346 | 117 | Q>L | No | 1000Genomes | |
| ENSVATH10765026 | 119 | R>M | No | 1000Genomes | |
| ENSVATH06479931 | 128 | S>G | No | 1000Genomes | |
| ENSVATH06479930 | 128 | S>N | No | 1000Genomes | |
| tmp_4_2591280_A_T | 134 | F>L | No | 1000Genomes | |
| tmp_4_2591126_C_T | 157 | E>K | No | 1000Genomes | |
| ENSVATH02665773 | 209 | H>N | No | 1000Genomes | |
| ENSVATH00465807 | 225 | N>K | No | 1000Genomes | |
| tmp_4_2590692_G_A | 226 | P>S | No | 1000Genomes | |
| ENSVATH02665772 | 228 | S>P | No | 1000Genomes | |
| ENSVATH06479921 | 231 | E>K | No | 1000Genomes | |
| ENSVATH02665761 | 252 | E>D | No | 1000Genomes | |
| tmp_4_2590444_G_A | 264 | L>F | No | 1000Genomes | |
| tmp_4_2590432_C_G | 268 | E>Q | No | 1000Genomes | |
| tmp_4_2590268_G_C | 281 | Q>E | No | 1000Genomes | |
| ENSVATH00465800 | 286 | A>S | No | 1000Genomes |
No associated diseases with Q8LPQ7
1 regional properties for Q8LPQ7
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Major sperm protein (MSP) domain | 99 - 221 | IPR000535 |
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| endoplasmic reticulum membrane | The lipid bilayer surrounding the endoplasmic reticulum. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
No GO annotations of molecular function
| Name | Definition |
|---|---|
| No GO annotations for molecular function |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| endoplasmic reticulum membrane organization | A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an endoplasmic reticulum membrane. |
| endoplasmic reticulum-plasma membrane tethering | The attachment of an endoplasmic reticulum membrane to the plasma membrane via molecular tethers. |
10 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q2T9W7 | MOSPD1 | Motile sperm domain-containing protein 1 | Bos taurus (Bovine) | PR |
| A2VDZ9 | VAPB | Vesicle-associated membrane protein-associated protein B | Bos taurus (Bovine) | PR |
| O95292 | VAPB | Vesicle-associated membrane protein-associated protein B/C | Homo sapiens (Human) | PR |
| Q8VEL0 | Mospd1 | Motile sperm domain-containing protein 1 | Mus musculus (Mouse) | PR |
| Q9QY76 | Vapb | Vesicle-associated membrane protein-associated protein B | Mus musculus (Mouse) | PR |
| Q5RJS6 | Mospd1 | Motile sperm domain-containing protein 1 | Rattus norvegicus (Rat) | PR |
| Q9Z269 | Vapb | Vesicle-associated membrane protein-associated protein B | Rattus norvegicus (Rat) | PR |
| Q1ECE0 | PVA41 | Vesicle-associated protein 4-1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q8VYN2 | PVA42 | Vesicle-associated protein 4-2 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q8VZ95 | PVA11 | Vesicle-associated protein 1-1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MALTEDKSDS | DGRRWGKFKL | PFRNSNSQAP | SASSSSSMAT | SSSSVTSSHL | NQNYIHQSRH |
| 70 | 80 | 90 | 100 | 110 | 120 |
| FQYHGPPVVE | GLGQNHHQSA | ATIPSMSSVA | RSLLPTKRRL | KLDPSAKLYF | PYEPGKQVRS |
| 130 | 140 | 150 | 160 | 170 | 180 |
| AIKIKNTSKS | HVAFKFQTTV | PKSCFMRPAG | AILAPGEEII | ATVFKFVEPP | ENNEKPMEQK |
| 190 | 200 | 210 | 220 | 230 | 240 |
| SGVKFKIMSL | KMKVPTDYMP | ELFEEQKDHV | SEEQVMRVVF | LDPENPNSMM | EKLKSQLAEA |
| 250 | 260 | 270 | 280 | ||
| DAADEARKKA | SEGIVGPKPI | GEGLVIDEWK | QRRERYLAQQ | QGGVDAA |