A2VDZ9
Gene name |
VAPB |
Protein name |
Vesicle-associated membrane protein-associated protein B |
Names |
VAMP-B, VAMP-associated protein B, VAP-B |
Species |
Bos taurus (Bovine) |
KEGG Pathway |
bta:326580 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for A2VDZ9
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-A2VDZ9-F1 | Predicted | AlphaFoldDB |
16 variants for A2VDZ9
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs480714707 | 10 | L>R | No | EVA | |
| rs462097967 | 14 | H>P | No | EVA | |
| rs440423122 | 15 | E>D | No | EVA | |
| rs460179270 | 20 | G>D | No | EVA | |
| rs477697633 | 22 | F>C | No | EVA | |
| rs462532387 | 23 | T>A | No | EVA | |
| rs462532387 | 23 | T>S | No | EVA | |
| rs443973867 | 48 | A>T | No | EVA | |
| rs473863925 | 54 | V>L | No | EVA | |
| rs455933450 | 58 | S>R | No | EVA | |
| rs473550704 | 69 | V>L | No | EVA | |
| rs482490519 | 78 | Y>* | No | EVA | |
| rs442113032 | 92 | S>T | No | EVA | |
| rs523603222 | 232 | F>L | No | EVA | |
| rs435152044 | 238 | I>R | No | EVA | |
| rs468187870 | 242 | A>T | No | EVA |
No associated diseases with A2VDZ9
1 regional properties for A2VDZ9
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Major sperm protein (MSP) domain | 7 - 124 | IPR000535 |
Functions
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| endoplasmic reticulum membrane | The lipid bilayer surrounding the endoplasmic reticulum. |
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| FFAT motif binding | Binding to a FFAT motif, a short motif containing diphenylalanine in an acidic tract that targets proteins to the cytosolic surface of the ER and to the nuclear membrane by binding directly to members of the VAP (VAMP-associated protein) protein family. |
4 GO annotations of biological process
| Name | Definition |
|---|---|
| cellular calcium ion homeostasis | Any process involved in the maintenance of an internal steady state of calcium ions at the level of a cell. |
| endoplasmic reticulum membrane organization | A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an endoplasmic reticulum membrane. |
| endoplasmic reticulum-plasma membrane tethering | The attachment of an endoplasmic reticulum membrane to the plasma membrane via molecular tethers. |
| IRE1-mediated unfolded protein response | The series of molecular signals mediated by the endoplasmic reticulum stress sensor IRE1 (Inositol-requiring transmembrane kinase/endonuclease). Begins with activation of IRE1 in response to endoplasmic reticulum (ER) stress, and ends with regulation of a downstream cellular process, e.g. transcription. One target of activated IRE1 is the transcription factor HAC1 in yeast, or XBP1 in mammals; IRE1 cleaves an intron of a mRNA coding for HAC1/XBP1 to generate an activated HAC1/XBP1 transcription factor, which controls the up regulation of UPR-related genes. At least in mammals, IRE1 can also signal through additional intracellular pathways including JNK and NF-kappaB. |
10 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q2T9W7 | MOSPD1 | Motile sperm domain-containing protein 1 | Bos taurus (Bovine) | PR |
| O95292 | VAPB | Vesicle-associated membrane protein-associated protein B/C | Homo sapiens (Human) | PR |
| Q8VEL0 | Mospd1 | Motile sperm domain-containing protein 1 | Mus musculus (Mouse) | PR |
| Q9QY76 | Vapb | Vesicle-associated membrane protein-associated protein B | Mus musculus (Mouse) | PR |
| Q5RJS6 | Mospd1 | Motile sperm domain-containing protein 1 | Rattus norvegicus (Rat) | PR |
| Q9Z269 | Vapb | Vesicle-associated membrane protein-associated protein B | Rattus norvegicus (Rat) | PR |
| Q1ECE0 | PVA41 | Vesicle-associated protein 4-1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q8LPQ7 | PVA43 | Vesicle-associated protein 4-3 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q8VYN2 | PVA42 | Vesicle-associated protein 4-2 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q8VZ95 | PVA11 | Vesicle-associated protein 1-1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MAKVEQVLSL | EPQHELKFRG | PFTDVVTTNL | KLGNPTDRNV | CFKVKTTAPR | RYCVRPNSGI |
| 70 | 80 | 90 | 100 | 110 | 120 |
| IDAGASINVS | VMLQPFDYDP | NEKSKHKFMV | QSMFAPTDTS | DMEAVWKEAK | PEDLMDSKLR |
| 130 | 140 | 150 | 160 | 170 | 180 |
| CVFELPAEND | KPHDVEINKI | IPTTASKTET | PTVSKALSSS | LDDTEVKKVM | EECKRLQSEV |
| 190 | 200 | 210 | 220 | 230 | 240 |
| QRLREENKQF | KEEDGLRMRK | TAQSNSPAPA | SAMAGKEEGL | STRLLALVVL | FFIVGVIIGK |
| IAL |