Q8VYN2

PR
Gene name
PVA42 (At4g21450, F18E5.70)
Protein name
Vesicle-associated protein 4-2
Names
Plant VAP homolog 4-2, AtPVA42, VAMP-associated protein 4-2
Species
Arabidopsis thaliana (Mouse-ear cress)
KEGG Pathway
ath:AT4G21450
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-131 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q8VYN2

Entry ID Method Resolution Chain Position Source
AF-Q8VYN2-F1 Predicted AlphaFoldDB

11 variants for Q8VYN2

Variant ID(s) Position Change Description Diseaes Association Provenance
tmp_4_11426157_C_T 8 P>S No 1000Genomes
tmp_4_11426199_C_T 22 P>S No 1000Genomes
ENSVATH12114000 31 N>S No 1000Genomes
ENSVATH06744210 32 A>T No 1000Genomes
tmp_4_11426233_C_G 33 A>G No 1000Genomes
tmp_4_11426240_T_A 35 S>R No 1000Genomes
ENSVATH06744211 54 L>P No 1000Genomes
tmp_4_11426422_C_A 96 S>Y No 1000Genomes
ENSVATH12114135 216 D>E No 1000Genomes
tmp_4_11427900_C_G 251 A>G No 1000Genomes
ENSVATH06744245 262 T>R No 1000Genomes

No associated diseases with Q8VYN2

1 regional properties for Q8VYN2

Type Name Position InterPro Accession
domain Major sperm protein (MSP) domain 107 - 229 IPR000535

Functions

Description
EC Number
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
endoplasmic reticulum membrane The lipid bilayer surrounding the endoplasmic reticulum.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

No GO annotations of molecular function

Name Definition
No GO annotations for molecular function

2 GO annotations of biological process

Name Definition
endoplasmic reticulum membrane organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an endoplasmic reticulum membrane.
endoplasmic reticulum-plasma membrane tethering The attachment of an endoplasmic reticulum membrane to the plasma membrane via molecular tethers.

10 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q2T9W7 MOSPD1 Motile sperm domain-containing protein 1 Bos taurus (Bovine) PR
A2VDZ9 VAPB Vesicle-associated membrane protein-associated protein B Bos taurus (Bovine) PR
O95292 VAPB Vesicle-associated membrane protein-associated protein B/C Homo sapiens (Human) PR
Q8VEL0 Mospd1 Motile sperm domain-containing protein 1 Mus musculus (Mouse) PR
Q9QY76 Vapb Vesicle-associated membrane protein-associated protein B Mus musculus (Mouse) PR
Q5RJS6 Mospd1 Motile sperm domain-containing protein 1 Rattus norvegicus (Rat) PR
Q9Z269 Vapb Vesicle-associated membrane protein-associated protein B Rattus norvegicus (Rat) PR
Q1ECE0 PVA41 Vesicle-associated protein 4-1 Arabidopsis thaliana (Mouse-ear cress) PR
Q8LPQ7 PVA43 Vesicle-associated protein 4-3 Arabidopsis thaliana (Mouse-ear cress) PR
Q8VZ95 PVA11 Vesicle-associated protein 1-1 Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MTMTEEKPTS DGKGGWGFFK IPFRNSSGHR NAASSAATSP FPSGASSSST SSHLHNHHQH
70 80 90 100 110 120
HHQHHHQHHH QLGYNGPHGD GSGQNQHPTP SPSVSSVAKS FLPTKRRLKL DPSEKLYFPY
130 140 150 160 170 180
EPGKQVRSAI KIKNTSKSHV AFKFQTTAPK SCFMRPPGAI LAPGETIIAT VFKFVEPPEN
190 200 210 220 230 240
NEKPMDQRSR VKFKIMSLKV KGPMDYVPEL FDEQKDDVSK EQILRVIFLD PERSNPALEK
250 260 270 280 290
LKRQLAEADA AVEARKKPPE ETGPKMIGEG LVIDEWKERR ERYLAQQQGE GADSV