Q8VI36

PR
Gene name
Pxn
Protein name
Paxillin
Names
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:19303
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

49-167 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

3 structures for Q8VI36

Entry ID Method Resolution Chain Position Source
5W93 X-ray 200 A D/E/F 1-20 PDB
6JMU X-ray 200 A C/D 260-282 PDB
AF-Q8VI36-F1 Predicted AlphaFoldDB

No variants for Q8VI36

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q8VI36

No associated diseases with Q8VI36

4 regional properties for Q8VI36

Type Name Position InterPro Accession
active_site Aspartic peptidase, active site 88 - 99 IPR001969-1
active_site Aspartic peptidase, active site 273 - 284 IPR001969-2
domain Aspartic peptidase, N-terminal 20 - 46 IPR012848
domain Peptidase family A1 domain 72 - 386 IPR033121

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm, cytoskeleton
  • Cell junction, focal adhesion
  • Cytoplasm, cell cortex
  • Colocalizes with integrins at the cell periphery
  • Colocalizes with PXN to membrane ruffles and the leading edge of migrating cells (By similarity)
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

8 GO annotations of cellular component

Name Definition
cell cortex The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins.
cell leading edge The area of a motile cell closest to the direction of movement.
cell-cell junction A cell junction that forms a connection between two or more cells of an organism; excludes direct cytoplasmic intercellular bridges, such as ring canals in insects.
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
focal adhesion A cell-substrate junction that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments. In insects focal adhesion has also been referred to as hemi-adherens junction (HAJ).
lamellipodium A thin sheetlike process extended by the leading edge of a migrating cell or extending cell process; contains a dense meshwork of actin filaments.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
stress fiber A contractile actin filament bundle that consists of short actin filaments with alternating polarity, cross-linked by alpha-actinin and possibly other actin bundling proteins, and with myosin present in a periodic distribution along the fiber.

12 GO annotations of molecular function

Name Definition
beta-catenin binding Binding to a catenin beta subunit.
BH4 domain binding Binding to a BH4 protein domain, present in Bcl-2 family members. All anti-apoptotic proteins contain BH1 and BH2 domains; some also contain an additional N-terminal BH4 domain, which is almost never seen in pro-apoptotic proteins. Loss of the BH4 domain can diminish or abrogate anti-apoptotic function or even impart outright death-promoting properties to the protein.
integrin binding Binding to an integrin.
MAP-kinase scaffold activity The binding activity of a molecule that functions as a physical support for the assembly of a multiprotein mitogen-activated protein kinase (MAPK) complex. Binds multiple kinases of the MAPKKK cascade, and also upstream signaling proteins, permitting those molecules to function in a coordinated way. Bringing together multiple enzymes and their substrates enables the signal to be transduced quickly and efficiently.
metal ion binding Binding to a metal ion.
neuropilin binding Binding to a member of the neuropilin family.
protein kinase binding Binding to a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate.
protein phosphatase binding Binding to a protein phosphatase.
protein-containing complex binding Binding to a macromolecular complex.
signaling receptor complex adaptor activity The binding activity of a molecule that provides a physical support for the assembly of a multiprotein receptor signaling complex.
transcription coregulator activity A transcription regulator activity that modulates the transcription of specific gene sets via binding to a DNA-bound DNA-binding transcription factor, either on its own or as part of a complex. Coregulators often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators.
vinculin binding Binding to vinculin, a protein found in muscle, fibroblasts, and epithelial cells that binds actin and appears to mediate attachment of actin filaments to integral proteins of the plasma membrane.

15 GO annotations of biological process

Name Definition
branching morphogenesis of an epithelial tube The process in which the anatomical structures of branches in an epithelial tube are generated and organized. A tube is a long hollow cylinder.
cytoskeleton organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures.
endothelial cell migration The orderly movement of an endothelial cell into the extracellular matrix to form an endothelium.
focal adhesion assembly The aggregation and bonding together of a set of components to form a focal adhesion, a complex of intracellular signaling and structural proteins that provides a structural link between the internal actin cytoskeleton and the ECM, and also function as a locus of signal transduction activity.
growth hormone receptor signaling pathway The series of molecular signals generated as a consequence of growth hormone receptor binding to its physiological ligand.
integrin-mediated signaling pathway The series of molecular signals initiated by an extracellular ligand binding to an integrin on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.
lamellipodium assembly Formation of a lamellipodium, a thin sheetlike extension of the surface of a migrating cell.
peptidyl-tyrosine phosphorylation The phosphorylation of peptidyl-tyrosine to form peptidyl-O4'-phospho-L-tyrosine.
positive regulation of angiogenesis Any process that activates or increases angiogenesis.
positive regulation of protein kinase activity Any process that activates or increases the frequency, rate or extent of protein kinase activity.
positive regulation of stress fiber assembly Any process that activates or increases the frequency, rate or extent of the assembly of a stress fiber, a bundle of microfilaments and other proteins found in fibroblasts.
regulation of cell shape Any process that modulates the surface configuration of a cell.
response to peptide Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a peptide stimulus.
substrate adhesion-dependent cell spreading The morphogenetic process that results in flattening of a cell as a consequence of its adhesion to a substrate.
transforming growth factor beta receptor signaling pathway The series of molecular signals initiated by an extracellular ligand binding to a transforming growth factor beta receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.

10 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q3SYZ8 PDLIM3 PDZ and LIM domain protein 3 Bos taurus (Bovine) PR
Q9PU47 PDLIM3 PDZ and LIM domain protein 3 Gallus gallus (Chicken) PR
P49024 PXN Paxillin Gallus gallus (Chicken) PR
Q53GG5 PDLIM3 PDZ and LIM domain protein 3 Homo sapiens (Human) PR
O43294 TGFB1I1 Transforming growth factor beta-1-induced transcript 1 protein Homo sapiens (Human) PR
P49023 PXN Paxillin Homo sapiens (Human) PR
O70209 Pdlim3 PDZ and LIM domain protein 3 Mus musculus (Mouse) PR
Q62219 Tgfb1i1 Transforming growth factor beta-1-induced transcript 1 protein Mus musculus (Mouse) PR
Q6QGC0 PDLIM3 PDZ and LIM domain protein 3 Sus scrofa (Pig) PR
Q66H76 Pxn Paxillin Rattus norvegicus (Rat) PR
10 20 30 40 50 60
MDDLDALLAD LESTTSHISK RPVFLSEEPP YSYPTGNHTY QEIAVPPPVP PPPSSEALNG
70 80 90 100 110 120
TVLDPLDQWQ PSGSRYAHQQ PPSPLPVYSS SAKNSSASNT QDGVGSLCSR AGEEEHVYSF
130 140 150 160 170 180
PNKQKSAEPS PTVMSSSLGS NLSELDRLLL ELNAVQHSPP GFPADEAESS PPLPGALSPL
190 200 210 220 230 240
YGIPENNTPL GGKAGPLVKE KPKRNGGRGL EDVRPSVESL LDELESSVPS PVPAITVNQG
250 260 270 280 290 300
EMSSPQRVTS SQQQTRISAS SATRELDELM ASLSDFKMQG LEQRVDGERP WAAGWPPSSR
310 320 330 340 350 360
QSSPEGQDEG GFMAQGKTGS SSPPGGLSKP GSQLDSMLGS LQSDLNKLGV ATVAKGVCGA
370 380 390 400 410 420
CKKPIAGQVV TAMGKTWHPE HFVCTHCQEE IGSRNFFERD GQPYCEKDYH SLFSPRCYYC
430 440 450 460 470 480
NGPILDKVVT ALDRTWHPEH FFCAQCGAFF GPEGFHEKDG KAYCRKDYFD MFAPKCGGCA
490 500 510 520 530 540
RAILENYISA LNTLWHPECF VCRECFTPFV NGSFFEHDGQ PYCEVHYHER RGSLCSGCQK
550 560 570 580 590
PITGRCITAM AKKFHPEHFV CAFCLKQLNK GTFKEQNDKP YCQSCFVKLF C