Q3SYZ8

PR
Gene name
PDLIM3
Protein name
PDZ and LIM domain protein 3
Names
Species
Bos taurus (Bovine)
KEGG Pathway
bta:538516
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

63-270 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q3SYZ8

Entry ID Method Resolution Chain Position Source
AF-Q3SYZ8-F1 Predicted AlphaFoldDB

56 variants for Q3SYZ8

Variant ID(s) Position Change Description Diseaes Association Provenance
rs455652570 2 P>A No EVA
rs435146058 2 P>R No EVA
rs466549757 4 N>D No EVA
rs452856641 4 N>I No EVA
rs432863983 4 N>K No EVA
rs464262364 8 P>T No EVA
rs445384990 11 A>P No EVA
rs483028919 11 A>V No EVA
rs449510054 14 G>A No EVA
rs469480136 14 G>C No EVA
rs449510054 14 G>D No EVA
rs469480136 14 G>R No EVA
rs480749218 16 R>S No EVA
rs460373298 17 L>P No EVA
rs440435963 18 S>A No EVA
rs440435963 18 S>P No EVA
rs478309843 21 I>M No EVA
rs458173993 22 D>H No EVA
rs444193647 23 F>S No EVA
rs475618579 24 N>D No EVA
rs433907879 44 C>* No EVA
rs447566148 44 C>F No EVA
rs447566148 44 C>S No EVA
rs464944612 45 P>H No EVA
rs444839789 46 G>W No EVA
rs482706134 57 T>A No EVA
rs469073533 61 T>A No EVA
rs440983062 69 I>S No EVA
rs463212789 111 E>D No EVA
rs467228261 153 S>N No EVA
rs433898979 197 T>P No EVA
rs464344604 220 P>R No EVA
rs450674286 227 R>T No EVA
rs462078810 237 A>V No EVA
rs447953968 238 G>C No EVA
rs479445892 241 Q>* No EVA
rs439260670 247 D>H No EVA
rs470545946 250 G>V No EVA
rs465906060 260 A>E No EVA
rs445569793 263 K>Q No EVA
rs476789876 267 P>L No EVA
rs476789876 267 P>Q No EVA
rs469792111 268 E>G No EVA
rs469792111 268 E>V No EVA
rs481217521 272 C>G No EVA
rs481217521 272 C>S No EVA
rs442244824 283 G>D No EVA
rs480080967 286 F>L No EVA
rs460052945 289 G>E No EVA
rs457317737 292 Y>D No EVA
rs443711790 292 Y>F No EVA
rs475121341 294 E>A No EVA
rs454667408 299 A>P No EVA
rs465832751 304 P>T No EVA
rs452267134 306 G>D No EVA
rs432296106 307 Y>* No EVA

No associated diseases with Q3SYZ8

4 regional properties for Q3SYZ8

Type Name Position InterPro Accession
domain PDZ domain 8 - 84 IPR001478
domain Zinc finger, LIM-type 244 - 303 IPR001781
domain Zasp-like motif 137 - 162 IPR006643
domain Domain of unknown function DUF4749 137 - 215 IPR031847

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm, myofibril, sarcomere, Z line
  • Localizes to myofiber Z-lines
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

4 GO annotations of cellular component

Name Definition
adherens junction A cell-cell junction composed of the epithelial cadherin-catenin complex. The epithelial cadherins, or E-cadherins, of each interacting cell extend through the plasma membrane into the extracellular space and bind to each other. The E-cadherins bind to catenins on the cytoplasmic side of the membrane, where the E-cadherin-catenin complex binds to cytoskeletal components and regulatory and signaling molecules.
filamentous actin A two-stranded helical polymer of the protein actin.
stress fiber A contractile actin filament bundle that consists of short actin filaments with alternating polarity, cross-linked by alpha-actinin and possibly other actin bundling proteins, and with myosin present in a periodic distribution along the fiber.
Z disc Platelike region of a muscle sarcomere to which the plus ends of actin filaments are attached.

3 GO annotations of molecular function

Name Definition
actin binding Binding to monomeric or multimeric forms of actin, including actin filaments.
metal ion binding Binding to a metal ion.
muscle alpha-actinin binding Binding to muscle isoforms of actinin. Muscle alpha-actinin isoforms are found in skeletal and cardiac muscle and are localized to the Z-disc.

3 GO annotations of biological process

Name Definition
actin cytoskeleton organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins.
heart development The process whose specific outcome is the progression of the heart over time, from its formation to the mature structure. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood.
muscle structure development The progression of a muscle structure over time, from its formation to its mature state. Muscle structures are contractile cells, tissues or organs that are found in multicellular organisms.

10 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P49024 PXN Paxillin Gallus gallus (Chicken) PR
Q9PU47 PDLIM3 PDZ and LIM domain protein 3 Gallus gallus (Chicken) PR
P49023 PXN Paxillin Homo sapiens (Human) PR
O43294 TGFB1I1 Transforming growth factor beta-1-induced transcript 1 protein Homo sapiens (Human) PR
Q53GG5 PDLIM3 PDZ and LIM domain protein 3 Homo sapiens (Human) PR
Q62219 Tgfb1i1 Transforming growth factor beta-1-induced transcript 1 protein Mus musculus (Mouse) PR
Q8VI36 Pxn Paxillin Mus musculus (Mouse) PR
O70209 Pdlim3 PDZ and LIM domain protein 3 Mus musculus (Mouse) PR
Q6QGC0 PDLIM3 PDZ and LIM domain protein 3 Sus scrofa (Pig) PR
Q66H76 Pxn Paxillin Rattus norvegicus (Rat) PR
10 20 30 40 50 60
MPQNVVLPGP APWGFRLSGG IDFNQPLVIT RITPGSKAAA ANLCPGDVIL AIDGFGTESM
70 80 90 100 110 120
THADAQDRIK AAGHQLCLKI DRAEARLWSP QVTEDGKAHP FKINLESEPQ EFKPIGAAHN
130 140 150 160 170 180
RRAQPFVAAA NIDDKRQVVS ASYNSPIGLY STSNIQDALH GQLRGLIPSS PQNEPTASVP
190 200 210 220 230 240
PESDVYRMLH DNRNEPTQPR QSGSFRVLQE LVNDGADDRP AGTRSVRAPV TKVHGGAGGT
250 260 270 280 290 300
QKMPFCDKCG SGIVGAVVKA RDKYRHPECF VCADCNLNLK QKGYFFVEGE LYCETHARAR
310
MRPPEGYDTV TLYPKA