P49024

PR
Gene name
PXN
Protein name
Paxillin
Names
Species
Gallus gallus (Chicken)
KEGG Pathway
gga:395832
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-342 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

5 structures for P49024

Entry ID Method Resolution Chain Position Source
2L6F NMR - PDB
2L6G NMR - A 140-161 PDB
2L6H NMR - A 263-276 PDB
4R32 X-ray 350 A B/C 139-162 PDB
AF-P49024-F1 Predicted AlphaFoldDB

No variants for P49024

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P49024

No associated diseases with P49024

7 regional properties for P49024

Type Name Position InterPro Accession
domain Zinc finger, LIM-type 324 - 383 IPR001781-1
domain Zinc finger, LIM-type 384 - 441 IPR001781-2
domain Zinc finger, LIM-type 442 - 501 IPR001781-3
domain Zinc finger, LIM-type 502 - 559 IPR001781-4
domain Paxillin, Lim domain 4 503 - 554 IPR001904
domain Paxillin, Lim domain 2 385 - 436 IPR047072
domain Paxillin/TGFB1I1, LIM domain 1 326 - 378 IPR047075

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm, cytoskeleton
  • Cell junction, focal adhesion
  • Cytoplasm, cell cortex
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

5 GO annotations of cellular component

Name Definition
cell cortex The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins.
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
focal adhesion A cell-substrate junction that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments. In insects focal adhesion has also been referred to as hemi-adherens junction (HAJ).
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
stress fiber A contractile actin filament bundle that consists of short actin filaments with alternating polarity, cross-linked by alpha-actinin and possibly other actin bundling proteins, and with myosin present in a periodic distribution along the fiber.

3 GO annotations of molecular function

Name Definition
metal ion binding Binding to a metal ion.
transcription coregulator activity A transcription regulator activity that modulates the transcription of specific gene sets via binding to a DNA-bound DNA-binding transcription factor, either on its own or as part of a complex. Coregulators often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators.
vinculin binding Binding to vinculin, a protein found in muscle, fibroblasts, and epithelial cells that binds actin and appears to mediate attachment of actin filaments to integral proteins of the plasma membrane.

5 GO annotations of biological process

Name Definition
cell-matrix adhesion The binding of a cell to the extracellular matrix via adhesion molecules.
endothelial cell migration The orderly movement of an endothelial cell into the extracellular matrix to form an endothelium.
response to muscle stretch Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a myofibril being extended beyond its slack length.
substrate adhesion-dependent cell spreading The morphogenetic process that results in flattening of a cell as a consequence of its adhesion to a substrate.
transforming growth factor beta receptor signaling pathway The series of molecular signals initiated by an extracellular ligand binding to a transforming growth factor beta receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.

10 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q3SYZ8 PDLIM3 PDZ and LIM domain protein 3 Bos taurus (Bovine) PR
Q9PU47 PDLIM3 PDZ and LIM domain protein 3 Gallus gallus (Chicken) PR
Q53GG5 PDLIM3 PDZ and LIM domain protein 3 Homo sapiens (Human) PR
O43294 TGFB1I1 Transforming growth factor beta-1-induced transcript 1 protein Homo sapiens (Human) PR
P49023 PXN Paxillin Homo sapiens (Human) PR
O70209 Pdlim3 PDZ and LIM domain protein 3 Mus musculus (Mouse) PR
Q62219 Tgfb1i1 Transforming growth factor beta-1-induced transcript 1 protein Mus musculus (Mouse) PR
Q8VI36 Pxn Paxillin Mus musculus (Mouse) PR
Q6QGC0 PDLIM3 PDZ and LIM domain protein 3 Sus scrofa (Pig) PR
Q66H76 Pxn Paxillin Rattus norvegicus (Rat) PR
10 20 30 40 50 60
MDDLDALLAD LESTTSHISK RPVFLTEETP YSYPTGNHTY QEIAVPPPVP PPPSSEALNG
70 80 90 100 110 120
TVIDPLDQWQ PSVSRYGHQQ PQSQSPIYSS SAKSSSASVP RDGLSSPSPR ASEEEHVYSF
130 140 150 160 170 180
PNKQKSAEPS PTMTSTSLGS NLSELDRLLL ELNAVQHNPP SGFSADEVSR SPSLPNVTGP
190 200 210 220 230 240
HYVIPESSSS AGGKAAPPTK EKPKRNGGRG IEDVRPSVES LLDELESSVP SPVPAITVSQ
250 260 270 280 290 300
GEVSSPQRVN ASQQQTRISA SSATRELDEL MASLSDFKFM AQGKAGGSSS PPSTTPKPGS
310 320 330 340 350 360
QLDTMLGSLQ SDLNKLGVAT VAKGVCGACK KPIAGQVVTA MGKTWHPEHF VCTHCQEEIG
370 380 390 400 410 420
SRNFFERDGQ PYCEKDYHNL FSPRCYYCNG PILDKVVTAL DRTWHPEHFF CAQCGVFFGP
430 440 450 460 470 480
EGFHEKDGKA YCRKDYFDMF APKCGGCARA ILENYISALN TLWHPECFVC RECFTPFING
490 500 510 520 530 540
SFFEHDGQPY CEVHYHERRG SLCSGCQKPI TGRCITAMGK KFHPEHFVCA FCLKQLNKGT
550
FKEQNDKPYC QNCFLKLFC