O70209

PR
Gene name
Pdlim3
Protein name
PDZ and LIM domain protein 3
Names
Actinin-associated LIM protein, Alpha-actinin-2-associated LIM protein
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:53318
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

64-269 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

3 structures for O70209

Entry ID Method Resolution Chain Position Source
1V5L NMR - A 4-93 PDB
1X64 NMR - A 226-301 PDB
AF-O70209-F1 Predicted AlphaFoldDB

12 variants for O70209

Variant ID(s) Position Change Description Diseaes Association Provenance
rs3388959488 34 P>L No EVA
rs3388978914 37 K>E No EVA
rs3388959449 56 G>R No EVA
rs3388962817 140 S>I No EVA
rs32908969 171 L>P No EVA
rs36918522 195 D>E No EVA
rs230046822 198 A>T No EVA
rs3388975686 233 V>D No EVA
rs3388982015 235 G>C No EVA
rs3388986441 256 A>V No EVA
rs3388981823 289 G>R No EVA
rs3388981598 317 A>K No EVA

No associated diseases with O70209

1 regional properties for O70209

Type Name Position InterPro Accession
domain Band 7 domain 26 - 205 IPR001107

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm, myofibril, sarcomere, Z line
  • Localizes to myofiber Z-lines
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

6 GO annotations of cellular component

Name Definition
actin cytoskeleton The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes.
adherens junction A cell-cell junction composed of the epithelial cadherin-catenin complex. The epithelial cadherins, or E-cadherins, of each interacting cell extend through the plasma membrane into the extracellular space and bind to each other. The E-cadherins bind to catenins on the cytoplasmic side of the membrane, where the E-cadherin-catenin complex binds to cytoskeletal components and regulatory and signaling molecules.
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
filamentous actin A two-stranded helical polymer of the protein actin.
stress fiber A contractile actin filament bundle that consists of short actin filaments with alternating polarity, cross-linked by alpha-actinin and possibly other actin bundling proteins, and with myosin present in a periodic distribution along the fiber.
Z disc Platelike region of a muscle sarcomere to which the plus ends of actin filaments are attached.

6 GO annotations of molecular function

Name Definition
actin binding Binding to monomeric or multimeric forms of actin, including actin filaments.
actinin binding Binding to actinin, any member of a family of proteins that crosslink F-actin.
cytoskeletal protein binding Binding to a protein component of a cytoskeleton (actin, microtubule, or intermediate filament cytoskeleton).
metal ion binding Binding to a metal ion.
muscle alpha-actinin binding Binding to muscle isoforms of actinin. Muscle alpha-actinin isoforms are found in skeletal and cardiac muscle and are localized to the Z-disc.
structural constituent of muscle The action of a molecule that contributes to the structural integrity of a muscle fiber.

4 GO annotations of biological process

Name Definition
actin cytoskeleton organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins.
actin filament organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments. Includes processes that control the spatial distribution of actin filaments, such as organizing filaments into meshworks, bundles, or other structures, as by cross-linking.
heart development The process whose specific outcome is the progression of the heart over time, from its formation to the mature structure. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood.
muscle structure development The progression of a muscle structure over time, from its formation to its mature state. Muscle structures are contractile cells, tissues or organs that are found in multicellular organisms.

10 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q3SYZ8 PDLIM3 PDZ and LIM domain protein 3 Bos taurus (Bovine) PR
P49024 PXN Paxillin Gallus gallus (Chicken) PR
Q9PU47 PDLIM3 PDZ and LIM domain protein 3 Gallus gallus (Chicken) PR
P49023 PXN Paxillin Homo sapiens (Human) PR
O43294 TGFB1I1 Transforming growth factor beta-1-induced transcript 1 protein Homo sapiens (Human) PR
Q53GG5 PDLIM3 PDZ and LIM domain protein 3 Homo sapiens (Human) PR
Q62219 Tgfb1i1 Transforming growth factor beta-1-induced transcript 1 protein Mus musculus (Mouse) PR
Q8VI36 Pxn Paxillin Mus musculus (Mouse) PR
Q6QGC0 PDLIM3 PDZ and LIM domain protein 3 Sus scrofa (Pig) PR
Q66H76 Pxn Paxillin Rattus norvegicus (Rat) PR
10 20 30 40 50 60
MPQNVVLPGP APWGFRLSGG IDFNQPLVIT RITPGSKAAA ANLCPGDVIL AIDGFGTESM
70 80 90 100 110 120
THADAQDRIK AASYQLCLKI DRAETRLWSP QVSEDGKAHP FKINLEAEPQ EFKPIGTAHN
130 140 150 160 170 180
RRAQPFVAAA NIDDKRQVVS ASYNSPIGLY STSNIQDALH GQLRGLIPGS LQNEPTASVP
190 200 210 220 230 240
PQSDVYRMLH DNRDDPAAPR QSGSFRVLQD LVNDGPDDRP AGTRSVRAPV TKVHGGAGSA
250 260 270 280 290 300
QRMPLCDKCG SGIVGAVVKA RDKYRHPECF VCADCNLNLK QKGYFFVEGE LYCETHARAR
310
TRPPEGYDTV TLYPKA