Q8VHG0

PR
Gene name
Fmo4
Protein name
Dimethylaniline monooxygenase [N-oxide-forming] 4
Names
Dimethylaniline oxidase 4, Hepatic flavin-containing monooxygenase 4, FMO 4
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:226564
EC number
1.14.13.8: With NADH or NADPH as one donor, and incorporation of one atom of oxygen
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

371-452 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q8VHG0

Entry ID Method Resolution Chain Position Source
AF-Q8VHG0-F1 Predicted AlphaFoldDB

40 variants for Q8VHG0

Variant ID(s) Position Change Description Diseaes Association Provenance
rs45992884 48 E>K No EVA
rs3388509797 61 N>Y No EVA
rs3388512450 63 C>S No EVA
rs3388512907 75 R>* No EVA
rs216713975 75 R>Q No EVA
rs249983809 77 D>G No EVA
rs3388509842 88 W>* No EVA
rs3388511983 110 V>M No EVA
rs253097828 127 V>I No EVA
rs235322879 135 R>Q No EVA
rs3388508353 178 I>F No EVA
rs3388510582 194 N>Y No EVA
rs3388513007 199 I>K No EVA
rs38663653 205 E>G No EVA
rs38663653 205 E>V No EVA
rs3388508206 206 I>K No EVA
rs36558626 249 R>H No EVA
rs220111934 255 H>L No EVA
rs32172242 310 I>V No EVA
rs3390926856 312 E>K No EVA
rs3390902079 321 D>H No EVA
rs3390828462 324 I>M No EVA
rs3390756966 324 I>N No EVA
rs3390908856 325 F>I No EVA
rs3388510570 337 E>D No EVA
rs3388506696 342 S>G No EVA
rs38079158 410 T>M No EVA
rs3388512900 432 Y>N No EVA
rs3388510282 440 I>K No EVA
rs3388512404 456 L>F No EVA
rs3388512493 491 R>G No EVA
rs3388512063 496 L>F No EVA
rs3390828427 506 E>K No EVA
rs3390911372 513 Y>* No EVA
rs3390756039 514 L>V No EVA
rs3388510273 544 P>L No EVA
rs3388512633 550 Y>* No EVA
rs225163221 551 R>Q No EVA
rs258655607 556 M>I No EVA
rs3388512675 558 Q>* No EVA

No associated diseases with Q8VHG0

2 regional properties for Q8VHG0

Type Name Position InterPro Accession
domain GRAM domain 96 - 203 IPR004182
domain VASt domain 372 - 543 IPR031968

Functions

Description
EC Number 1.14.13.8 With NADH or NADPH as one donor, and incorporation of one atom of oxygen
Subcellular Localization
  • Microsome membrane ; Single-pass membrane protein
  • Endoplasmic reticulum membrane ; Single-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
endoplasmic reticulum membrane The lipid bilayer surrounding the endoplasmic reticulum.
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.

4 GO annotations of molecular function

Name Definition
flavin adenine dinucleotide binding Binding to FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2.
monooxygenase activity Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water.
N,N-dimethylaniline monooxygenase activity Catalysis of the reaction: N,N-dimethylaniline + NADPH + H+ + O2 = N,N-dimethylaniline N-oxide + NADP+ + H2O.
NADP binding Binding to nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP+, or the reduced form, NADPH.

3 GO annotations of biological process

Name Definition
energy homeostasis Any process involved in the balance between food intake (energy input) and energy expenditure.
negative regulation of fatty acid oxidation Any process that stops, prevents, or reduces the frequency, rate or extent of fatty acid oxidation.
xenobiotic catabolic process The chemical reactions and pathways resulting in the breakdown of a xenobiotic compound, a compound foreign to the organim exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical.

12 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P49326 FMO5 Flavin-containing monooxygenase 5 Homo sapiens (Human) PR
P31512 FMO4 Dimethylaniline monooxygenase [N-oxide-forming] 4 Homo sapiens (Human) PR
P97501 Fmo3 Dimethylaniline monooxygenase [N-oxide-forming] 3 Mus musculus (Mouse) PR
P97872 Fmo5 Flavin-containing monooxygenase 5 Mus musculus (Mouse) PR
Q8K2I3 Fmo2 Dimethylaniline monooxygenase [N-oxide-forming] 2 Mus musculus (Mouse) PR
Q6IRI9 Fmo2 Dimethylaniline monooxygenase [N-oxide-forming] 2 Rattus norvegicus (Rat) PR
Q9EQ76 Fmo3 Dimethylaniline monooxygenase [N-oxide-forming] 3 Rattus norvegicus (Rat) PR
Q8K4C0 Fmo5 Flavin-containing monooxygenase 5 Rattus norvegicus (Rat) PR
Q8K4B7 Fmo4 Dimethylaniline monooxygenase [N-oxide-forming] 4 Rattus norvegicus (Rat) PR
Q9SVU0 YUC8 Probable indole-3-pyruvate monooxygenase YUCCA8 Arabidopsis thaliana (Mouse-ear cress) PR
Q9SXD9 At1g62580 Flavin-containing monooxygenase FMO GS-OX-like 7 Arabidopsis thaliana (Mouse-ear cress) PR
Q9C8T8 At1g63340 Putative flavin-containing monooxygenase FMO GS-OX-like 10 Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MAKKVAVIGA GVSGLSSIKC CLDENLEPTC FERTSDFGGL WKFADTSEDG MTRVYRSLVT
70 80 90 100 110 120
NVCKEMSCYS DFPFREDYPN FMSHEKFWDY LREFAEHFGL LRYIRFKTTV LSVTKRPDFS
130 140 150 160 170 180
ETGQWDVVTE TEGKRDRAVF DAVMVCTGQF LSPHLPLESF PGIHKFKGQI LHSQEYRIPD
190 200 210 220 230 240
AFRGKRILVV GLGNTGGDIA VELSEIAAQV FLSTRTGTWV LSRSSPGGYP FNMIQTRWLN
250 260 270 280 290 300
FLVRVLPSRF INWTHERKMN KILNHENYGL SIAKGKKPKF IVNDELPTCI LCGKVTMKTS
310 320 330 340 350 360
VKDFTESSVI FEDGTTEANI DVVIFTTGYE FSFPFFEEPL KSLCTKKIIL YKRVFPPNLE
370 380 390 400 410 420
RATLAIIGLI SLNGSILVGT EFQARWATRV FKGLCSIPPS QKLMAEATKT EQLIKRGVIK
430 440 450 460 470 480
DTSQDKLDFI TYMDELTQCI GAKPSIPLLF IKDPRLAWEV FFGPCTPYQY RLVGPGRWDG
490 500 510 520 530 540
ARNAILTQWD RTLKPLKTRI VPKSPEPTSL SHYLIAWGAP VLLVSLLLIY KSSHFLELVQ
550
GKLPRRFPPY RLLWYMPQNS