AiPD: Autoinhibited Protein Database

P49326

Gene name	FMO5
Protein name	Flavin-containing monooxygenase 5
Names	FMO 5, Baeyer-Villiger monooxygenase 1, hBVMO1, Dimethylaniline monooxygenase [N-oxide-forming] 5, Dimethylaniline oxidase 5, NADPH oxidase
Species	Homo sapiens (Human)
KEGG Pathway	hsa:2330
EC number	1.6.3.1: With oxygen as acceptor
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-43 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

1-43 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

1 structures for P49326

Entry ID	Method	Resolution	Chain	Position	Source
AF-P49326-F1	Predicted				AlphaFoldDB

493 variants for P49326

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
rs782280167 CA1063079	2	T>I		No	ClinGen ExAC TOPMed gnomAD
rs782280167 CA342200137	2	T>N		No	ClinGen ExAC TOPMed gnomAD
COSM1333650 COSM1333649 CA342200129 rs1553927342	3	K>N	large_intestine [Cosmic]	No	ClinGen cosmic curated gnomAD
CA342200135 rs1553927346	3	K>Q		No	ClinGen gnomAD
CA342200127 rs1553927341	4	K>*		No	ClinGen gnomAD
rs1308543418 CA342200115	5	R>I		No	ClinGen TOPMed gnomAD
rs1308543418 CA342200117	5	R>K		No	ClinGen TOPMed gnomAD
rs1553927316 CA342200106	6	I>M		No	ClinGen gnomAD
CA342200112 rs1398487288	6	I>V		No	ClinGen TOPMed
CA342200102 rs1384895237	7	A>D		No	ClinGen TOPMed gnomAD
CA342200101 rs1384895237	7	A>G		No	ClinGen TOPMed gnomAD
CA342200089 rs1331343533	9	I>T		No	ClinGen TOPMed gnomAD
rs150343605 CA1063077	10	G>R		No	ClinGen ESP ExAC TOPMed gnomAD
CA1063076 rs150343605	10	G>W		No	ClinGen ESP ExAC TOPMed gnomAD
CA342200080 rs1553927287	11	G>R		No	ClinGen gnomAD
CA1063075 rs782731754	12	G>R		No	ClinGen ExAC
rs1553927282 CA342200063	14	S>C		No	ClinGen gnomAD
rs1553927282 CA342200065	14	S>R		No	ClinGen gnomAD
TCGA novel	17	S>G	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs781855435 COSM3375336 COSM74686 CA1063073	17	S>Y	ovary Variant assessed as Somatic; 0.0 impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
CA1063072 rs373414071	18	S>F	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
rs1553927261 CA342200040	18	S>T		No	ClinGen gnomAD
rs1553927251 CA342200034	19	I>V		No	ClinGen gnomAD
rs1553927246 CA342200017	21	C>Y		No	ClinGen gnomAD
rs1553927245 CA342200009	22	C>Y		No	ClinGen gnomAD
rs587653353 CA1063070	23	V>I	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
CA342200004 rs587653353	23	V>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA1063069 rs782686115	24	E>D		No	ClinGen ExAC TOPMed gnomAD
CA342199981 rs587621484	26	G>A		No	ClinGen 1000Genomes ExAC
CA1063068 rs587621484	26	G>D		No	ClinGen 1000Genomes ExAC
rs1553927232 CA342199974	27	L>F		No	ClinGen gnomAD
CA1063066 rs781943524	28	E>*		No	ClinGen ExAC TOPMed
CA342199958 rs1553927221	29	P>H		No	ClinGen gnomAD
rs1374729846 CA342199947	31	C>S		No	ClinGen TOPMed gnomAD
rs1553927215 CA342199943	32	F>I		No	ClinGen gnomAD
rs1456277239 CA1063063	36	D>Y		No	ClinGen TOPMed
CA342199907 rs1391184417	37	D>N		No	ClinGen TOPMed gnomAD
rs1442699875 CA342199884	39	G>R		No	ClinGen TOPMed
CA342199856 rs1553927183	41	L>F		No	ClinGen gnomAD
rs782022440 CA1063060	42	W>*		No	ClinGen ExAC gnomAD
CA1063059 rs782330792	42	W>C		No	ClinGen ExAC TOPMed gnomAD
CA342199817 rs1228538453	43	R>S		No	ClinGen TOPMed
rs1363948427 CA342199829	43	R>W		No	ClinGen TOPMed
CA1063039 rs138739313	47	N>D		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1553924994 CA342199069	48	P>S		No	ClinGen gnomAD
rs782297433 CA1063038	49	E>K		No	ClinGen ExAC
CA29872647 rs1013838609	50	E>K		No	ClinGen Ensembl
rs782664070 CA1063036	52	R>G		No	ClinGen ExAC gnomAD
CA342199012 rs1275569164	53	A>D		No	ClinGen TOPMed gnomAD
rs201023390 CA1063034	53	A>T		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA342199008 rs1275569164	53	A>V		No	ClinGen TOPMed gnomAD
CA29872638 rs201690973	54	S>G		No	ClinGen 1000Genomes
CA342199000 rs1553924975	54	S>N		No	ClinGen gnomAD
CA1063033 rs782621445	54	S>R		No	ClinGen ExAC gnomAD
rs1553924968 CA342198982	55	I>T		No	ClinGen gnomAD
rs1553924967 CA342198963	56	Y>C		No	ClinGen gnomAD
CA342198927 rs1463852620	58	S>L		No	ClinGen TOPMed
rs1204907492 CA342198921	59	V>G		No	ClinGen TOPMed
rs782458920 CA1063032	59	V>L		No	ClinGen ExAC gnomAD
rs781864791 CA1063031	61	I>F		No	ClinGen ExAC gnomAD
rs1553924937 CA342198883	62	N>D		No	ClinGen gnomAD
CA342198848 rs1448965440	64	S>C		No	ClinGen TOPMed
CA1063027 rs782706521	66	E>G		No	ClinGen ExAC
rs1553924918 CA342198800	67	M>V		No	ClinGen gnomAD
rs1167068971 CA342198771	68	M>I		No	ClinGen TOPMed
rs141961654 CA1063026	68	M>K		No	ClinGen ESP ExAC TOPMed
CA342198776 rs141961654	68	M>T		No	ClinGen ESP ExAC TOPMed
TCGA novel	68	M>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA342198755 rs1409659937	69	C>F		No	ClinGen TOPMed
rs1553924906 CA342198654	76	P>T		No	ClinGen gnomAD
TCGA novel	78	H>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA1063025 rs781824470	80	P>H		No	ClinGen ExAC TOPMed gnomAD
rs1553924900 CA342198573	81	N>S		No	ClinGen gnomAD
CA1063024 rs185244734	82	F>L		No	ClinGen 1000Genomes ExAC gnomAD
CA342198540 rs1386781691	83	M>T		No	ClinGen TOPMed
rs782113433 CA1063023	84	H>R		No	ClinGen ExAC gnomAD
rs782795060 CA1063020	86	A>D		No	ClinGen ExAC gnomAD
CA342198489 rs1393958255	86	A>T		No	ClinGen TOPMed
CA1063019 rs782274844	88	V>I		No	ClinGen ExAC TOPMed gnomAD
COSM458629 CA342198453 COSM1134399 rs1355592356	90	E>Q	cervix Variant assessed as Somatic; impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated NCI-TCGA TOPMed
CA1063017 rs782357986	91	Y>C		No	ClinGen ExAC gnomAD
CA342198421 rs1416054632	94	M>T		No	ClinGen TOPMed gnomAD
rs781994979 CA1063015	95	Y>H		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	96	A>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	97	K>E	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1327721540 CA342198394	97	K>N		No	ClinGen TOPMed
CA1063014 rs782372330	98	E>*		No	ClinGen ExAC TOPMed gnomAD
CA342198387 rs1553924863	98	E>D		No	ClinGen gnomAD
TCGA novel	98	E>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs782594931 CA1063012	100	D>A		No	ClinGen ExAC gnomAD
CA342198374 rs1553924854	100	D>E		No	ClinGen gnomAD
rs782594931 CA1063013	100	D>G		No	ClinGen ExAC gnomAD
CA29872516 rs894955788	100	D>H		No	ClinGen TOPMed gnomAD
rs894955788 CA342198377	100	D>N		No	ClinGen TOPMed gnomAD
CA342198370 rs1353231634	101	L>I		No	ClinGen TOPMed
CA1063009 rs769261130	106	R>*		No	ClinGen ExAC gnomAD
rs782514474 CA1063008	106	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA1063007 rs781856596	107	F>L		No	ClinGen ExAC gnomAD
rs1571373670 CA342198334	107	F>L		No	ClinGen Ensembl
rs368761669 CA1062990	110	T>A		No	ClinGen ESP ExAC TOPMed gnomAD
rs1553924254 CA342198286	112	C>Y		No	ClinGen gnomAD
CA1062988 rs782593257	113	S>R		No	ClinGen ExAC TOPMed gnomAD
CA1062987 rs373669935	116	K>Q		No	ClinGen ESP ExAC TOPMed gnomAD
rs1381666493 CA342198240	118	P>L		No	ClinGen TOPMed
CA1062985 rs367897328	119	D>H		No	ClinGen ESP ExAC TOPMed gnomAD
CA1062986 rs367897328	119	D>N		No	ClinGen ESP ExAC TOPMed gnomAD
CA1062982 rs781849588	122	T>A		No	ClinGen ExAC gnomAD
CA1062981 rs782794854	124	G>D		No	ClinGen ExAC gnomAD
CA342198174 rs1553924223	128	V>A		No	ClinGen gnomAD
rs1553924227 CA342198176	128	V>L		No	ClinGen gnomAD
rs782137341 CA1062980	132	S>F		No	ClinGen ExAC gnomAD
CA1062978 rs782767440	133	E>D		No	ClinGen ExAC gnomAD
CA1062979 rs781795531	133	E>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA
CA29871634 rs950779253	134	G>E		No	ClinGen TOPMed gnomAD
CA29871640 rs1005361263	134	G>R		No	ClinGen Ensembl
CA1062975 rs782377974	135	K>N		No	ClinGen ExAC
CA1062976 rs782003965	135	K>R		No	ClinGen ExAC
CA342198127 rs868940730	136	K>M		No	ClinGen gnomAD
TCGA novel	136	K>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA1062974 rs782167673	136	K>Q		No	ClinGen ExAC
CA342198128 rs868940730	136	K>R		No	ClinGen gnomAD
CA1062972 rs782320213	137	E>D		No	ClinGen ExAC gnomAD
CA29871625 rs145368007	137	E>K		No	ClinGen ESP ExAC gnomAD
rs145368007 CA1062973	137	E>Q		No	ClinGen ESP ExAC gnomAD
rs782177308 CA1062971	138	M>K		No	ClinGen ExAC
CA1062970 rs781886015	138	M>RT*		No	ClinGen ExAC
CA342198103 rs1553924203	139	N>K		No	ClinGen gnomAD
CA342198090 rs1334328841	141	F>L		No	ClinGen TOPMed
CA1062969 rs782606292	141	F>V		No	ClinGen ExAC gnomAD
CA1062967 rs782259613	144	V>I		No	ClinGen ExAC TOPMed gnomAD
CA342198065 rs1310262027	145	M>R		No	ClinGen TOPMed gnomAD
CA342198066 rs1310262027	145	M>T		No	ClinGen TOPMed gnomAD
rs782547260 CA1062965	147	C>G		No	ClinGen ExAC gnomAD
rs901100743 CA29871602	147	C>Y		No	ClinGen TOPMed gnomAD
rs587710509 CA1062964	148	T>N		No	ClinGen 1000Genomes ExAC gnomAD
CA1062963 rs782585785	149	G>S		No	ClinGen ExAC gnomAD
CA342198035 rs1553924179	150	H>R		No	ClinGen gnomAD
rs1571351583 CA342198037	150	H>Y		No	ClinGen Ensembl
rs587652629 CA342198022	152	T>A		No	ClinGen 1000Genomes ExAC gnomAD
CA1062961 rs587652629	152	T>P		No	ClinGen 1000Genomes ExAC gnomAD
CA1062960 rs782776197	153	N>S		No	ClinGen ExAC TOPMed gnomAD
CA342198006 rs1255422384	154	A>V		No	ClinGen TOPMed gnomAD
rs782120560 CA1062959	155	H>Y		No	ClinGen ExAC gnomAD
rs781910099 CA342197997	156	L>V		No	ClinGen ExAC gnomAD
CA1062957 rs782796413	157	P>R		No	ClinGen ExAC gnomAD
CA29871542 rs1039562387	157	P>T		No	ClinGen Ensembl
CA1062956 rs782068768	158	L>P		No	ClinGen ExAC gnomAD
rs781920064 CA1062955	159	E>*		No	ClinGen ExAC TOPMed gnomAD
rs1553924152 CA342197973	160	S>I		No	ClinGen gnomAD
CA342197972 rs1559668302	160	S>R		No	ClinGen Ensembl
rs1006691533 CA29871511	162	P>S		No	ClinGen Ensembl
rs782768099 CA1062935	164	I>T		No	ClinGen ExAC TOPMed gnomAD
rs1466905136 CA342197939	164	I>V		No	ClinGen TOPMed
rs1348861978 CA342197934	165	E>K		No	ClinGen TOPMed gnomAD
RCV000967806 rs58351438 CA1062934	166	K>E		No	ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
CA1062932 rs782787091	168	K>N		No	ClinGen ExAC TOPMed gnomAD
rs1347971901 CA342197882	170	Q>R		No	ClinGen TOPMed gnomAD
CA1062931 rs782061860	171	Y>*		No	ClinGen ExAC TOPMed gnomAD
rs781979585 CA1062930	172	F>L		No	ClinGen ExAC gnomAD
CA342197841 rs1319002970	173	H>R		No	ClinGen TOPMed
rs143647812 CA1062929	173	H>Y		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
COSM1333641 COSM1333642 CA1062928 rs587682197	175	R>*	large_intestine [Cosmic]	No	ClinGen cosmic curated 1000Genomes ExAC gnomAD
rs782690948 CA342197815	175	R>L		No	ClinGen ExAC TOPMed gnomAD
rs782690948 CA1062927	175	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA342197794 rs1451190224	176	D>E		No	ClinGen TOPMed gnomAD
CA1062926 rs200936105	177	Y>*		No	ClinGen ExAC TOPMed gnomAD
COSM161112 CA342197785 rs1222401972	177	Y>C	breast [Cosmic]	No	ClinGen cosmic curated TOPMed gnomAD
CA1062925 rs782278097	178	K>Q		No	ClinGen ExAC gnomAD
rs1553923941 CA342197770	178	K>R		No	ClinGen gnomAD
rs782576772 CA1062924	181	E>*		No	ClinGen ExAC gnomAD
CA342197730 rs1476811833	181	E>A		No	ClinGen TOPMed
rs782228735 CA1062922	182	G>*		No	ClinGen ExAC gnomAD
CA342197688 rs1553923929	184	T>A		No	ClinGen gnomAD
rs782516404 CA1062920	186	K>R		No	ClinGen ExAC gnomAD
CA342197651 rs781850993	187	R>K	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs782816480 CA1062918	187	R>S		No	ClinGen ExAC gnomAD
CA1062919 rs781850993	187	R>T	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs1424121018 CA342197637	188	V>D		No	ClinGen TOPMed
rs1553923920 CA342197628	189	I>T		No	ClinGen gnomAD
TCGA novel	189	I>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1571344330 CA342197620	190	I>V		No	ClinGen Ensembl
CA1062916 rs781797303	191	I>M		No	ClinGen ExAC gnomAD
rs782524155 CA1062917	191	I>T		No	ClinGen ExAC TOPMed gnomAD
CA1062915 rs370710329	192	G>S		No	ClinGen ESP ExAC TOPMed gnomAD
CA1062914 rs782092443	193	I>T	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs1324982224 CA342197540	196	S>A		No	ClinGen TOPMed
CA342197530 rs1553923908	197	G>R		No	ClinGen gnomAD
rs1571344163 CA342197510	198	G>E		No	ClinGen Ensembl
rs376305166 CA29871133	198	G>R		No	ClinGen gnomAD
COSM1667896 rs782766791 CA1062912 COSM1667897	199	D>H	lung central_nervous_system [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
CA1062910 rs782018520	202	V>A		No	ClinGen ExAC TOPMed gnomAD
rs782167223 CA1062911	202	V>I		No	ClinGen ExAC gnomAD
rs200593411 CA29871116	203	E>A		No	ClinGen TOPMed gnomAD
rs1553923897 CA342197414	205	S>R		No	ClinGen gnomAD
CA1062908 rs782176597	206	Q>R		No	ClinGen ExAC TOPMed gnomAD
CA1062907 rs781963495	208	A>T		No	ClinGen ExAC gnomAD
CA1062889 rs782078934	213	L>F		No	ClinGen ExAC gnomAD
CA342196720 rs1553923154	214	S>I	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA1062887 rs782373884	214	S>R		No	ClinGen ExAC gnomAD
rs1553923146 CA342196677	217	R>S		No	ClinGen gnomAD
rs898699397 CA29870003	218	G>R		No	ClinGen gnomAD
CA342196670 rs782011777	219	A>P		No	ClinGen ExAC TOPMed gnomAD
CA1062884 rs782011777	219	A>T		No	ClinGen ExAC TOPMed gnomAD
CA342196668 rs1559661636	219	A>V		No	ClinGen Ensembl
CA1062883 rs782318371	221	I>S		No	ClinGen ExAC TOPMed gnomAD
rs1553923133 CA342196649	222	L>P		No	ClinGen gnomAD
rs782170956 CA1062882	222	L>V		No	ClinGen ExAC gnomAD
rs782619685 CA342196638	224	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs782390826 CA1062880	224	R>P		No	ClinGen ExAC gnomAD
rs782619685 CA1062881	224	R>S		No	ClinGen ExAC TOPMed gnomAD
CA1062879 rs782247603	225	V>A		No	ClinGen ExAC gnomAD
rs782690942 CA1062878	226	G>E		No	ClinGen ExAC TOPMed gnomAD
rs1553923128 CA342196628	226	G>R		No	ClinGen gnomAD
rs782573507 CA1062875	228	Y>C		No	ClinGen ExAC gnomAD
TCGA novel	228	Y>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs142613638 CA1062874	229	G>R	Variant assessed as Somatic; 4.619e-05 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ESP ExAC NCI-TCGA TOPMed gnomAD
rs143515661 CA1062872	232	A>V		No	ClinGen ESP ExAC TOPMed
TCGA novel	233	D>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs782111398 CA1062871	233	D>V		No	ClinGen ExAC gnomAD
CA1062869 rs782790150	234	V>M		No	ClinGen ExAC TOPMed gnomAD
rs1553923090 CA342196484	239	R>G		No	ClinGen gnomAD
CA1062868 rs782060976	239	R>P		No	ClinGen ExAC gnomAD
CA1062866 rs782348340	241	T>P		No	ClinGen ExAC gnomAD
CA342196433 rs150291421	243	F>L		No	ClinGen ESP TOPMed
CA29869913 rs150291421	243	F>V		No	ClinGen ESP TOPMed
rs148462233 CA342196408	244	I>M		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA1062863 CA1062864 rs782441743	245	W>C		No	ClinGen ExAC gnomAD
CA342196306 rs1553923075	251	S>L		No	ClinGen Ensembl
CA1062859 rs782235792	251	S>P		No	ClinGen ExAC gnomAD
rs782611488 CA1062858	252	L>S		No	ClinGen ExAC gnomAD
rs782238891 CA1062856	253	A>E		No	ClinGen ExAC TOPMed gnomAD
CA1062857 rs782509696	253	A>T		No	ClinGen ExAC TOPMed gnomAD
rs1553923066 CA342196280	254	N>D		No	ClinGen gnomAD
rs782673844 CA1062855	254	N>K		No	ClinGen ExAC gnomAD
rs72549315	260	K>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs72549315	261	I>D	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
CA1062853 rs587730252	262	N>K		No	ClinGen 1000Genomes ExAC gnomAD
CA1062852 rs781800019	263	Q>H		No	ClinGen ExAC gnomAD
TCGA novel	264	R>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA29869840 rs977925691	264	R>W		No	ClinGen Ensembl
rs1559661068 CA342196117	265	F>L		No	ClinGen Ensembl
COSM895275 rs1348262929 CA342196104 COSM1151825	266	D>N	endometrium [Cosmic]	No	ClinGen cosmic curated TOPMed gnomAD
rs782693538 CA1062851	267	H>Y		No	ClinGen ExAC gnomAD
CA1062850 rs140667185	268	E>*		No	ClinGen ESP ExAC TOPMed gnomAD
rs781820238 CA1062849	271	G>S		No	ClinGen ExAC gnomAD
CA342196008 rs1201279141	271	G>V		No	ClinGen TOPMed gnomAD
CA29869820 rs1024755340	273	K>R		No	ClinGen Ensembl
CA342195978 rs1553923050	274	P>A		No	ClinGen gnomAD
CA1062848 rs370843382	276	H>N		No	ClinGen ESP ExAC TOPMed
CA342194413 rs1553920995	278	A>T		No	ClinGen gnomAD
CA1062830 rs587632947	280	S>R		No	ClinGen 1000Genomes ExAC gnomAD
rs781791745 CA342194393	281	Q>L		No	ClinGen ExAC TOPMed gnomAD
CA1062829 rs781791745	281	Q>R		No	ClinGen ExAC TOPMed gnomAD
CA1062828 rs375828487	284	T>A		No	ClinGen ESP ExAC TOPMed gnomAD
CA1062827 rs782088450	284	T>I		No	ClinGen ExAC TOPMed gnomAD
CA342194368 rs1553920985	285	L>*		No	ClinGen gnomAD
CA29866981 rs917646951	286	N>S		No	ClinGen Ensembl
rs782007251 CA342194344	288	D>E		No	ClinGen ExAC TOPMed gnomAD
rs143729816 CA1062824	292	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
rs143729816 CA342194322	292	R>G		No	ClinGen ESP ExAC TOPMed gnomAD
CA1062823 rs372716556	292	R>H		No	ClinGen ESP ExAC TOPMed gnomAD
TCGA novel	292	R>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs782017216 CA1062822	293	I>V		No	ClinGen ExAC gnomAD
CA29866968 rs370263774	294	I>V		No	ClinGen Ensembl
TCGA novel	295	S>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA1062821 rs587767140	298	V>L		No	ClinGen 1000Genomes ExAC gnomAD
CA342194280 rs1473153633	299	K>T		No	ClinGen TOPMed
CA1062820 rs587683297	300	V>M		No	ClinGen 1000Genomes ExAC gnomAD
TCGA novel	301	K>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA342194260 rs1559649647	302	G>E		No	ClinGen Ensembl
CA1062819 CA342194262 rs369165742	302	G>R		No	ClinGen ESP ExAC TOPMed gnomAD
rs782258305 CA1062816	304	V>A		No	ClinGen ExAC gnomAD
rs1553920954 CA342194241	305	K>M		No	ClinGen gnomAD
CA29866938 rs145231434	306	E>*		No	ClinGen ESP TOPMed gnomAD
CA1062815 rs375148951	308	T>M		No	ClinGen ESP ExAC TOPMed gnomAD
rs1553920942 CA342194212	309	E>G		No	ClinGen gnomAD
rs782199174 CA1062813	310	T>I		No	ClinGen ExAC
CA342194201 rs1450052424	311	A>D		No	ClinGen TOPMed gnomAD
rs782585776 CA1062812	311	A>P		No	ClinGen ExAC gnomAD
CA1062810 rs587673087	313	I>L		No	ClinGen 1000Genomes ExAC gnomAD
CA1062811 rs587673087	313	I>V		No	ClinGen 1000Genomes ExAC gnomAD
rs139232242 CA1062809	314	F>I		No	ClinGen ESP ExAC TOPMed gnomAD
rs782502476 CA1062808	315	E>K		No	ClinGen ExAC gnomAD
TCGA novel	318	S>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA1062807 rs142335408	319	R>G		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs782793382 CA1062806	320	E>K		No	ClinGen ExAC TOPMed gnomAD
CA1062805 rs781783469	321	D>E		No	ClinGen ExAC gnomAD
CA342194140 rs1553920923	321	D>N		No	ClinGen gnomAD
CA1062802 rs782075632	323	I>T		No	ClinGen ExAC TOPMed gnomAD
rs781998990 CA1062801	325	A>V		No	ClinGen ExAC gnomAD
CA1062800 rs782425210	326	V>I		No	ClinGen ExAC gnomAD
COSM1138582 COSM528283 CA342194099 rs1553920917	327	I>F	lung Variant assessed as Somatic; 0.0 impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated NCI-TCGA gnomAD
CA1062799 rs202145159	327	I>S		No	ClinGen ExAC TOPMed gnomAD
CA1062798 rs202145159	327	I>T		No	ClinGen ExAC TOPMed gnomAD
CA1062796 rs782227201	328	F>L		No	ClinGen ExAC TOPMed gnomAD
rs199667610 CA1062797	328	F>L		No	ClinGen 1000Genomes ExAC gnomAD
rs1553920903 CA342194085	329	A>V		No	ClinGen gnomAD
TCGA novel	331	G>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	333	S>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs587740648 CA342194045	335	D>A		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA1062794 rs587740648	335	D>V		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs782678465 CA1062793	337	P>A	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs782405859 CA29866861	337	P>L		No	ClinGen Ensembl
CA1062792 rs782678465	337	P>T		No	ClinGen ExAC gnomAD
rs1553920885 CA342194003	341	D>V		No	ClinGen gnomAD
COSM1185574 CA1062789 COSM1185573 rs201890460	343	V>I	lung large_intestine [Cosmic]	No	ClinGen cosmic curated 1000Genomes ExAC TOPMed gnomAD
CA29866839 rs782484284	344	K>N		No	ClinGen TOPMed gnomAD
rs1553920876 CA342193971	346	V>I		No	ClinGen gnomAD
rs1553920874 CA342193950	347	K>N		No	ClinGen gnomAD
rs782472747 CA1062787	350	I>L		No	ClinGen ExAC TOPMed gnomAD
CA342193902 rs1571243695	350	I>M		No	ClinGen Ensembl
rs782472747 CA342193912	350	I>V		No	ClinGen ExAC TOPMed gnomAD
CA29866822 rs1044848	351	S>P		No	ClinGen gnomAD
CA1062785 rs782764302	354	K>E		No	ClinGen ExAC gnomAD
CA342193838 rs1335745543	355	K>Q		No	ClinGen TOPMed gnomAD
rs138976736 CA1062783	356	V>F	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
rs782720672 CA1062782	356	V>G		No	ClinGen ExAC
rs138976736 CA1062784	356	V>I		No	ClinGen ESP ExAC TOPMed gnomAD
CA342193754 rs1334615714	358	P>S		No	ClinGen TOPMed
CA342193732 rs1571243389	359	P>R		No	ClinGen Ensembl
CA1062779 rs782058937	359	P>S		No	ClinGen ExAC TOPMed gnomAD
rs1222060131 CA342193681	362	E>G		No	ClinGen TOPMed
rs781974050 CA1062776	363	R>K		No	ClinGen ExAC TOPMed
CA342193660 rs781974050	363	R>T		No	ClinGen ExAC TOPMed
TCGA novel	364	P>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1553920832 CA342193636	365	T>A		No	ClinGen gnomAD
rs1345995407 CA342193623	365	T>I		No	ClinGen TOPMed
rs1553920831 CA342193614	366	L>F		No	ClinGen gnomAD
CA1062774 rs151065604	367	A>G		No	ClinGen ESP ExAC TOPMed gnomAD
CA342193594 rs151065604	367	A>V		No	ClinGen ESP ExAC TOPMed gnomAD
rs148940888 CA1062772	368	I>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs148940888 CA342193584	368	I>V		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1553920823 CA342193564	369	I>L		No	ClinGen gnomAD
CA342193549 rs1253874785	369	I>M		No	ClinGen TOPMed
CA1062770 rs189477318	369	I>T		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1175101050 CA342193514	371	L>F		No	ClinGen TOPMed gnomAD
rs371682227 CA1062769	371	L>M		No	ClinGen ESP ExAC TOPMed gnomAD
CA1062768 rs781936783	372	I>F		No	ClinGen ExAC gnomAD
TCGA novel	373	Q>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1377935007 CA342193451	375	L>F		No	ClinGen TOPMed
rs1553920812 CA342193446	376	G>R		No	ClinGen gnomAD
TCGA novel	377	A>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA342193418 rs1553920811	377	A>V		No	ClinGen gnomAD
CA1062766 rs375231884	379	M>I		No	ClinGen ESP ExAC gnomAD
rs896249198 CA29866725	380	P>T		No	ClinGen gnomAD
CA342193336 rs1553920802	381	I>V		No	ClinGen gnomAD
rs1467286698 CA342193254	384	L>F		No	ClinGen TOPMed
CA342193218 rs1165757897	386	G>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
rs200894114 CA1062765	387	R>C		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs372175539 CA1062764	387	R>H		No	ClinGen ESP ExAC TOPMed gnomAD
CA1062763 rs372175539	387	R>L		No	ClinGen ESP ExAC TOPMed gnomAD
rs1553920791 CA342193170	388	W>C		No	ClinGen gnomAD
CA342193161 rs1553920787	389	A>D		No	ClinGen gnomAD
rs782678982 CA342193168	389	A>S		No	ClinGen ExAC gnomAD
rs782678982 CA1062762	389	A>T		No	ClinGen ExAC gnomAD
rs56134376 CA342193125	391	Q>P		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs56134376 CA1062761 RCV000963061	391	Q>R		No	ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs1403574339 CA342193112	392	V>A	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
CA342193116 rs1553920780	392	V>L		No	ClinGen gnomAD
CA342193108 rs1301044606	393	F>I		No	ClinGen TOPMed
TCGA novel	395	G>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA29891708 rs781918962	398	T>S		No	ClinGen Ensembl
rs1553918172 CA342200306	399	L>F		No	ClinGen gnomAD
VAR_022308 CA1062744 rs28381218	400	P>A		No	ClinGen UniProt 1000Genomes ExAC TOPMed dbSNP gnomAD
rs28381218 CA342200304	400	P>S		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
TCGA novel	402	Q>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1469332068 CA342200275	403	S>N		No	ClinGen TOPMed
CA29891686 rs922635792	404	E>A		No	ClinGen Ensembl
rs1553918160 CA342200264	404	E>D		No	ClinGen gnomAD
CA1062741 rs782503129	406	M>I		No	ClinGen ExAC gnomAD
rs782565858 CA1062742	406	M>T		No	ClinGen ExAC gnomAD
rs782221869 CA342200247	407	A>S		No	ClinGen ExAC TOPMed gnomAD
rs782221869 CA1062740	407	A>T		No	ClinGen ExAC TOPMed gnomAD
rs782652642 CA1062739	407	A>V		No	ClinGen ExAC TOPMed
CA342200213 rs782506028	412	A>P		No	ClinGen ExAC gnomAD
CA1062738 rs782506028	412	A>S		No	ClinGen ExAC gnomAD
CA1062737 rs781910024	413	Q>*		No	ClinGen ExAC gnomAD
CA342200208 rs781910024	413	Q>E		No	ClinGen ExAC gnomAD
rs1302457745 CA342200200	414	E>*		No	ClinGen TOPMed gnomAD
CA342200198 rs1363704533	414	E>G		No	ClinGen TOPMed gnomAD
rs1302457745 CA342200202	414	E>K		No	ClinGen TOPMed gnomAD
CA342200191 rs1411701659	415	E>G		No	ClinGen TOPMed
rs782810821 CA1062736	416	I>T		No	ClinGen ExAC TOPMed gnomAD
rs782444225 CA1062735	417	D>G		No	ClinGen ExAC gnomAD
rs781788968 CA1062734	418	K>I		No	ClinGen ExAC TOPMed gnomAD
CA342200168 rs1553918143	418	K>N		No	ClinGen gnomAD
TCGA novel	419	R>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA342199876 rs1553917377	420	Y>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs1478875458 CA342199861	421	V>A		No	ClinGen TOPMed
CA29890495 rs961562235	422	E>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen Ensembl NCI-TCGA
CA1062710 rs199847833	425	R>C		No	ClinGen ExAC TOPMed gnomAD
rs782498502 CA1062709	425	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs782791087 CA1062707	427	T>A		No	ClinGen ExAC gnomAD
CA342199785 rs1571120292	427	T>N		No	ClinGen Ensembl
CA342199779 rs1160444538	428	I>L		No	ClinGen TOPMed gnomAD
CA342199778 rs1160444538	428	I>V		No	ClinGen TOPMed gnomAD
TCGA novel	429	Q>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA29890472 rs782302089	430	G>A		No	ClinGen TOPMed gnomAD
CA1062705 rs367729050 CA29890474	430	G>R		No	ClinGen ESP ExAC TOPMed gnomAD
CA342199746 rs1553917352	432	Y>C		No	ClinGen gnomAD
rs145252386 CA1062703	433	I>T		No	ClinGen ESP ExAC TOPMed gnomAD
CA1062704 rs781844490	433	I>V		No	ClinGen ExAC TOPMed
CA1062701 rs587668808	435	T>N		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA1062699 rs782153963	436	M>L		No	ClinGen ExAC gnomAD
CA342199696 rs1553917344	439	L>P		No	ClinGen gnomAD
rs1242940197 CA342199689	440	A>D		No	ClinGen TOPMed gnomAD
rs1242940197 CA342199690	440	A>G		No	ClinGen TOPMed gnomAD
CA342199679 rs1287447390	442	L>V		No	ClinGen TOPMed gnomAD
rs1353765170 CA342199671	443	V>L		No	ClinGen TOPMed
CA1062698 rs781937936	445	V>L		No	ClinGen ExAC gnomAD
rs1008460202 CA29890442	446	R>G		No	ClinGen Ensembl
CA1062696 rs782223954	448	N>K		No	ClinGen ExAC gnomAD
CA1062697 rs782306324	448	N>S		No	ClinGen ExAC gnomAD
rs782603045 CA1062695	449	L>M		No	ClinGen ExAC gnomAD
CA1062693 rs782670809	451	S>F		No	ClinGen ExAC gnomAD
CA1062692 rs782670809	451	S>Y		No	ClinGen ExAC gnomAD
CA29890389 rs373872924	455	T>A		No	ClinGen ESP TOPMed
CA29890388 rs148620163	455	T>N		No	ClinGen ESP
rs373872924 CA342199605	455	T>P		No	ClinGen ESP TOPMed
VAR_015370 rs72549314 CA29890386	457	P>L		No	ClinGen UniProt Ensembl dbSNP
rs782675203 CA342199580	459	L>V		No	ClinGen TOPMed gnomAD
rs142319282 CA1062690	461	L>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs370720513 CA1062689	462	H>Q		No	ClinGen ESP ExAC gnomAD
rs892808249 CA29890385	463	L>V		No	ClinGen TOPMed
rs1052687286 CA29890376	464	L>*		No	ClinGen Ensembl
CA342199537 rs1380892136	466	G>E		No	ClinGen TOPMed
rs781869629 CA1062687	466	G>R		No	ClinGen ExAC gnomAD
TCGA novel	467	P>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA29890351 rs907429343	467	P>L		No	ClinGen Ensembl
CA1062686 rs782785362	467	P>S		No	ClinGen ExAC gnomAD
CA1062685 rs782551856	469	T>A		No	ClinGen ExAC gnomAD
rs782551856 CA342199521	469	T>P		No	ClinGen ExAC gnomAD
CA1062684 rs781893420	470	P>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA342199501 rs1553917301	472	H>R		No	ClinGen gnomAD
CA1062683 rs782720469	473	Y>C		No	ClinGen ExAC TOPMed gnomAD
rs377635959 CA1062682	474	R>C		No	ClinGen ESP ExAC TOPMed gnomAD
rs374261975 CA1062681	474	R>H		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs782724832 CA1062680	475	V>L		No	ClinGen ExAC gnomAD
TCGA novel	477	G>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA342199473 rs1406190798	477	G>S		No	ClinGen TOPMed
rs782121441 CA1062679	479	G>E		No	ClinGen ExAC gnomAD
rs782121441 CA342199458	479	G>V		No	ClinGen ExAC gnomAD
CA1062676 rs782432147	482	D>N		No	ClinGen ExAC gnomAD
rs1553917282 CA342199432	483	G>R		No	ClinGen gnomAD
CA342199425 rs1553917275	484	A>T		No	ClinGen gnomAD
CA1062674 rs781933672	484	A>V		No	ClinGen ExAC gnomAD
rs916036504 CA29890260	485	R>*		No	ClinGen gnomAD
CA342199421 rs916036504	485	R>G		No	ClinGen gnomAD
rs376858269 CA1062673	485	R>Q		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1376842917 CA342199417	486	K>*		No	ClinGen TOPMed
CA342199395 rs1553917259	489	L>F		No	ClinGen gnomAD
rs782217619 CA1062672	492	D>G		No	ClinGen ExAC
rs143837136 CA1062669	493	D>H		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs143837136 CA1062670	493	D>N		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs143837136 CA1062671	493	D>Y		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA1062668 rs150439781	494	R>C		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs782471177 CA1062667	494	R>H		No	ClinGen ExAC TOPMed gnomAD
CA342199323 rs1559629560	500	M>I		No	ClinGen Ensembl
rs1457263874 CA342199317	501	T>K		No	ClinGen TOPMed gnomAD
CA342199312 rs1370260244	502	R>K		No	ClinGen TOPMed
rs751841669 CA29890229	503	V>I		No	ClinGen Ensembl
rs1553917244 CA342199298	504	V>A		No	ClinGen gnomAD
TCGA novel	506	R>G	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
VAR_022309 rs28381223 CA1062661	506	R>S		No	ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs1553917240 CA342199273	508	S>R		No	ClinGen gnomAD
CA342199261 rs1162861810	509	S>F		No	ClinGen TOPMed gnomAD
rs1162861810 CA342199263	509	S>Y		No	ClinGen TOPMed gnomAD
CA1062659 rs781868437	510	M>I		No	ClinGen ExAC
CA342199258 rs782462768	510	M>R		No	ClinGen ExAC TOPMed gnomAD
CA1062660 rs782462768	510	M>T		No	ClinGen ExAC TOPMed gnomAD
rs148972947 CA29890219	510	M>V		No	ClinGen 1000Genomes gnomAD
rs782763612 CA1062658	513	T>A		No	ClinGen ExAC gnomAD
CA29890174 rs912455922	514	M>T		No	ClinGen Ensembl
rs1553917230 CA342199227	515	T>A		No	ClinGen gnomAD
CA1062657 rs782158650	516	I>T		No	ClinGen ExAC TOPMed gnomAD
rs1553917228 CA342199222	516	I>V		No	ClinGen gnomAD
rs782015138 CA1062656	518	K>R		No	ClinGen ExAC TOPMed gnomAD
rs1553917218 CA342199199	519	F>C		No	ClinGen gnomAD
rs1553917205 CA342199188	520	M>I		No	ClinGen gnomAD
CA1062654 rs782703640	521	L>V		No	ClinGen ExAC gnomAD
rs782101886 CA1062653	522	A>D		No	ClinGen ExAC gnomAD
CA342199177 rs1390154956	523	L>V		No	ClinGen TOPMed gnomAD
rs781959760 CA1062652	524	A>D		No	ClinGen ExAC TOPMed gnomAD
CA29890157 rs111246446	525	F>L		No	ClinGen Ensembl
rs782394369 CA1062651	525	F>S		No	ClinGen ExAC gnomAD
rs373956596 CA1062650	526	F>L		No	ClinGen ESP ExAC gnomAD
rs1553917191 CA342199159	526	F>S		No	ClinGen gnomAD
rs1341706049 CA342199146	528	I>L		No	ClinGen TOPMed gnomAD
CA342199147 rs1341706049	528	I>V		No	ClinGen TOPMed gnomAD
CA1062648 rs782424053	529	I>L		No	ClinGen ExAC gnomAD
rs1553917181 CA342199131	530	I>T		No	ClinGen gnomAD
rs1553917183 CA342199134	530	I>V		No	ClinGen gnomAD
rs782197162 CA1062647	531	A>P		No	ClinGen ExAC gnomAD

No associated diseases with P49326

No regional properties for P49326

Type	Name	Position	InterPro Accession
No domain, repeats, and functional sites for P49326

Functions

		Description
EC Number	1.6.3.1	With oxygen as acceptor
Subcellular Localization	Microsome membrane Endoplasmic reticulum membrane
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

4 GO annotations of cellular component

Name	Definition
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
endoplasmic reticulum	The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
endoplasmic reticulum membrane	The lipid bilayer surrounding the endoplasmic reticulum.
integral component of membrane	The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.

6 GO annotations of molecular function

Name	Definition
aldehyde oxidase activity	Catalysis of the reaction: an aldehyde + H2O + O2 = a carboxylic acid + hydrogen peroxide.
flavin adenine dinucleotide binding	Binding to FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2.
monooxygenase activity	Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water.
N,N-dimethylaniline monooxygenase activity	Catalysis of the reaction: N,N-dimethylaniline + NADPH + H+ + O2 = N,N-dimethylaniline N-oxide + NADP+ + H2O.
NADP binding	Binding to nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP+, or the reduced form, NADPH.
NADPH oxidase H202-forming activity	Catalysis of the reaction: NADPH + H+ + O2 = NADP + hydrogen peroxide (H2O2).

4 GO annotations of biological process

Name	Definition
lipid metabolic process	The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids.
NADPH oxidation	A metabolic process that results in the oxidation of reduced nicotinamide adenine dinucleotide, NADPH, to the oxidized form, NADP.
regulation of cholesterol metabolic process	Any process that modulates the rate, frequency, or extent of cholesterol metabolism, the chemical reactions and pathways involving cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones.
xenobiotic metabolic process	The chemical reactions and pathways involving a xenobiotic compound, a compound foreign to the organim exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical.

12 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
P31512	FMO4	Dimethylaniline monooxygenase [N-oxide-forming] 4	Homo sapiens (Human)	PR
P97501	Fmo3	Dimethylaniline monooxygenase [N-oxide-forming] 3	Mus musculus (Mouse)	PR
Q8K2I3	Fmo2	Dimethylaniline monooxygenase [N-oxide-forming] 2	Mus musculus (Mouse)	PR
Q8VHG0	Fmo4	Dimethylaniline monooxygenase [N-oxide-forming] 4	Mus musculus (Mouse)	PR
P97872	Fmo5	Flavin-containing monooxygenase 5	Mus musculus (Mouse)	PR
Q8K4B7	Fmo4	Dimethylaniline monooxygenase [N-oxide-forming] 4	Rattus norvegicus (Rat)	PR
Q6IRI9	Fmo2	Dimethylaniline monooxygenase [N-oxide-forming] 2	Rattus norvegicus (Rat)	PR
Q9EQ76	Fmo3	Dimethylaniline monooxygenase [N-oxide-forming] 3	Rattus norvegicus (Rat)	PR
Q8K4C0	Fmo5	Flavin-containing monooxygenase 5	Rattus norvegicus (Rat)	PR
Q9SVU0	YUC8	Probable indole-3-pyruvate monooxygenase YUCCA8	Arabidopsis thaliana (Mouse-ear cress)	PR
Q9SXD9	At1g62580	Flavin-containing monooxygenase FMO GS-OX-like 7	Arabidopsis thaliana (Mouse-ear cress)	PR
Q9C8T8	At1g63340	Putative flavin-containing monooxygenase FMO GS-OX-like 10	Arabidopsis thaliana (Mouse-ear cress)	PR

10	20	30	40	50	60
MTKKRIAVIG	GGVSGLSSIK	CCVEEGLEPV	CFERTDDIGG	LWRFQENPEE	GRASIYKSVI
70	80	90	100	110	120
INTSKEMMCF	SDYPIPDHYP	NFMHNAQVLE	YFRMYAKEFD	LLKYIRFKTT	VCSVKKQPDF
130	140	150	160	170	180
ATSGQWEVVT	ESEGKKEMNV	FDGVMVCTGH	HTNAHLPLES	FPGIEKFKGQ	YFHSRDYKNP
190	200	210	220	230	240
EGFTGKRVII	IGIGNSGGDL	AVEISQTAKQ	VFLSTRRGAW	ILNRVGDYGY	PADVLFSSRL
250	260	270	280	290	300
THFIWKICGQ	SLANKYLEKK	INQRFDHEMF	GLKPKHRALS	QHPTLNDDLP	NRIISGLVKV
310	320	330	340	350	360
KGNVKEFTET	AAIFEDGSRE	DDIDAVIFAT	GYSFDFPFLE	DSVKVVKNKI	SLYKKVFPPN
370	380	390	400	410	420
LERPTLAIIG	LIQPLGAIMP	ISELQGRWAT	QVFKGLKTLP	SQSEMMAEIS	KAQEEIDKRY
430	440	450	460	470	480
VESQRHTIQG	DYIDTMEELA	DLVGVRPNLL	SLAFTDPKLA	LHLLLGPCTP	IHYRVQGPGK
490	500	510	520	530
WDGARKAILT	TDDRIRKPLM	TRVVERSSSM	TSTMTIGKFM	LALAFFAIII	AYF