Q8K4B7
Gene name |
Fmo4 |
Protein name |
Dimethylaniline monooxygenase [N-oxide-forming] 4 |
Names |
Dimethylaniline oxidase 4, Hepatic flavin-containing monooxygenase 4, FMO 4 |
Species |
Rattus norvegicus (Rat) |
KEGG Pathway |
rno:246247 |
EC number |
1.14.13.8: With NADH or NADPH as one donor, and incorporation of one atom of oxygen |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q8K4B7
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q8K4B7-F1 | Predicted | AlphaFoldDB |
2 variants for Q8K4B7
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs8155736 | 244 | Q>R | No | EVA | |
| rs198241335 | 249 | R>C | No | EVA |
No associated diseases with Q8K4B7
No regional properties for Q8K4B7
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for Q8K4B7 | |||
Functions
| Description | ||
|---|---|---|
| EC Number | 1.14.13.8 | With NADH or NADPH as one donor, and incorporation of one atom of oxygen |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| endoplasmic reticulum membrane | The lipid bilayer surrounding the endoplasmic reticulum. |
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
4 GO annotations of molecular function
| Name | Definition |
|---|---|
| flavin adenine dinucleotide binding | Binding to FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2. |
| monooxygenase activity | Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. |
| N,N-dimethylaniline monooxygenase activity | Catalysis of the reaction: N,N-dimethylaniline + NADPH + H+ + O2 = N,N-dimethylaniline N-oxide + NADP+ + H2O. |
| NADP binding | Binding to nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP+, or the reduced form, NADPH. |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| energy homeostasis | Any process involved in the balance between food intake (energy input) and energy expenditure. |
| negative regulation of fatty acid oxidation | Any process that stops, prevents, or reduces the frequency, rate or extent of fatty acid oxidation. |
| xenobiotic catabolic process | The chemical reactions and pathways resulting in the breakdown of a xenobiotic compound, a compound foreign to the organim exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical. |
12 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P49326 | FMO5 | Flavin-containing monooxygenase 5 | Homo sapiens (Human) | PR |
| P31512 | FMO4 | Dimethylaniline monooxygenase [N-oxide-forming] 4 | Homo sapiens (Human) | PR |
| P97501 | Fmo3 | Dimethylaniline monooxygenase [N-oxide-forming] 3 | Mus musculus (Mouse) | PR |
| Q8K2I3 | Fmo2 | Dimethylaniline monooxygenase [N-oxide-forming] 2 | Mus musculus (Mouse) | PR |
| P97872 | Fmo5 | Flavin-containing monooxygenase 5 | Mus musculus (Mouse) | PR |
| Q8VHG0 | Fmo4 | Dimethylaniline monooxygenase [N-oxide-forming] 4 | Mus musculus (Mouse) | PR |
| Q9EQ76 | Fmo3 | Dimethylaniline monooxygenase [N-oxide-forming] 3 | Rattus norvegicus (Rat) | PR |
| Q6IRI9 | Fmo2 | Dimethylaniline monooxygenase [N-oxide-forming] 2 | Rattus norvegicus (Rat) | PR |
| Q8K4C0 | Fmo5 | Flavin-containing monooxygenase 5 | Rattus norvegicus (Rat) | PR |
| Q9SVU0 | YUC8 | Probable indole-3-pyruvate monooxygenase YUCCA8 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9SXD9 | At1g62580 | Flavin-containing monooxygenase FMO GS-OX-like 7 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9C8T8 | At1g63340 | Putative flavin-containing monooxygenase FMO GS-OX-like 10 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MAKKVAVIGA | GVSGLSSIKC | CLDENLEPTC | FERSSDFGGL | WKFAEASEDG | MTRVYRSLVT |
| 70 | 80 | 90 | 100 | 110 | 120 |
| NVCKEMSCYS | DFPFHEDYPN | FMSHEKFWDY | LREFAEHFGL | LKYIRFKTTV | RSVTKRPDFS |
| 130 | 140 | 150 | 160 | 170 | 180 |
| ETGQWEVVTE | TEGKQDRAVF | DAVMVCTGQF | LSPRLPLESF | PGIHKFKGQI | LHSQEYRIPD |
| 190 | 200 | 210 | 220 | 230 | 240 |
| AFRGKRILVV | GLGNTGGDVA | VELSGIAAQV | FLSTRTGAWV | RSRSSVGGYP | LNMMQTRWRN |
| 250 | 260 | 270 | 280 | 290 | 300 |
| FLAQVLPSRF | VSWNQERQMN | KIFNHENYGL | SIAKGKKPKF | IVNDELPTCI | LCGKITMKTS |
| 310 | 320 | 330 | 340 | 350 | 360 |
| VKDFTESSIV | FEDGTIEANI | DVVIFTTGYE | FSFPFFEEPL | KSLCTKKVIL | YKRVFPPNLE |
| 370 | 380 | 390 | 400 | 410 | 420 |
| RSTLAIIGLI | SLTGSILVGT | EFQARWATRV | FKGLCNIPPS | QKLMAEAIKK | EELIKRGVIK |
| 430 | 440 | 450 | 460 | 470 | 480 |
| DTSQDKLDFI | SYMDELTQCI | GAKPNIPLLF | LKDPRLAWEV | FFGPCTPYQY | RLMGPGRWDG |
| 490 | 500 | 510 | 520 | 530 | 540 |
| ARNAILTQWD | RTVKPLKTRT | VPKSQEPASL | SRYLKTWGAP | VLIVSLLLIY | KSSLFLELVQ |
| 550 | |||||
| SKLQGRFSPS | RILWYIPQNS |