AiPD: Autoinhibited Protein Database

Gene name	Fmo2
Protein name	Dimethylaniline monooxygenase [N-oxide-forming] 2
Names	Dimethylaniline oxidase 2, Pulmonary flavin-containing monooxygenase 2, FMO 2
Species	Mus musculus (Mouse)
KEGG Pathway	mmu:55990
EC number
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

465-535 (Predicted disordered autoinhibitory region) PR

465-535 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q8K2I3-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
rs3388506697	2	A>T	No	EVA
rs3410929130	43	F>I	No	EVA
rs3390856823	89	E>K	No	EVA
rs3390829106	94	F>L	No	EVA
rs3388506743	112	S>C	No	EVA
rs3388511558	135	E>D	No	EVA
rs3388509963	205	K>M	No	EVA
rs3388509827	210	V>M	No	EVA
rs226699669	251	V>I	No	EVA
rs235924735	259	Q>H	No	EVA
rs3388512478	314	E>V	No	EVA
rs3388508377	318	V>L	No	EVA
rs3413053070	322	V>L	No	EVA
rs3388511943	344	K>E	No	EVA
rs3388512093	346	E>D	No	EVA
rs3388512681	398	S>R	No	EVA
rs37258889	403	T>M	No	EVA
rs264514213	412	R>K	No	EVA
rs244094298	418	N>D	No	EVA
rs3388512474	423	S>G	No	EVA
rs3388510605	433	V>I	No	EVA
rs3388514406	461	V>L	No	EVA
rs3388508229	500	K>R	No	EVA
rs3388510347	515	L>M	No	EVA
rs3388508383	522	L>F	No	EVA
rs3388512017	529	F>L	No	EVA

Type	Name	Position	InterPro Accession
No domain, repeats, and functional sites for Q8K2I3

		Description
EC Number
Subcellular Localization	Microsome membrane ; Single-pass membrane protein Endoplasmic reticulum membrane ; Single-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
endoplasmic reticulum membrane	The lipid bilayer surrounding the endoplasmic reticulum.
integral component of membrane	The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
membrane	A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.

Name	Definition
flavin adenine dinucleotide binding	Binding to FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2.
monooxygenase activity	Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water.
N,N-dimethylaniline monooxygenase activity	Catalysis of the reaction: N,N-dimethylaniline + NADPH + H+ + O2 = N,N-dimethylaniline N-oxide + NADP+ + H2O.
NADP binding	Binding to nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP+, or the reduced form, NADPH.

Name	Definition
energy homeostasis	Any process involved in the balance between food intake (energy input) and energy expenditure.
NADP metabolic process	The chemical reactions and pathways involving nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; metabolism may be of either the oxidized form, NADP, or the reduced form, NADPH.
NADPH oxidation	A metabolic process that results in the oxidation of reduced nicotinamide adenine dinucleotide, NADPH, to the oxidized form, NADP.
negative regulation of fatty acid oxidation	Any process that stops, prevents, or reduces the frequency, rate or extent of fatty acid oxidation.
organic acid metabolic process	The chemical reactions and pathways involving organic acids, any acidic compound containing carbon in covalent linkage.
oxygen metabolic process	The chemical reactions and pathways involving diatomic oxygen (O2).
toxin metabolic process	The chemical reactions and pathways involving a toxin, a poisonous compound (typically a protein) that is produced by cells or organisms and that can cause disease when introduced into the body or tissues of an organism.
xenobiotic metabolic process	The chemical reactions and pathways involving a xenobiotic compound, a compound foreign to the organim exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
P49326	FMO5	Flavin-containing monooxygenase 5	Homo sapiens (Human)	PR
P31512	FMO4	Dimethylaniline monooxygenase [N-oxide-forming] 4	Homo sapiens (Human)	PR
P97501	Fmo3	Dimethylaniline monooxygenase [N-oxide-forming] 3	Mus musculus (Mouse)	PR
P97872	Fmo5	Flavin-containing monooxygenase 5	Mus musculus (Mouse)	PR
Q8VHG0	Fmo4	Dimethylaniline monooxygenase [N-oxide-forming] 4	Mus musculus (Mouse)	PR
Q8K4B7	Fmo4	Dimethylaniline monooxygenase [N-oxide-forming] 4	Rattus norvegicus (Rat)	PR
Q9EQ76	Fmo3	Dimethylaniline monooxygenase [N-oxide-forming] 3	Rattus norvegicus (Rat)	PR
Q8K4C0	Fmo5	Flavin-containing monooxygenase 5	Rattus norvegicus (Rat)	PR
Q6IRI9	Fmo2	Dimethylaniline monooxygenase [N-oxide-forming] 2	Rattus norvegicus (Rat)	PR
Q9SVU0	YUC8	Probable indole-3-pyruvate monooxygenase YUCCA8	Arabidopsis thaliana (Mouse-ear cress)	PR
Q9SXD9	At1g62580	Flavin-containing monooxygenase FMO GS-OX-like 7	Arabidopsis thaliana (Mouse-ear cress)	PR
Q9C8T8	At1g63340	Putative flavin-containing monooxygenase FMO GS-OX-like 10	Arabidopsis thaliana (Mouse-ear cress)	PR