AiPD: Autoinhibited Protein Database

Gene name	Fmo5
Protein name	Flavin-containing monooxygenase 5
Names	FMO 5, Dimethylaniline monooxygenase [N-oxide-forming] 5, Dimethylaniline oxidase 5, Hepatic flavin-containing monooxygenase 5, NADPH oxidase
Species	Mus musculus (Mouse)
KEGG Pathway	mmu:14263
EC number	1.6.3.1: With oxygen as acceptor
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

234-313 (Predicted disordered autoinhibitory region) PR

234-313 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
AF-P97872-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
rs37557226	47	A>T	No	EVA
rs232178366	82	Y>F	No	EVA
rs3388651186	90	E>*	No	EVA
rs3388638395	98	E>D	No	EVA
rs3388654944	109	T>I	No	EVA
rs3388643934	130	T>I	No	EVA
rs1134264990	155	H>L	No	EVA
rs3388654075	170	K>E	No	EVA
rs3388647614	178	K>M	No	EVA
rs36298704	181	V>M	No	EVA
rs214803069	209	K>M	No	EVA
rs3388649493	231	P>L	No	EVA
rs237794467	234	L>M	No	EVA
rs3388654996	255	N>S	No	EVA
rs36785610	313	V>I	No	EVA
rs3388654119	326	V>I	No	EVA
rs3388644014	354	K>Q	No	EVA
rs3388651213	394	K>Q	No	EVA
rs3388649504	414	E>K	No	EVA
rs242145991	458	R>K	No	EVA
rs3388647671	469	T>A	No	EVA
rs3388654973	532	Y>C	No	EVA

Type	Name	Position	InterPro Accession
No domain, repeats, and functional sites for P97872

		Description
EC Number	1.6.3.1	With oxygen as acceptor
Subcellular Localization	Microsome membrane Endoplasmic reticulum membrane
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
endoplasmic reticulum	The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
endoplasmic reticulum membrane	The lipid bilayer surrounding the endoplasmic reticulum.
integral component of membrane	The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.

Name	Definition
aldehyde oxidase activity	Catalysis of the reaction: an aldehyde + H2O + O2 = a carboxylic acid + hydrogen peroxide.
flavin adenine dinucleotide binding	Binding to FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2.
monooxygenase activity	Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water.
N,N-dimethylaniline monooxygenase activity	Catalysis of the reaction: N,N-dimethylaniline + NADPH + H+ + O2 = N,N-dimethylaniline N-oxide + NADP+ + H2O.
NADP binding	Binding to nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP+, or the reduced form, NADPH.
NADPH oxidase H202-forming activity	Catalysis of the reaction: NADPH + H+ + O2 = NADP + hydrogen peroxide (H2O2).

Name	Definition
lipid metabolic process	The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids.
NADPH oxidation	A metabolic process that results in the oxidation of reduced nicotinamide adenine dinucleotide, NADPH, to the oxidized form, NADP.
regulation of cholesterol metabolic process	Any process that modulates the rate, frequency, or extent of cholesterol metabolism, the chemical reactions and pathways involving cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones.
xenobiotic metabolic process	The chemical reactions and pathways involving a xenobiotic compound, a compound foreign to the organim exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
P31512	FMO4	Dimethylaniline monooxygenase [N-oxide-forming] 4	Homo sapiens (Human)	PR
P49326	FMO5	Flavin-containing monooxygenase 5	Homo sapiens (Human)	PR
P97501	Fmo3	Dimethylaniline monooxygenase [N-oxide-forming] 3	Mus musculus (Mouse)	PR
Q8K2I3	Fmo2	Dimethylaniline monooxygenase [N-oxide-forming] 2	Mus musculus (Mouse)	PR
Q8VHG0	Fmo4	Dimethylaniline monooxygenase [N-oxide-forming] 4	Mus musculus (Mouse)	PR
Q8K4B7	Fmo4	Dimethylaniline monooxygenase [N-oxide-forming] 4	Rattus norvegicus (Rat)	PR
Q6IRI9	Fmo2	Dimethylaniline monooxygenase [N-oxide-forming] 2	Rattus norvegicus (Rat)	PR
Q9EQ76	Fmo3	Dimethylaniline monooxygenase [N-oxide-forming] 3	Rattus norvegicus (Rat)	PR
Q8K4C0	Fmo5	Flavin-containing monooxygenase 5	Rattus norvegicus (Rat)	PR
Q9SVU0	YUC8	Probable indole-3-pyruvate monooxygenase YUCCA8	Arabidopsis thaliana (Mouse-ear cress)	PR
Q9SXD9	At1g62580	Flavin-containing monooxygenase FMO GS-OX-like 7	Arabidopsis thaliana (Mouse-ear cress)	PR
Q9C8T8	At1g63340	Putative flavin-containing monooxygenase FMO GS-OX-like 10	Arabidopsis thaliana (Mouse-ear cress)	PR