AiPD: Autoinhibited Protein Database

Gene name	Fmo3
Protein name	Dimethylaniline monooxygenase [N-oxide-forming] 3
Names	Dimethylaniline oxidase 3, Hepatic flavin-containing monooxygenase 3, FMO 3, Trimethylamine monooxygenase
Species	Mus musculus (Mouse)
KEGG Pathway	mmu:14262
EC number	1.14.13.8: With NADH or NADPH as one donor, and incorporation of one atom of oxygen
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

469-534 (Predicted disordered autoinhibitory region) PR

469-534 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
AF-P97501-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
rs3388512106	17	A>V	No	EVA
rs3388512991	46	H>R	No	EVA
rs246719414	60	T>A	No	EVA
rs3388509838	60	T>N	No	EVA
rs3388511618	68	C>S	No	EVA
rs3388509968	72	F>S	No	EVA
rs50797400	76	D>N	No	EVA
rs3388512689	77	D>V	No	EVA
rs3388510594	84	H>Q	No	EVA
rs3388511542	88	Q>H	No	EVA
rs3388510629	89	E>D	No	EVA
rs3388510588	90	Y>H	No	EVA
rs222873067	111	T>S	No	EVA
rs36935260	118	N>D	No	EVA
rs3390909993	124	K>N	No	EVA
rs3388512462	126	E>K	No	EVA
rs3388511998	151	I>M	No	EVA
rs37325482	161	P>S	No	EVA
rs3388512429	175	D>G	No	EVA
rs50521266	201	A>S	No	EVA
rs3388512128	242	F>L	No	EVA
rs3388508386	246	N>D	No	EVA
rs3388510281	285	N>D	No	EVA
rs3388512690	296	M>L	No	EVA
rs32758001	318	M>V	No	EVA
rs36964758	321	A>D	No	EVA
rs3390909043	323	D>A	No	EVA
rs3388511536	324	C>Y	No	EVA
rs3390890993	325	V>G	No	EVA
rs3390890990	328	A>D	No	EVA
rs3388506758	329	T>I	No	EVA
rs3390909073	330	G>V	No	EVA
rs227463171	355	G>D	No	EVA
rs266242565	356	V>I	No	EVA
rs3388514359	361	L>P	No	EVA
rs3388511986	408	D>E	No	EVA
rs3388510614	408	D>V	No	EVA
rs3388512419	409	I>S	No	EVA
rs3388511982	410	D>G*	No	EVA
rs244712117	411	E>K	No	EVA
rs3388512147	412	K>N	No	EVA
rs3388511927	413	M>V	No	EVA
rs3388511613	421	G>D	No	EVA
rs3388509911	483	R>W	No	EVA
rs3388512684	500	R>H	No	EVA
rs265421007	509	C>S	No	EVA
rs3388506756	519	L>I	No	EVA
rs3388509897	520	L>Q	No	EVA
rs37584253	526	L>I	No	EVA

Type	Name	Position	InterPro Accession
No domain, repeats, and functional sites for P97501

		Description
EC Number	1.14.13.8	With NADH or NADPH as one donor, and incorporation of one atom of oxygen
Subcellular Localization	Microsome membrane ; Single-pass membrane protein Endoplasmic reticulum membrane ; Single-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
endoplasmic reticulum membrane	The lipid bilayer surrounding the endoplasmic reticulum.
integral component of membrane	The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
intracellular membrane-bounded organelle	Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.

Name	Definition
amino acid binding	Binding to an amino acid, organic acids containing one or more amino substituents.
flavin adenine dinucleotide binding	Binding to FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2.
monooxygenase activity	Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water.
N,N-dimethylaniline monooxygenase activity	Catalysis of the reaction: N,N-dimethylaniline + NADPH + H+ + O2 = N,N-dimethylaniline N-oxide + NADP+ + H2O.
NADP binding	Binding to nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP+, or the reduced form, NADPH.
trimethylamine monooxygenase activity	Catalysis of the reaction: N,N,N-trimethylamine + NADPH + H+ + O2 = N,N,N-trimethylamine N-oxide + NADP+ + H2O.

Name	Definition
xenobiotic metabolic process	The chemical reactions and pathways involving a xenobiotic compound, a compound foreign to the organim exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
P49326	FMO5	Flavin-containing monooxygenase 5	Homo sapiens (Human)	PR
P31512	FMO4	Dimethylaniline monooxygenase [N-oxide-forming] 4	Homo sapiens (Human)	PR
P97872	Fmo5	Flavin-containing monooxygenase 5	Mus musculus (Mouse)	PR
Q8K2I3	Fmo2	Dimethylaniline monooxygenase [N-oxide-forming] 2	Mus musculus (Mouse)	PR
Q8VHG0	Fmo4	Dimethylaniline monooxygenase [N-oxide-forming] 4	Mus musculus (Mouse)	PR
Q8K4B7	Fmo4	Dimethylaniline monooxygenase [N-oxide-forming] 4	Rattus norvegicus (Rat)	PR
Q6IRI9	Fmo2	Dimethylaniline monooxygenase [N-oxide-forming] 2	Rattus norvegicus (Rat)	PR
Q8K4C0	Fmo5	Flavin-containing monooxygenase 5	Rattus norvegicus (Rat)	PR
Q9EQ76	Fmo3	Dimethylaniline monooxygenase [N-oxide-forming] 3	Rattus norvegicus (Rat)	PR
Q9SVU0	YUC8	Probable indole-3-pyruvate monooxygenase YUCCA8	Arabidopsis thaliana (Mouse-ear cress)	PR
Q9SXD9	At1g62580	Flavin-containing monooxygenase FMO GS-OX-like 7	Arabidopsis thaliana (Mouse-ear cress)	PR
Q9C8T8	At1g63340	Putative flavin-containing monooxygenase FMO GS-OX-like 10	Arabidopsis thaliana (Mouse-ear cress)	PR