Q8RW96
PR
Gene name |
B'GAMMA (At4g15415, dl3750w, FCAALL.118) |
Protein name |
Serine/threonine protein phosphatase 2A 59 kDa regulatory subunit B' gamma isoform |
Names |
AtB' gamma, PP2A, B' subunit, gamma isoform |
Species |
Arabidopsis thaliana (Mouse-ear cress) |
KEGG Pathway |
ath:AT4G15415 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q8RW96
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q8RW96-F1 | Predicted | AlphaFoldDB |
44 variants for Q8RW96
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| tmp_4_8817746_T_C | 14 | S>P | No | 1000Genomes | |
| tmp_4_8817758_C_A | 18 | H>N | No | 1000Genomes | |
| tmp_4_8817773_C_T | 23 | P>S | No | 1000Genomes | |
| tmp_4_8817806_A_G | 34 | I>V | No | 1000Genomes | |
| tmp_4_8817834_C_T | 43 | S>L | No | 1000Genomes | |
| ENSVATH11790104 | 55 | N>I | No | 1000Genomes | |
| tmp_4_8817887_G_A | 61 | V>I | No | 1000Genomes | |
| tmp_4_8817900_C_T | 65 | S>F | No | 1000Genomes | |
| ENSVATH06676804 | 78 | V>F | No | 1000Genomes | |
| ENSVATH11790126 | 113 | P>L | No | 1000Genomes | |
| ENSVATH00507801 | 139 | T>A | No | 1000Genomes | |
| ENSVATH06676806 | 143 | D>G | No | 1000Genomes | |
| tmp_4_8818144_G_A | 146 | M>I | No | 1000Genomes | |
| tmp_4_8818184_A_G | 160 | T>A | No | 1000Genomes | |
| tmp_4_8818262_G_A | 186 | A>T | No | 1000Genomes | |
| tmp_4_8818344_G_T | 213 | R>I | No | 1000Genomes | |
| tmp_4_8818385_T_C | 227 | F>L | No | 1000Genomes | |
| tmp_4_8818499_T_C | 265 | Y>H | No | 1000Genomes | |
| tmp_4_8818589_T_G | 295 | L>V | No | 1000Genomes | |
| ENSVATH06676811 | 318 | A>V | No | 1000Genomes | |
| ENSVATH06676812 | 328 | V>I | No | 1000Genomes | |
| ENSVATH06676813 | 335 | F>L | No | 1000Genomes | |
| ENSVATH00507802 | 343 | R>I | No | 1000Genomes | |
| tmp_4_8818775_G_A | 357 | E>K | No | 1000Genomes | |
| ENSVATH11790151 | 384 | F>C | No | 1000Genomes | |
| ENSVATH11790153 | 388 | A>S | No | 1000Genomes | |
| ENSVATH11790156 | 393 | S>C | No | 1000Genomes | |
| ENSVATH06676815 | 411 | I>V | No | 1000Genomes | |
| tmp_4_8819029_C_G | 417 | Q>E | No | 1000Genomes | |
| ENSVATH06676817 | 423 | M>I | No | 1000Genomes | |
| tmp_4_8819047_A_G | 423 | M>V | No | 1000Genomes | |
| tmp_4_8819081_C_T | 434 | T>I | No | 1000Genomes | |
| tmp_4_8819101_G_A | 441 | A>T | No | 1000Genomes | |
| ENSVATH11790185 | 459 | I>S | No | 1000Genomes | |
| tmp_4_8819177_C_T | 466 | A>V | No | 1000Genomes | |
| ENSVATH06676819 | 473 | A>V | No | 1000Genomes | |
| ENSVATH06676820 | 476 | T>S | No | 1000Genomes | |
| ENSVATH11790187 | 491 | E>D | No | 1000Genomes | |
| tmp_4_8819264_C_T | 495 | S>L | No | 1000Genomes | |
| tmp_4_8819273_T_G | 498 | V>G | No | 1000Genomes | |
| ENSVATH06676821 | 498 | V>I | No | 1000Genomes | |
| ENSVATH11790188 | 505 | V>I | No | 1000Genomes | |
| ENSVATH11790188 | 505 | V>L | No | 1000Genomes | |
| ENSVATH11790189 | 515 | A>T | No | 1000Genomes |
No associated diseases with Q8RW96
No regional properties for Q8RW96
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for Q8RW96 | |||
4 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
| protein phosphatase type 2A complex | A protein complex that has protein serine/threonine phosphatase activity that is polycation-stimulated (PCS), being directly stimulated by protamine, polylysine, or histone H1; it constitutes a subclass of several enzymes activated by different histones and polylysine, and consists of catalytic, scaffolding, and regulatory subunits. The catalytic and scaffolding subunits form the core enzyme, and the holoenzyme also includes the regulatory subunit. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| poly(U) RNA binding | Binding to a sequence of uracil residues in an RNA molecule. |
| protein phosphatase regulator activity | Binds to and modulates the activity of a protein phosphatase, an enzyme which catalyzes of the removal of a phosphate group from a protein substrate molecule. |
11 GO annotations of biological process
| Name | Definition |
|---|---|
| brassinosteroid mediated signaling pathway | The series of molecular signals mediated by the detection of brassinosteroid. |
| defense response | Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. |
| flower development | The process whose specific outcome is the progression of the flower over time, from its formation to the mature structure. The flower is the reproductive structure in a plant, and its development begins with the transition of the vegetative or inflorescence meristem into a floral meristem. |
| indole glucosinolate biosynthetic process | The chemical reactions and pathways resulting in the formation of indole glucosinolates, sulfur-containing compounds that have a common structure linked to an R group derived from tryptophan. |
| methionine metabolic process | The chemical reactions and pathways involving methionine (2-amino-4-(methylthio)butanoic acid), a sulfur-containing, essential amino acid found in peptide linkage in proteins. |
| negative regulation of defense response | Any process that stops, prevents, or reduces the frequency, rate or extent of a defense response. |
| negative regulation of leaf senescence | Any process that stops, prevents or reduces the frequency, rate or extent of leaf senescence. |
| regulation of reactive oxygen species metabolic process | Any process that modulates the frequency, rate or extent of reactive oxygen species metabolic process. |
| regulation of salicylic acid mediated signaling pathway | Any process that modulates the frequency, rate or extent of salicylic acid mediated signaling pathway. |
| S-adenosylmethionine cycle | A cyclic series of interconversions involving S-adenosylmethionine, S-adenosyl-L-homocysteine, L-cysteine, and L-methionine. Couples utilization of the methyl group of SAM with recycling of the homocysteinyl group and regeneration of methionine. |
| trichome morphogenesis | The process in which the structures of a hair cell (trichome) cell are generated and organized. This process occurs while the initially relatively unspecialized epidermal cell is acquiring the specialized features of a hair cell. An example of this process is found in Arabidopsis thaliana. |
13 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| A4FV68 | PPP2R5E | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform | Bos taurus (Bovine) | PR |
| Q15172 | PPP2R5A | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform | Homo sapiens (Human) | PR |
| Q15173 | PPP2R5B | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform | Homo sapiens (Human) | PR |
| Q16537 | PPP2R5E | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform | Homo sapiens (Human) | PR |
| Q14738 | PPP2R5D | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform | Homo sapiens (Human) | PR |
| Q61151 | Ppp2r5e | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform | Mus musculus (Mouse) | PR |
| Q6PD03 | Ppp2r5a | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform | Mus musculus (Mouse) | PR |
| O04375 | B'ALPHA | Serine/threonine protein phosphatase 2A 57 kDa regulatory subunit B' alpha isoform | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q8LF36 | B'THETA | Serine/threonine protein phosphatase 2A 57 kDa regulatory subunit B' theta isoform | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q93YV6 | B'KAPPA | Serine/threonine protein phosphatase 2A 57 kDa regulatory subunit B' kappa isoform | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9LVE2 | B'ZETA | Serine/threonine protein phosphatase 2A 59 kDa regulatory subunit B' zeta isoform | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9ZQY6 | B'DELTA | Serine/threonine protein phosphatase 2A 55 kDa regulatory subunit B' delta isoform | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9LU89 | B'ETA | Serine/threonine protein phosphatase 2A 59 kDa regulatory subunit B' eta isoform | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MIKQIFGKLP | RKPSKSSHND | SNPNGEGGVN | SYYIPNSGIS | SISKPSSKSS | ASNSNGANGT |
| 70 | 80 | 90 | 100 | 110 | 120 |
| VIAPSSTSSN | RTNQVNGVYE | ALPSFRDVPT | SEKPNLFIKK | LSMCCVVFDF | NDPSKNLREK |
| 130 | 140 | 150 | 160 | 170 | 180 |
| EIKRQTLLEL | VDYIATVSTK | LSDAAMQEIA | KVAVVNLFRT | FPSANHESKI | LETLDVDDEE |
| 190 | 200 | 210 | 220 | 230 | 240 |
| PALEPAWPHL | QVVYELLLRF | VASPMTDAKL | AKRYIDHSFV | LKLLDLFDSE | DQREREYLKT |
| 250 | 260 | 270 | 280 | 290 | 300 |
| ILHRIYGKFM | VHRPFIRKAI | NNIFYRFIFE | TEKHNGIAEL | LEILGSIING | FALPLKEEHK |
| 310 | 320 | 330 | 340 | 350 | 360 |
| LFLIRALIPL | HRPKCASAYH | QQLSYCIVQF | VEKDFKLADT | VIRGLLKYWP | VTNSSKEVMF |
| 370 | 380 | 390 | 400 | 410 | 420 |
| LGELEEVLEA | TQAAEFQRCM | VPLFRQIARC | LNSSHFQVAE | RALFLWNNDH | IRNLITQNHK |
| 430 | 440 | 450 | 460 | 470 | 480 |
| VIMPIVFPAM | ERNTRGHWNQ | AVQSLTLNVR | KVMAETDQIL | FDECLAKFQE | DEANETEVVA |
| 490 | 500 | 510 | 520 | ||
| KREATWKLLE | ELAASKSVSN | EAVLVPRFSS | SVTLATGKTS | GS |