Q8LF36
PR
Gene name |
B'THETA (At1g13460, T6J4.19) |
Protein name |
Serine/threonine protein phosphatase 2A 57 kDa regulatory subunit B' theta isoform |
Names |
AtB' theta, PP2A, B' subunit, theta isoform |
Species |
Arabidopsis thaliana (Mouse-ear cress) |
KEGG Pathway |
ath:AT1G13460 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q8LF36
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q8LF36-F1 | Predicted | AlphaFoldDB |
30 variants for Q8LF36
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| ENSVATH00021898 | 7 | S>T | No | 1000Genomes | |
| ENSVATH00021900 | 31 | N>S | No | 1000Genomes | |
| ENSVATH00021901 | 34 | S>G | No | 1000Genomes | |
| ENSVATH01047137 | 34 | S>R | No | 1000Genomes | |
| ENSVATH04570851 | 36 | S>L | No | 1000Genomes | |
| ENSVATH04570852 | 40 | Q>E | No | 1000Genomes | |
| tmp_1_4616622_A_T | 40 | Q>L | No | 1000Genomes | |
| ENSVATH00021902 | 42 | Q>K | No | 1000Genomes | |
| ENSVATH04570854 | 60 | L>W | No | 1000Genomes | |
| ENSVATH13891275 | 64 | G>C | No | 1000Genomes | |
| ENSVATH04570855 | 69 | P>A | No | 1000Genomes | |
| tmp_1_4616885_C_T | 128 | P>S | No | 1000Genomes | |
| ENSVATH11149112 | 138 | Q>E | No | 1000Genomes | |
| tmp_1_4616991_A_G | 163 | D>G | No | 1000Genomes | |
| ENSVATH11149113 | 183 | L>I | No | 1000Genomes | |
| ENSVATH01047138 | 206 | I>M | No | 1000Genomes | |
| ENSVATH11149114 | 213 | R>S | No | 1000Genomes | |
| tmp_1_4617159_A_G | 219 | D>G | No | 1000Genomes | |
| tmp_1_4617171_C_T | 223 | P>L | No | 1000Genomes | |
| tmp_1_4617296_C_T | 265 | H>Y | No | 1000Genomes | |
| ENSVATH04570857 | 334 | R>K | No | 1000Genomes | |
| ENSVATH00021904 | 358 | V>A | No | 1000Genomes | |
| tmp_1_4617617_G_T | 372 | V>F | No | 1000Genomes | |
| ENSVATH04570858 | 380 | R>W | No | 1000Genomes | |
| tmp_1_4617653_A_T | 384 | S>C | No | 1000Genomes | |
| tmp_1_4617941_C_T | 414 | L>F | No | 1000Genomes | |
| ENSVATH11149256 | 420 | A>G | No | 1000Genomes | |
| ENSVATH01047140 | 470 | G>A | No | 1000Genomes | |
| ENSVATH04570859 | 488 | Q>K | No | 1000Genomes | |
| ENSVATH11149259 | 488 | Q>P | No | 1000Genomes |
No associated diseases with Q8LF36
No regional properties for Q8LF36
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for Q8LF36 | |||
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| peroxisome | A small organelle enclosed by a single membrane, and found in most eukaryotic cells. Contains peroxidases and other enzymes involved in a variety of metabolic processes including free radical detoxification, lipid catabolism and biosynthesis, and hydrogen peroxide metabolism. |
| protein phosphatase type 2A complex | A protein complex that has protein serine/threonine phosphatase activity that is polycation-stimulated (PCS), being directly stimulated by protamine, polylysine, or histone H1; it constitutes a subclass of several enzymes activated by different histones and polylysine, and consists of catalytic, scaffolding, and regulatory subunits. The catalytic and scaffolding subunits form the core enzyme, and the holoenzyme also includes the regulatory subunit. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| protein phosphatase regulator activity | Binds to and modulates the activity of a protein phosphatase, an enzyme which catalyzes of the removal of a phosphate group from a protein substrate molecule. |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| brassinosteroid mediated signaling pathway | The series of molecular signals mediated by the detection of brassinosteroid. |
| negative regulation of brassinosteroid mediated signaling pathway | Any process that stops, prevents or reduces the frequency, rate or extent of brassinosteroid mediated signaling pathway. |
| positive regulation of fatty acid beta-oxidation | Any process that activates or increases the frequency, rate or extent of fatty acid beta-oxidation. |
13 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| A4FV68 | PPP2R5E | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform | Bos taurus (Bovine) | PR |
| Q15172 | PPP2R5A | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform | Homo sapiens (Human) | PR |
| Q15173 | PPP2R5B | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform | Homo sapiens (Human) | PR |
| Q16537 | PPP2R5E | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform | Homo sapiens (Human) | PR |
| Q14738 | PPP2R5D | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform | Homo sapiens (Human) | PR |
| Q61151 | Ppp2r5e | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform | Mus musculus (Mouse) | PR |
| Q6PD03 | Ppp2r5a | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform | Mus musculus (Mouse) | PR |
| O04375 | B'ALPHA | Serine/threonine protein phosphatase 2A 57 kDa regulatory subunit B' alpha isoform | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q8RW96 | B'GAMMA | Serine/threonine protein phosphatase 2A 59 kDa regulatory subunit B' gamma isoform | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q93YV6 | B'KAPPA | Serine/threonine protein phosphatase 2A 57 kDa regulatory subunit B' kappa isoform | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9LVE2 | B'ZETA | Serine/threonine protein phosphatase 2A 59 kDa regulatory subunit B' zeta isoform | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9ZQY6 | B'DELTA | Serine/threonine protein phosphatase 2A 55 kDa regulatory subunit B' delta isoform | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9LU89 | B'ETA | Serine/threonine protein phosphatase 2A 59 kDa regulatory subunit B' eta isoform | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MWKQILSKLP | KKSSSKNHSS | SSSSTSKSSD | NGASKSGNSQ | TQNAPPVKPS | ADSGFKEGNL |
| 70 | 80 | 90 | 100 | 110 | 120 |
| KGNGNGFTPY | EALPGFKDVP | NAEKQNLFVR | KLSLCCVVFD | FSDPTKNVKE | KDIKRQTLLE |
| 130 | 140 | 150 | 160 | 170 | 180 |
| LVDYVASPNG | KFSETVIQEV | VRMVSVNIFR | TLNPQPRENK | VIDALDLEEE | EPSMDPTWPH |
| 190 | 200 | 210 | 220 | 230 | 240 |
| LQLVYEILLR | LIASPETDTK | LAKKYIDQSF | VSRLLDLFDS | EDPRERDCLK | TVLHRIYGKF |
| 250 | 260 | 270 | 280 | 290 | 300 |
| MVHRPFIRKS | INNIFYRFVF | ETEKHNGIAE | FLEILGSIIN | GFALPLKDEH | KVFLVRALVP |
| 310 | 320 | 330 | 340 | 350 | 360 |
| LHKPKSLQMY | HQQLSYCITQ | FVEKDCKLAD | TVIRGLLKSW | PVTNSSKEVM | FLNELEEVLE |
| 370 | 380 | 390 | 400 | 410 | 420 |
| ATQPPEFQRC | MVPLFRQVAR | CLNSLHFQVA | ERALFLWNND | HIENLIMQNR | KVILPIIFPA |
| 430 | 440 | 450 | 460 | 470 | 480 |
| LERNTQKHWN | QAVHSLTLNV | QKIFNDIDAE | LFKDCLAKFR | EDESKEAEIG | AKREATWKRL |
| 490 | |||||
| EEIGNQKQKS | SL |