AiPD: Autoinhibited Protein Database

Q15172

Gene name	PPP2R5A
Protein name	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform
Names	PP2A B subunit isoform B'-alpha, PP2A B subunit isoform B56-alpha, PP2A B subunit isoform PR61-alpha, PR61alpha, PP2A B subunit isoform R5-alpha
Species	Homo sapiens (Human)
KEGG Pathway	hsa:5525
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-89 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

1-89 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

2 structures for Q15172

Entry ID	Method	Resolution	Chain	Position	Source
6NTS	EM	363 A	B	1-486	PDB
AF-Q15172-F1	Predicted				AlphaFoldDB

282 variants for Q15172

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
rs1242389317 CA344885615	2	S>A		No	ClinGen TOPMed
rs759946224 CA1383438	2	S>L		No	ClinGen ExAC TOPMed gnomAD
rs1435988405 CA344885623	3	S>L		No	ClinGen gnomAD
TCGA novel	5	S>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs866673374 CA37246403	5	S>P		No	ClinGen TOPMed
rs1558135638 CA344885637	6	P>S		No	ClinGen Ensembl
CA37246404 rs1002847154	7	P>L		No	ClinGen gnomAD
rs1324894825 CA344885648	8	A>S		No	ClinGen TOPMed
CA344885655 rs1467540062	9	G>E		No	ClinGen gnomAD
CA344885659 rs1257977138	10	A>T		No	ClinGen TOPMed
rs753173935 CA1383441	11	A>P		No	ClinGen ExAC TOPMed gnomAD
rs1015768432 CA37246405	12	S>G		No	ClinGen Ensembl
rs867673779 CA37246406	12	S>R		No	ClinGen Ensembl
CA1383442 rs758450872	12	S>T		No	ClinGen ExAC
CA344885674 rs1404677156	13	A>T		No	ClinGen gnomAD
CA1383443 rs777724403	13	A>V		No	ClinGen ExAC TOPMed gnomAD
CA37246407 rs866711977	16	S>*		No	ClinGen gnomAD
CA344885696 rs866711977	16	S>L		No	ClinGen gnomAD
rs745634075 CA1383447	18	S>W		No	ClinGen ExAC gnomAD
CA344885712 rs1460914404	19	E>G		No	ClinGen gnomAD
rs1201917147 CA344885729	21	V>G		No	ClinGen gnomAD
rs1250133679 CA344885736	22	D>E		No	ClinGen TOPMed gnomAD
rs1450336837 CA344885739	23	G>R		No	ClinGen gnomAD
rs779994978 CA1383449	24	F>L		No	ClinGen ExAC gnomAD
CA344885763 rs1168204845	27	K>Q		No	ClinGen TOPMed
rs1411193203 CA344885774	28	S>W		No	ClinGen TOPMed
rs749196942 CA1383450	30	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA344885783 rs749196942	30	R>G		No	ClinGen ExAC TOPMed gnomAD
rs768146082 CA1383451	30	R>L		No	ClinGen ExAC gnomAD
rs773733633 CA1383452	31	K>R		No	ClinGen ExAC TOPMed gnomAD
CA1383453 rs536847573	32	A>T		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs996038513 CA344885799	33	Q>*		No	ClinGen TOPMed gnomAD
rs996038513 CA37246409	33	Q>K		No	ClinGen TOPMed gnomAD
rs1288614821 CA344885802	33	Q>L		No	ClinGen TOPMed gnomAD
CA344885805 rs1221346275	34	R>G		No	ClinGen gnomAD
rs1246927856 CA344885807	34	R>K		No	ClinGen gnomAD
CA1383454 rs771692473	35	Q>K		No	ClinGen ExAC gnomAD
CA344885831 rs1238156341	37	R>L		No	ClinGen TOPMed
rs868609509 CA37246410	37	R>S		No	ClinGen TOPMed
rs765539889 CA1383457	39	Q>P		No	ClinGen ExAC gnomAD
CA1383458 rs776003767	40	G>D		No	ClinGen ExAC gnomAD
CA344885845 rs1465479679	40	G>S		No	ClinGen gnomAD
CA344885853 rs1240627208	41	S>L		No	ClinGen gnomAD
rs1191625387 CA344885863	43	Q>*		No	ClinGen gnomAD
rs764729691 CA1383460	45	R>C		No	ClinGen ExAC gnomAD
rs1479424247 CA344885882	45	R>L		No	ClinGen TOPMed gnomAD
rs1399657182 CA344885899	48	G>S		No	ClinGen gnomAD
CA344885911 rs1351321959	49	S>R		No	ClinGen gnomAD
rs1439049401 CA344885914	50	Q>E		No	ClinGen gnomAD
TCGA novel	50	Q>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA37246413 rs866190911	51	A>E		No	ClinGen gnomAD
CA344885924 rs866190911	51	A>V		No	ClinGen gnomAD
rs75232123 CA1383466	55	P>A		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs977767402 CA37246414	55	P>L		No	ClinGen gnomAD
rs1221955101 CA344885974	59	L>P		No	ClinGen gnomAD
rs199996030 CA1383483	61	D>G		No	ClinGen ESP ExAC gnomAD
CA37250925 rs141270790	62	A>D		No	ClinGen ESP gnomAD
rs949285552 CA37250924	62	A>P		No	ClinGen TOPMed
CA344886842 rs1158162163	63	T>S		No	ClinGen gnomAD
CA344886854 rs1193969423	65	N>D		No	ClinGen gnomAD
CA1383484 rs767719968	65	N>S		No	ClinGen ExAC TOPMed gnomAD
CA37250926 rs1046244917	66	E>D		No	ClinGen TOPMed
rs771923439	68	Q>missing	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
rs750606106 CA1383486	69	E>*		No	ClinGen ExAC gnomAD
rs1558148963 CA344886908	72	C>F		No	ClinGen Ensembl
CA1383487 rs756286291	73	Q>H		No	ClinGen ExAC gnomAD
rs766685836 CA1383488	76	Q>E		No	ClinGen ExAC gnomAD
CA344886947 rs1475315719	77	Q>H		No	ClinGen gnomAD
CA344886941 rs1374022737	77	Q>K		No	ClinGen gnomAD
CA1383489 rs753556980	79	C>Y		No	ClinGen ExAC gnomAD
CA1383490 rs754844288	80	I>V		No	ClinGen ExAC gnomAD
CA344886987 rs1404112253	83	D>G		No	ClinGen gnomAD
CA37250927 rs922667117	85	M>L		No	ClinGen Ensembl
TCGA novel	87	S>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA344887015 rs1571597343	87	S>P		No	ClinGen Ensembl
CA344887058 rs1319271158	93	S>N		No	ClinGen gnomAD
rs113571279 CA344887077	95	E>D		No	ClinGen TOPMed
CA1383491 rs371438723	96	I>V		No	ClinGen ESP ExAC TOPMed gnomAD
rs1276538036 CA344887086	97	K>E		No	ClinGen gnomAD
TCGA novel	98	R>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs748103080 CA1383492	99	A>T		No	ClinGen ExAC gnomAD
rs374962053 CA37250931	100	T>I		No	ClinGen ESP TOPMed gnomAD
rs374962053 CA37250930	100	T>K		No	ClinGen ESP TOPMed gnomAD
CA344887121 rs1194137862	102	N>K		No	ClinGen TOPMed
rs866356975 CA37250932	106	E>*		No	ClinGen Ensembl
rs757843672 CA1383493	107	Y>F		No	ClinGen ExAC gnomAD
CA344887148 rs1205322898	107	Y>N		No	ClinGen gnomAD
TCGA novel	108	V>G	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA1383494 rs777266097	112	R>H		No	ClinGen ExAC TOPMed gnomAD
CA344887202 rs1185563281	115	I>T		No	ClinGen TOPMed
CA1383495 rs746596004	119	A>V	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs776392856 CA1383497	121	S>F		No	ClinGen ExAC gnomAD
rs1237499018 CA344887247	122	D>G		No	ClinGen TOPMed
CA344887244 rs1175746482	122	D>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA344887256 rs1458927396	123	I>M		No	ClinGen gnomAD
rs184178657 CA1383498	123	I>T		No	ClinGen 1000Genomes ExAC gnomAD
TCGA novel	124	V>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	126	M>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs911610042 CA37251385	133	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
rs202004074 CA37251386	134	T>I		No	ClinGen 1000Genomes gnomAD
CA1383520 rs779415573	136	P>S		No	ClinGen ExAC TOPMed
CA37251387 rs878872531	138	S>G		No	ClinGen Ensembl
rs748582305 CA1383521	141	P>T		No	ClinGen ExAC gnomAD
CA1383524 rs182683116	151	T>K		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA1383522 rs182683116	151	T>M		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs182683116 CA1383523	151	T>R		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA344887475 rs1481912761	154	A>T		No	ClinGen gnomAD
rs1196405048 CA344887480	154	A>V		No	ClinGen TOPMed gnomAD
rs1374526182 CA344887494	156	W>C		No	ClinGen TOPMed
rs1185631390 CA344887511	159	I>V		No	ClinGen gnomAD
CA344887523 TCGA novel rs1386158224	160	Q>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen gnomAD NCI-TCGA
CA344762761 rs1169634665	162	V>L		No	ClinGen gnomAD
rs778096953 CA1383541	164	E>D		No	ClinGen ExAC gnomAD
CA1383542 rs747560993	172	S>N		No	ClinGen ExAC gnomAD
rs1450048800 CA344763117	173	P>A		No	ClinGen gnomAD
rs17852039 CA36814478	176	Q>R		No	ClinGen Ensembl
CA344763238 rs1290304600	178	S>G		No	ClinGen gnomAD
CA344763243 rs1364493497	178	S>N		No	ClinGen gnomAD
CA1383544 rs776766301	179	I>T		No	ClinGen ExAC gnomAD
rs1306274604 CA344763298	180	A>V	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA344763311 rs1225367278	181	K>E		No	ClinGen gnomAD
CA1383545 rs192765953	182	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
CA36814493 rs965269011	183	Y>C		No	ClinGen Ensembl
CA36814497 rs369698862	184	I>V		No	ClinGen ESP TOPMed
CA1383546 rs374082551	185	D>H		No	ClinGen ESP ExAC TOPMed gnomAD
rs374082551 CA344763381	185	D>N		No	ClinGen ESP ExAC TOPMed gnomAD
rs374082551 CA1383547	185	D>Y		No	ClinGen ESP ExAC TOPMed gnomAD
rs1774249 CA344763473	188	F>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA1383550 rs147962315	189	V>I		No	ClinGen ESP ExAC TOPMed gnomAD
rs147962315 CA1383551	189	V>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA36814556 rs931751731	191	Q>*		No	ClinGen TOPMed gnomAD
CA344763522 rs931751731	191	Q>K		No	ClinGen TOPMed gnomAD
rs373523104 CA1383571	194	E>D		No	ClinGen ESP ExAC TOPMed gnomAD
CA344764592 rs1358993216	197	D>G		No	ClinGen TOPMed gnomAD
CA1383573 rs765582793	204	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
TCGA novel	205	D>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	206	F>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA344764684 rs1195585084	210	V>A		No	ClinGen TOPMed gnomAD
CA344764685 rs1195585084	210	V>G		No	ClinGen TOPMed gnomAD
CA36817186 rs942433088	210	V>L		No	ClinGen TOPMed
CA344764701 rs1281369362	213	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA36817189 rs143781873	215	Y>H		No	ClinGen ESP TOPMed gnomAD
CA1383576 rs764853636	216	G>R		No	ClinGen ExAC gnomAD
rs1435143688 CA344764756	221	L>F		No	ClinGen gnomAD
CA1383578 rs757601495	223	A>G		No	ClinGen ExAC TOPMed gnomAD
CA344764765 rs1386418221	223	A>T		No	ClinGen TOPMed
rs1295337355 CA344764785	226	R>*		No	ClinGen TOPMed
CA1383579 rs781693767	227	K>E		No	ClinGen ExAC gnomAD
rs886638175 CA36817243	228	Q>H		No	ClinGen Ensembl
rs780103900 CA1383583	232	I>T		No	ClinGen ExAC gnomAD
CA344764849 rs1386773347	235	R>G		No	ClinGen gnomAD
CA344764850 rs1386773347	235	R>W		No	ClinGen gnomAD
rs766701370 CA36818501	237	I>V		No	ClinGen Ensembl
CA344764902 rs1409448654	240	T>I		No	ClinGen gnomAD
CA344764928 rs1329458838	244	N>H		No	ClinGen gnomAD
CA344764939 rs1408543591	245	G>D	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs1336354749 CA344764971	249	L>I		No	ClinGen gnomAD
TCGA novel	251	E>Q	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA344765026 rs1243707756	253	L>F		No	ClinGen TOPMed
CA344765113 rs1398030746	256	I>F	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
TCGA novel	262	L>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1285441380 CA344765418	275	V>A		No	ClinGen gnomAD
rs778938337 CA36819298	277	I>T		No	ClinGen Ensembl
CA1383629 rs778186085	279	M>T		No	ClinGen ExAC gnomAD
TCGA novel	279	M>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1192067111 CA344765545	282	A>T		No	ClinGen gnomAD
CA344765562 rs1166597031	283	K>E		No	ClinGen TOPMed
TCGA novel	284	G>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA344765582 rs1558153771	284	G>R		No	ClinGen Ensembl
CA1383630 rs140243249	286	A>G		No	ClinGen ESP ExAC TOPMed gnomAD
rs563230469 CA1383631	287	L>S		No	ClinGen 1000Genomes ExAC gnomAD
rs781225971 CA1383632	289	H>P		No	ClinGen ExAC gnomAD
rs781225971 CA344765679	289	H>R		No	ClinGen ExAC gnomAD
CA1383633 rs745804683	290	A>T		No	ClinGen ExAC gnomAD
CA1383634 rs769280608	290	A>V		No	ClinGen ExAC gnomAD
CA344765715 rs1571608941	291	Q>R		No	ClinGen Ensembl
CA344766444 rs1571609414	304	T>I		No	ClinGen Ensembl
CA344766437 rs1352421705	304	T>S		No	ClinGen TOPMed
rs758587827 CA1383648	309	P>L		No	ClinGen ExAC gnomAD
rs550743255 CA36825222	310	V>L		No	ClinGen gnomAD
rs550743255 CA344768262	310	V>M		No	ClinGen gnomAD
rs766203588 CA1383694	312	R>G		No	ClinGen ExAC gnomAD
CA344768290 rs1269590169	313	G>R		No	ClinGen TOPMed
rs1558156458 CA344768358	317	F>C		No	ClinGen Ensembl
CA1383696 rs377097219	321	T>I		No	ClinGen ESP ExAC gnomAD
CA36825232 rs528269132	322	C>Y		No	ClinGen 1000Genomes
TCGA novel	323	S>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs942654759 CA36825488	327	V>M		No	ClinGen Ensembl
TCGA novel	330	L>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA1383720 rs763662131	333	I>T		No	ClinGen ExAC TOPMed gnomAD
CA344768733 rs1325626424	337	L>F		No	ClinGen Ensembl
rs1172688487 CA344768739	338	D>A		No	ClinGen gnomAD
TCGA novel	338	D>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1401263874 CA344768747	339	V>I		No	ClinGen gnomAD
CA1383723 rs149320403	340	I>T		No	ClinGen ESP ExAC TOPMed gnomAD
rs79437056 CA36825506	345	F>L		No	ClinGen Ensembl
CA344768858 rs1213717489	347	K>N		No	ClinGen gnomAD
rs1257756350 CA344768867	348	I>T		No	ClinGen gnomAD
rs1384652302 CA344768872	349	E>K		No	ClinGen gnomAD
rs1384604197 CA344768885	350	E>Q		No	ClinGen TOPMed
CA344768916 rs1179866637	353	F>L		No	ClinGen TOPMed
CA1383724 rs749630804	356	I>V		No	ClinGen ExAC gnomAD
CA344768972 rs1558156615	357	S>F		No	ClinGen Ensembl
CA1383725 rs755416936	358	K>R		No	ClinGen ExAC gnomAD
CA1383728 rs772523863	361	S>A		No	ClinGen ExAC
rs1051500380 CA36825535	363	S>F		No	ClinGen TOPMed
CA344769076 rs1333319637	367	V>I		No	ClinGen gnomAD
rs1432755922 CA344769132	371	A>S	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
rs1278787806 CA344769153	372	L>F		No	ClinGen gnomAD
rs751057246 CA1383740	377	N>K		No	ClinGen ExAC TOPMed gnomAD
CA344769239 rs1216332203	377	N>S		No	ClinGen gnomAD
CA1383741 rs756757799	378	E>K	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA344769296 rs1278312752	380	I>T		No	ClinGen gnomAD
rs767231100 CA1383742	382	S>R		No	ClinGen ExAC gnomAD
CA1383744 rs750115208	384	I>T		No	ClinGen ExAC gnomAD
rs970868939 CA36825724	388	I>L		No	ClinGen TOPMed gnomAD
CA344769434 rs1379566913	388	I>T		No	ClinGen gnomAD
CA344769432 rs970868939	388	I>V		No	ClinGen TOPMed gnomAD
CA1383746 rs779417635	389	D>G		No	ClinGen ExAC gnomAD
rs17852038 CA36825726	389	D>N		No	ClinGen Ensembl
TCGA novel	390	K>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA344769530 rs1177604596	395	M>I		No	ClinGen gnomAD
rs1399726705 CA344769529	395	M>T		No	ClinGen gnomAD
rs1172240206 CA344769516	395	M>V		No	ClinGen gnomAD
CA344769546 rs1298658905	397	A>S		No	ClinGen gnomAD
rs1157798977 CA344769558	398	S>R		No	ClinGen TOPMed
CA1383749 rs778179116	401	K>R		No	ClinGen ExAC gnomAD
rs747076704 CA1383750	402	I>T		No	ClinGen ExAC TOPMed gnomAD
rs1253612006 CA344769620	403	S>C		No	ClinGen TOPMed
CA1383751 rs771025750	408	N>H		No	ClinGen ExAC TOPMed gnomAD
CA1383752 rs776779360	409	P>L		No	ClinGen ExAC gnomAD
CA1383790 rs761836623	417	N>S		No	ClinGen ExAC TOPMed gnomAD
rs753460155 CA1383795	424	E>A		No	ClinGen ExAC gnomAD
rs766012039 CA1383794	424	E>Q		No	ClinGen ExAC TOPMed gnomAD
rs763322752 CA1383796	425	M>I		No	ClinGen ExAC gnomAD
rs764373826 CA1383797	427	G>S		No	ClinGen ExAC gnomAD
rs752030312 CA1383799	431	D>H		No	ClinGen ExAC gnomAD
CA1383798 rs752030312	431	D>N		No	ClinGen ExAC gnomAD
CA1383800 rs750008940	432	D>Y		No	ClinGen ExAC TOPMed gnomAD
CA344770302 rs1231723709	439	A>T		No	ClinGen TOPMed
CA344770408 rs1266749763	444	E>K		No	ClinGen TOPMed
CA1383821 rs766364145	448	E>K		No	ClinGen ExAC gnomAD
CA344770454 rs755132136	450	E>K	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs755132136 CA1383823	450	E>Q		No	ClinGen ExAC gnomAD
rs779233052 CA1383824	451	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs1412060471 CA344770465	451	R>L		No	ClinGen gnomAD
CA344770468 rs1198599806	452	E>K	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA344770466 rs1198599806	452	E>Q		No	ClinGen gnomAD
rs747909101 CA1383825	453	E>K		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	455	W>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA1383827 rs777798963	456	K>N		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	457	K>Q	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs977317471 CA36828412	457	K>R		No	ClinGen Ensembl
CA36828425 rs746751008	459	E>D		No	ClinGen Ensembl
rs1440333259 CA344770579	460	E>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs1328135667 CA344770615	462	K>N		No	ClinGen TOPMed gnomAD
CA1383830 rs770971667	465	K>N		No	ClinGen ExAC gnomAD
CA344770695 rs1311588181	466	A>G		No	ClinGen TOPMed gnomAD
TCGA novel	466	A>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA36828447 rs573098347	467	L>Q		No	ClinGen TOPMed gnomAD
CA344770712 rs1363071777	467	L>V		No	ClinGen gnomAD
TCGA novel	468	E>G	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1297700537 CA344770792	470	Q>R		No	ClinGen gnomAD
rs1014789613 CA36828472	473	A>T		No	ClinGen TOPMed
rs745433703 CA344770898	474	Y>*		No	ClinGen ExAC gnomAD
rs775156232 CA1383834	475	N>K		No	ClinGen ExAC gnomAD
CA1383833 rs769301353	475	N>S		No	ClinGen ExAC gnomAD
CA1383835 rs762117528	476	M>T		No	ClinGen ExAC gnomAD
CA344770944 rs1230873880	476	M>V		No	ClinGen gnomAD
rs1488603284 CA344770990	477	H>P		No	ClinGen gnomAD
CA344770996 rs1215849375	477	H>Q		No	ClinGen gnomAD
CA1383836 rs767872976	478	S>N		No	ClinGen ExAC TOPMed gnomAD
rs761071796 CA1383838	481	S>G		No	ClinGen ExAC gnomAD
CA1383839 rs766957659	481	S>R		No	ClinGen ExAC gnomAD
rs753828171 CA1383840	483	T>A		No	ClinGen ExAC gnomAD
CA36828554 rs765503592	485	A>P		No	ClinGen ExAC TOPMed gnomAD
rs765503592 CA1383842	485	A>T		No	ClinGen ExAC TOPMed gnomAD
rs916598455 CA36828561	486	E>D		No	ClinGen Ensembl
CA1383843 rs752977429	486	E>K	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
TCGA novel	487	E>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs755633598 CA1383844	487	E>L		No	ClinGen ExAC gnomAD
CA344771198 rs1268836453	487	E>Q		No	ClinGen TOPMed

No associated diseases with Q15172

8 regional properties for Q15172

Type	Name	Position	InterPro Accession
domain	F-box domain	277 - 332	IPR001810
repeat	Leucine-rich repeat, cysteine-containing subtype	400 - 425	IPR006553-1
repeat	Leucine-rich repeat, cysteine-containing subtype	450 - 475	IPR006553-2
repeat	Leucine-rich repeat, cysteine-containing subtype	478 - 503	IPR006553-3
repeat	Leucine-rich repeat, cysteine-containing subtype	504 - 524	IPR006553-4
repeat	Leucine-rich repeat, cysteine-containing subtype	532 - 557	IPR006553-5
repeat	Leucine-rich repeat, cysteine-containing subtype	558 - 583	IPR006553-6
repeat	Leucine-rich repeat, cysteine-containing subtype	584 - 609	IPR006553-7

Functions

		Description
EC Number
Subcellular Localization	Cytoplasm Nucleus Chromosome, centromere	From mitotic prophase to metaphase, localizes at the inner centromere between a pair of sister kinetochores Decreased expression at the onset of anaphase
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

9 GO annotations of cellular component

Name	Definition
centrosome	A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle.
chromosome, centromeric region	The region of a chromosome that includes the centromeric DNA and associated proteins. In monocentric chromosomes, this region corresponds to a single area of the chromosome, whereas in holocentric chromosomes, it is evenly distributed along the chromosome.
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
M band	The midline of aligned thick filaments in a sarcomere; location of specific proteins that link thick filaments. Depending on muscle type the M band consists of different numbers of M lines.
membrane	A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
protein phosphatase type 2A complex	A protein complex that has protein serine/threonine phosphatase activity that is polycation-stimulated (PCS), being directly stimulated by protamine, polylysine, or histone H1; it constitutes a subclass of several enzymes activated by different histones and polylysine, and consists of catalytic, scaffolding, and regulatory subunits. The catalytic and scaffolding subunits form the core enzyme, and the holoenzyme also includes the regulatory subunit.
Z disc	Platelike region of a muscle sarcomere to which the plus ends of actin filaments are attached.

4 GO annotations of molecular function

Name	Definition
kinase binding	Binding to a kinase, any enzyme that catalyzes the transfer of a phosphate group.
phosphoprotein phosphatase activity	Catalysis of the reaction: a phosphoprotein + H2O = a protein + phosphate. Together with protein kinases, these enzymes control the state of phosphorylation of cellular proteins and thereby provide an important mechanism for regulating cellular activity.
protein phosphatase activator activity	Binds to and increases the activity of a protein phosphatase, an enzyme which catalyzes of the removal of a phosphate group from a protein substrate molecule.
protein phosphatase regulator activity	Binds to and modulates the activity of a protein phosphatase, an enzyme which catalyzes of the removal of a phosphate group from a protein substrate molecule.

5 GO annotations of biological process

Name	Definition
negative regulation of lipid kinase activity	Any process that decreases the frequency, rate or extent of lipid kinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to a simple or complex lipid.
negative regulation of protein localization to plasma membrane	Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to plasma membrane.
positive regulation of protein dephosphorylation	Any process that activates or increases the frequency, rate or extent of removal of phosphate groups from a protein.
protein dephosphorylation	The process of removing one or more phosphoric residues from a protein.
signal transduction	The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.

13 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
A4FV68	PPP2R5E	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform	Bos taurus (Bovine)	PR
Q15173	PPP2R5B	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform	Homo sapiens (Human)	PR
Q16537	PPP2R5E	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform	Homo sapiens (Human)	PR
Q14738	PPP2R5D	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform	Homo sapiens (Human)	PR
Q61151	Ppp2r5e	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform	Mus musculus (Mouse)	PR
Q6PD03	Ppp2r5a	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform	Mus musculus (Mouse)	PR
O04375	B'ALPHA	Serine/threonine protein phosphatase 2A 57 kDa regulatory subunit B' alpha isoform	Arabidopsis thaliana (Mouse-ear cress)	PR
Q93YV6	B'KAPPA	Serine/threonine protein phosphatase 2A 57 kDa regulatory subunit B' kappa isoform	Arabidopsis thaliana (Mouse-ear cress)	PR
Q8LF36	B'THETA	Serine/threonine protein phosphatase 2A 57 kDa regulatory subunit B' theta isoform	Arabidopsis thaliana (Mouse-ear cress)	PR
Q9ZQY6	B'DELTA	Serine/threonine protein phosphatase 2A 55 kDa regulatory subunit B' delta isoform	Arabidopsis thaliana (Mouse-ear cress)	PR
Q9LVE2	B'ZETA	Serine/threonine protein phosphatase 2A 59 kDa regulatory subunit B' zeta isoform	Arabidopsis thaliana (Mouse-ear cress)	PR
Q8RW96	B'GAMMA	Serine/threonine protein phosphatase 2A 59 kDa regulatory subunit B' gamma isoform	Arabidopsis thaliana (Mouse-ear cress)	PR
Q9LU89	B'ETA	Serine/threonine protein phosphatase 2A 59 kDa regulatory subunit B' eta isoform	Arabidopsis thaliana (Mouse-ear cress)	PR

10	20	30	40	50	60
MSSSSPPAGA	ASAAISASEK	VDGFTRKSVR	KAQRQKRSQG	SSQFRSQGSQ	AELHPLPQLK
70	80	90	100	110	120
DATSNEQQEL	FCQKLQQCCI	LFDFMDSVSD	LKSKEIKRAT	LNELVEYVST	NRGVIVESAY
130	140	150	160	170	180
SDIVKMISAN	IFRTLPPSDN	PDFDPEEDEP	TLEASWPHIQ	LVYEFFLRFL	ESPDFQPSIA
190	200	210	220	230	240
KRYIDQKFVQ	QLLELFDSED	PRERDFLKTV	LHRIYGKFLG	LRAFIRKQIN	NIFLRFIYET
250	260	270	280	290	300
EHFNGVAELL	EILGSIINGF	ALPLKAEHKQ	FLMKVLIPMH	TAKGLALFHA	QLAYCVVQFL
310	320	330	340	350	360
EKDTTLTEPV	IRGLLKFWPK	TCSQKEVMFL	GEIEEILDVI	EPTQFKKIEE	PLFKQISKCV
370	380	390	400	410	420
SSSHFQVAER	ALYFWNNEYI	LSLIEENIDK	ILPIMFASLY	KISKEHWNPT	IVALVYNVLK
430	440	450	460	470	480
TLMEMNGKLF	DDLTSSYKAE	RQREKKKELE	REELWKKLEE	LKLKKALEKQ	NSAYNMHSIL

SNTSAE