O04375
PR
Gene name |
B'ALPHA (At5g03470, F12E4.240) |
Protein name |
Serine/threonine protein phosphatase 2A 57 kDa regulatory subunit B' alpha isoform |
Names |
AtB' alpha, PP2A, B' subunit, alpha isoform |
Species |
Arabidopsis thaliana (Mouse-ear cress) |
KEGG Pathway |
ath:AT5G03470 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for O04375
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-O04375-F1 | Predicted | AlphaFoldDB |
24 variants for O04375
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| ENSVATH06915806 | 16 | A>T | No | 1000Genomes | |
| tmp_5_866863_G_C | 23 | M>I | No | 1000Genomes | |
| tmp_5_866927_C_A | 45 | R>S | No | 1000Genomes | |
| ENSVATH03015905 | 46 | G>A | No | 1000Genomes | |
| tmp_5_866939_G_A | 49 | V>I | No | 1000Genomes | |
| tmp_5_866984_C_A | 64 | P>T | No | 1000Genomes | |
| ENSVATH06915807 | 96 | F>C | No | 1000Genomes | |
| tmp_5_867137_C_G | 115 | Q>E | No | 1000Genomes | |
| ENSVATH06915808 | 121 | V>I | No | 1000Genomes | |
| tmp_5_867173_G_A | 127 | G>R | No | 1000Genomes | |
| tmp_5_867174_G_T | 127 | G>V | No | 1000Genomes | |
| tmp_5_867184_G_T | 130 | K>N | No | 1000Genomes | |
| tmp_5_867185_C_G | 131 | L>V | No | 1000Genomes | |
| ENSVATH06915809 | 186 | L>F | No | 1000Genomes | |
| ENSVATH06915810 | 191 | I>V | No | 1000Genomes | |
| tmp_5_867405_A_G | 204 | Y>C | No | 1000Genomes | |
| tmp_5_867417_C_G | 208 | S>C | No | 1000Genomes | |
| ENSVATH10533576 | 298 | I>L | No | 1000Genomes | |
| tmp_5_867747_T_A | 318 | V>D | No | 1000Genomes | |
| tmp_5_867927_C_G | 378 | A>G | No | 1000Genomes | |
| tmp_5_868633_T_C | 417 | F>L | No | 1000Genomes | |
| ENSVATH10533583 | 422 | K>N | No | 1000Genomes | |
| tmp_5_868756_T_G | 458 | Y>D | No | 1000Genomes | |
| ENSVATH00604355 | 461 | K>N | No | 1000Genomes |
No associated diseases with O04375
No regional properties for O04375
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for O04375 | |||
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
| protein phosphatase type 2A complex | A protein complex that has protein serine/threonine phosphatase activity that is polycation-stimulated (PCS), being directly stimulated by protamine, polylysine, or histone H1; it constitutes a subclass of several enzymes activated by different histones and polylysine, and consists of catalytic, scaffolding, and regulatory subunits. The catalytic and scaffolding subunits form the core enzyme, and the holoenzyme also includes the regulatory subunit. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| protein phosphatase regulator activity | Binds to and modulates the activity of a protein phosphatase, an enzyme which catalyzes of the removal of a phosphate group from a protein substrate molecule. |
5 GO annotations of biological process
| Name | Definition |
|---|---|
| brassinosteroid mediated signaling pathway | The series of molecular signals mediated by the detection of brassinosteroid. |
| megasporogenesis | The process in which the megasporocyte undergoes meiosis, giving rise to four haploid megaspores in the nucellus. |
| meiotic sister chromatid cohesion | The cell cycle process in which sister chromatids of a replicated chromosome are joined along the entire length of the chromosome during meiosis. |
| microsporogenesis | The process in which the microsporocyte undergoes meiosis, giving rise to four haploid microspores. |
| regulation of phosphorylation | Any process that modulates the frequency, rate or extent of addition of phosphate groups into a molecule. |
13 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| A4FV68 | PPP2R5E | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform | Bos taurus (Bovine) | PR |
| Q15172 | PPP2R5A | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform | Homo sapiens (Human) | PR |
| Q15173 | PPP2R5B | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform | Homo sapiens (Human) | PR |
| Q16537 | PPP2R5E | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform | Homo sapiens (Human) | PR |
| Q14738 | PPP2R5D | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform | Homo sapiens (Human) | PR |
| Q61151 | Ppp2r5e | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform | Mus musculus (Mouse) | PR |
| Q6PD03 | Ppp2r5a | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform | Mus musculus (Mouse) | PR |
| Q8LF36 | B'THETA | Serine/threonine protein phosphatase 2A 57 kDa regulatory subunit B' theta isoform | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q8RW96 | B'GAMMA | Serine/threonine protein phosphatase 2A 59 kDa regulatory subunit B' gamma isoform | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q93YV6 | B'KAPPA | Serine/threonine protein phosphatase 2A 57 kDa regulatory subunit B' kappa isoform | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9LVE2 | B'ZETA | Serine/threonine protein phosphatase 2A 59 kDa regulatory subunit B' zeta isoform | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9ZQY6 | B'DELTA | Serine/threonine protein phosphatase 2A 55 kDa regulatory subunit B' delta isoform | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9LU89 | B'ETA | Serine/threonine protein phosphatase 2A 59 kDa regulatory subunit B' eta isoform | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MFKKIMKGAN | RKASKAEAND | SSMYGFDPPG | RSGPGSNMIV | NHASRGSLVP | SSPNSMAAAT |
| 70 | 80 | 90 | 100 | 110 | 120 |
| TQPPPMYSVE | PLPLFRDVSV | SERQSLFLRK | LQICCFQFDF | TDTLKNAREK | EIKRQTLLEL |
| 130 | 140 | 150 | 160 | 170 | 180 |
| VDFIQSGAGK | LTEVCQEEMV | KMISVNIFRC | LPPASHENTG | QEPADLEEEE | PYLEPSWPHL |
| 190 | 200 | 210 | 220 | 230 | 240 |
| QLIYELLLRY | IVPSDTDTKV | AKRYIDHSFV | LRLLELFETE | DPREREYLKT | ILHRIYGKFM |
| 250 | 260 | 270 | 280 | 290 | 300 |
| VHRPFIRKAM | NHIFYRFIYE | TERHSGIGEL | LEILGSIING | FALPMKEEHK | LFLIRALIPL |
| 310 | 320 | 330 | 340 | 350 | 360 |
| HKPKPIAMYH | QQLSYCIVQF | VEKDYKLADT | VIRGLLKFWP | VTNCTKEVLF | LGELEEVLEA |
| 370 | 380 | 390 | 400 | 410 | 420 |
| TQTVEFQRCM | VPLFQQIARC | LSSSNFQVAE | RALFLWNNEH | VVGLIAQNRG | VILPIIFASL |
| 430 | 440 | 450 | 460 | 470 | 480 |
| EKNIESHWNQ | AVHGLSANIK | RMFMEMDPEL | FEECQQQYEE | KQAKSKQVEE | QRQNRWRRLD |
| 490 | |||||
| EAVEERERED | PMITS |