Q15173
PR
Gene name |
PPP2R5B |
Protein name |
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform |
Names |
PP2A B subunit isoform B'-beta, PP2A B subunit isoform B56-beta, PP2A B subunit isoform PR61-beta, PP2A B subunit isoform R5-beta |
Species |
Homo sapiens (Human) |
KEGG Pathway |
hsa:5526 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q15173
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q15173-F1 | Predicted | AlphaFoldDB |
319 variants for Q15173
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
|
rs772148043 CA6086691 |
3 | T>M | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA381197697 rs1165886194 |
5 | L>V | No |
ClinGen gnomAD |
|
|
rs199949257 CA381197707 |
7 | P>A | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
rs1368764132 TCGA novel CA381197710 |
7 | P>L | Variant assessed as Somatic; impact. [NCI-TCGA] | No |
ClinGen gnomAD NCI-TCGA |
|
rs199949257 CA6086695 |
7 | P>S | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
rs199949257 CA6086694 |
7 | P>T | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
rs762839446 CA6086696 |
9 | S>N | No |
ClinGen ExAC gnomAD |
|
|
CA381197721 rs762839446 |
9 | S>T | No |
ClinGen ExAC gnomAD |
|
|
CA381197728 rs1297738369 |
10 | T>I | No |
ClinGen TOPMed gnomAD |
|
|
rs1297738369 CA381197729 |
10 | T>N | No |
ClinGen TOPMed gnomAD |
|
|
CA381197724 rs1590675774 |
10 | T>P | No |
ClinGen Ensembl |
|
|
rs763889029 CA6086697 |
11 | P>L | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs201904964 CA6086698 |
12 | T>I | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
CA381197736 rs1357488841 |
12 | T>P | No |
ClinGen TOPMed gnomAD |
|
|
CA223918687 rs201904964 |
12 | T>S | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
rs1590675802 CA381197742 |
13 | S>N | No |
ClinGen Ensembl |
|
|
rs761908185 CA6086699 |
14 | P>L | No |
ClinGen ExAC gnomAD |
|
|
rs879729360 CA223918723 |
15 | S>P | No |
ClinGen TOPMed gnomAD |
|
|
rs750000794 CA6086701 |
16 | S>P | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs755690336 CA6086702 |
17 | P>A | No |
ClinGen ExAC gnomAD |
|
|
rs1326486257 CA381197765 |
17 | P>R | No |
ClinGen TOPMed |
|
|
CA381197768 TCGA novel rs1369331128 CA381197767 |
18 | G>R | Variant assessed as Somatic; impact. [NCI-TCGA] | No |
NCI-TCGA ClinGen TOPMed gnomAD |
|
rs755378834 CA6086705 |
19 | L>M | No |
ClinGen ExAC gnomAD |
|
|
rs1166883378 CA381197782 |
20 | S>L | No |
ClinGen gnomAD |
|
|
CA6086707 rs748653089 |
22 | V>M | No |
ClinGen ExAC gnomAD |
|
|
rs1363460775 CA381197799 |
23 | P>L | No |
ClinGen gnomAD |
|
|
CA381197805 rs1380096084 |
24 | P>Q | No |
ClinGen gnomAD |
|
|
CA6086709 rs762299687 |
25 | P>H | No |
ClinGen ExAC gnomAD |
|
|
CA6086708 rs762299687 |
25 | P>R | No |
ClinGen ExAC gnomAD |
|
|
CA381197810 rs781499863 |
26 | D>H | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs781499863 CA6086712 |
26 | D>N | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs781499863 CA381197811 |
26 | D>Y | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1590675888 CA381197835 |
29 | D>G | No |
ClinGen Ensembl |
|
|
CA6086714 rs768493300 |
30 | G>S | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA6086715 rs774346245 |
31 | F>S | No |
ClinGen ExAC gnomAD |
|
|
CA381197856 rs1204682464 |
32 | S>F | No |
ClinGen gnomAD |
|
|
CA6086716 rs761818150 |
33 | R>C | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs772174283 CA6086717 |
33 | R>H | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA TOPMed gnomAD |
|
rs772806139 CA6086718 |
34 | R>C | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs760251777 CA381197863 |
34 | R>H | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs760251777 CA6086720 |
34 | R>L | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs760251777 CA6086719 |
34 | R>P | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA381197861 rs772806139 |
34 | R>S | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs753530198 CA6086722 |
37 | R>C | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs753530198 CA6086721 |
37 | R>G | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA6086723 rs765577553 |
37 | R>H | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA6086724 rs753111857 |
38 | R>G | No |
ClinGen ExAC gnomAD |
|
|
CA381197880 rs1340070230 |
38 | R>K | No |
ClinGen TOPMed |
|
|
CA381197891 rs778284880 |
40 | R>G | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA6086727 rs751546233 |
40 | R>L | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA6086728 rs751546233 |
40 | R>Q | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA6086726 rs778284880 |
40 | R>W | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA381197901 rs1229465441 |
42 | R>C | No |
ClinGen TOPMed gnomAD |
|
|
CA381197900 rs1229465441 |
42 | R>G | No |
ClinGen TOPMed gnomAD |
|
|
rs781205992 CA6086730 |
42 | R>H | No |
ClinGen ExAC TOPMed gnomAD |
|
| TCGA novel | 42 | R>L | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA6086731 rs139878967 |
43 | R>C | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA6086732 rs139878967 |
43 | R>G | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA6086734 rs201162064 |
43 | R>H | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
CA6086733 rs139878967 |
43 | R>S | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA6086735 rs772084007 |
44 | S>F | No |
ClinGen ExAC gnomAD |
|
|
CA6086736 rs773293765 |
45 | H>R | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA381197913 rs1397763181 |
45 | H>Y | No |
ClinGen TOPMed |
|
|
rs1485215891 CA381197943 |
49 | Q>L | No |
ClinGen gnomAD |
|
|
rs770466967 CA6086738 |
54 | S>G | No |
ClinGen ExAC gnomAD |
|
|
rs770486698 CA223918873 |
56 | Q>H | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs759207412 CA6086740 |
58 | E>Q | No |
ClinGen ExAC gnomAD |
|
|
CA6086741 rs764913889 |
59 | L>F | No |
ClinGen ExAC gnomAD |
|
|
CA381198031 rs887668274 |
61 | P>L | No |
ClinGen TOPMed gnomAD |
|
|
CA223918898 rs887668274 |
61 | P>Q | No |
ClinGen TOPMed gnomAD |
|
|
CA6086743 rs763330401 |
63 | P>T | No |
ClinGen ExAC gnomAD |
|
|
rs1371749828 CA381198092 |
67 | D>H | No |
ClinGen gnomAD |
|
|
CA6086763 rs375715449 |
69 | P>L | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs1452310026 CA381198764 |
72 | E>D | No |
ClinGen TOPMed |
|
|
CA381198753 rs1565099942 |
72 | E>K | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen Ensembl NCI-TCGA |
|
rs762348200 CA6086765 |
73 | L>V | No |
ClinGen ExAC gnomAD |
|
|
rs767940124 CA6086766 |
74 | H>N | No |
ClinGen ExAC gnomAD |
|
|
CA6086768 rs537733346 |
75 | E>K | No |
ClinGen ExAC gnomAD |
|
|
CA381198834 rs1372578752 |
78 | S>R | No |
ClinGen TOPMed |
|
|
CA381198823 rs1470615098 |
78 | S>R | No |
ClinGen TOPMed |
|
|
rs142378216 CA6086773 |
79 | R>L | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs142378216 CA6086772 |
79 | R>Q | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD |
|
CA6086771 rs201702050 |
79 | R>W | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA223919572 rs1056820524 |
85 | G>V | No |
ClinGen Ensembl |
|
|
rs1590676702 CA381198888 |
86 | V>G | No |
ClinGen Ensembl |
|
|
CA6086774 rs757182568 |
86 | V>L | No |
ClinGen ExAC gnomAD |
|
|
rs1459790633 CA381198897 |
87 | M>I | No |
ClinGen TOPMed |
|
|
rs1346970590 CA381198893 |
87 | M>T | No |
ClinGen gnomAD |
|
|
rs915657267 CA223919581 |
89 | D>N | No |
ClinGen Ensembl |
|
|
CA381198915 rs1460356059 |
90 | F>V | No |
ClinGen gnomAD |
|
|
rs971684498 CA223919587 |
93 | C>S | No |
ClinGen TOPMed |
|
|
CA381198957 rs1345864703 |
96 | D>N | No |
ClinGen TOPMed gnomAD |
|
|
rs1228897518 CA381198970 |
98 | K>E | No |
ClinGen TOPMed |
|
|
rs1361584692 CA381199002 |
102 | V>E | No |
ClinGen gnomAD |
|
|
rs570547041 CA381199043 |
108 | N>K | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
rs1272547286 CA381199074 |
113 | C>Y | No |
ClinGen gnomAD |
|
|
CA223919648 rs201218993 |
115 | G>R | No |
ClinGen TOPMed gnomAD |
|
|
rs762106002 CA6086783 |
116 | S>N | No |
ClinGen ExAC gnomAD |
|
|
CA381199095 rs1474894428 |
116 | S>R | No |
ClinGen gnomAD |
|
|
CA6086784 rs781016892 |
117 | T>I | No |
ClinGen ExAC gnomAD |
|
|
CA381199097 rs1590676817 |
117 | T>P | No |
ClinGen Ensembl |
|
|
CA6086785 rs781016892 |
117 | T>S | No |
ClinGen ExAC gnomAD |
|
|
CA6086787 rs766551486 |
118 | R>Q | No |
ClinGen ExAC gnomAD |
|
|
CA223919686 rs910379059 |
118 | R>W | No |
ClinGen TOPMed gnomAD |
|
|
CA6086789 rs755222755 |
124 | P>L | No |
ClinGen ExAC gnomAD |
|
|
CA6086790 rs765412987 |
125 | V>I | No |
ClinGen ExAC TOPMed gnomAD |
|
| TCGA novel | 125 | V>R | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs1415643571 CA381199252 |
131 | R>C | No |
ClinGen gnomAD |
|
|
CA223919717 rs751323043 |
131 | R>H | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA TOPMed gnomAD |
|
CA6086791 rs751323043 |
131 | R>L | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1251706894 COSM689635 CA381199381 |
135 | V>M | lung Variant assessed as Somatic; 0.0 impact. [Cosmic, NCI-TCGA] | No |
ClinGen cosmic curated NCI-TCGA gnomAD |
|
rs1018676282 COSM3723172 CA223920421 |
139 | R>Q | upper_aerodigestive_tract [Cosmic] | No |
ClinGen cosmic curated TOPMed gnomAD |
|
rs1016936346 CA223920416 |
139 | R>W | Variant assessed as Somatic; impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA TOPMed |
|
rs750257738 CA6086812 |
142 | P>A | No |
ClinGen ExAC gnomAD |
|
|
rs756002778 CA6086813 |
142 | P>L | No |
ClinGen ExAC gnomAD |
|
| TCGA novel | 145 | E>Q | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA6086818 rs747739371 |
146 | N>I | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1326749211 CA381199523 |
147 | P>L | No |
ClinGen gnomAD |
|
|
CA6086819 rs771803603 |
147 | P>S | No |
ClinGen ExAC gnomAD |
|
|
rs1590677497 CA381199545 |
150 | D>A | No |
ClinGen Ensembl |
|
| TCGA novel | 150 | D>G | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs973020818 CA223920447 |
151 | P>L | No |
ClinGen TOPMed gnomAD |
|
|
CA6086820 rs778255430 |
151 | P>S | No |
ClinGen ExAC gnomAD |
|
|
rs1368264276 CA381199572 |
154 | D>N | No |
ClinGen gnomAD |
|
|
CA381199575 rs1365416033 |
154 | D>V | No |
ClinGen gnomAD |
|
|
CA381199596 rs1232085000 |
157 | N>S | No |
ClinGen gnomAD |
|
|
CA248471 RCV000201444 rs747411292 |
161 | S>L | Variant assessed as Somatic; 4.621e-05 impact. [NCI-TCGA] | No |
ClinGen ClinVar ExAC NCI-TCGA dbSNP gnomAD |
|
rs1469332461 CA381199635 |
163 | P>A | No |
ClinGen gnomAD |
|
|
rs1452806550 CA381199674 |
167 | L>V | No |
ClinGen TOPMed |
|
|
rs147663616 CA6086839 |
174 | R>C | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA223920555 rs150933072 |
174 | R>H | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen 1000Genomes ExAC NCI-TCGA TOPMed gnomAD |
|
CA6086840 rs150933072 |
174 | R>L | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
rs1205841503 CA381199738 |
176 | L>F | No |
ClinGen gnomAD |
|
|
CA223920566 rs898688637 |
177 | E>A | No |
ClinGen TOPMed |
|
| TCGA novel | 177 | E>G | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA6086842 rs781732494 |
178 | S>N | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs775390875 CA6086845 |
185 | V>M | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA TOPMed gnomAD |
|
COSM194109 rs1210760499 CA381199828 |
189 | Y>C | large_intestine Variant assessed as Somatic; impact. [Cosmic, NCI-TCGA] | No |
ClinGen cosmic curated NCI-TCGA TOPMed |
|
CA6086846 rs745568548 |
189 | Y>N | No |
ClinGen ExAC gnomAD |
|
|
rs1017403845 CA223920610 |
190 | V>L | No |
ClinGen TOPMed gnomAD |
|
|
rs962758997 CA223920616 |
191 | D>E | No |
ClinGen TOPMed |
|
|
rs200228197 CA223920618 |
193 | K>T | No |
ClinGen TOPMed |
|
| TCGA novel | 198 | L>F | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA6086867 rs756527409 |
201 | L>V | No |
ClinGen ExAC TOPMed gnomAD |
|
| TCGA novel | 202 | F>V | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA381200068 rs1379019983 |
204 | S>G | No |
ClinGen gnomAD |
|
|
rs1332151588 CA381200111 |
206 | D>E | No |
ClinGen TOPMed |
|
|
rs1315189653 CA381200127 |
208 | R>G | No |
ClinGen gnomAD |
|
|
CA6086870 rs768717776 |
208 | R>Q | No |
ClinGen ExAC gnomAD |
|
|
CA381200128 rs1315189653 |
208 | R>W | No |
ClinGen gnomAD |
|
|
rs557535443 CA223920742 |
210 | R>C | No |
ClinGen 1000Genomes |
|
|
CA381200155 rs1590677869 |
210 | R>H | No |
ClinGen Ensembl |
|
|
CA381200166 rs1402359629 |
211 | E>A | No |
ClinGen TOPMed |
|
|
rs1415654382 CA381200161 |
211 | E>K | No |
ClinGen TOPMed |
|
|
CA381200183 rs1166949734 |
212 | Y>C | No |
ClinGen TOPMed |
|
|
CA381200182 rs1166949734 |
212 | Y>S | No |
ClinGen TOPMed |
|
|
rs1212695693 CA381200219 |
215 | T>N | No |
ClinGen gnomAD |
|
|
rs1590677890 CA381200217 |
215 | T>P | No |
ClinGen Ensembl |
|
|
rs774467612 CA6086871 |
217 | L>V | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA223920760 rs748344083 |
219 | R>W | No |
ClinGen ExAC gnomAD |
|
| TCGA novel | 222 | G>A | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA381200356 rs1252647594 |
228 | R>W | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA gnomAD |
|
rs772317762 CA6086873 |
229 | A>P | No |
ClinGen ExAC gnomAD |
|
|
rs1450503256 CA381200384 |
230 | Y>C | No |
ClinGen TOPMed |
|
|
rs759399865 CA6086875 |
231 | I>V | No |
ClinGen ExAC gnomAD |
|
|
rs765029913 CA6086876 |
232 | R>C | No |
ClinGen ExAC gnomAD |
|
|
rs1444177483 CA381200425 |
232 | R>H | No |
ClinGen TOPMed |
|
|
CA381200540 rs1369072358 |
237 | H>N | No |
ClinGen gnomAD |
|
|
rs1386885933 CA381200592 |
240 | L>F | No |
ClinGen TOPMed gnomAD |
|
|
rs577391569 CA6086878 |
241 | R>Q | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
rs775505111 COSM1509518 CA6086877 |
241 | R>W | lung Variant assessed as Somatic; 0.0 impact. central_nervous_system [Cosmic, NCI-TCGA] | No |
ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD |
|
CA223922110 TCGA novel rs1024493580 |
242 | F>L | Variant assessed as Somatic; impact. [NCI-TCGA] | No |
NCI-TCGA ClinGen Ensembl |
| TCGA novel | 243 | I>M | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA6086901 rs761420051 |
243 | I>V | No |
ClinGen ExAC gnomAD |
|
|
CA381201511 rs1280693623 |
246 | F>V | No |
ClinGen TOPMed |
|
|
rs142324941 CA6086903 |
250 | N>S | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs1315924261 CA381201703 |
260 | G>R | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA gnomAD |
|
rs77695690 CA223922237 |
263 | I>S | No |
ClinGen Ensembl |
|
| TCGA novel | 266 | F>S | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA381201860 rs1189140107 |
267 | A>V | No |
ClinGen gnomAD |
|
|
rs147891521 CA6086927 |
272 | T>M | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA381201953 rs1565104242 |
274 | H>N | No |
ClinGen Ensembl |
|
|
CA223922282 rs374703944 |
280 | R>C | Variant assessed as Somatic; impact. [NCI-TCGA] | No |
ClinGen ESP NCI-TCGA TOPMed |
|
CA381202047 rs1435915662 |
280 | R>H | No |
ClinGen TOPMed |
|
|
COSM930267 CA6086930 rs148879767 |
281 | V>I | endometrium Variant assessed as Somatic; 4.62e-05 impact. [Cosmic, NCI-TCGA] | No |
ClinGen cosmic curated ESP ExAC NCI-TCGA TOPMed gnomAD |
|
rs751632297 CA6086931 |
282 | L>P | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA gnomAD |
|
rs757462485 CA6086932 |
283 | I>L | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1590679463 CA381202493 |
286 | H>P | No |
ClinGen Ensembl |
|
|
rs1283596211 CA381202521 |
290 | S>L | No |
ClinGen TOPMed gnomAD |
|
|
CA223922332 rs982373883 |
293 | V>I | No |
ClinGen TOPMed |
|
|
CA381202549 rs1283395310 |
295 | H>R | No |
ClinGen TOPMed gnomAD |
|
|
CA6086958 rs143547442 |
299 | A>V | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA381202646 rs1195721151 |
307 | E>D | No |
ClinGen gnomAD |
|
|
CA6086959 rs770343997 |
309 | D>N | No |
ClinGen ExAC gnomAD |
|
|
rs1476903232 CA381202659 |
309 | D>V | No |
ClinGen gnomAD |
|
|
CA381202667 rs1171810280 |
310 | A>V | No |
ClinGen gnomAD |
|
|
CA223922971 rs752477669 |
318 | R>G | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs375513129 CA6086973 |
318 | R>Q | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA6086972 rs752477669 |
318 | R>W | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1279275198 CA381202732 |
319 | G>E | No |
ClinGen TOPMed |
|
| TCGA novel | 325 | P>S | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
| TCGA novel | 327 | T>P | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA6086978 rs745418108 |
330 | Q>H | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs368393421 CA6087002 |
333 | V>M | No |
ClinGen ESP ExAC gnomAD |
|
|
CA381202882 rs1431143540 |
337 | G>E | No |
ClinGen gnomAD |
|
|
rs1369818255 CA381202892 |
338 | E>G | No |
ClinGen gnomAD |
|
|
rs1214107284 CA381202886 |
338 | E>K | No |
ClinGen gnomAD |
|
| TCGA novel | 342 | I>F | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA6087004 rs773858189 |
343 | L>F | No |
ClinGen ExAC |
|
| TCGA novel | 345 | V>A | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs371550514 CA6087005 |
346 | I>T | No |
ClinGen ESP ExAC gnomAD |
|
|
rs1565105692 CA381203066 |
349 | S>F | No |
ClinGen Ensembl |
|
|
rs1218742306 CA381203077 |
350 | Q>R | No |
ClinGen TOPMed |
|
|
rs554550266 CA6087007 |
351 | F>L | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
rs759647455 CA6087008 |
352 | V>M | No |
ClinGen ExAC gnomAD |
|
|
rs1422702510 CA381203129 |
354 | I>L | No |
ClinGen TOPMed gnomAD |
|
|
rs765528912 CA6087009 |
355 | Q>L | No |
ClinGen ExAC gnomAD |
|
|
rs773972870 CA6087010 |
356 | E>K | No |
ClinGen ExAC gnomAD |
|
|
rs1439954999 CA381203182 |
357 | P>T | No |
ClinGen gnomAD |
|
|
COSM1704231 CA381203197 rs1291108101 |
358 | L>F | skin [Cosmic] | No |
ClinGen cosmic curated TOPMed |
| TCGA novel | 359 | F>L | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA223923160 rs1018532000 |
363 | A>T | No |
ClinGen Ensembl |
|
|
rs138534603 CA6087012 |
364 | R>C | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs141499148 CA6087013 |
364 | R>H | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ESP ExAC NCI-TCGA gnomAD |
|
CA6087014 rs141499148 |
364 | R>L | No |
ClinGen ESP ExAC gnomAD |
|
|
CA381203370 rs1409835003 |
370 | H>Y | No |
ClinGen TOPMed |
|
|
CA381203385 rs1301579962 |
371 | F>L | No |
ClinGen gnomAD |
|
| TCGA novel | 371 | F>S | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs1157249345 CA381204193 |
375 | E>Q | No |
ClinGen TOPMed |
|
|
rs1267100475 CA381204220 |
379 | Y>F | No |
ClinGen gnomAD |
|
|
rs1478385898 CA381204239 |
381 | W>C | No |
ClinGen gnomAD |
|
|
CA6087038 rs368921406 |
390 | I>S | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA6087037 rs368921406 |
390 | I>T | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs1465131307 CA381204300 |
390 | I>V | No |
ClinGen gnomAD |
|
|
CA381204317 rs1483156280 |
392 | D>V | No |
ClinGen TOPMed gnomAD |
|
|
rs75667682 CA223923963 |
393 | N>T | No |
ClinGen Ensembl |
|
|
rs764718744 CA6087039 |
396 | T>I | No |
ClinGen ExAC gnomAD |
|
|
CA381204364 rs1400440434 |
399 | P>L | No |
ClinGen gnomAD |
|
| TCGA novel | 400 | A>V | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA223923977 rs1036521798 |
404 | T>A | No |
ClinGen TOPMed |
|
|
CA381204398 rs1316024916 |
405 | L>F | No |
ClinGen TOPMed gnomAD |
|
|
CA381204407 rs1283557212 |
406 | Y>C | No |
ClinGen TOPMed |
|
|
rs1289987376 CA381204414 |
407 | Q>R | No |
ClinGen gnomAD |
|
|
CA223923987 rs972607175 |
410 | K>T | No |
ClinGen Ensembl |
|
|
CA381204461 rs1590681282 |
413 | W>C | No |
ClinGen Ensembl |
|
|
rs1465397691 CA381204490 |
416 | T>P | No |
ClinGen TOPMed gnomAD |
|
|
rs1239774511 CA381204497 |
417 | I>V | No |
ClinGen gnomAD |
|
|
rs762655633 CA6087059 |
418 | V>I | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA gnomAD |
|
CA6087060 rs762655633 |
418 | V>L | No |
ClinGen ExAC gnomAD |
|
|
CA6087061 rs751918657 |
422 | Y>C | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA381204529 rs751918657 |
422 | Y>F | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA381204533 rs1565107164 |
423 | N>D | No |
ClinGen Ensembl |
|
|
rs1441792354 CA381204548 |
425 | L>F | No |
ClinGen TOPMed gnomAD |
|
|
rs1565107190 CA381204552 |
426 | K>Q | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen Ensembl NCI-TCGA |
|
rs369675898 CA6087065 |
427 | T>I | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs369675898 CA6087064 |
427 | T>S | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs373704138 CA223924188 COSM255491 |
429 | M>I | central_nervous_system [Cosmic] | No |
ClinGen cosmic curated ESP |
|
rs1444027966 CA381204572 |
429 | M>L | No |
ClinGen TOPMed |
|
|
rs780065724 CA6087066 |
431 | M>I | No |
ClinGen ExAC gnomAD |
|
|
rs960885050 CA223924191 |
433 | G>E | No |
ClinGen TOPMed |
|
|
CA381204613 rs1334703545 |
434 | K>R | No |
ClinGen gnomAD |
|
|
CA6087068 rs768805610 |
435 | L>Q | No |
ClinGen ExAC gnomAD |
|
| TCGA novel | 436 | F>C | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA223924198 rs774805248 |
438 | E>K | No |
ClinGen TOPMed |
|
|
CA6087070 rs748385615 |
440 | T>A | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1306708149 CA381204654 |
440 | T>I | No |
ClinGen gnomAD |
|
|
CA6087072 rs776337900 |
442 | S>F | No |
ClinGen ExAC gnomAD |
|
|
rs1281301325 CA381204672 |
443 | Y>* | No |
ClinGen gnomAD |
|
|
rs561074218 CA6087073 |
445 | L>M | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
CA6087074 rs201780164 |
446 | E>Q | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
rs1436091601 CA381204697 |
447 | K>R | No |
ClinGen gnomAD |
|
|
CA6087075 rs775092275 |
449 | Q>* | No |
ClinGen ExAC gnomAD |
|
|
rs1325193145 CA381204737 |
451 | Q>E | No |
ClinGen gnomAD |
|
|
CA6087093 rs749308648 |
453 | K>N | No |
ClinGen ExAC gnomAD |
|
|
rs1342958764 CA381204809 |
455 | Q>H | No |
ClinGen gnomAD |
|
|
CA6087094 rs146213589 |
455 | Q>K | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA381204830 rs1250832517 |
457 | R>C | No |
ClinGen TOPMed gnomAD |
|
|
CA223924759 rs977094131 |
457 | R>H | No |
ClinGen TOPMed gnomAD |
|
|
CA381204863 rs1313322634 |
459 | E>K | No |
ClinGen Ensembl |
|
|
rs1376859184 CA381204899 |
461 | W>* | No |
ClinGen TOPMed |
|
|
rs1288047705 CA381204895 |
461 | W>R | No |
ClinGen gnomAD |
|
|
CA381204915 rs1489786301 |
462 | Q>* | No |
ClinGen gnomAD |
|
|
rs1198462965 CA381204937 |
463 | G>V | No |
ClinGen gnomAD |
|
|
rs761483935 CA381204941 |
464 | L>V | No |
ClinGen ExAC gnomAD |
|
|
rs773562827 CA6087098 |
468 | R>Q | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA6087097 COSM1221810 rs767095459 |
468 | R>W | large_intestine [Cosmic] | No |
ClinGen cosmic curated ExAC TOPMed gnomAD |
|
rs137914776 CA223924808 |
470 | R>C | No |
ClinGen ESP TOPMed gnomAD |
|
|
rs1164607685 CA381205022 |
470 | R>H | No |
ClinGen gnomAD |
|
|
CA223924801 rs137914776 |
470 | R>S | No |
ClinGen ESP TOPMed gnomAD |
|
|
rs959789177 CA381205031 |
471 | R>L | No |
ClinGen TOPMed gnomAD |
|
|
rs959789177 CA223924827 |
471 | R>Q | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA TOPMed gnomAD |
|
rs1424367874 CA381205024 |
471 | R>W | No |
ClinGen TOPMed gnomAD |
|
|
rs1398686984 CA381205063 |
473 | Q>H | No |
ClinGen gnomAD |
|
|
CA381205087 rs1295564192 |
475 | T>N | No |
ClinGen gnomAD |
|
|
CA381205090 rs1295564192 |
475 | T>S | No |
ClinGen gnomAD |
|
|
rs761027924 CA6087099 |
476 | Q>E | No |
ClinGen ExAC gnomAD |
|
|
rs1247137866 CA381205130 |
478 | A>P | No |
ClinGen TOPMed gnomAD |
|
|
rs1247137866 CA381205128 |
478 | A>T | No |
ClinGen TOPMed gnomAD |
|
|
CA381205173 rs1590682114 |
481 | A>P | No |
ClinGen Ensembl |
|
|
CA381205185 rs1221390294 |
482 | P>A | No |
ClinGen gnomAD |
|
|
CA381205192 rs1286478650 |
482 | P>L | No |
ClinGen gnomAD |
|
|
rs992580191 CA223924832 |
483 | L>F | No |
ClinGen Ensembl |
|
|
rs1423849546 CA381205235 |
485 | R>Q | No |
ClinGen TOPMed gnomAD |
|
|
CA6087101 rs192831260 |
485 | R>W | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
rs755525873 CA6087103 |
488 | P>L | No |
ClinGen ExAC gnomAD |
|
|
rs1382941140 CA381205271 |
488 | P>S | No |
ClinGen TOPMed gnomAD |
|
|
rs1382941140 CA381205267 |
488 | P>T | No |
ClinGen TOPMed gnomAD |
|
|
rs1362830236 CA381205283 |
489 | Q>* | No |
ClinGen gnomAD |
|
|
CA223924857 rs895929534 |
489 | Q>H | No |
ClinGen TOPMed gnomAD |
|
|
rs1288763110 CA381205309 |
490 | V>A | No |
ClinGen gnomAD |
|
|
rs1288763110 CA381205308 |
490 | V>G | No |
ClinGen gnomAD |
|
|
rs752753102 CA6087105 |
492 | A>P | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA381205328 rs752753102 |
492 | A>T | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1382224091 CA381205340 |
493 | S>G | No |
ClinGen gnomAD |
|
|
CA223924862 rs368931364 |
495 | G>C | No |
ClinGen Ensembl |
|
|
CA223924863 rs948615315 |
495 | G>D | No |
ClinGen TOPMed |
|
|
CA381205395 rs1311811630 |
497 | S>G | No |
ClinGen gnomAD |
|
|
rs1355556877 CA381205400 |
497 | S>N | No |
ClinGen TOPMed gnomAD |
|
|
CA223924864 rs1037611314 |
498 | S>Y | No |
ClinGen TOPMed |
No associated diseases with Q15173
No regional properties for Q15173
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for Q15173 | |||
4 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
| protein phosphatase type 2A complex | A protein complex that has protein serine/threonine phosphatase activity that is polycation-stimulated (PCS), being directly stimulated by protamine, polylysine, or histone H1; it constitutes a subclass of several enzymes activated by different histones and polylysine, and consists of catalytic, scaffolding, and regulatory subunits. The catalytic and scaffolding subunits form the core enzyme, and the holoenzyme also includes the regulatory subunit. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| protein phosphatase activator activity | Binds to and increases the activity of a protein phosphatase, an enzyme which catalyzes of the removal of a phosphate group from a protein substrate molecule. |
| protein phosphatase regulator activity | Binds to and modulates the activity of a protein phosphatase, an enzyme which catalyzes of the removal of a phosphate group from a protein substrate molecule. |
12 GO annotations of biological process
| Name | Definition |
|---|---|
| cellular response to growth factor stimulus | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a growth factor stimulus. |
| negative regulation of G0 to G1 transition | A cell cycle process that stops, prevents, or reduces the rate or extent of the transition from the G0 quiescent state to the G1 phase. |
| positive regulation of DNA-binding transcription factor activity | Any process that activates or increases the frequency, rate or extent of activity of a transcription factor, any factor involved in the initiation or regulation of transcription. |
| positive regulation of neuron projection development | Any process that increases the rate, frequency or extent of neuron projection development. Neuron projection development is the process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites). |
| positive regulation of neurotrophin TRK receptor signaling pathway | Any process that activates or increases the frequency, rate or extent of the neurotrophin TRK receptor signaling pathway. |
| positive regulation of protein-containing complex assembly | Any process that activates or increases the frequency, rate or extent of protein complex assembly. |
| positive regulation of transcription by RNA polymerase II | Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter. |
| protein dephosphorylation | The process of removing one or more phosphoric residues from a protein. |
| regulation of peptidyl-tyrosine phosphorylation | Any process that modulates the frequency, rate or extent of the phosphorylation of peptidyl-tyrosine. |
| regulation of protein autophosphorylation | Any process that modulates the frequency, rate or extent of addition of the phosphorylation by a protein of one or more of its own residues. |
| regulation of signaling receptor activity | Any process that modulates the frequency, rate or extent of a signaling receptor activity. Receptor activity is when a molecule combines with an extracellular or intracellular messenger to initiate a change in cell activity. |
| signal transduction | The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell. |
13 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| A4FV68 | PPP2R5E | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform | Bos taurus (Bovine) | PR |
| Q15172 | PPP2R5A | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform | Homo sapiens (Human) | PR |
| Q16537 | PPP2R5E | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform | Homo sapiens (Human) | PR |
| Q14738 | PPP2R5D | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform | Homo sapiens (Human) | PR |
| Q61151 | Ppp2r5e | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform | Mus musculus (Mouse) | PR |
| Q6PD03 | Ppp2r5a | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform | Mus musculus (Mouse) | PR |
| O04375 | B'ALPHA | Serine/threonine protein phosphatase 2A 57 kDa regulatory subunit B' alpha isoform | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q93YV6 | B'KAPPA | Serine/threonine protein phosphatase 2A 57 kDa regulatory subunit B' kappa isoform | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q8LF36 | B'THETA | Serine/threonine protein phosphatase 2A 57 kDa regulatory subunit B' theta isoform | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9ZQY6 | B'DELTA | Serine/threonine protein phosphatase 2A 55 kDa regulatory subunit B' delta isoform | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9LVE2 | B'ZETA | Serine/threonine protein phosphatase 2A 59 kDa regulatory subunit B' zeta isoform | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q8RW96 | B'GAMMA | Serine/threonine protein phosphatase 2A 59 kDa regulatory subunit B' gamma isoform | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9LU89 | B'ETA | Serine/threonine protein phosphatase 2A 59 kDa regulatory subunit B' eta isoform | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| METKLPPAST | PTSPSSPGLS | PVPPPDKVDG | FSRRSLRRAR | PRRSHSSSQF | RYQSNQQELT |
| 70 | 80 | 90 | 100 | 110 | 120 |
| PLPLLKDVPA | SELHELLSRK | LAQCGVMFDF | LDCVADLKGK | EVKRAALNEL | VECVGSTRGV |
| 130 | 140 | 150 | 160 | 170 | 180 |
| LIEPVYPDII | RMISVNIFRT | LPPSENPEFD | PEEDEPNLEP | SWPHLQLVYE | FFLRFLESPD |
| 190 | 200 | 210 | 220 | 230 | 240 |
| FQPSVAKRYV | DQKFVLMLLE | LFDSEDPRER | EYLKTILHRV | YGKFLGLRAY | IRKQCNHIFL |
| 250 | 260 | 270 | 280 | 290 | 300 |
| RFIYEFEHFN | GVAELLEILG | SIINGFALPL | KTEHKQFLVR | VLIPLHSVKS | LSVFHAQLAY |
| 310 | 320 | 330 | 340 | 350 | 360 |
| CVVQFLEKDA | TLTEHVIRGL | LKYWPKTCTQ | KEVMFLGEME | EILDVIEPSQ | FVKIQEPLFK |
| 370 | 380 | 390 | 400 | 410 | 420 |
| QVARCVSSPH | FQVAERALYF | WNNEYILSLI | EDNCHTVLPA | VFGTLYQVSK | EHWNQTIVSL |
| 430 | 440 | 450 | 460 | 470 | 480 |
| IYNVLKTFME | MNGKLFDELT | ASYKLEKQQE | QQKAQERQEL | WQGLEELRLR | RLQGTQGAKE |
| 490 | |||||
| APLQRLTPQV | AASGGQS |