Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

Autoinhibited structure

Activated structure

1 structures for Q16537

Entry ID Method Resolution Chain Position Source
AF-Q16537-F1 Predicted AlphaFoldDB

172 variants for Q16537

Variant ID(s) Position Change Description Diseaes Association Provenance
CA390113666
rs1468595054
3 S>A No ClinGen
TOPMed
rs373172813
CA262469082
3 S>L Variant assessed as Somatic; impact. [NCI-TCGA] No ClinGen
Ensembl
NCI-TCGA
CA262469081
rs1028023177
6 T>A No ClinGen
TOPMed
rs746635308
CA7218504
7 T>P No ClinGen
ExAC
gnomAD
CA390113594
rs1470907942
9 P>L No ClinGen
TOPMed
rs753518402 9 P>missing Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] No NCI-TCGA
rs779891878
CA7218503
9 P>A No ClinGen
ExAC
TOPMed
gnomAD
rs758176830
CA7218501
10 S>L No ClinGen
ExAC
gnomAD
CA262469080
rs79843138
11 V>G No ClinGen
Ensembl
TCGA novel 12 D>G Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
rs964950280
CA262469079
14 V>A No ClinGen
TOPMed
rs111360318
CA390113473
19 R>W No ClinGen
gnomAD
rs753998212
CA7218497
22 V>I No ClinGen
ExAC
gnomAD
rs1367516565
CA390113391
25 A>P No ClinGen
gnomAD
CA262469076
rs866128704
28 K>R No ClinGen
Ensembl
CA7218496
rs764048030
29 R>S No ClinGen
ExAC
TOPMed
gnomAD
CA7218494
rs775838926
33 S>F No ClinGen
ExAC
gnomAD
rs535219008
CA7218493
36 F>L No ClinGen
1000Genomes
ExAC
gnomAD
CA7218492
rs759988254
38 S>P No ClinGen
ExAC
gnomAD
rs774544013
CA7218491
39 Q>E Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] No ClinGen
ExAC
NCI-TCGA
gnomAD
CA390113211
rs1260833884
39 Q>R No ClinGen
gnomAD
rs146814235
CA262469074
41 K>R No ClinGen
ESP
rs144779635
CA7218489
43 I>T No ClinGen
ESP
ExAC
TOPMed
gnomAD
CA390113168
rs1266064094
43 I>V No ClinGen
gnomAD
rs776246979
CA7218488
46 T>A No ClinGen
ExAC
gnomAD
rs566526940
CA262469073
47 P>S No ClinGen
1000Genomes
gnomAD
rs1335995706
CA390113094
49 P>L No ClinGen
TOPMed
TCGA novel 49 P>S Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
CA262469072
rs1042484228
50 L>P No ClinGen
TOPMed
rs200507102
CA390111561
53 D>E No ClinGen
ExAC
TOPMed
gnomAD
CA390113056
rs1477269632
53 D>N No ClinGen
gnomAD
TCGA novel 53 D>T Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
CA390111567
rs1399471875
53 D>V No ClinGen
gnomAD
COSM956874
rs777853785
CA7218460
54 V>I Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic] No ClinGen
cosmic curated
ExAC
NCI-TCGA
gnomAD
CA262459094
rs376032244
58 E>G No ClinGen
ESP
TCGA novel 63 F>L Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
CA262459092
rs900434873
77 M>T No ClinGen
TOPMed
rs903965809
CA262459093
77 M>V No ClinGen
TOPMed
rs752850551
CA7218458
78 D>G No ClinGen
ExAC
gnomAD
rs781401535
CA7218457
79 T>M Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] No ClinGen
ExAC
NCI-TCGA
gnomAD
rs1594892048
CA390111136
80 L>P No ClinGen
Ensembl
rs1342679678
CA390111101
83 L>V No ClinGen
TOPMed
gnomAD
CA262459091
rs1045456091
85 M>T No ClinGen
TOPMed
CA390110986
rs1238132393
90 R>C No ClinGen
gnomAD
CA390110975
rs1204903966
92 T>A No ClinGen
gnomAD
rs751728433
CA7218455
97 V>M No ClinGen
ExAC
gnomAD
TCGA novel 98 D>G Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
TCGA novel 98 D>N Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
rs1274479082
CA390110926
99 Y>C No ClinGen
TOPMed
gnomAD
rs763242209
CA7218453
99 Y>H No ClinGen
ExAC
gnomAD
CA390110922
rs1214604524
100 I>V No ClinGen
TOPMed
rs78672940
CA262459090
107 L>F No ClinGen
Ensembl
CA390110851
rs1281294574
110 Q>P No ClinGen
TOPMed
gnomAD
rs778408710
CA262459089
111 T>P No ClinGen
Ensembl
CA7218452
rs140807440
114 E>G No ClinGen
1000Genomes
ESP
ExAC
TOPMed
gnomAD
rs1472137558
CA390110797
118 M>T No ClinGen
TOPMed
TCGA novel 121 C>F Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
CA390110741
rs1311149860
123 I>T No ClinGen
Ensembl
rs866115201
CA262455356
125 R>K No ClinGen
Ensembl
CA390110679
rs1422095788
132 S>N No ClinGen
gnomAD
rs768572945
CA7218420
133 N>S No ClinGen
ExAC
gnomAD
rs1477585762
CA390110624
139 E>D No ClinGen
gnomAD
CA390110501
rs1177867935
155 Y>C No ClinGen
gnomAD
TCGA novel 156 E>D Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
CA390110478
rs1471092368
158 F>S No ClinGen
gnomAD
CA390110463
rs1197977354
160 R>Q Variant assessed as Somatic; 4.627e-05 impact. [NCI-TCGA] No ClinGen
NCI-TCGA
TOPMed
gnomAD
CA390110459
rs1313412531
161 F>V Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] No ClinGen
NCI-TCGA
TOPMed
TCGA novel 162 L>W Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
CA390110435
rs1264837726
164 S>N No ClinGen
gnomAD
rs935647997
CA262454562
166 E>G No ClinGen
TOPMed
rs764926589
CA7218404
169 P>T No ClinGen
ExAC
gnomAD
CA262454561
rs926961157
171 I>T No ClinGen
TOPMed
gnomAD
TCGA novel 174 K>N Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
CA262454560
rs989854341
175 Y>C No ClinGen
TOPMed
rs1376119775 175 Y>I Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] No NCI-TCGA
CA262454558
rs979994932
176 I>V No ClinGen
TOPMed
CA7218403
rs776446375
177 D>E No ClinGen
ExAC
gnomAD
rs763945045
CA7218383
198 Y>C No ClinGen
ExAC
TOPMed
gnomAD
rs1312867741
CA390110148
203 L>V No ClinGen
TOPMed
CA7218380
rs771927271
204 H>Y No ClinGen
ExAC
gnomAD
TCGA novel 207 Y>* Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
TCGA novel 215 A>S Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
rs1221708697
CA390110059
216 F>L No ClinGen
TOPMed
TCGA novel 218 R>Q Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
rs200722873
CA262452475
223 N>S No ClinGen
1000Genomes
gnomAD
TCGA novel 227 R>= Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
CA390109958
rs1361660690
228 F>Y No ClinGen
TOPMed
CA390109916
rs1213230498
234 H>Y No ClinGen
TOPMed
rs778623597
CA7218345
236 N>S No ClinGen
ExAC
TOPMed
gnomAD
rs949723341
CA262452224
250 N>S No ClinGen
Ensembl
TCGA novel 255 P>H Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
CA262452220
rs919105059
262 Q>* No ClinGen
TOPMed
rs765520957
CA7218333
263 F>L No ClinGen
ExAC
gnomAD
rs1351478162
CA390109014
265 V>L No ClinGen
gnomAD
CA390108982
rs1237782576
269 I>M No ClinGen
gnomAD
rs1285733607
CA390108974
271 L>V No ClinGen
TOPMed
rs1395844536
CA390108966
272 H>Y No ClinGen
Ensembl
TCGA novel 275 R>K Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
CA390108940
rs1213935296
276 S>G No ClinGen
TOPMed
CA390108938
rs1270220161
276 S>N No ClinGen
TOPMed
CA390108918
rs1333073416
279 L>F No ClinGen
TOPMed
gnomAD
CA262452218
rs972109757
279 L>R No ClinGen
TOPMed
rs1191828179
CA390108866
285 A>S No ClinGen
gnomAD
TCGA novel 286 Y>C Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
CA390108841
rs1566669270
288 I>M No ClinGen
Ensembl
TCGA novel 288 I>T Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
COSM3386619
CA7218310
rs761151881
288 I>V pancreas [Cosmic] No ClinGen
cosmic curated
ExAC
TOPMed
gnomAD
CA7218309
rs368179547
289 V>I No ClinGen
ESP
ExAC
TOPMed
gnomAD
CA390108808
rs1313692823
293 E>D No ClinGen
TOPMed
rs772679993
CA390108789
296 P>A No ClinGen
ExAC
gnomAD
rs1566669242
CA390108787
296 P>R No ClinGen
Ensembl
rs772679993
CA7218308
296 P>S No ClinGen
ExAC
gnomAD
rs1275882867
CA390108772
299 T>A No ClinGen
gnomAD
rs1012484270
CA262452013
301 P>L No ClinGen
Ensembl
CA390108759
rs1217698623
301 P>T No ClinGen
gnomAD
TCGA novel 302 V>A Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
rs1566669111
CA390108735
303 I>V No ClinGen
Ensembl
CA390108591
rs1446463144
320 M>I No ClinGen
gnomAD
rs1304794357
CA390108533
328 I>M No ClinGen
gnomAD
CA7218286
rs771407076
331 V>E No ClinGen
ExAC
gnomAD
CA390108437
rs1260712831
342 E>G No ClinGen
TOPMed
CA7218280
rs771776472
349 A>T Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] No ClinGen
ExAC
NCI-TCGA
TOPMed
gnomAD
CA390108357
rs1263207190
353 S>C No ClinGen
TOPMed
gnomAD
CA390108356
rs1263207190
353 S>F No ClinGen
TOPMed
gnomAD
CA390108342
rs1399716150
355 P>H No ClinGen
TOPMed
CA390108346
rs1425483367
355 P>S No ClinGen
TOPMed
rs771713749
CA7218260
360 A>E No ClinGen
ExAC
rs775008339
CA7218261
360 A>T No ClinGen
ExAC
gnomAD
rs745671841
CA7218258
363 A>S No ClinGen
ExAC
gnomAD
CA7218254
rs778053464
376 I>T No ClinGen
ExAC
gnomAD
CA262451174
rs950547340
COSM1300730
380 S>C Variant assessed as Somatic; impact. urinary_tract [NCI-TCGA, Cosmic] No ClinGen
cosmic curated
Ensembl
NCI-TCGA
CA7218250
rs61732995
381 N>K No ClinGen
1000Genomes
ESP
ExAC
TOPMed
gnomAD
CA7218251
rs781304785
381 N>S No ClinGen
ExAC
gnomAD
CA7218248
rs61756433
382 V>I No ClinGen
1000Genomes
ESP
ExAC
TOPMed
gnomAD
CA7218247
rs374189416
389 S>C No ClinGen
ESP
ExAC
TOPMed
gnomAD
CA7218246
rs750917234
396 K>E No ClinGen
ExAC
gnomAD
TCGA novel 399 W>* Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
CA7218244
rs760132062
400 N>S No ClinGen
ExAC
gnomAD
rs775015888
CA7218243
401 P>L No ClinGen
ExAC
gnomAD
CA390107131
rs1334386552
403 I>V No ClinGen
gnomAD
CA7218221
COSM1221811
rs759166639
405 A>V large_intestine [Cosmic] No ClinGen
cosmic curated
ExAC
gnomAD
rs773096948
CA7218217
413 A>T No ClinGen
ExAC
gnomAD
CA390106971
rs1566662303
415 M>V No ClinGen
Ensembl
rs1161019914
CA390106949
416 E>A No ClinGen
gnomAD
CA262450921
rs1018169045
419 S>N No ClinGen
Ensembl
rs142027245
CA7218216
420 T>A No ClinGen
ESP
ExAC
TOPMed
gnomAD
CA262450919
rs1012030269
421 M>I No ClinGen
TOPMed
rs1023770547
CA262450920
421 M>L No ClinGen
TOPMed
rs776642897
CA7218215
423 D>E No ClinGen
ExAC
TOPMed
gnomAD
CA390106872
rs1444354743
424 E>K No ClinGen
gnomAD
CA7218210
rs138474600
433 R>C No ClinGen
ESP
ExAC
TOPMed
gnomAD
rs1214433807
CA390106807
433 R>H No ClinGen
gnomAD
rs138474600
CA390106810
433 R>S No ClinGen
ESP
ExAC
TOPMed
gnomAD
TCGA novel 434 Q>R Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
TCGA novel 435 R>C Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
TCGA novel 435 R>H Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
CA390106762
rs1326388002
437 K>R No ClinGen
gnomAD
CA7218190
rs768412393
438 K>R No ClinGen
ExAC
TOPMed
gnomAD
CA390106744
rs1179039658
439 K>N No ClinGen
TOPMed
CA7218189
rs146316789
440 E>Q Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] No ClinGen
ESP
ExAC
NCI-TCGA
TOPMed
gnomAD
TCGA novel 443 R>H Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
rs550344803
CA262450200
449 K>E No ClinGen
Ensembl
TCGA novel 449 K>N Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
rs1384955396
CA390106648
452 D>G No ClinGen
TOPMed
rs1184880844
CA390106652
452 D>Y No ClinGen
gnomAD
rs774751561
CA7218185
455 L>V No ClinGen
ExAC
gnomAD
CA7218182
rs201561330
461 R>C No ClinGen
ExAC
TOPMed
gnomAD
rs201561330
CA7218183
461 R>G No ClinGen
ExAC
TOPMed
gnomAD
rs746570920
CA7218180
461 R>H No ClinGen
ExAC
TOPMed
gnomAD
rs746570920
CA7218181
461 R>L No ClinGen
ExAC
TOPMed
gnomAD
CA390106525
rs1566658242
465 I>V No ClinGen
Ensembl
CA7218178
rs758191720
466 P>S No ClinGen
ExAC
gnomAD

No associated diseases with Q16537

No regional properties for Q16537

Type Name Position InterPro Accession
No domain, repeats, and functional sites for Q16537

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

4 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
protein phosphatase type 2A complex A protein complex that has protein serine/threonine phosphatase activity that is polycation-stimulated (PCS), being directly stimulated by protamine, polylysine, or histone H1; it constitutes a subclass of several enzymes activated by different histones and polylysine, and consists of catalytic, scaffolding, and regulatory subunits. The catalytic and scaffolding subunits form the core enzyme, and the holoenzyme also includes the regulatory subunit.

2 GO annotations of molecular function

Name Definition
protein phosphatase activator activity Binds to and increases the activity of a protein phosphatase, an enzyme which catalyzes of the removal of a phosphate group from a protein substrate molecule.
protein phosphatase regulator activity Binds to and modulates the activity of a protein phosphatase, an enzyme which catalyzes of the removal of a phosphate group from a protein substrate molecule.

2 GO annotations of biological process

Name Definition
protein dephosphorylation The process of removing one or more phosphoric residues from a protein.
signal transduction The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.

13 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
A4FV68 PPP2R5E Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform Bos taurus (Bovine) PR
Q15172 PPP2R5A Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform Homo sapiens (Human) PR
Q15173 PPP2R5B Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform Homo sapiens (Human) PR
Q14738 PPP2R5D Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform Homo sapiens (Human) PR
Q6PD03 Ppp2r5a Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform Mus musculus (Mouse) PR
Q61151 Ppp2r5e Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform Mus musculus (Mouse) PR
O04375 B'ALPHA Serine/threonine protein phosphatase 2A 57 kDa regulatory subunit B' alpha isoform Arabidopsis thaliana (Mouse-ear cress) PR
Q93YV6 B'KAPPA Serine/threonine protein phosphatase 2A 57 kDa regulatory subunit B' kappa isoform Arabidopsis thaliana (Mouse-ear cress) PR
Q8LF36 B'THETA Serine/threonine protein phosphatase 2A 57 kDa regulatory subunit B' theta isoform Arabidopsis thaliana (Mouse-ear cress) PR
Q9ZQY6 B'DELTA Serine/threonine protein phosphatase 2A 55 kDa regulatory subunit B' delta isoform Arabidopsis thaliana (Mouse-ear cress) PR
Q9LVE2 B'ZETA Serine/threonine protein phosphatase 2A 59 kDa regulatory subunit B' zeta isoform Arabidopsis thaliana (Mouse-ear cress) PR
Q8RW96 B'GAMMA Serine/threonine protein phosphatase 2A 59 kDa regulatory subunit B' gamma isoform Arabidopsis thaliana (Mouse-ear cress) PR
Q9LU89 B'ETA Serine/threonine protein phosphatase 2A 59 kDa regulatory subunit B' eta isoform Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MSSAPTTPPS VDKVDGFSRK SVRKARQKRS QSSSQFRSQG KPIELTPLPL LKDVPSSEQP
70 80 90 100 110 120
ELFLKKLQQC CVIFDFMDTL SDLKMKEYKR STLNELVDYI TISRGCLTEQ TYPEVVRMVS
130 140 150 160 170 180
CNIFRTLPPS DSNEFDPEED EPTLEASWPH LQLVYEFFIR FLESQEFQPS IAKKYIDQKF
190 200 210 220 230 240
VLQLLELFDS EDPRERDYLK TVLHRIYGKF LGLRAFIRKQ INNIFLRFVY ETEHFNGVAE
250 260 270 280 290 300
LLEILGSIIN GFALPLKAEH KQFLVKVLIP LHTVRSLSLF HAQLAYCIVQ FLEKDPSLTE
310 320 330 340 350 360
PVIRGLMKFW PKTCSQKEVM FLGELEEILD VIEPSQFVKI QEPLFKQIAK CVSSPHFQVA
370 380 390 400 410 420
ERALYYWNNE YIMSLIEENS NVILPIMFSS LYRISKEHWN PAIVALVYNV LKAFMEMNST
430 440 450 460
MFDELTATYK SDRQREKKKE KEREELWKKL EDLELKRGLR RDGIIPT