Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q8K4K5
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q8K4K5-F1 | Predicted | AlphaFoldDB |
No variants for Q8K4K5
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q8K4K5 | |||||
No associated diseases with Q8K4K5
7 regional properties for Q8K4K5
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| repeat | WD40 repeat | 18 - 62 | IPR001680-1 |
| repeat | WD40 repeat | 64 - 103 | IPR001680-2 |
| repeat | WD40 repeat | 187 - 223 | IPR001680-3 |
| repeat | WD40 repeat | 226 - 264 | IPR001680-4 |
| repeat | WD40 repeat | 424 - 460 | IPR001680-5 |
| domain | Lethal giant larvae homologue 2 | 279 - 379 | IPR013577 |
| domain | Lethal giant larvae (Lgl)-like, C-terminal domain | 823 - 958 | IPR013905 |
Functions
11 GO annotations of cellular component
| Name | Definition |
|---|---|
| axon | The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter. |
| basolateral plasma membrane | The region of the plasma membrane that includes the basal end and sides of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis. |
| cortical actin cytoskeleton | The portion of the actin cytoskeleton, comprising filamentous actin and associated proteins, that lies just beneath the plasma membrane. |
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| cytoskeleton | A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles. |
| early endosome membrane | The lipid bilayer surrounding an early endosome. |
| Golgi cis cisterna | The Golgi cisterna closest to the endoplasmic reticulum; the first processing compartment through which proteins pass after export from the ER. |
| Golgi membrane | The lipid bilayer surrounding any of the compartments of the Golgi apparatus. |
| myelin sheath abaxonal region | The region of the myelin sheath furthest from the axon. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
| trans-Golgi network membrane | The lipid bilayer surrounding any of the compartments that make up the trans-Golgi network. |
4 GO annotations of molecular function
| Name | Definition |
|---|---|
| GTPase activator activity | Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP. |
| myosin II binding | Binding to a class II myosin, any member of the class of 'conventional' double-headed myosins that includes muscle myosin. |
| protein kinase binding | Binding to a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate. |
| small GTPase binding | Binding to a small monomeric GTPase. |
10 GO annotations of biological process
| Name | Definition |
|---|---|
| axonogenesis | De novo generation of a long process of a neuron, including the terminal branched region. Refers to the morphogenesis or creation of shape or form of the developing axon, which carries efferent (outgoing) action potentials from the cell body towards target cells. |
| cortical actin cytoskeleton organization | A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of actin-based cytoskeletal structures in the cell cortex, i.e. just beneath the plasma membrane. |
| establishment of spindle orientation | Any process that set the alignment of spindle relative to other cellular structures. |
| exocytosis | A process of secretion by a cell that results in the release of intracellular molecules (e.g. hormones, matrix proteins) contained within a membrane-bounded vesicle. Exocytosis can occur either by full fusion, when the vesicle collapses into the plasma membrane, or by a kiss-and-run mechanism that involves the formation of a transient contact, a pore, between a granule (for exemple of chromaffin cells) and the plasma membrane. The latter process most of the time leads to only partial secretion of the granule content. Exocytosis begins with steps that prepare vesicles for fusion with the membrane (tethering and docking) and ends when molecules are secreted from the cell. |
| Golgi to plasma membrane transport | The directed movement of substances from the Golgi to the plasma membrane in transport vesicles that move from the trans-Golgi network to the plasma membrane, where they fuse and release their contents by exocytosis. |
| maintenance of apical/basal cell polarity | Retaining the established polarization of a cell along its apical/basal axis. |
| protein-containing complex assembly | The aggregation, arrangement and bonding together of a set of macromolecules to form a protein-containing complex. |
| regulation of establishment or maintenance of cell polarity | Any process that modulates the frequency, rate or extent of the specification, formation or maintenance of anisotropic intracellular organization or cell growth patterns. |
| regulation of Notch signaling pathway | Any process that modulates the frequency, rate or extent of the Notch signaling pathway. |
| regulation of protein secretion | Any process that modulates the frequency, rate or extent of the controlled release of a protein from a cell. |
13 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P38163 | SRO77 | Lethal(2) giant larvae protein homolog SRO77 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| Q12038 | SRO7 | Lethal(2) giant larvae protein homolog SRO7 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| Q8MKF0 | LLGL1 | Lethal(2) giant larvae protein homolog 1 | Bos taurus (Bovine) | PR |
| Q9Y2K9 | STXBP5L | Syntaxin-binding protein 5-like | Homo sapiens (Human) | PR |
| Q5T5C0 | STXBP5 | Syntaxin-binding protein 5 | Homo sapiens (Human) | PR |
| Q6P1M3 | LLGL2 | LLGL scribble cell polarity complex component 2 | Homo sapiens (Human) | PR |
| Q15334 | LLGL1 | Lethal(2) giant larvae protein homolog 1 | Homo sapiens (Human) | PR |
| Q5DQR4 | Stxbp5l | Syntaxin-binding protein 5-like | Mus musculus (Mouse) | PR |
| Q8K400 | Stxbp5 | Syntaxin-binding protein 5 | Mus musculus (Mouse) | PR |
| Q80Y17 | Llgl1 | Lethal(2) giant larvae protein homolog 1 | Mus musculus (Mouse) | PR |
| Q9WU70 | Stxbp5 | Syntaxin-binding protein 5 | Rattus norvegicus (Rat) | PR |
| Q5SQE2 | stxbp5l | Syntaxin-binding protein 5-like | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| Q7SZE3 | llgl2 | LLGL scribble cell polarity complex component 2 | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MMKFRFRRQG | ADPQREKLKQ | ELFTFHKTVE | HGFPNQPSAL | AFDPELRIMA | IGTRSGAVKI |
| 70 | 80 | 90 | 100 | 110 | 120 |
| YGAPGVEFTG | LHRDAATVTQ | MHFLPGQGRL | LTLLDDSSLH | LWEIIQRNGC | AHLEEGLSFH |
| 130 | 140 | 150 | 160 | 170 | 180 |
| PPSRPSFGNA | SFPAGLTRVT | VVLLAAGDTV | VLGTESGSIF | FLDVATLALL | EGQTLSPDEV |
| 190 | 200 | 210 | 220 | 230 | 240 |
| LRSVPDDYRC | GKALGPVESL | QGHLQDPSKI | LIGYSRGLLV | IWSQATQSVE | HVFLGNQQLE |
| 250 | 260 | 270 | 280 | 290 | 300 |
| SLCWGRGGSN | IISSHSDGSY | AIWSTDTGSP | PTLQPTVVTT | PYGPFPCKAI | NKILWRSCES |
| 310 | 320 | 330 | 340 | 350 | 360 |
| GDHFIIFSGG | MPRASYGDRH | CVSVLRAETL | VTLDFTSRVI | DFFTVHSTQP | EDGFDNPQAL |
| 370 | 380 | 390 | 400 | 410 | 420 |
| AVLLEEELVV | LDLQTPGWPA | VPAPYLAPLH | SSAITCSAHV | ANVPSKLWAR | IVSAGERQSP |
| 430 | 440 | 450 | 460 | 470 | 480 |
| QPASSALSWP | ITGGRNLAQE | PSQRGLLLTG | HEDGTVRFWD | ASGVALRPLY | KLSTAGLFQT |
| 490 | 500 | 510 | 520 | 530 | 540 |
| DCEHADSLAQ | AVEDDWPPFR | KVGCFDPYSD | DPRLGIQKVA | LCKYTAQMVV | AGTAGQVLVL |
| 550 | 560 | 570 | 580 | 590 | 600 |
| ELSDVPGEHT | VSVASVDLLQ | DREGFTWKGH | ERLSPHTGPL | PWPAGFQPRV | LIQCLPPAAV |
| 610 | 620 | 630 | 640 | 650 | 660 |
| TAVALHAEWS | LVAFGTSHGF | GLFDYQRKSP | VLARCTLHPN | DSLAMEGPLS | RVKSLKKSLR |
| 670 | 680 | 690 | 700 | 710 | 720 |
| QSFRRIRKSR | VSGKKRATTA | SSKLQEANAQ | LAEQTCPHDV | EMTPVQRRIE | PRSADDSLSG |
| 730 | 740 | 750 | 760 | 770 | 780 |
| VVRCLYFADT | FLRDATHHGP | TMWAGTNSGS | VFAYALEVPA | ATAGGEKRPE | QAVEAVLGKE |
| 790 | 800 | 810 | 820 | 830 | 840 |
| VQLMHRAPVV | AIAVLDGRGR | PLPEPYEASR | DLAQAPDMQG | GHAVLIASEE | QFKVFTLPKV |
| 850 | 860 | 870 | 880 | 890 | 900 |
| SAKTKFKLTA | HEGCRVRKVA | LATFASVMSE | DYAETCLACL | TNLGDVHVFS | VPGLRPQVHY |
| 910 | 920 | 930 | 940 | 950 | 960 |
| SCIRKEDISG | IASCVFTRHG | QGFYLISPSE | FERFSLSARN | ITEPLCSLDI | SWPQNATQPR |
| 970 | 980 | 990 | 1000 | 1010 | 1020 |
| LQESPKLSQA | NGTRDIILAP | ESCEGSPSSA | HSKRADTMEP | PEAALSPVSI | DSAASGDTML |
| 1030 | |||||
| DTTGDVTVEY | VKDFLG |