AiPD: Autoinhibited Protein Database

Q15334

Gene name	LLGL1 (DLG4, HUGL, HUGL1)
Protein name	Lethal(2) giant larvae protein homolog 1
Names	LLGL, DLG4, Hugl-1, Human homolog to the D-lgl gene protein
Species	Homo sapiens (Human)
KEGG Pathway	hsa:3996
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

617-741 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

617-741 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

1 structures for Q15334

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q15334-F1	Predicted				AlphaFoldDB

932 variants for Q15334

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
CA398588353 rs1489396501	2	M>L		No	ClinGen TOPMed gnomAD
CA398588366 rs1203200603	3	K>R		No	gnomAD ClinGen
rs1201637677 CA398588379	5	R>W		No	TOPMed ClinGen
rs1322957849 CA398588383	6	F>V		No	TOPMed ClinGen
rs1263874188 CA398588392	7	R>W		No	TOPMed ClinGen
CA398588398 rs1240319536	8	R>Q		No	Ensembl ClinGen
rs1260702126 CA398588397	8	R>W		No	gnomAD ClinGen
CA8426336 rs200829360	11	A>T		No	1000Genomes ESP ExAC TOPMed gnomAD ClinGen
rs1383002095 CA398588423	12	D>G		No	ClinGen gnomAD
CA398588431 rs1443526113	13	P>Q		No	ClinGen TOPMed gnomAD
rs779701944 CA398588464	18	L>I		No	ExAC TOPMed gnomAD ClinGen
CA8426337 rs779701944	18	L>V		No	ClinGen ExAC TOPMed gnomAD
rs1335359921 CA398588475	19	K>N		No	TOPMed ClinGen
rs1288659546 CA398588510	22	L>P		No	gnomAD ClinGen
CA398588525 rs1056821372	23	F>L		No	ClinGen TOPMed gnomAD
rs1386053897 CA398588517	23	F>V		No	gnomAD ClinGen
rs751173255 CA8426338	24	A>S		No	ExAC gnomAD ClinGen
CA398588560 rs1302983559	25	F>L		No	ClinGen TOPMed
CA288427491 rs896304706	27	K>R		No	ClinGen TOPMed gnomAD
CA398588781 rs1375589655	28	T>A		No	TOPMed ClinGen
rs1335087294 CA398588784	28	T>I		No	ClinGen gnomAD
rs1335087294 CA398588782	28	T>N		No	gnomAD ClinGen
TCGA novel	32	G>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs115967277 RCV000957558 CA8426347	35	N>S		No	ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs115967277 CA8426348	35	N>T		No	1000Genomes ESP ExAC TOPMed gnomAD ClinGen
CA398588855 rs772520170	38	S>R		No	ExAC TOPMed gnomAD ClinGen
rs376398557 CA8426350 COSM1213449	39	A>T	large_intestine [Cosmic]	No	ClinGen cosmic curated ESP ExAC gnomAD
CA398588865 rs1371355472	40	L>P		No	ClinGen gnomAD
CA8426351 rs760918366	41	A>S		No	ExAC gnomAD ClinGen
CA398588867 rs760918366	41	A>T		No	ClinGen ExAC gnomAD
rs1597859284 CA398588880	43	D>N		No	Ensembl ClinGen
rs1317423015 CA398588889	44	P>A		No	ClinGen TOPMed gnomAD
rs141705015 CA8426353	44	P>L		No	ClinGen ESP ExAC TOPMed gnomAD
rs141705015 CA398588892	44	P>R		No	ClinGen ESP ExAC TOPMed gnomAD
CA398588906 rs1322407439	46	L>H		No	gnomAD ClinGen
rs540140275 CA8426355	47	R>C		No	1000Genomes ExAC TOPMed gnomAD ClinGen
CA8426356 rs368206803	47	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ESP ExAC TOPMed gnomAD ClinGen NCI-TCGA
CA8426357 rs368206803	47	R>L		No	ESP ExAC TOPMed gnomAD ClinGen
CA398588910 rs1479408293	48	I>V		No	TOPMed gnomAD ClinGen
CA8426358 rs766097233	49	M>T		No	ExAC gnomAD ClinGen
CA398588918 rs1180516758	49	M>V		No	TOPMed ClinGen
CA8426360 rs751226368	51	I>F		No	ExAC gnomAD ClinGen
CA398588935 rs145857913	51	I>M		No	ESP ExAC TOPMed gnomAD ClinGen
rs751226368 CA8426359	51	I>V		No	ExAC gnomAD ClinGen
CA8426362 rs752191168	52	G>S		No	ClinGen ExAC gnomAD
CA398588957 rs755632435	54	R>S		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	56	G>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs746307176 CA8426365	59	K>R		No	ClinGen ExAC gnomAD
CA8426385 rs759038245	61	Y>C		No	ClinGen ExAC gnomAD
CA398589530 rs1364849320	61	Y>N		No	gnomAD ClinGen
rs780673566 CA8426386	63	A>V		No	ClinGen ExAC gnomAD
rs918284262 CA398589575	64	P>A		No	ClinGen TOPMed gnomAD
rs747380008 CA8426387	64	P>L		No	ClinGen ExAC gnomAD
CA398589580 rs747380008	64	P>R		No	ClinGen ExAC gnomAD
rs918284262 CA288429173	64	P>S		No	ClinGen TOPMed gnomAD
rs374850782 CA288429175	66	V>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen ESP NCI-TCGA TOPMed
CA398589655 rs1183168383	68	F>L		No	Ensembl ClinGen
rs1219582722 CA398589661	69	T>A		No	ClinGen gnomAD
TCGA novel	69	T>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1490642915 CA398589689	70	G>D		No	ClinGen gnomAD
CA398589695 rs139741665	71	L>V		No	1000Genomes ExAC TOPMed gnomAD ClinGen
CA8426393 COSM3402647 rs369006714	73	R>Q	central_nervous_system Variant assessed as Somatic; 4.627e-05 impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated ESP ExAC NCI-TCGA TOPMed gnomAD
CA288429178 rs1024725728	73	R>W		No	TOPMed ClinGen
CA8426395 rs774253367	74	D>E		No	ExAC gnomAD ClinGen
CA8426394 rs576744666	74	D>N		No	ClinGen ExAC TOPMed gnomAD
rs759275617 CA8426396	77	T>A		No	ClinGen ExAC gnomAD
rs767307584 CA8426397	79	T>A		No	ExAC TOPMed gnomAD ClinGen
CA8426398 rs767307584	79	T>S		No	ExAC TOPMed gnomAD ClinGen
CA398589764 rs1325298231	81	M>T		No	gnomAD ClinGen
rs1431722178 CA398589772	82	H>R		No	ClinGen TOPMed
rs753436865 CA8426401	85	T>I		No	ClinGen ExAC
rs940190734 CA288429190	86	G>S		No	ClinGen gnomAD
CA8426403 rs767014581	87	Q>R		No	ClinGen ExAC gnomAD
TCGA novel	88	G>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA288429208 rs779949594	88	G>S		No	ClinGen Ensembl
COSM1381311 rs775418941 CA8426417	89	R>C	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
rs775418941 CA398589826	89	R>G		No	ClinGen ExAC TOPMed gnomAD
CA8426418 rs749131027	89	R>H		No	ClinGen ExAC TOPMed gnomAD
rs71367436 CA288429211	90	L>F		No	Ensembl ClinGen
TCGA novel	92	S>F	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	96	D>G	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1597863482 CA398589873	97	S>G		No	Ensembl ClinGen
rs761438520 CA8426421	98	S>G		No	ClinGen ExAC gnomAD
rs998383327 CA288429215	98	S>N		No	ClinGen TOPMed
TCGA novel	100	H>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1479734964 CA398589895	100	H>R		No	TOPMed ClinGen
rs1179723273 CA398589909	102	W>S		No	ClinGen gnomAD
rs1266211375 CA398589927	104	I>T		No	ClinGen TOPMed
rs1231129089 CA398589931	105	V>F		No	ClinGen TOPMed gnomAD
CA398589929 rs1231129089	105	V>I		No	TOPMed gnomAD ClinGen
rs1025290378 CA398589938	106	H>P		No	ClinGen TOPMed gnomAD
rs767907165 CA8426425	106	H>Q		No	ExAC TOPMed gnomAD ClinGen
rs1025290378 CA288429218	106	H>R		No	ClinGen TOPMed gnomAD
rs760147317 CA8426424	106	H>Y		No	ExAC gnomAD ClinGen
rs373799486 CA8426428	107	H>R		No	ClinGen ESP ExAC TOPMed gnomAD
CA8426427 rs558854973	107	H>Y		No	1000Genomes ExAC TOPMed gnomAD ClinGen
rs754022666 CA8426429	110	C>Y		No	ExAC gnomAD ClinGen
CA398589978 rs1597863619	112	H>P		No	Ensembl ClinGen
rs1326223817 CA398589987	114	E>Q		No	gnomAD ClinGen
rs1335717718 CA398589991	114	E>V		No	ClinGen gnomAD
CA288429227 rs1017100617	115	E>Q		No	ClinGen TOPMed
rs1282519481 CA398590001	116	A>T		No	TOPMed ClinGen
rs1410905624 CA398590007	117	L>F		No	gnomAD ClinGen
rs1290741505 CA398590012	117	L>R		No	gnomAD ClinGen
CA8426430 rs757338252	118	S>G		No	ExAC TOPMed gnomAD ClinGen
rs1567687678 CA398590025	119	F>S		No	Ensembl ClinGen
COSM110168 rs140543375 CA288429230	120	Q>*	skin [Cosmic]	No	Ensembl ClinGen cosmic curated
rs772083796 CA8426433	124	R>Q		No	ClinGen ExAC TOPMed gnomAD
rs745927303 CA8426432	124	R>W		No	ClinGen ExAC TOPMed gnomAD
CA8426434 rs779831824	125	P>L		No	ExAC gnomAD ClinGen
CA8426436 rs768529419	126	G>S	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ExAC TOPMed gnomAD ClinGen NCI-TCGA
CA288429235 rs924730992	128	D>N		No	TOPMed ClinGen
CA8426461 rs770309166	133	P>A		No	ExAC gnomAD ClinGen
rs149627877 CA8426462	133	P>L		No	ESP ExAC TOPMed gnomAD ClinGen
rs1597865184 CA398590910	137	T>P		No	Ensembl ClinGen
CA8426465 rs777016863	138	R>G		No	ExAC TOPMed gnomAD ClinGen
rs532188095 CA8426466	138	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ExAC NCI-TCGA gnomAD
rs758508072 CA8426469	139	V>A		No	ExAC ClinGen
CA8426468 rs750569469	139	V>I		No	ClinGen ExAC TOPMed gnomAD
CA398590923 rs1597865223	140	T>P		No	Ensembl ClinGen
rs1468685547 CA398590933	141	V>A		No	ClinGen TOPMed
rs1389700764 CA398590937	142	V>F		No	gnomAD ClinGen
CA398590955 rs1478042049	145	V>A		No	TOPMed ClinGen
rs148767669 CA288430680	147	A>V		No	ESP gnomAD ClinGen
rs2290505 CA398590969	148	S>C		No	1000Genomes ESP ExAC TOPMed gnomAD ClinGen
VAR_058710 rs2290505 CA8426476	148	S>G		No	ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs2290505 CA398590968	148	S>R		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA8426478 rs777515946	149	D>N		No	ClinGen ExAC gnomAD
rs1260858294 CA398590988	150	I>M		No	ClinGen gnomAD
CA8426479 rs139586754	151	A>V		No	ESP ExAC gnomAD ClinGen
CA398590994 rs1258898048	152	A>T		No	gnomAD ClinGen
rs779012833 CA8426480 COSM321407	152	A>V	lung [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
rs1413085163 CA398591031	158	S>G		No	ClinGen gnomAD
CA8426483 rs769212595	160	V>I		No	ClinGen ExAC gnomAD
CA398591063 rs1597865403	162	F>S		No	Ensembl ClinGen
rs1219905152 CA398591073	164	D>H		No	TOPMed ClinGen
CA398591080 rs1304620114	165	V>I		No	ClinGen gnomAD
rs1597865428 CA398591086	166	T>P		No	ClinGen Ensembl
CA398591094 rs1597865435	167	T>P		No	ClinGen Ensembl
CA398591103 rs1597865445	169	T>P		No	ClinGen Ensembl
rs140418988 CA8426489	172	E>K		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1446512968 CA398591128 CA398591129	173	G>R		No	TOPMed ClinGen
CA8426490 rs751755671	175	T>M		No	ClinGen ExAC gnomAD
CA398591160 rs1179042246	178	P>S		No	Ensembl ClinGen
CA398591169 rs1479951682	179	G>A		No	ClinGen TOPMed gnomAD
CA8426492 COSM240495 rs767574625	180	E>K	prostate [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
rs752613461 CA398591177	181	V>F		No	ExAC TOPMed gnomAD ClinGen
rs1597865533 CA398591181	181	V>G		No	ClinGen Ensembl
rs752613461 CA8426493	181	V>I		No	ExAC TOPMed gnomAD ClinGen
rs752613461 CA398591178	181	V>L		No	ExAC TOPMed gnomAD ClinGen
rs1036846915 COSM472383 CA288430700	183	R>C	kidney [Cosmic]	No	TOPMed gnomAD ClinGen cosmic curated
rs755966163 CA8426494	183	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA398591214 rs1321356951	185	V>A		No	ClinGen gnomAD
RCV000894275 rs115399906 CA8426511	185	V>M		No	ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs372427725 CA8426512	187	D>G		No	ClinGen ESP ExAC TOPMed gnomAD
CA398591223 rs1436923796	187	D>N		No	ClinGen gnomAD
CA8426514 rs756991504	188	D>N		No	ClinGen ExAC TOPMed gnomAD
CA8426516 rs750040535	190	R>C		No	ClinGen ExAC TOPMed gnomAD
COSM1679628 rs757927589 CA8426517	190	R>H	Variant assessed as Somatic; 0.0 impact. haematopoietic_and_lymphoid_tissue [NCI-TCGA, Cosmic]	No	ExAC gnomAD ClinGen cosmic curated NCI-TCGA
TCGA novel	191	C>F	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1249765972 CA398591251	191	C>Y		No	TOPMed ClinGen
rs1322742767 CA398591260	192	G>A		No	gnomAD ClinGen
rs1322742767 CA398591259	192	G>E		No	ClinGen gnomAD
CA398591257 rs1181590424	192	G>R		No	TOPMed ClinGen
CA398591285 rs1277040400	196	G>A		No	ClinGen TOPMed
CA8426518 rs779589017	197	P>S		No	ExAC gnomAD ClinGen
CA8426520 rs770272015	198	V>M		No	ExAC gnomAD ClinGen
CA8426521 rs778330511	202	Q>*		No	ClinGen ExAC gnomAD
TCGA novel	202	Q>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1166600948 CA398591328	203	G>A		No	gnomAD ClinGen
rs1386002613 CA398591332	204	H>Y		No	gnomAD ClinGen
rs1253880646 CA398591340	205	L>P		No	ClinGen gnomAD
rs1433828535 CA398591339	205	L>V		No	ClinGen gnomAD
rs759780470 CA8426525	206	R>Q		No	ExAC TOPMed gnomAD ClinGen
rs774743121 CA8426524	206	R>W		No	ClinGen ExAC TOPMed gnomAD
rs1284180579 CA398591346	207	D>H		No	TOPMed gnomAD ClinGen
rs1284180579 CA398591348	207	D>N		No	TOPMed gnomAD ClinGen
rs775468676 CA8426527	210	K>T		No	ExAC gnomAD ClinGen
CA398591373 rs1266550940	211	I>L		No	ClinGen gnomAD
rs1328766677 CA398591382	212	L>F		No	gnomAD ClinGen
CA8426528 rs760800353	215	Y>*		No	ClinGen ExAC TOPMed gnomAD
CA398591409 rs984797366	216	S>N	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
rs753745117 CA8426531	216	S>R		No	ExAC gnomAD ClinGen
rs984797366 CA288430737	216	S>T		No	ClinGen TOPMed gnomAD
CA398591413 rs1183392423	217	R>Q		No	ClinGen TOPMed gnomAD
CA288430739 rs866315621	217	R>W		No	gnomAD ClinGen
CA398591432 rs1159502964	221	V>I		No	gnomAD ClinGen
CA398591444 rs1412285420	222	I>M		No	ClinGen gnomAD
CA8426534 rs758087102	224	N>K		No	ClinGen ExAC gnomAD
rs373843544 CA8426535	227	S>L		No	ExAC gnomAD ClinGen
CA8426538 rs149080712	228	Q>K		No	ESP ExAC TOPMed gnomAD ClinGen
rs145917490 CA288430746	228	Q>R		No	ESP TOPMed gnomAD ClinGen
rs1462783940 CA398591487	229	C>R		No	TOPMed ClinGen
CA8426539 rs749760771	230	V>M		No	ExAC TOPMed gnomAD ClinGen
rs1472997591 CA398591502	231	D>G		No	TOPMed ClinGen
rs779466517 CA398591499	231	D>H		No	ExAC TOPMed gnomAD ClinGen
CA8426541 rs779466517	231	D>N		No	ClinGen ExAC TOPMed gnomAD
rs1444188863 CA398591510	232	H>R		No	ClinGen TOPMed gnomAD
CA8426542 rs746200923	232	H>Y		No	ClinGen ExAC gnomAD
TCGA novel	234	F>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs138737182 CA8426543	236	G>A		No	ClinGen ESP ExAC TOPMed gnomAD
CA8426544 rs775727708	237	N>I		No	ClinGen ExAC TOPMed gnomAD
CA8426565 rs757876816	242	S>N		No	ExAC TOPMed gnomAD ClinGen
CA398591617 rs1324515627	242	S>R		No	ClinGen gnomAD
CA398591635 rs1296878887	245	W>*		No	ClinGen gnomAD
CA398591637 rs1341380896	245	W>*		No	ClinGen gnomAD
rs1239878261 CA398591633	245	W>G		No	ClinGen TOPMed gnomAD
CA288430794 rs1034438992	246	G>A		No	ClinGen Ensembl
rs1229124114 CA398591641	246	G>R		No	ClinGen gnomAD
CA8426568 rs376301967	247	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
rs1208994454 CA398591665	249	S>I		No	ClinGen gnomAD
rs1208994454 CA398591669	249	S>N		No	gnomAD ClinGen
CA398591674 rs780174211	249	S>R		No	ExAC gnomAD ClinGen
rs1230466743 CA398591679	250	S>G		No	TOPMed ClinGen
CA398591702 rs1311043672	252	V>M		No	TOPMed ClinGen
rs1186139535 CA398591730	254	S>T		No	TOPMed gnomAD ClinGen
CA398591747 rs1449541989 COSM1302475	255	S>L	Variant assessed as Somatic; 0.0 impact. urinary_tract [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA TOPMed gnomAD
rs768739480 CA8426571	256	H>D		No	ClinGen ExAC gnomAD
CA398591764 rs776813488	257	S>C		No	ClinGen ExAC TOPMed gnomAD
CA8426572 rs776813488	257	S>G		No	ExAC TOPMed gnomAD ClinGen
CA398591776 rs550170712	258	D>N		No	gnomAD ClinGen
rs550170712 CA288430809	258	D>Y		No	ClinGen gnomAD
rs748223416 CA8426573	260	S>R		No	ClinGen ExAC gnomAD
rs769781235 CA8426574	262	A>S		No	ClinGen ExAC gnomAD
CA398591844 rs1300947465	263	V>A		No	TOPMed ClinGen
rs1597866498 CA398591869	265	S>A		No	Ensembl ClinGen
rs773075939 CA8426575	266	V>A		No	ExAC gnomAD ClinGen
rs142729015 CA8426576	267	D>H		No	ClinGen ESP ExAC TOPMed gnomAD
CA398591911 rs773895330	268	A>G		No	ExAC gnomAD ClinGen
CA8426578 rs773895330	268	A>V		No	ClinGen ExAC gnomAD
rs1039273683 CA288430818	269	G>S		No	ClinGen TOPMed gnomAD
rs1189647686 CA398591951	272	P>R		No	ClinGen TOPMed
rs933462750 CA288430822	273	T>A		No	TOPMed gnomAD ClinGen
CA8426581 rs572067853	273	T>M	Variant assessed as Somatic; 4.834e-05 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
CA398591956 rs572067853	273	T>R		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs765847950 CA8426583	275	Q>H		No	ClinGen ExAC TOPMed gnomAD
CA398591969 rs1423678439	276	P>T		No	gnomAD ClinGen
rs541724642 CA288430830	277	T>K		No	1000Genomes ExAC TOPMed gnomAD ClinGen
CA8426584 rs541724642	277	T>M		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA398591975 rs1597866598	277	T>P		No	ClinGen Ensembl
CA398591979 rs1158754832	278	V>I		No	ClinGen gnomAD
rs1158754832 CA398591981	278	V>L		No	gnomAD ClinGen
CA8426587 rs751840897	280	T>A		No	ExAC gnomAD ClinGen
CA398591995 rs1301123851	280	T>I		No	ClinGen gnomAD
rs1567689191 CA398591997	281	T>A		No	ClinGen Ensembl
rs781379755 CA8426589	282	P>A		No	ClinGen ExAC gnomAD
rs1296351196 CA398592006	282	P>L		No	TOPMed ClinGen
CA8426590 rs767559015	283	Y>*		No	ClinGen ExAC gnomAD
CA8426617 rs760456293	285	P>H		No	ExAC gnomAD ClinGen
CA398592035 rs1259794786	285	P>T		No	ClinGen gnomAD
rs1366405617 CA398592045	286	F>L		No	ClinGen gnomAD
CA8426618 rs768394902	287	P>T		No	ClinGen ExAC gnomAD
rs776347706 CA8426619	290	A>P		No	ExAC gnomAD ClinGen
TCGA novel	292	N>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA398592099 rs1397132164	294	I>T		No	TOPMed ClinGen
rs1275935937 CA398592108	296	W>R		No	gnomAD ClinGen
CA8426620 rs761217001	297	R>Q		No	ExAC TOPMed gnomAD ClinGen
CA288430978 rs914359986	297	R>W		No	TOPMed ClinGen
CA625315992 rs1219764329	299	C>*		No	gnomAD ClinGen
CA398592130 rs1246381038	299	C>Y		No	ClinGen gnomAD
rs766923153 CA8426621	300	E>G		No	ClinGen ExAC gnomAD
rs1021368688 CA288431071	303	G>D		No	TOPMed ClinGen
CA8426649 rs575031000	303	G>S		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA8426650 rs750487037	307	I>V		No	ClinGen ExAC TOPMed gnomAD
CA398592200 rs1264405374	308	F>V		No	ClinGen gnomAD
rs1045480644 CA288431084	309	S>G		No	ClinGen TOPMed
CA8426652 CA398592231 rs372476783	312	M>I		No	ClinGen ESP ExAC gnomAD
CA8426654 rs754753711	314	R>C		No	ClinGen ExAC TOPMed gnomAD
CA398592241 rs1286359996	314	R>H		No	TOPMed gnomAD ClinGen
CA8426655 rs780930152	317	Y>C		No	ExAC TOPMed gnomAD ClinGen
CA398592281 rs1471753872	320	R>C		No	TOPMed ClinGen
rs1236793920 CA398592282	320	R>H		No	TOPMed ClinGen
rs769466162 CA398592292	321	H>Q		No	ExAC gnomAD ClinGen
CA398592294 rs1188777529	322	C>R		No	ClinGen TOPMed
TCGA novel	323	V>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1485889954 CA398592301	323	V>I		No	TOPMed gnomAD ClinGen
rs748791635 CA398592327	327	R>*		No	ExAC TOPMed gnomAD ClinGen
rs748791635 CA8426659	327	R>G		No	ClinGen ExAC TOPMed gnomAD
CA8426660 COSM269498 rs150688696	327	R>Q	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ESP ExAC TOPMed gnomAD ClinGen cosmic curated NCI-TCGA
CA8426662 rs761027899	329	E>K	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ExAC TOPMed gnomAD ClinGen NCI-TCGA
TCGA novel	332	V>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA398592367 rs1334135770	333	T>M		No	ClinGen gnomAD
rs761985510 CA8426665	339	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ExAC gnomAD ClinGen NCI-TCGA
rs1417041190 CA398592401	339	R>S		No	ClinGen gnomAD
CA398592414 rs1240100045	341	I>V		No	gnomAD ClinGen
rs763070749 CA8426669	342	D>E		No	ClinGen ExAC gnomAD
CA398592420 rs1343021624	342	D>N	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA8426670 rs751503572	343	F>S		No	ClinGen ExAC gnomAD
CA8426671 rs754841562	345	T>A		No	ExAC TOPMed gnomAD ClinGen
CA398592462 rs1212774836	347	H>R		No	gnomAD ClinGen
rs780898751 CA8426672	348	S>G		No	ClinGen ExAC gnomAD
rs752504126 CA8426673	349	T>A		No	ExAC gnomAD ClinGen
CA8426676 rs142159009	350	R>Q		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA8426675 rs374862629	350	R>W		No	ESP ExAC TOPMed gnomAD ClinGen
rs780566991 CA8426678	352	E>K	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA8426679 rs747567402	354	E>K	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ExAC TOPMed gnomAD ClinGen NCI-TCGA
CA8426700 CA8426701 rs572830833	357	D>E		No	ClinGen 1000Genomes ExAC gnomAD
TCGA novel	359	Q>P	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA8426702 rs146350733	362	A>T		No	1000Genomes ESP ExAC TOPMed gnomAD ClinGen
rs1419688034 CA398592719	366	E>K		No	TOPMed ClinGen
rs769051014 CA8426706	370	V>L		No	ExAC TOPMed gnomAD ClinGen
TCGA novel	373	D>G	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1253991128 CA398592818	374	L>M		No	ClinGen TOPMed
CA398592867 rs1216138391	378	G>D		No	TOPMed ClinGen
CA398592894 rs1597868320	380	P>A		No	ClinGen Ensembl
rs1319899736 CA398592930	383	P>L		No	gnomAD ClinGen
CA288431232 rs1045071932	385	P>A		No	ClinGen TOPMed
CA398592953 rs1384184580	385	P>L		No	ClinGen TOPMed gnomAD
rs201923491 CA288431235	386	Y>H		No	ClinGen TOPMed
CA398592988 rs1338527373	388	A>V		No	gnomAD ClinGen
CA288431238 rs557754934	389	P>L		No	ClinGen gnomAD
CA398593007 rs1597868396	391	H>P		No	Ensembl ClinGen
rs1370044522 CA398593016	392	S>C		No	ClinGen TOPMed
TCGA novel	392	S>F	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA398593023 rs1226054204	393	S>F		No	TOPMed gnomAD ClinGen
CA8426711 rs372720962	394	A>V		No	ClinGen ESP ExAC TOPMed gnomAD
CA8426713 rs144290841	395	I>V		No	ESP ExAC TOPMed gnomAD ClinGen
CA398593048 rs1254657194	397	C>*		No	gnomAD ClinGen
rs1207449138 CA398593046	397	C>F		No	gnomAD ClinGen
rs1207449138 CA398593044	397	C>Y		No	gnomAD ClinGen
rs370740868 CA8426714	398	S>L		No	ESP ExAC TOPMed gnomAD ClinGen
CA398593058 rs1238461177	399	A>V		No	gnomAD ClinGen
CA398593067 rs145217563	400	H>Q		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1597868483 CA398593071	401	V>G		No	Ensembl ClinGen
rs756557977 CA398593069	401	V>L		No	ExAC TOPMed gnomAD ClinGen
rs756557977 CA8426717	401	V>M	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ExAC TOPMed gnomAD ClinGen NCI-TCGA
rs1158643631 CA398593077	402	A>S		No	ClinGen gnomAD
rs1597868504 CA398593108	404	V>A		No	Ensembl ClinGen
rs778321001 CA8426718	405	P>A		No	ClinGen ExAC gnomAD
CA8426720 rs142722516	406	A>T		No	ESP ExAC TOPMed gnomAD ClinGen
CA288431280 rs943348595	406	A>V		No	ClinGen Ensembl
CA8426721 rs774656989	407	K>N		No	ClinGen ExAC gnomAD
rs1357116437 CA398593166	409	W>*		No	gnomAD ClinGen
CA8426722 rs745937164	410	A>T		No	ExAC gnomAD ClinGen
CA398593186 rs1305809175	410	A>V		No	gnomAD ClinGen
CA398593192 rs1317036340	411	R>C		No	ClinGen TOPMed gnomAD
CA8426723 rs772147066 COSM3818970	411	R>H	Variant assessed as Somatic; 0.0 impact. breast [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
CA398593199 rs1597868600	412	I>L		No	Ensembl ClinGen
rs1212066757 CA398593211	413	V>M		No	ClinGen gnomAD
CA398593232 rs1260130755	414	S>N		No	gnomAD ClinGen
CA398593236 rs760713823	414	S>R		No	ClinGen ExAC gnomAD
rs764017987 CA8426726	415	A>T		No	ClinGen ExAC TOPMed gnomAD
CA8426728 rs761542780	417	E>K		No	ExAC TOPMed gnomAD ClinGen
CA8426730 rs151016611	418	Q>H		No	ClinGen ESP ExAC TOPMed gnomAD
rs373996132 CA288431305	418	Q>R		No	ClinGen ESP
rs1393210408 CA398593302	419	Q>H		No	TOPMed gnomAD ClinGen
CA398593314 rs1294840890	420	S>I		No	TOPMed ClinGen
rs184038029 CA8426731	420	S>R		No	ClinGen 1000Genomes ExAC gnomAD
rs1174179332 CA398593347	423	P>S		No	gnomAD ClinGen
rs751001689 CA398593376	425	S>F		No	ClinGen ExAC gnomAD
CA398593373 rs1297270815	425	S>T		No	ClinGen gnomAD
rs751001689 CA8426733	425	S>Y		No	ClinGen ExAC gnomAD
rs1292938743 CA398593524	430	W>*		No	ClinGen gnomAD
rs770630309 CA288431415	430	W>*		No	ClinGen ExAC gnomAD
rs770630309 CA8426772	430	W>C		No	ExAC gnomAD ClinGen
CA398593562 rs1446500828	433	T>I		No	ClinGen gnomAD
CA8426774 rs201308585	433	T>S		No	1000Genomes ESP ExAC TOPMed gnomAD ClinGen
CA398593561 rs1446500828	433	T>S		No	ClinGen gnomAD
CA398593573 rs1242612680	435	G>A		No	gnomAD ClinGen
rs752229503 CA8426776	436	R>*		No	ExAC TOPMed gnomAD ClinGen
rs376382164 CA8426777	436	R>Q		No	ESP ExAC TOPMed gnomAD ClinGen
CA398593582 rs1416722210	437	N>S		No	gnomAD ClinGen
rs186995213 CA8426778	439	A>S		No	ClinGen 1000Genomes ExAC gnomAD
rs1405214472 CA398593600	440	Q>R		No	ClinGen gnomAD
rs890214481 CA288431437	441	E>G		No	TOPMed ClinGen
CA8426779 rs371262121	442	P>L		No	1000Genomes ESP ExAC gnomAD ClinGen
rs1042985836 CA398593642	443	S>*		No	gnomAD ClinGen
rs1042985836 CA288431445	443	S>L		No	gnomAD ClinGen
rs1182080597 CA398593645	444	Q>K		No	TOPMed ClinGen
CA398593661 rs1413321606	445	R>*	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs376148449 CA8426782	445	R>L		No	1000Genomes ESP ExAC TOPMed gnomAD ClinGen
rs376148449 CA8426781	445	R>Q		No	1000Genomes ESP ExAC TOPMed gnomAD ClinGen
rs147811258 CA8426783	446	G>E		No	ESP ExAC TOPMed gnomAD ClinGen
CA398593679 rs1416932184	447	L>M		No	gnomAD ClinGen
rs1350111873 CA398593698	449	L>M		No	gnomAD ClinGen
CA8426787 rs141275484	450	T>M		No	ClinGen ESP ExAC gnomAD
rs1455880387 CA398594043	452	H>Y		No	ClinGen gnomAD
rs1396060229 CA398594055	453	E>D		No	gnomAD ClinGen
CA8426810 rs771867490	453	E>Q		No	ExAC TOPMed gnomAD ClinGen
CA8426812 rs746563628	455	G>S		No	ExAC TOPMed gnomAD ClinGen
CA8426814 rs529354628	457	V>M		No	ExAC TOPMed gnomAD ClinGen
CA8426816 rs368131949	458	R>K		No	ESP ExAC gnomAD ClinGen
TCGA novel	458	R>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs763411085 CA8426815	458	R>W		No	ExAC gnomAD ClinGen
rs1334728254 CA398594103	461	D>H		No	ClinGen TOPMed gnomAD
CA398594119 rs1338497657	463	S>*		No	gnomAD ClinGen
CA398594121 rs1338497657	463	S>L	Variant assessed as Somatic; 9.311e-05 impact. [NCI-TCGA]	No	gnomAD ClinGen NCI-TCGA
rs776966875 CA8426819	466	A>V		No	ExAC TOPMed gnomAD ClinGen
CA8426822 rs764124548	468	R>Q		No	ExAC TOPMed gnomAD ClinGen
CA8426823 rs544675510	469	P>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs761575582 CA8426825	470	L>I		No	ClinGen ExAC gnomAD
rs149027239 CA8426827	471	Y>C		No	ClinGen ESP ExAC TOPMed gnomAD
CA398594185 rs1415904646	474	S>R		No	TOPMed gnomAD ClinGen
CA8426828 rs779878241	475	T>I		No	ClinGen ExAC TOPMed gnomAD
rs746693280 CA8426829	477	G>D		No	ClinGen ExAC gnomAD
rs200589712 CA8426830	478	L>F		No	1000Genomes ExAC TOPMed gnomAD ClinGen
rs549478417 CA288431762	483	C>R		No	ExAC TOPMed gnomAD ClinGen
rs549478417 CA8426831	483	C>S		No	ExAC TOPMed gnomAD ClinGen
CA8426832 rs747682790	484	E>G		No	ExAC gnomAD ClinGen
CA398594278 rs1325693797	485	H>P		No	ClinGen gnomAD
rs1063682 CA288431766	486	A>S		No	ClinGen ESP ExAC TOPMed gnomAD
rs1063682 CA8426834	486	A>T	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
CA398594339 rs772373097	490	A>D		No	ClinGen ExAC TOPMed gnomAD
rs759924065 CA8426835	490	A>T		No	ExAC TOPMed gnomAD ClinGen
CA8426836 rs772373097	490	A>V		No	ClinGen ExAC TOPMed gnomAD
CA398594355 rs1597871252	491	Q>H		No	Ensembl ClinGen
CA8426838 rs148379302	493	A>D		No	ClinGen ESP ExAC TOPMed gnomAD
CA398594391 rs1567691558	494	E>D		No	Ensembl ClinGen
rs761888691 CA8426841	494	E>K		No	ClinGen ExAC gnomAD
rs750340360 CA8426843	496	D>N		No	ClinGen ExAC gnomAD
rs1400878692 CA398594448	498	P>L		No	TOPMed ClinGen
CA8426845 rs780035374	499	P>S		No	ClinGen ExAC TOPMed gnomAD
CA8426846 COSM3937277 rs751365881	501	R>C	oesophagus [Cosmic]	No	ExAC TOPMed gnomAD ClinGen cosmic curated
rs371648907 CA8426847	501	R>H		No	ESP ExAC gnomAD ClinGen
rs371648907 CA398594481	501	R>L		No	ClinGen ESP ExAC gnomAD
rs1597871501 CA398594596	507	D>E		No	Ensembl ClinGen
rs1567691664 CA398594584	507	D>N		No	Ensembl ClinGen
rs1420293004 CA398594610	508	P>L		No	gnomAD ClinGen
CA8426861 rs202012728	511	D>E		No	1000Genomes ExAC TOPMed gnomAD ClinGen
rs766407468 CA8426862	512	D>E		No	ExAC gnomAD ClinGen
CA398594656 rs1373442315	512	D>N	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	gnomAD ClinGen NCI-TCGA
rs751327252 CA398594674	513	P>S		No	ExAC TOPMed gnomAD ClinGen
CA8426863 rs751327252	513	P>T		No	ClinGen ExAC TOPMed gnomAD
rs372430699 CA398594686	514	R>P		No	ESP TOPMed gnomAD ClinGen
CA288431793 rs372430699	514	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP NCI-TCGA TOPMed gnomAD
CA288431794 rs952086581	515	L>F		No	TOPMed gnomAD ClinGen
CA398594708 rs1389190696	516	G>A		No	ClinGen TOPMed gnomAD
CA8426866 rs145135032	517	V>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA8426865 rs145135032	517	V>M		No	1000Genomes ESP ExAC TOPMed gnomAD ClinGen
TCGA novel	518	Q>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA288431804 rs1001456408	518	Q>R		No	ClinGen TOPMed
rs1395698871 CA398594729	519	K>M		No	ClinGen TOPMed gnomAD
TCGA novel	520	V>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs200183472 CA8426869	521	A>G		No	1000Genomes ESP ExAC TOPMed gnomAD ClinGen
CA8426868 rs200183472	521	A>V		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1347642646 CA398594744	522	L>F		No	ClinGen TOPMed gnomAD
CA398594743 rs1347642646	522	L>V		No	TOPMed gnomAD ClinGen
rs758961125 CA8426870	524	K>R		No	ClinGen ExAC gnomAD
rs1466779777 CA398594785	526	T>A		No	TOPMed ClinGen
CA8426871 rs146378867	527	A>T		No	ESP ExAC TOPMed gnomAD ClinGen
rs1441589377 CA398594820	529	M>V		No	ClinGen gnomAD
CA398594858 rs1393148003	532	A>T		No	gnomAD ClinGen
CA398594881 rs1323159739	534	T>A		No	TOPMed ClinGen
CA398594996 rs1320196496	538	V>L		No	gnomAD ClinGen
rs1320196496 CA398594992	538	V>M		No	ClinGen gnomAD
rs138406543 CA288431990	539	L>V		No	ClinGen ESP ExAC TOPMed gnomAD
CA398595004 rs1269813675	540	V>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
CA8426890 rs755410073	542	E>Q		No	ClinGen ExAC
CA8426891 rs781669092	543	L>F		No	ClinGen ExAC gnomAD
rs748514739 CA398595047	544	S>N		No	ExAC gnomAD ClinGen
rs748514739 CA8426892	544	S>T		No	ClinGen ExAC gnomAD
rs1263478058 CA398595090	547	P>L		No	ClinGen gnomAD
rs1416579219 CA398595124	550	Q>*		No	ClinGen TOPMed gnomAD
rs1416579219 CA398595123	550	Q>E		No	TOPMed gnomAD ClinGen
rs1063683 VAR_058711	550	Q>H		No	UniProt dbSNP
rs749413165 CA8426895	551	A>V		No	ExAC TOPMed gnomAD ClinGen
CA398595152 rs1343877721	552	V>I		No	ClinGen gnomAD
CA8426898 rs759554948	554	V>M		No	ClinGen ExAC TOPMed gnomAD
rs373780909 CA8426899	555	A>V		No	ESP ExAC TOPMed gnomAD ClinGen
rs1230059297 CA398595220	557	I>T		No	ClinGen TOPMed gnomAD
rs1048417132 CA288432021	557	I>V		No	TOPMed gnomAD ClinGen
TCGA novel	558	D>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA398595246 rs1359446937	559	L>H		No	TOPMed ClinGen
CA398595256 rs1214972176	560	L>F		No	gnomAD ClinGen
CA398595252 rs1214972176	560	L>I		No	ClinGen gnomAD
rs1597872642 CA398595262	561	Q>K		No	ClinGen Ensembl
CA8426902 rs760402511	562	D>E		No	ExAC gnomAD ClinGen
rs763738289 CA8426903	563	R>C		No	ClinGen ExAC TOPMed gnomAD
CA8426905 rs377512205	563	R>H		No	ESP ExAC TOPMed gnomAD ClinGen
CA8426904 rs377512205	563	R>L		No	ClinGen ESP ExAC TOPMed gnomAD
rs764843900 CA8426906	564	E>K		No	ExAC gnomAD ClinGen
CA8426907 rs749897947	567	T>A		No	ClinGen ExAC TOPMed gnomAD
rs1400705772 CA398595354	568	W>*		No	gnomAD ClinGen
rs753120323 CA398595409	572	E>*		No	ExAC TOPMed gnomAD ClinGen
rs753120323 CA8426910	572	E>K	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA8426912 rs531770044	573	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	1000Genomes ExAC TOPMed gnomAD ClinGen NCI-TCGA
CA8426911 rs756510000	573	R>W		No	ExAC TOPMed gnomAD ClinGen
CA8426914 rs771024336	575	S>T		No	ExAC gnomAD ClinGen
CA8426916 rs377198347	577	R>C		No	ClinGen ExAC TOPMed gnomAD
CA288432054 rs1006575220	577	R>H		No	TOPMed gnomAD ClinGen
rs1006575220 CA398595470	577	R>L		No	TOPMed gnomAD ClinGen
CA8426917 rs772059315	578	T>M		No	ClinGen ExAC TOPMed gnomAD
rs1279174501 CA398595483	579	G>R		No	gnomAD ClinGen
CA8426920 rs1063685	580	P>L		No	ExAC TOPMed gnomAD ClinGen
CA398595498 rs1063685	580	P>Q		No	ExAC TOPMed gnomAD ClinGen
CA398595533 rs1278439187	583	W>*		No	ClinGen TOPMed
rs1246242094 CA398595553	585	A>T		No	gnomAD ClinGen
rs764784217 CA8426923	587	F>L		No	ClinGen ExAC gnomAD
CA8426924 rs749966761	587	F>L		No	ExAC TOPMed gnomAD ClinGen
CA398595576 rs1567692502	588	Q>*		No	ClinGen Ensembl
rs1063686 CA288432071	590	R>C		No	TOPMed gnomAD ClinGen
CA8426925 rs776809019	590	R>H		No	ExAC TOPMed gnomAD ClinGen
rs571000675 CA288432082	597	P>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen 1000Genomes NCI-TCGA TOPMed
CA8426931 rs757553068	598	P>S		No	ClinGen ExAC gnomAD
rs139750751 CA398595760	603	A>S		No	ClinGen ESP ExAC TOPMed gnomAD
rs139750751 CA8426933	603	A>T	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
rs780087503 CA8426935	604	V>A		No	ClinGen ExAC gnomAD
rs1220640932 CA398595833	609	E>K		No	ClinGen gnomAD
CA8426938 rs776468893	613	V>M		No	ClinGen ExAC TOPMed gnomAD
CA398595933 rs1240585109	615	F>Y		No	gnomAD ClinGen
CA398595943 rs1467572089	616	G>S		No	ClinGen gnomAD
CA8426939 rs747843543	617	T>N		No	ExAC TOPMed gnomAD ClinGen
rs547373553 CA8426940	618	S>G		No	ClinGen 1000Genomes ExAC gnomAD
CA8426941 rs772703554	619	H>R		No	ExAC gnomAD ClinGen
rs536563008 CA8426944	625	D>N		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1392367069 CA398596104	626	Y>C		No	TOPMed gnomAD ClinGen
rs1392367069 CA398596102	626	Y>S		No	ClinGen TOPMed gnomAD
CA8426945 rs374938197	627	Q>R		No	ClinGen ESP ExAC TOPMed gnomAD
CA8426946 rs764681199	628	R>C		No	ClinGen ExAC TOPMed gnomAD
rs144655159 CA8426947	628	R>H		No	ESP ExAC TOPMed gnomAD ClinGen
rs144655159 CA398596136	628	R>L		No	ESP ExAC TOPMed gnomAD ClinGen
rs757496603 CA8426948	629	K>E		No	ExAC TOPMed gnomAD ClinGen
rs1381742172 CA398596176	630	S>R		No	TOPMed gnomAD ClinGen
CA8426949 rs765526913	631	P>S		No	ExAC gnomAD ClinGen
CA8426950 rs140611231	633	L>P		No	ESP ExAC TOPMed gnomAD ClinGen
CA398596203 rs1316852425	633	L>V		No	gnomAD ClinGen
CA398596216 rs1164212159	634	A>S		No	ClinGen TOPMed
rs758589415 CA8426951	635	R>G		No	ExAC gnomAD ClinGen
rs1420033864 CA398597372	639	H>D		No	TOPMed gnomAD ClinGen
CA398597385 rs1597873710	639	H>P		No	ClinGen Ensembl
CA398597376 rs1420033864	639	H>Y		No	ClinGen TOPMed gnomAD
rs1050330292 CA288433475	640	P>R		No	Ensembl ClinGen
CA8426981 rs377588818	641	N>K		No	ClinGen ESP ExAC TOPMed gnomAD
CA8426979 rs369658890	641	N>S		No	ESP ExAC TOPMed gnomAD ClinGen
CA398597504 rs1339260331	645	A>V		No	TOPMed ClinGen
rs771657062 CA8426982	646	M>I		No	ExAC ClinGen
rs1454153481 CA398597520	646	M>R		No	ClinGen TOPMed
rs1397470665 CA398597560	648	G>D		No	ClinGen TOPMed
rs775042224 CA8426983	648	G>S		No	ExAC gnomAD ClinGen
CA8426985 rs770323651	649	P>L		No	ClinGen ExAC gnomAD
CA8426987 rs763236973	651	S>F		No	ExAC gnomAD ClinGen
CA8426988 rs766623464	652	R>G		No	ClinGen ExAC gnomAD
CA8426989 rs751735771	652	R>L		No	ClinGen ExAC TOPMed gnomAD
rs751735771 CA8426991	652	R>P		No	ExAC TOPMed gnomAD ClinGen
CA8426990 COSM1679629 rs751735771	652	R>Q	Variant assessed as Somatic; 0.0 impact. haematopoietic_and_lymphoid_tissue [NCI-TCGA, Cosmic]	No	ExAC TOPMed gnomAD ClinGen cosmic curated NCI-TCGA
CA398597622 rs766623464	652	R>W		No	ClinGen ExAC gnomAD
rs752814889 CA8426992	653	V>L		No	ClinGen ExAC gnomAD
rs1436132822 CA398597673	655	S>T		No	gnomAD ClinGen
rs777704176 CA8426995	656	L>V		No	ExAC gnomAD ClinGen
rs1379571928 CA398597779	661	R>C		No	TOPMed gnomAD ClinGen
CA8426996 COSM976242 rs138562673	661	R>H	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated 1000Genomes ESP ExAC NCI-TCGA TOPMed gnomAD
rs200739800 CA8426997	662	Q>H		No	ClinGen ESP ExAC TOPMed gnomAD
rs778729916 CA8426998	663	S>F		No	ExAC ClinGen
CA8427000 rs771752705	664	F>L		No	ExAC gnomAD ClinGen
rs376194405 CA8427001	665	R>Q		No	ESP ExAC TOPMed gnomAD ClinGen
CA288433525 rs182677018	665	R>W		No	ClinGen 1000Genomes TOPMed gnomAD
CA8427002 rs746469588	666	R>C		No	ClinGen ExAC TOPMed gnomAD
CA8427003 rs770208654	666	R>H	Variant assessed as Somatic; 4.761e-05 impact. [NCI-TCGA]	No	ExAC TOPMed gnomAD ClinGen NCI-TCGA
CA398597852 rs746469588	666	R>S		No	ClinGen ExAC TOPMed gnomAD
CA398597861 rs1301778941	667	I>M		No	gnomAD ClinGen
CA8427004 rs147834323	667	I>V		No	1000Genomes ESP ExAC TOPMed gnomAD ClinGen
CA398597864 rs1311945895	668	R>C		No	ClinGen TOPMed gnomAD
CA8427006 rs531828914	668	R>H		No	1000Genomes ExAC TOPMed gnomAD ClinGen
CA8427005 rs531828914	668	R>P		No	1000Genomes ExAC TOPMed gnomAD ClinGen
rs1479716864 CA398597874	669	K>E		No	ClinGen gnomAD
CA398597883 rs759817745	669	K>N		No	ExAC gnomAD ClinGen
rs370235992 CA8427009	670	S>T		No	ClinGen ESP ExAC TOPMed gnomAD
CA398597912 rs1458206874	671	R>C		No	gnomAD ClinGen
rs374663368 CA8427010	671	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ESP ExAC TOPMed gnomAD ClinGen NCI-TCGA
CA8427011 rs374663368	671	R>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA8427012 rs763968580	674	G>A		No	ClinGen ExAC gnomAD
CA398598012 rs1176366997	676	K>E		No	gnomAD ClinGen
rs757236980 CA8427014	677	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA8427013 rs377439323	677	R>W		No	ClinGen ESP ExAC gnomAD
rs1169411774 CA398598098	681	A>T		No	ClinGen gnomAD
CA398598111 rs1400383134	681	A>V		No	ClinGen gnomAD
rs1449701375 CA398598119	682	S>C		No	ClinGen gnomAD
rs1324448024 CA398598122	682	S>N		No	gnomAD ClinGen
CA8427015 rs778891148	682	S>R		No	ClinGen ExAC gnomAD
rs1387668413 CA398598145	683	S>N		No	gnomAD ClinGen
rs750231815 CA8427017	684	K>R		No	ClinGen ExAC gnomAD
rs750231815 CA8427016	684	K>T		No	ExAC gnomAD ClinGen
TCGA novel	685	L>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs765210628 CA398598268	686	Q>P		No	ClinGen ExAC TOPMed gnomAD
CA8427033 rs765210628	686	Q>R		No	ClinGen ExAC TOPMed gnomAD
CA398598333 rs1567693533	689	N>H		No	Ensembl ClinGen
rs140298639 CA8427034	689	N>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA8427035 rs371605062	690	A>T		No	ESP ExAC TOPMed gnomAD ClinGen
rs765973200 CA8427036	693	A>V		No	ClinGen ExAC TOPMed gnomAD
rs1379946062 CA398598430	694	E>V		No	ClinGen gnomAD
CA8427037 rs751277985	696	A>D		No	ExAC gnomAD ClinGen
CA288433724 rs751277985	696	A>V		No	ClinGen ExAC gnomAD
rs111836247 CA398598498	697	C>F		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs111836247 RCV000955519 CA8427038	697	C>Y		No	ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs529634225 CA288433728	698	P>L		No	1000Genomes ExAC TOPMed gnomAD ClinGen
rs529634225 CA8427039	698	P>R		No	1000Genomes ExAC TOPMed gnomAD ClinGen
rs1286305114 CA398598518	699	H>N		No	ClinGen TOPMed gnomAD
CA398598525 rs1172079015	699	H>P		No	TOPMed ClinGen
CA8427041 rs150963270	699	H>Q		No	ClinGen ESP ExAC TOPMed gnomAD
rs1286305114 CA398598523	699	H>Y		No	TOPMed gnomAD ClinGen
rs746245675 CA8427043	700	D>N		No	ClinGen ExAC TOPMed gnomAD
rs374576025 CA8427045	701	V>M		No	ClinGen ESP ExAC TOPMed gnomAD
TCGA novel	702	E>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs747293622 CA8427046	703	M>V		No	ExAC TOPMed gnomAD ClinGen
rs367727740 CA398598612	704	T>K		No	ESP ExAC TOPMed gnomAD ClinGen
rs367727740 CA8427047	704	T>M		No	ESP ExAC TOPMed gnomAD ClinGen
rs1184140144 CA398598607	704	T>S		No	gnomAD ClinGen
CA8427049 rs761920223	706	V>M		No	ExAC TOPMed gnomAD ClinGen
rs1323584704 CA398598644	707	Q>R		No	ClinGen TOPMed
rs1427717726 CA398598655	708	R>C		No	TOPMed gnomAD ClinGen
rs145768685 CA8427051	708	R>H		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA8427052 rs762781844	709	R>C		No	ClinGen ExAC TOPMed gnomAD
CA8427053 rs766240619	709	R>H	Variant assessed as Somatic; 4.746e-05 impact. [NCI-TCGA]	No	ExAC TOPMed gnomAD ClinGen NCI-TCGA
CA398598670 rs766240619	709	R>L		No	ExAC TOPMed gnomAD ClinGen
CA8427055 rs754721408	713	R>C		No	ClinGen ExAC TOPMed gnomAD
rs767095694 CA8427056	713	R>H		No	ExAC TOPMed gnomAD ClinGen
CA8427057 rs767095694	713	R>P		No	ClinGen ExAC TOPMed gnomAD
rs186632359 CA8427058	715	A>V		No	1000Genomes ESP ExAC TOPMed gnomAD ClinGen
rs779411587 CA8427059	716	D>N		No	ClinGen ExAC TOPMed gnomAD
rs1235811122 CA398598726	717	D>V		No	ClinGen TOPMed gnomAD
CA398598735 rs1420423222	718	S>F		No	ClinGen TOPMed
rs1179779082 CA398598738	719	L>S		No	gnomAD ClinGen
CA8427061 rs150088817	720	S>L		No	1000Genomes ESP ExAC TOPMed gnomAD ClinGen
rs747320752 CA8427063	721	G>R		No	ClinGen ExAC gnomAD
CA288433799 rs1054009589	723	V>M		No	ClinGen TOPMed
rs138380942 CA8427065	724	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ESP ExAC gnomAD ClinGen NCI-TCGA
COSM976244 CA398598766 rs1168692993	724	R>H	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA gnomAD
rs773136651 CA8427068	727	Y>C		No	ClinGen ExAC TOPMed gnomAD
rs1337336803 CA398598790	728	F>V		No	gnomAD ClinGen
rs553954291 CA8427071	730	D>E		No	1000Genomes ExAC gnomAD ClinGen
CA8427070 rs770764753	730	D>N		No	ClinGen ExAC gnomAD
CA8427074 rs752294347	732	F>S		No	ClinGen ExAC gnomAD
CA398598828 rs760297874	734	R>*	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ExAC gnomAD ClinGen NCI-TCGA
CA8427075 rs760297874	734	R>G		No	ClinGen ExAC gnomAD
rs763698681 CA8427076	735	D>V		No	ExAC gnomAD ClinGen
rs749412345 CA8427110	737	A>V		No	ClinGen ExAC gnomAD
rs745844805 CA8427113	738	H>Q		No	ExAC gnomAD ClinGen
rs779025594 CA8427112	738	H>Y		No	ClinGen ExAC TOPMed gnomAD
CA398599725 rs771990753	739	H>D		No	ExAC TOPMed gnomAD ClinGen
rs771990753 CA8427115	739	H>N		No	ClinGen ExAC TOPMed gnomAD
rs752464459 CA8427117	739	H>Q		No	ExAC TOPMed gnomAD ClinGen
rs771990753 CA8427114	739	H>Y		No	ClinGen ExAC TOPMed gnomAD
rs776098319 CA8427118	740	G>R		No	ExAC gnomAD ClinGen
CA8427119 rs761506647	741	P>A		No	ClinGen ExAC gnomAD
rs1426633626 CA398599781	742	T>P		No	gnomAD ClinGen
CA398599803 rs1351145641	743	M>I		No	ClinGen TOPMed
CA398599793 rs1254226083	743	M>V		No	gnomAD ClinGen
TCGA novel	745	A>P	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA8427121 rs772847310	745	A>V		No	ClinGen ExAC TOPMed gnomAD
rs1385714475 CA398599843	746	G>S		No	gnomAD ClinGen
CA288435050 rs943949485	748	N>S		No	ClinGen Ensembl
CA8427123 rs373022414	749	S>L		No	ClinGen ESP ExAC TOPMed gnomAD
rs1419975310 CA398599952	752	V>A		No	ClinGen TOPMed gnomAD
CA8427124 rs753120501	752	V>L		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	753	F>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs899664455 CA288435060	754	A>T		No	ClinGen Ensembl
rs376499580 CA288435064	754	A>V		No	ClinGen ESP TOPMed gnomAD
rs1044239600 CA288435078	759	V>G		No	TOPMed ClinGen
rs754054096 CA8427128 CA8427127	759	V>L		No	ClinGen ExAC gnomAD
rs779030616 CA8427129	760	P>L		No	ExAC TOPMed gnomAD ClinGen
rs138439781 CA288435082	762	A>T		No	ESP TOPMed ClinGen
rs1597878326 CA398600135	762	A>V		No	ClinGen Ensembl
rs371026248 CA8427133	764	V>L		No	ESP ExAC TOPMed gnomAD ClinGen
rs371026248 CA398600158	764	V>M		No	ESP ExAC TOPMed gnomAD ClinGen
CA8427134 rs779899852	767	E>K		No	ExAC gnomAD ClinGen
CA398600271 rs746829631	769	R>G		No	ClinGen ExAC gnomAD
CA288435101 rs762237113	769	R>Q		No	ClinGen Ensembl
CA8427135 rs746829631	769	R>W		No	ExAC gnomAD ClinGen
rs1201050179 CA398600282	770	P>R		No	gnomAD ClinGen
rs1344405027 CA398600277	770	P>S		No	gnomAD ClinGen
rs1311993467 CA398600321	772	Q>R		No	TOPMed ClinGen
CA8427136 rs768385606	773	A>V		No	ExAC TOPMed gnomAD ClinGen
CA398600352 rs1313348836	774	V>M		No	gnomAD ClinGen
rs1176668823 CA398600393	776	A>T		No	ClinGen gnomAD
rs200044915 CA8427139	777	V>L		No	ESP ExAC TOPMed gnomAD ClinGen
rs200044915 CA8427140 COSM1381314	777	V>M	large_intestine [Cosmic]	No	ClinGen cosmic curated ESP ExAC TOPMed gnomAD
rs1160882932 CA398600442	779	G>S		No	ClinGen gnomAD
CA288435131 rs71367438	781	E>K		No	ClinGen Ensembl
rs1597878483 CA398600491	782	V>G		No	ClinGen Ensembl
CA398600502 rs1176607445	783	Q>*		No	ClinGen gnomAD
rs1354016846 CA398600510	783	Q>R		No	TOPMed gnomAD ClinGen
CA398600577 rs776086566	786	H>Q		No	ClinGen ExAC gnomAD
rs1010301473 CA288435139	786	H>R		No	TOPMed ClinGen
CA398600564 rs1331204481	786	H>Y		No	gnomAD ClinGen
rs1013140459 CA288435166	787	R>Q		No	gnomAD ClinGen
rs761220197 CA8427145	787	R>W		No	ExAC TOPMed gnomAD ClinGen
CA398600599 rs1330800868	788	A>T		No	ClinGen gnomAD
CA8427146 rs764402601	788	A>V		No	ClinGen ExAC gnomAD
CA398600653 rs1416165320	791	V>M		No	ClinGen TOPMed
rs765385109 CA8427149	793	I>V		No	ClinGen ExAC TOPMed gnomAD
CA398600719 rs1257304921	794	A>V		No	gnomAD ClinGen
CA8427151 rs371253354	795	V>M		No	ClinGen ESP ExAC TOPMed gnomAD
CA8427152 rs780085591	796	L>W		No	ClinGen ExAC TOPMed gnomAD
CA8427154 rs754941025	798	G>R		No	ExAC gnomAD ClinGen
rs973507004 CA288435246	799	R>C		No	gnomAD ClinGen
rs780909473 CA8427155	799	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ExAC TOPMed gnomAD ClinGen NCI-TCGA
rs747922114 CA8427156	800	G>D		No	ClinGen ExAC TOPMed gnomAD
rs769578330 CA8427157	801	R>C		No	ExAC TOPMed gnomAD ClinGen
rs777531176 CA8427158	801	R>H		No	ClinGen ExAC TOPMed gnomAD
rs148326696 CA288435293	805	E>K		No	ClinGen ESP gnomAD
CA8427160 rs770610597	806	P>L		No	ClinGen ExAC gnomAD
rs761149558 CA8427162	807	Y>H		No	ExAC TOPMed gnomAD ClinGen
rs962174759 CA288435312	808	E>K		No	ClinGen TOPMed gnomAD
CA398600934 rs1307362627	809	A>G		No	TOPMed ClinGen
CA8427164 rs776872146	809	A>S		No	ExAC TOPMed gnomAD ClinGen
rs751648322 CA8427170	811	R>Q		No	ExAC TOPMed gnomAD ClinGen
rs368288709 CA8427169	811	R>W		No	ESP ExAC TOPMed gnomAD ClinGen
rs1184013270 CA398600995	812	D>V		No	ClinGen TOPMed
CA8427173 rs575121495	814	A>E		No	1000Genomes ExAC gnomAD ClinGen
CA288435363 rs575121495	814	A>V		No	1000Genomes ExAC gnomAD ClinGen
CA8427175 rs777686147	816	A>T		No	ClinGen ExAC TOPMed gnomAD
rs1399620566 CA398601070	816	A>V		No	ClinGen gnomAD
CA288435374 rs1063688	818	D>H		No	ClinGen TOPMed
CA398601098 rs1063688	818	D>N		No	TOPMed ClinGen
rs1063688 CA398601100	818	D>Y		No	ClinGen TOPMed
CA398601135 rs902971774 CA288435397	819	M>I		No	gnomAD ClinGen
rs1289558675 CA398601122 CA398601118	819	M>L		No	ClinGen TOPMed gnomAD
rs1320791785 CA398601155	820	Q>R		No	ClinGen TOPMed
rs1364140346 CA398601169	821	G>S		No	ClinGen gnomAD
CA288435413 rs998576964	822	G>S		No	gnomAD ClinGen
rs1310435977 CA398601206	823	H>Y		No	gnomAD ClinGen
CA398601228 rs1246363175	824	A>T		No	gnomAD ClinGen
TCGA novel	824	A>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA8427177 rs770700565	825	V>A		No	ExAC gnomAD ClinGen
CA398601261 rs1242245617	826	L>F		No	ClinGen gnomAD
CA288435436 rs927210820	827	I>V		No	ClinGen TOPMed gnomAD
COSM976246 rs769047769 CA8427180	828	A>T	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
CA8427181 rs777155560	828	A>V		No	ClinGen ExAC gnomAD
CA398601371 rs1160037993	831	E>K		No	gnomAD ClinGen
rs1445826394 CA398601388	832	Q>E		No	gnomAD ClinGen
rs1301025525 CA398601418	833	F>L		No	ClinGen gnomAD
rs1382016360 CA398601428	834	K>R		No	TOPMed gnomAD ClinGen
CA8427201 rs770273813	837	T>I		No	ClinGen ExAC gnomAD
CA8427202 rs773581655	839	P>S		No	ClinGen ExAC gnomAD
CA398601580 rs1433873177	842	S>N		No	ClinGen gnomAD
rs774588509 CA8427205	843	A>T		No	ExAC TOPMed gnomAD ClinGen
CA8427206 rs202238913	843	A>V		No	ClinGen ExAC TOPMed gnomAD
CA8427208 rs147425213	845	T>S		No	ClinGen ESP ExAC TOPMed gnomAD
rs753689203 CA398601634	850	T>K		No	ClinGen ExAC TOPMed gnomAD
rs753689203 CA8427211	850	T>M	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ExAC TOPMed gnomAD ClinGen NCI-TCGA
TCGA novel	851	A>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA8427213 rs764819010	852	H>R		No	ClinGen ExAC gnomAD
rs757983633 CA8427215	853	E>A		No	ClinGen ExAC TOPMed gnomAD
CA398601655 rs56406965	853	E>D		No	ClinGen gnomAD
rs773392427 CA8427217	855	C>Y		No	ExAC TOPMed gnomAD ClinGen
CA8427218 rs370606765	856	R>C		No	ClinGen ESP ExAC TOPMed gnomAD
CA8427219 rs778217024	856	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ExAC TOPMed gnomAD ClinGen NCI-TCGA
CA398601672 rs778217024	856	R>L		No	ExAC TOPMed gnomAD ClinGen
rs1302175961 CA398601677	857	V>A		No	gnomAD ClinGen
CA8427220 rs139736306	858	R>C		No	ClinGen ESP ExAC TOPMed gnomAD
CA8427221 rs374323156	858	R>H		No	ClinGen ESP ExAC TOPMed gnomAD
CA8427222 rs201514093	861	A>T		No	ExAC TOPMed gnomAD ClinGen
CA8427223 rs746164885	861	A>V		No	ClinGen ExAC gnomAD
CA8427225 rs149935184	864	T>K		No	ESP ExAC TOPMed gnomAD ClinGen
rs149935184 CA8427226	864	T>M		No	ClinGen ESP ExAC TOPMed gnomAD
CA288436091 rs56367302	867	S>N		No	ClinGen Ensembl
rs761633860 CA8427229	871	E>D		No	ClinGen ExAC gnomAD
CA398601757 rs1261196043	871	E>K	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	gnomAD ClinGen NCI-TCGA
rs1243730400 CA398601770	872	D>E		No	TOPMed gnomAD ClinGen
CA8427230 rs544061480	872	D>G		No	1000Genomes ExAC TOPMed gnomAD ClinGen
CA398601775 rs1471758694	873	Y>C		No	ClinGen gnomAD
CA398601772 rs1399853987	873	Y>H		No	gnomAD ClinGen
rs1385631206 CA398601796	876	T>I		No	ClinGen gnomAD
rs1597880191 CA398601793	876	T>P		No	ClinGen Ensembl
rs1156396016 CA398601802	877	C>Y		No	TOPMed gnomAD ClinGen
CA8427233 rs765883586	879	A>V		No	ClinGen ExAC
rs1320876946 CA398601829	881	L>P		No	ClinGen gnomAD
CA398601835 rs1452507148	882	T>S		No	ClinGen gnomAD
CA8427236 rs780662788	884	L>V		No	ExAC gnomAD ClinGen
rs1376913641 CA398601866	887	V>A		No	ClinGen TOPMed gnomAD
CA8427238 rs368324953	887	V>I		No	ESP ExAC TOPMed gnomAD ClinGen
CA8427240 rs746158258	889	V>I	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA8427241 rs772341281	890	F>C		No	ClinGen ExAC
rs1182899552 CA398601893	891	S>L		No	TOPMed gnomAD ClinGen
rs1446160158 CA398601895	892	V>L		No	ClinGen gnomAD
CA398601902 rs1179261251	893	P>S		No	gnomAD ClinGen
rs148650631 CA8427243	894	G>A		No	ESP ExAC TOPMed gnomAD ClinGen
rs1035106704 CA288436210	896	R>Q		No	TOPMed gnomAD ClinGen
CA8427245 rs776846353	896	R>W		No	ExAC gnomAD ClinGen
rs372321860 CA8427246	897	P>R		No	ESP ExAC gnomAD ClinGen
rs1063691 CA288436228	898	Q>E		No	ClinGen Ensembl
rs1349461957 CA398601927	898	Q>R		No	TOPMed ClinGen
CA398601931 rs1337894246	899	V>M		No	TOPMed gnomAD ClinGen
rs200261115 CA8427248	900	H>R		No	ExAC TOPMed gnomAD ClinGen
CA8427250 rs766039892	902	S>T		No	ClinGen ExAC gnomAD
CA398601973 rs1445509696	904	I>M		No	TOPMed ClinGen
rs372721254 CA8427251	904	I>V		No	ESP ExAC TOPMed gnomAD ClinGen
rs374728959 CA8427252	905	R>Q		No	ClinGen ESP ExAC TOPMed gnomAD
CA398601977 rs1241448295 COSM1381315	905	R>W	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	gnomAD ClinGen cosmic curated NCI-TCGA
rs1313438656 CA398601991	906	K>*		No	TOPMed ClinGen
CA288436299 rs920246553	908	D>N		No	ClinGen Ensembl
rs767085574 CA8427253	909	I>V		No	ClinGen ExAC TOPMed gnomAD
CA8427255 rs752194023	910	S>R		No	ExAC gnomAD ClinGen
rs368834647 CA8427256	911	G>S		No	ClinGen ESP ExAC TOPMed gnomAD
rs750833588 CA8427257	912	I>V		No	ClinGen ExAC gnomAD
CA8427259 COSM976248 rs546007050	913	A>T	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
rs1419371061 CA398602087	914	S>L		No	ClinGen TOPMed gnomAD
CA398602099 rs1426603015	915	C>Y		No	gnomAD ClinGen
CA8427262 rs781433997	916	V>I	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA398602156 rs1298034286	918	T>M		No	ClinGen gnomAD
rs146676364 CA8427266	919	R>C		No	ClinGen ESP ExAC TOPMed gnomAD
COSM976254 CA8427267 rs749223309	919	R>H	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
CA398602181 rs1258609297	920	H>R		No	ClinGen TOPMed
rs770749833 CA8427268	920	H>Y		No	ClinGen ExAC gnomAD
CA8427296 rs546417717	924	F>L		No	1000Genomes ExAC gnomAD ClinGen
CA398603499 rs1425596468	929	P>A		No	TOPMed gnomAD ClinGen
TCGA novel	929	P>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	930	S>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	931	E>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA8427297 rs566558385	931	E>Q		No	ClinGen 1000Genomes ExAC gnomAD
CA8427300 rs767898770	932	F>L		No	ClinGen ExAC gnomAD
rs752002417 CA8427298	932	F>L		No	ExAC gnomAD ClinGen
rs755343498 CA8427299	932	F>S		No	ExAC gnomAD ClinGen
CA8427301 rs765248170	934	R>C		No	ExAC TOPMed gnomAD ClinGen
CA8427302 rs756351159	934	R>H		No	ClinGen ExAC gnomAD
rs983088433 CA288437232	936	S>T		No	Ensembl ClinGen
CA8427304 rs753901245	937	L>V		No	ExAC gnomAD ClinGen
rs907559516 CA288437248	938	S>N		No	TOPMed gnomAD ClinGen
rs367698200 CA8427306	940	R>Q		No	ESP ExAC TOPMed gnomAD ClinGen
rs757193789 CA8427305	940	R>W	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs1260770571 CA398603622	942	I>V		No	ClinGen gnomAD
rs140224169 CA8427308	943	T>I		No	ESP ExAC gnomAD ClinGen
CA8427310 rs746707281	945	P>L		No	ClinGen ExAC TOPMed gnomAD
rs776008239 CA8427312	946	L>F		No	ExAC gnomAD ClinGen
CA8427313 rs756544370	947	C>*		No	ClinGen ExAC
CA8427316 rs771585541	948	S>F		No	ClinGen ExAC gnomAD
rs1347029868 CA398603715	950	D>N		No	gnomAD ClinGen
TCGA novel	950	D>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1597881140 CA398603732	951	I>V		No	ClinGen Ensembl
rs760086303 CA8427318	952	N>K		No	ClinGen ExAC TOPMed gnomAD
rs767833603 CA8427319	953	W>*		No	ExAC gnomAD ClinGen
rs1370777305 CA398603782	954	P>R		No	gnomAD ClinGen
rs753088713 CA8427320	954	P>S		No	ClinGen ExAC TOPMed gnomAD
rs753088713 CA398603775	954	P>T		No	ClinGen ExAC TOPMed gnomAD
rs760825714 COSM96804 CA8427321	955	R>C	haematopoietic_and_lymphoid_tissue [Cosmic]	No	ExAC TOPMed gnomAD ClinGen cosmic curated
rs145213300 CA8427322	955	R>H		No	ClinGen ESP ExAC TOPMed gnomAD
rs145213300 CA288437308	955	R>P		No	ClinGen ESP ExAC TOPMed gnomAD
CA8427325 rs200133079	956	D>N	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ExAC TOPMed gnomAD ClinGen NCI-TCGA
rs1263015990 CA398603821	957	A>V		No	gnomAD ClinGen
rs1462060257 CA398603860	959	Q>H		No	gnomAD ClinGen
rs758352284 CA8427328	960	A>D		No	ExAC TOPMed gnomAD ClinGen
rs750401231 CA8427326	960	A>S		No	ClinGen ExAC gnomAD
rs758352284 CA8427327	960	A>V		No	ClinGen ExAC TOPMed gnomAD
rs146640740 CA8427329	961	S>T		No	ClinGen ESP ExAC TOPMed
rs1463146391 CA398604037	964	I>V		No	ClinGen TOPMed
CA8427347 rs537626619	965	R>*	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA288437494 rs537626619	965	R>G		No	ClinGen ExAC gnomAD
CA398604055 rs758272132	965	R>P		No	ExAC TOPMed gnomAD ClinGen
rs758272132 CA8427348	965	R>Q		No	ClinGen ExAC TOPMed gnomAD
rs1007327686 CA398604062	966	E>*		No	TOPMed gnomAD ClinGen
CA288437516 rs1007327686	966	E>K		No	ClinGen TOPMed gnomAD
CA8427350 rs751331580	968	P>R		No	ExAC TOPMed gnomAD ClinGen
rs766299600 CA8427349	968	P>S		No	ExAC gnomAD ClinGen
rs1402718142 CA398604111	969	K>R		No	ClinGen gnomAD
CA288437520 rs113789104	970	L>P		No	ClinGen Ensembl
CA8427352 rs781100746	971	S>R		No	ClinGen ExAC gnomAD
rs747874447 CA8427353	972	Q>P		No	ClinGen ExAC gnomAD
CA8427354 rs755811344	974	N>Y		No	ClinGen ExAC gnomAD
CA8427356 rs780960319	975	G>R		No	ExAC TOPMed gnomAD ClinGen
rs772491096 CA8427357	977	P>A		No	ExAC gnomAD ClinGen
CA8427358 rs150245335	977	P>L		No	1000Genomes ESP ExAC TOPMed gnomAD ClinGen
rs368197421 CA8427359	978	S>G		No	1000Genomes ESP ExAC TOPMed gnomAD ClinGen
rs762080475 CA8427362	982	A>V		No	ExAC TOPMed gnomAD ClinGen
rs773311507 CA8427364	983	P>S		No	ClinGen ExAC gnomAD
rs1287036922 CA398604320	984	Q>E		No	ClinGen TOPMed
CA8427365 rs763039590	985	S>R		No	ClinGen ExAC TOPMed gnomAD
rs149387516 CA8427366	985	S>R		No	ClinGen ExAC TOPMed gnomAD
rs1406553043 CA398604395	988	G>A		No	gnomAD ClinGen
TCGA novel	988	G>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA398604421 rs1448658070	990	P>R		No	ClinGen gnomAD
TCGA novel	991	D>G	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1391788447 CA398604459	992	P>L		No	TOPMed ClinGen
CA398604466 rs1326400002	993	A>S		No	gnomAD ClinGen
CA398604472 rs1164008398	993	A>V		No	TOPMed ClinGen
rs1597881916 CA398604496	995	S>R		No	Ensembl ClinGen
CA8427371 rs755829668	996	M>I		No	ClinGen ExAC TOPMed gnomAD
rs777531029 CA8427372	997	G>R		No	ExAC gnomAD ClinGen
CA8427374 rs756844509	998	P>L		No	ExAC gnomAD ClinGen
CA398604563 rs1203519133	999	D>H		No	TOPMed gnomAD ClinGen
rs1203519133 CA398604559	999	D>N		No	TOPMed gnomAD ClinGen
CA288437951 rs978312386	1000	T>I		No	TOPMed ClinGen
CA398604632 rs1597882367	1000	T>P		No	Ensembl ClinGen
rs143856264 CA8427389	1001	P>A		No	ESP ExAC TOPMed gnomAD ClinGen
CA8427390 rs548640506	1001	P>L		No	ClinGen 1000Genomes ExAC gnomAD
rs778545274 CA8427392	1004	P>S		No	ClinGen ExAC gnomAD
CA8427394 rs755481281	1005	E>K	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ExAC gnomAD ClinGen NCI-TCGA
rs781626874 CA8427395	1007	A>T		No	ExAC gnomAD ClinGen
rs748632290 CA8427396	1008	L>F		No	ExAC gnomAD ClinGen
rs377496629 CA8427397	1010	P>R		No	ClinGen ESP ExAC TOPMed gnomAD
rs1230363788 CA398604779	1011	M>T		No	gnomAD ClinGen
CA398604795 rs1213554926	1012	S>T		No	TOPMed ClinGen
CA8427400 rs2290510	1013	I>M		No	ExAC TOPMed gnomAD ClinGen
rs777994495 CA8427398	1013	I>V		No	ExAC gnomAD ClinGen
CA398604825 rs1256379537	1014	D>G		No	ClinGen gnomAD
CA8427401 rs774490299	1014	D>N		No	ExAC TOPMed gnomAD ClinGen
CA398604821 rs774490299	1014	D>Y		No	ExAC TOPMed gnomAD ClinGen
rs1313608479 CA398604844	1015	S>L		No	TOPMed ClinGen
rs1245605334 CA398604855	1016	A>V		No	ClinGen gnomAD
TCGA novel	1017	T>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs147236233 CA288438016	1021	T>A		No	ESP TOPMed gnomAD ClinGen
CA398604930 rs1193747098	1021	T>I		No	ClinGen TOPMed gnomAD
CA8427402 rs139770091	1022	T>M		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA288438025 rs975803890	1024	D>Y		No	ClinGen Ensembl
CA8427403 rs141785202	1025	T>A		No	ClinGen ESP ExAC TOPMed gnomAD
CA398604982 rs1475191155	1025	T>M		No	TOPMed ClinGen
CA288438026 rs181243082	1026	T>I		No	ClinGen 1000Genomes
TCGA novel	1028	D>G	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA8427408 rs764049583	1028	D>H		No	ClinGen ExAC TOPMed gnomAD
CA8427407 rs764049583	1028	D>N		No	ExAC TOPMed gnomAD ClinGen
rs145328108 CA8427412	1029	V>A		No	1000Genomes ESP ExAC TOPMed gnomAD ClinGen
CA8427410 rs374758088	1029	V>I	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ESP ExAC TOPMed gnomAD ClinGen NCI-TCGA
CA8427411 rs374758088	1029	V>L		No	ClinGen ESP ExAC TOPMed gnomAD
TCGA novel	1030	T>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1411894053 CA398605041	1034	V>M		No	gnomAD ClinGen
TCGA novel CA398605051 rs1344900825	1035	K>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen gnomAD NCI-TCGA
TCGA novel	1037	F>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs12944747 CA288438254	1040	S>F		No	ClinGen Ensembl
rs12944748 CA398605105	1041	S>C		No	gnomAD ClinGen
rs12944748 CA288438257	1041	S>F		No	ClinGen gnomAD
rs776480787 CA8427446	1042	E>A		No	ExAC gnomAD ClinGen
rs1269264604 CA398605128	1043	E>G		No	TOPMed gnomAD ClinGen
CA288438289 rs868564294	1046	K>N		No	ClinGen gnomAD
CA398605178 rs1597883125	1047	N>D		No	Ensembl ClinGen
CA288438293 rs979703198	1047	N>I		No	Ensembl ClinGen
CA398605208 rs1483732508	1049	R>S		No	ClinGen TOPMed gnomAD
rs1183754896 CA398605214	1050	N>D		No	gnomAD ClinGen
rs139560669 CA288438306	1050	N>K		No	ClinGen ESP TOPMed gnomAD
rs1384645713 CA398605240	1052	A>S		No	TOPMed ClinGen
rs1159977138 CA398605245	1052	A>V		No	ClinGen gnomAD
rs149699735 CA8427450	1055	E>K		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA398605288 rs1358302873	1056	A>T		No	gnomAD ClinGen
rs866303561 CA288438308	1057	H>N		No	TOPMed ClinGen
rs866303561 CA398605294	1057	H>Y		No	TOPMed ClinGen
CA398605309 rs146701026	1058	A>P		No	1000Genomes ESP ExAC TOPMed gnomAD ClinGen
CA8427451 rs146701026 COSM976258	1058	A>T	endometrium [Cosmic]	No	ClinGen cosmic curated 1000Genomes ESP ExAC TOPMed gnomAD
CA8427452 rs564274000	1058	A>V		No	1000Genomes ExAC gnomAD ClinGen
CA288438340 rs573168513	1059	C>R		No	gnomAD ClinGen
CA288438343 rs918103135	1060	A>D		No	ClinGen gnomAD
CA398605342 rs918103135	1060	A>V		No	gnomAD ClinGen
rs1222204199 CA398605348	1061	I>F		No	ClinGen gnomAD
rs1262920068 CA398605358	1062	L>M		No	gnomAD ClinGen
rs1212547463 CA398605369	1063	I>L		No	ClinGen gnomAD

No associated diseases with Q15334

6 regional properties for Q15334

Type	Name	Position	InterPro Accession
repeat	WD40 repeat	18 - 62	IPR001680-1
repeat	WD40 repeat	64 - 103	IPR001680-2
repeat	WD40 repeat	188 - 224	IPR001680-3
repeat	WD40 repeat	227 - 265	IPR001680-4
repeat	WD40 repeat	425 - 461	IPR001680-5
domain	Lethal giant larvae homologue 2	280 - 380	IPR013577

Functions

		Description
EC Number
Subcellular Localization	Early endosome membrane Golgi apparatus, trans-Golgi network membrane Golgi apparatus membrane Cell projection, axon Cytoplasm, cytoskeleton	Localized to the lateral membrane during the polarization and formation cell-cell contacts Enriched in developing axons (By similarity)
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

10 GO annotations of cellular component

Name	Definition
adherens junction	A cell-cell junction composed of the epithelial cadherin-catenin complex. The epithelial cadherins, or E-cadherins, of each interacting cell extend through the plasma membrane into the extracellular space and bind to each other. The E-cadherins bind to catenins on the cytoplasmic side of the membrane, where the E-cadherin-catenin complex binds to cytoskeletal components and regulatory and signaling molecules.
axon	The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter.
cortical actin cytoskeleton	The portion of the actin cytoskeleton, comprising filamentous actin and associated proteins, that lies just beneath the plasma membrane.
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytoskeleton	A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles.
early endosome membrane	The lipid bilayer surrounding an early endosome.
Golgi cis cisterna	The Golgi cisterna closest to the endoplasmic reticulum; the first processing compartment through which proteins pass after export from the ER.
Golgi membrane	The lipid bilayer surrounding any of the compartments of the Golgi apparatus.
plasma membrane	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
trans-Golgi network membrane	The lipid bilayer surrounding any of the compartments that make up the trans-Golgi network.

4 GO annotations of molecular function

Name	Definition
GTPase activator activity	Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP.
myosin II binding	Binding to a class II myosin, any member of the class of 'conventional' double-headed myosins that includes muscle myosin.
protein kinase binding	Binding to a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate.
structural molecule activity	The action of a molecule that contributes to the structural integrity of a complex or its assembly within or outside a cell.

10 GO annotations of biological process

Name	Definition
axonogenesis	De novo generation of a long process of a neuron, including the terminal branched region. Refers to the morphogenesis or creation of shape or form of the developing axon, which carries efferent (outgoing) action potentials from the cell body towards target cells.
cortical actin cytoskeleton organization	A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of actin-based cytoskeletal structures in the cell cortex, i.e. just beneath the plasma membrane.
establishment of spindle orientation	Any process that set the alignment of spindle relative to other cellular structures.
establishment or maintenance of epithelial cell apical/basal polarity	Any cellular process that results in the specification, formation or maintenance of the apicobasal polarity of an epithelial cell.
exocytosis	A process of secretion by a cell that results in the release of intracellular molecules (e.g. hormones, matrix proteins) contained within a membrane-bounded vesicle. Exocytosis can occur either by full fusion, when the vesicle collapses into the plasma membrane, or by a kiss-and-run mechanism that involves the formation of a transient contact, a pore, between a granule (for exemple of chromaffin cells) and the plasma membrane. The latter process most of the time leads to only partial secretion of the granule content. Exocytosis begins with steps that prepare vesicles for fusion with the membrane (tethering and docking) and ends when molecules are secreted from the cell.
Golgi to plasma membrane transport	The directed movement of substances from the Golgi to the plasma membrane in transport vesicles that move from the trans-Golgi network to the plasma membrane, where they fuse and release their contents by exocytosis.
protein-containing complex assembly	The aggregation, arrangement and bonding together of a set of macromolecules to form a protein-containing complex.
regulation of establishment or maintenance of cell polarity	Any process that modulates the frequency, rate or extent of the specification, formation or maintenance of anisotropic intracellular organization or cell growth patterns.
regulation of Notch signaling pathway	Any process that modulates the frequency, rate or extent of the Notch signaling pathway.
regulation of protein secretion	Any process that modulates the frequency, rate or extent of the controlled release of a protein from a cell.

13 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
P38163	SRO77	Lethal(2) giant larvae protein homolog SRO77	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)	PR
Q12038	SRO7	Lethal(2) giant larvae protein homolog SRO7	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)	PR
Q8MKF0	LLGL1	Lethal(2) giant larvae protein homolog 1	Bos taurus (Bovine)	PR
Q6P1M3	LLGL2	LLGL scribble cell polarity complex component 2	Homo sapiens (Human)	PR
Q9Y2K9	STXBP5L	Syntaxin-binding protein 5-like	Homo sapiens (Human)	PR
Q5T5C0	STXBP5	Syntaxin-binding protein 5	Homo sapiens (Human)	PR
Q8K400	Stxbp5	Syntaxin-binding protein 5	Mus musculus (Mouse)	PR
Q5DQR4	Stxbp5l	Syntaxin-binding protein 5-like	Mus musculus (Mouse)	PR
Q80Y17	Llgl1	Lethal(2) giant larvae protein homolog 1	Mus musculus (Mouse)	PR
Q9WU70	Stxbp5	Syntaxin-binding protein 5	Rattus norvegicus (Rat)	PR
Q8K4K5	Llgl1	Lethal(2) giant larvae protein homolog 1	Rattus norvegicus (Rat)	PR
Q5SQE2	stxbp5l	Syntaxin-binding protein 5-like	Danio rerio (Zebrafish) (Brachydanio rerio)	PR
Q7SZE3	llgl2	LLGL scribble cell polarity complex component 2	Danio rerio (Zebrafish) (Brachydanio rerio)	PR

10	20	30	40	50	60
MMKFRFRRQG	ADPQREKLKQ	ELFAFNKTVE	HGFPNQPSAL	AFDPELRIMA	IGTRSGAVKI
70	80	90	100	110	120
YGAPGVEFTG	LHRDAATVTQ	MHFLTGQGRL	LSLLDDSSLH	LWEIVHHNGC	AHLEEALSFQ
130	140	150	160	170	180
LPSRPGFDGA	SAPLSLTRVT	VVLLVAASDI	AALGTEGSSV	FFLDVTTLTL	LEGQTLAPGE
190	200	210	220	230	240
VLRSVPDDYR	CGKALGPVES	LQGHLRDPTK	ILIGYSRGLL	VIWNQASQCV	DHIFLGNQQL
250	260	270	280	290	300
ESLCWGRDSS	TVVSSHSDGS	YAVWSVDAGS	FPTLQPTVAT	TPYGPFPCKA	INKILWRNCE
310	320	330	340	350	360
SGGHFIIFSG	GMPRASYGDR	HCVSVLRAET	LVTLDFTSRI	IDFFTVHSTR	PEDEFDDPQA
370	380	390	400	410	420
LAVLLEEELV	VLDLQTPGWP	AVPAPYLAPL	HSSAITCSAH	VASVPAKLWA	RIVSAGEQQS
430	440	450	460	470	480
PQPVSSALSW	PITGGRNLAQ	EPSQRGLLLT	GHEDGTVRFW	DASGVALRPL	YKLSTAGLFQ
490	500	510	520	530	540
TDCEHADSLA	QAAEDDWPPF	RKVGCFDPYS	DDPRLGVQKV	ALCKYTAQMV	VAGTAGQVLV
550	560	570	580	590	600
LELSDVPVEQ	AVSVAIIDLL	QDREGFTWKG	HERLSPRTGP	LPWPAGFQPR	VLVQCLPPAA
610	620	630	640	650	660
VTAVTLHTEW	SLVAFGTSHG	FGLFDYQRKS	PVLARCTLHP	NDSLAMEGPL	SRVKSLKKSL
670	680	690	700	710	720
RQSFRRIRKS	RVSGKKRAAN	ASSKLQEANA	QLAEQACPHD	VEMTPVQRRI	EPRSADDSLS
730	740	750	760	770	780
GVVRCLYFAD	TFLRDGAHHG	PTMWAGTNSG	SVFAYALEVP	AAAVGGEKRP	EQAVEAVLGK
790	800	810	820	830	840
EVQLMHRAPV	VAIAVLDGRG	RPLPEPYEAS	RDLAQAPDMQ	GGHAVLIASE	EQFKVFTLPK
850	860	870	880	890	900
VSAKTKFKLT	AHEGCRVRKV	ALATFASVAC	EDYAETCLAC	LTNLGDVHVF	SVPGLRPQVH
910	920	930	940	950	960
YSCIRKEDIS	GIASCVFTRH	GQGFYLISPS	EFERFSLSAR	NITEPLCSLD	INWPRDATQA
970	980	990	1000	1010	1020
SYRIRESPKL	SQANGTPSIL	LAPQSLDGSP	DPAHSMGPDT	PEPPEAALSP	MSIDSATSAD
1030	1040	1050	1060
TTLDTTGDVT	VEDVKDFLGS	SEESEKNLRN	LAEDEAHACA	ILIK