Q7SZE3

PR
Gene name
llgl2 (pen)
Protein name
LLGL scribble cell polarity complex component 2
Names
Lethal(2) giant larvae protein homolog 2, Protein penner
Species
Danio rerio (Zebrafish) (Brachydanio rerio)
KEGG Pathway
dre:795670
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-52 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q7SZE3

Entry ID Method Resolution Chain Position Source
AF-Q7SZE3-F1 Predicted AlphaFoldDB

No variants for Q7SZE3

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q7SZE3

No associated diseases with Q7SZE3

5 regional properties for Q7SZE3

Type Name Position InterPro Accession
repeat WD40 repeat 24 - 60 IPR001680-1
repeat WD40 repeat 62 - 110 IPR001680-2
repeat WD40 repeat 220 - 258 IPR001680-3
repeat WD40 repeat 392 - 449 IPR001680-4
domain Lethal giant larvae homologue 2 272 - 370 IPR013577

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm, cytoskeleton
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
cortical actin cytoskeleton The portion of the actin cytoskeleton, comprising filamentous actin and associated proteins, that lies just beneath the plasma membrane.
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

2 GO annotations of molecular function

Name Definition
GTPase activator activity Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP.
myosin II binding Binding to a class II myosin, any member of the class of 'conventional' double-headed myosins that includes muscle myosin.

21 GO annotations of biological process

Name Definition
cell projection assembly Formation of a prolongation or process extending from a cell, e.g. a flagellum or axon.
cortical actin cytoskeleton organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of actin-based cytoskeletal structures in the cell cortex, i.e. just beneath the plasma membrane.
cytoskeleton organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures.
epidermis development The process whose specific outcome is the progression of the epidermis over time, from its formation to the mature structure. The epidermis is the outer epithelial layer of an animal, it may be a single layer that produces an extracellular material (e.g. the cuticle of arthropods) or a complex stratified squamous epithelium, as in the case of many vertebrate species.
establishment of spindle orientation Any process that set the alignment of spindle relative to other cellular structures.
exocytosis A process of secretion by a cell that results in the release of intracellular molecules (e.g. hormones, matrix proteins) contained within a membrane-bounded vesicle. Exocytosis can occur either by full fusion, when the vesicle collapses into the plasma membrane, or by a kiss-and-run mechanism that involves the formation of a transient contact, a pore, between a granule (for exemple of chromaffin cells) and the plasma membrane. The latter process most of the time leads to only partial secretion of the granule content. Exocytosis begins with steps that prepare vesicles for fusion with the membrane (tethering and docking) and ends when molecules are secreted from the cell.
hemidesmosome assembly Assembly of hemidesmosomes, integrin-containing protein complexes that bind to laminin in the basal lamina. Hemidesmosomes form the contact between the basal surface of epithelial cells and the underlying basal lamina.
Kupffer's vesicle development The progression of the Kupffer's vesicle over time from its initial formation until its mature state. The Kupffer's vesicle is a small but distinctive epithelial sac containing fluid, located midventrally posterior to the yolk cell or its extension, and transiently present during most of the segmentation period.
motile cilium assembly The aggregation, arrangement and bonding together of a set of components to form a motile cilium.
negative regulation of cell migration Any process that stops, prevents, or reduces the frequency, rate or extent of cell migration.
negative regulation of cell population proliferation Any process that stops, prevents or reduces the rate or extent of cell proliferation.
negative regulation of epithelial cell proliferation Any process that stops, prevents or reduces the rate or extent of epithelial cell proliferation.
negative regulation of epithelial to mesenchymal transition Any process that decreases the rate, frequency, or extent of epithelial to mesenchymal transition. Epithelial to mesenchymal transition where an epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell.
photoreceptor cell morphogenesis The process in which the structures of a photoreceptor cell are generated and organized. This process occurs while the initially relatively unspecialized cell is acquiring the specialized features of a photoreceptor cell, a sensory cell that reacts to the presence of light. An example of this is found in Drosophila melanogaster.
posterior lateral line neuromast development The process whose specific outcome is the progression of the posterior lateral line neuromast over time, from its formation to the mature structure. The neuromast is the sensory receptor of the anterior lateral line system and is composed of a population of sensory hair cells, and nonsensory supporting cells and mantle cells. Neuromast are located superficially on the epithelium or in lateral line canals.
regulation of epidermis development Any process that modulates the frequency, rate or extent of epidermis development.
regulation of establishment or maintenance of cell polarity Any process that modulates the frequency, rate or extent of the specification, formation or maintenance of anisotropic intracellular organization or cell growth patterns.
regulation of Notch signaling pathway Any process that modulates the frequency, rate or extent of the Notch signaling pathway.
regulation of protein secretion Any process that modulates the frequency, rate or extent of the controlled release of a protein from a cell.
skin development The process whose specific outcome is the progression of the skin over time, from its formation to the mature structure. The skin is the external membranous integument of an animal. In vertebrates the skin generally consists of two layers, an outer nonsensitive and nonvascular epidermis (cuticle or skarfskin) composed of cells which are constantly growing and multiplying in the deeper, and being thrown off in the superficial layers, as well as an inner vascular dermis (cutis, corium or true skin) composed mostly of connective tissue.
skin epidermis development The process whose specific outcome is the progression of the skin epidermis over time, from its formation to the mature structure.

12 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P38163 SRO77 Lethal(2) giant larvae protein homolog SRO77 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PR
Q12038 SRO7 Lethal(2) giant larvae protein homolog SRO7 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PR
Q15334 LLGL1 Lethal(2) giant larvae protein homolog 1 Homo sapiens (Human) PR
Q5T5C0 STXBP5 Syntaxin-binding protein 5 Homo sapiens (Human) PR
Q9Y2K9 STXBP5L Syntaxin-binding protein 5-like Homo sapiens (Human) PR
Q6P1M3 LLGL2 LLGL scribble cell polarity complex component 2 Homo sapiens (Human) PR
Q80Y17 Llgl1 Lethal(2) giant larvae protein homolog 1 Mus musculus (Mouse) PR
Q8K400 Stxbp5 Syntaxin-binding protein 5 Mus musculus (Mouse) PR
Q5DQR4 Stxbp5l Syntaxin-binding protein 5-like Mus musculus (Mouse) PR
Q8K4K5 Llgl1 Lethal(2) giant larvae protein homolog 1 Rattus norvegicus (Rat) PR
Q9WU70 Stxbp5 Syntaxin-binding protein 5 Rattus norvegicus (Rat) PR
Q5SQE2 stxbp5l Syntaxin-binding protein 5-like Danio rerio (Zebrafish) (Brachydanio rerio) PR
10 20 30 40 50 60
MKRFRRHGHE SQRDKHKQDL YQFNKTVEHG FPHQPSALGF SPSLELLAIG TRSGAIKLYG
70 80 90 100 110 120
APGVEFMGLH DENAAVTQVH FLPNQVELVT LLEDNSLHMW TLRAHNSMCE LLEIGRFTLS
130 140 150 160 170 180
GPPGAIPSVT RVTAVLAHSS GELLLLGTEG GHVFVVEVPG FRELEENNIS VEDVQNRVPE
190 200 210 220 230 240
DYVGRRNLES VETLHENPLN PRQVLIGYSR GLMVLWDLDR QRPVQHFLGT QQLESVWWME
250 260 270 280 290 300
DGESILSSHS DGSYCQWTVT GEDPQTEPEK QETPYGAFPC KAISKIIQLP SKQGPPFLIF
310 320 330 340 350 360
SGGMPRASYG DRHCISVIHS KTHEALDFTS RIIDFFVIRE GENHKGEPSA LVVLVEEELV
370 380 390 400 410 420
VVDLQTEGWP VIQTPYLVPL HCSAITCSHH VSSIPLKLWE RVQAAGAHQN THYSRKPWPI
430 440 450 460 470 480
NGGKNLAPDP PQRDLLLTGH EDGTVRFWDA SGVCLYPMYK LSTAGVFHTD ADPNDNMNQG
490 500 510 520 530 540
SEGEWPPFRK VGCFDPYSDD PRLGIQKIHL CKYSGYLTVA GTAGQILVLE LNDEAAEQMV
550 560 570 580 590 600
EATVVDLLQG QEGFRWKGQA RLDVREEPVL FPPGFQPFAL VQCQPPAVVT AIALHSEWKL
610 620 630 640 650 660
VGFGTSHGFG LYDYNQRNNI MVKCTLNPSD QMAMEGPLSR VKSIKKSLRQ SFRRIRRSRV
670 680 690 700 710 720
SMRKHHTNNA AKLQEINARL EAEALQEMEL APVQRKIEAR SSDDSFTGLV RTLYFADTFV
730 740 750 760 770 780
SDSSHSTPSL WAGTNGGAVF AYVLRVPPQE RRAEDPVTAH AAKEIQLMHR APVVGLVVLD
790 800 810 820 830 840
GKGAPLPEPL EVAHDLARSP EMHGSHHLLV VSEEQFKLFT LPKVSSKSKL KLTAVDGSRV
850 860 870 880 890 900
RRVGVAWFGS RTDEQLESCL VVLTNQGELH VISLPSIKML VHYPCIRRED VSGIASCVFT
910 920 930 940 950 960
KYGQGFYLIS PSEFERFSLS TRWVVQPHCL VEPPLQMRSK SPSSPVHRDL PDGVPTEHRN
970 980 990 1000 1010
FKGDSEGYEN SARQVMEHAL LNDESVLQEI QKSLEGDQTT FLENNLKTKP KAGNVLSNGD