Q9WU70

PR
Gene name
Stxbp5 (Llgl3)
Protein name
Syntaxin-binding protein 5
Names
Lethal(2) giant larvae protein homolog 3, Tomosyn-1
Species
Rattus norvegicus (Rat)
KEGG Pathway
rno:81022
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-69 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

2 structures for Q9WU70

Entry ID Method Resolution Chain Position Source
1URQ X-ray 200 A A 1086-1145 PDB
AF-Q9WU70-F1 Predicted AlphaFoldDB

No variants for Q9WU70

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q9WU70

No associated diseases with Q9WU70

No regional properties for Q9WU70

Type Name Position InterPro Accession
No domain, repeats, and functional sites for Q9WU70

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm
  • Cell membrane ; Peripheral membrane protein
  • Cytoplasmic vesicle membrane ; Peripheral membrane protein
  • Synapse
  • Cytoplasmic vesicle, secretory vesicle, synaptic vesicle
  • Cytoplasmic, and associated with vesicular membranes and the plasma membrane
  • Detected at synapses and on synaptic vesicles
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

14 GO annotations of cellular component

Name Definition
acetylcholine-gated channel complex A homo- or hetero-pentameric protein complex that forms a transmembrane channel through which ions may pass in response to acetylcholine binding.
anchoring junction A cell junction that mechanically attaches a cell (and its cytoskeleton) to neighboring cells or to the extracellular matrix.
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
extrinsic component of neuronal dense core vesicle membrane The component of the neuronal dense core vesicle membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region.
extrinsic component of presynaptic membrane The component of the presynaptic membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region.
hippocampal mossy fiber to CA3 synapse One of the giant synapses that form between the mossy fiber axons of dentate gyrus granule cells and the large complex spines of CA3 pyramidal cells. It consists of a giant bouton known as the mossy fiber expansion, synapsed to the complex, multiheaded spine (thorny excresence) of a CA3 pyramidal cell.
neuromuscular junction The junction between the axon of a motor neuron and a muscle fiber. In response to the arrival of action potentials, the presynaptic button releases molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane of the muscle fiber, leading to a change in post-synaptic potential.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
presynapse The part of a synapse that is part of the presynaptic cell.
presynaptic cytosol The region of the cytosol consisting of all cytosol that is part of the presynapse.
Schaffer collateral - CA1 synapse A synapse between the Schaffer collateral axon of a CA3 pyramidal cell and a CA1 pyramidal cell.
secretory granule A small subcellular vesicle, surrounded by a membrane, that is formed from the Golgi apparatus and contains a highly concentrated protein destined for secretion. Secretory granules move towards the periphery of the cell and upon stimulation, their membranes fuse with the cell membrane, and their protein load is exteriorized. Processing of the contained protein may take place in secretory granules.
SNARE complex A protein complex involved in membrane fusion; a stable ternary complex consisting of a four-helix bundle, usually formed from one R-SNARE and three Q-SNAREs with an ionic layer sandwiched between hydrophobic layers. One well-characterized example is the neuronal SNARE complex formed of synaptobrevin 2, syntaxin 1a, and SNAP-25.
synaptic vesicle A secretory organelle, typically 50 nm in diameter, of presynaptic nerve terminals; accumulates in high concentrations of neurotransmitters and secretes these into the synaptic cleft by fusion with the 'active zone' of the presynaptic plasma membrane.

4 GO annotations of molecular function

Name Definition
GTPase activator activity Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP.
myosin II binding Binding to a class II myosin, any member of the class of 'conventional' double-headed myosins that includes muscle myosin.
syntaxin binding Binding to a syntaxin, a SNAP receptor involved in the docking of synaptic vesicles at the presynaptic zone of a synapse.
syntaxin-1 binding Binding to a syntaxin-1 SNAP receptor.

8 GO annotations of biological process

Name Definition
exocytosis A process of secretion by a cell that results in the release of intracellular molecules (e.g. hormones, matrix proteins) contained within a membrane-bounded vesicle. Exocytosis can occur either by full fusion, when the vesicle collapses into the plasma membrane, or by a kiss-and-run mechanism that involves the formation of a transient contact, a pore, between a granule (for exemple of chromaffin cells) and the plasma membrane. The latter process most of the time leads to only partial secretion of the granule content. Exocytosis begins with steps that prepare vesicles for fusion with the membrane (tethering and docking) and ends when molecules are secreted from the cell.
positive regulation of exocytosis Any process that activates or increases the frequency, rate or extent of exocytosis.
protein transport The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
regulation of exocytosis Any process that modulates the frequency, rate or extent of exocytosis.
regulation of protein secretion Any process that modulates the frequency, rate or extent of the controlled release of a protein from a cell.
regulation of synaptic vesicle exocytosis Any process that modulates the frequency, rate or extent of synaptic vesicle exocytosis.
regulation of synaptic vesicle priming Any process that modulates the frequency, rate or extent of synaptic vesicle priming. Synaptic vesicle priming is the formation of SNARE-containing complexes, bringing synaptic vesicle membrane and plasma membranes into close proximity and thereby facilitating membrane fusion.
synaptic vesicle cycle A biological process in which synaptic vesicles are loaded with neurotransmitters, move to the active zone, exocytose and are then recycled via endocytosis, ultimately leading to reloading with neurotransmitters.

10 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q9Y2K9 STXBP5L Syntaxin-binding protein 5-like Homo sapiens (Human) PR
Q15334 LLGL1 Lethal(2) giant larvae protein homolog 1 Homo sapiens (Human) PR
Q6P1M3 LLGL2 LLGL scribble cell polarity complex component 2 Homo sapiens (Human) PR
Q5T5C0 STXBP5 Syntaxin-binding protein 5 Homo sapiens (Human) PR
Q80Y17 Llgl1 Lethal(2) giant larvae protein homolog 1 Mus musculus (Mouse) PR
Q5DQR4 Stxbp5l Syntaxin-binding protein 5-like Mus musculus (Mouse) PR
Q8K400 Stxbp5 Syntaxin-binding protein 5 Mus musculus (Mouse) PR
Q8K4K5 Llgl1 Lethal(2) giant larvae protein homolog 1 Rattus norvegicus (Rat) PR
Q5SQE2 stxbp5l Syntaxin-binding protein 5-like Danio rerio (Zebrafish) (Brachydanio rerio) PR
Q7SZE3 llgl2 LLGL scribble cell polarity complex component 2 Danio rerio (Zebrafish) (Brachydanio rerio) PR
10 20 30 40 50 60
MRKFNIRKVL DGLTAGSSSA SQQQQQQQHP PGNREPEIQE TLQSEHFQLC KTVRHGFPYQ
70 80 90 100 110 120
PSALAFDPVQ KILAVGTQTG ALRLFGRPGV ECYCQHDSGA AVIQLQFLIN EGALVSALAD
130 140 150 160 170 180
DTLHLWNLRQ KRPAVLHSLK FCRERVTFCH LPFQSKWLYV GTERGNIHIV NVESFTLSGY
190 200 210 220 230 240
VIMWNKAIEL SSKSHPGPVV HISDNPMDEG KLLIGFESGT VVLWDLKSKK ADYRYTYDEA
250 260 270 280 290 300
IHSVAWHHEG KQFICSHSDG TLTIWNVRSP TKPVQTITPH GKQLKDGKKP EPCKPILKVE
310 320 330 340 350 360
FKTTRSGEPF IILSGGLSYD TVGRRPCLTV MHGKSTAVLE MDYSIVDFLT LCETPYPNDF
370 380 390 400 410 420
QEPYAVVVLL EKDLVLIDLA QNGYPIFENP YPLSIHESPV TCCEYFADCP VDLIPALYSV
430 440 450 460 470 480
GARQKRQGYS KKEWPINGGN WGLGAQSYPE IIITGHADGS IKFWDASAIT LQVLYKLKTS
490 500 510 520 530 540
KVFEKSRNKD DRQNTDIVDE DPYAIQIISW CPESRMLCIA GVSAHVIIYR FSKQEVVTEV
550 560 570 580 590 600
IPMLEVRLLY EINDVETPEG EQPPPLSTPV GSSTSQPIPP QSHPSTSSSS SDGLRDNVPC
610 620 630 640 650 660
LKVKNSPLKQ SPGYQTELVI QLVWVGGEPP QQITSLALNS SYGLVVFGNS NGIAMVDYLQ
670 680 690 700 710 720
KAVLLNLSTI ELYGSNDPYR REPRSPRKSR QPSGAGLCDI TEGTVVPEDR CKSPTSGSSS
730 740 750 760 770 780
PHNSDDEQKV NNFIEKVKTQ SRKFSKMVAS DLAKMSRKLS LPTDLKPDLD VKDNSFSRSR
790 800 810 820 830 840
SSSVTSIDKE SREAISALHF CETFTRKADS SPSPCLWVGT TVGTAFVITL NLPLGPEQRL
850 860 870 880 890 900
LQPVIVSPSG TILRLKGAIL RMAFLDAAGC LMPPAYEPWT EHNVPEEKDE KEKLKKRRPV
910 920 930 940 950 960
SVSPSSSQEI SENQYAVICS EKQAKVISLP TQNCAYKQNI TETSFVLRGD IVALSNSVCL
970 980 990 1000 1010 1020
ACFCANGHIM TFSLPSLRPL LDVYYLPLTN MRIARTFCFA NSGQALYLVS PTEIQRLTYS
1030 1040 1050 1060 1070 1080
QETCENLQEM LGELFTPVET PEAPNRGFFK GLFGGGAQSL DREELFGESS SGKASRSLAQ
1090 1100 1110 1120 1130 1140
HIPGPGGIEG VKGAASGVVG ELARARLALD ERGQKLSDLE ERTAAMMSSA DSFSKHAHEM
1150
MLKYKDKKWY QF