Q5DQR4
PR
Gene name |
Stxbp5l (Llgl4) |
Protein name |
Syntaxin-binding protein 5-like |
Names |
Lethal(2) giant larvae protein homolog 4, Tomosyn-2 |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:207227 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q5DQR4
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q5DQR4-F1 | Predicted | AlphaFoldDB |
38 variants for Q5DQR4
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs241998023 | 41 | T>I | No | EVA | |
| rs1133610005 | 79 | P>S | No | EVA | |
| rs1134790332 | 81 | Q>H | No | EVA | |
| rs3389412536 | 96 | L>F | No | EVA | |
| rs3389414273 | 98 | R>G | No | EVA | |
| rs264543461 | 109 | S>N | No | EVA | |
| rs3389418267 | 121 | N>D | No | EVA | |
| rs3389421292 | 231 | T>I | No | EVA | |
| rs3389408831 | 245 | R>K | No | EVA | |
| rs3389414339 | 246 | V>L | No | EVA | |
| rs3389425827 | 247 | Y>* | No | EVA | |
| rs3389396774 | 323 | I>K | No | EVA | |
| rs3389407582 | 333 | A>T | No | EVA | |
| rs3389421293 | 361 | T>M | No | EVA | |
| rs3389410427 | 361 | T>S | No | EVA | |
| rs3406803198 | 461 | E>K | No | EVA | |
| rs249449441 | 547 | V>I | No | EVA | |
| rs3405178122 | 586 | S>* | No | EVA | |
| rs3406522304 | 735 | P>Q | No | EVA | |
| rs3406803180 | 738 | L>R | No | EVA | |
| rs3406522269 | 738 | L>V | No | EVA | |
| rs3389364698 | 821 | S>F | No | EVA | |
| rs3389414346 | 822 | S>N | No | EVA | |
| rs3389376018 | 826 | D>N | No | EVA | |
| rs218152744 | 848 | V>I | No | EVA | |
| rs3389425873 | 856 | T>I | No | EVA | |
| rs3406698003 | 909 | Q>E | No | EVA | |
| rs4173885 | 937 | S>L | results in attenuation of insulin secretion; increased protein stability [UniProt] | No | EVA |
| rs3389412583 | 1024 | M>I | No | EVA | |
| rs3389432501 | 1048 | Q>K | No | EVA | |
| rs3389415301 | 1064 | L>* | No | EVA | |
| rs3389396730 | 1099 | F>* | No | EVA | |
| rs3389418261 | 1117 | G>R | No | EVA | |
| rs3389331965 | 1120 | S>T | No | EVA | |
| rs3389412612 | 1127 | A>D | No | EVA | |
| rs3389408869 | 1128 | A>G | No | EVA | |
| rs3389410425 | 1148 | R>C | No | EVA | |
| rs3389432458 | 1154 | E>K | No | EVA |
No associated diseases with Q5DQR4
4 regional properties for Q5DQR4
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Signal recognition particle, SRP54 subunit, GTPase domain | 96 - 293 | IPR000897 |
| domain | AAA+ ATPase domain | 95 - 298 | IPR003593 |
| domain | Signal recognition particle, SRP54 subunit, M-domain | 327 - 426 | IPR004125 |
| domain | Signal recognition particle SRP54, helical bundle | 1 - 82 | IPR013822 |
Functions
5 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| neuromuscular junction | The junction between the axon of a motor neuron and a muscle fiber. In response to the arrival of action potentials, the presynaptic button releases molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane of the muscle fiber, leading to a change in post-synaptic potential. |
| neuronal dense core vesicle | A dense core vesicle (granule) that is part of a neuron. These vesicles typically contain neuropeptides. They can be found in all parts of neurons, including the soma, dendrites, axonal swellings (varicosities) and synaptic terminals. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
| SNARE complex | A protein complex involved in membrane fusion; a stable ternary complex consisting of a four-helix bundle, usually formed from one R-SNARE and three Q-SNAREs with an ionic layer sandwiched between hydrophobic layers. One well-characterized example is the neuronal SNARE complex formed of synaptobrevin 2, syntaxin 1a, and SNAP-25. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| GTPase activator activity | Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP. |
| myosin II binding | Binding to a class II myosin, any member of the class of 'conventional' double-headed myosins that includes muscle myosin. |
| syntaxin binding | Binding to a syntaxin, a SNAP receptor involved in the docking of synaptic vesicles at the presynaptic zone of a synapse. |
7 GO annotations of biological process
| Name | Definition |
|---|---|
| exocytosis | A process of secretion by a cell that results in the release of intracellular molecules (e.g. hormones, matrix proteins) contained within a membrane-bounded vesicle. Exocytosis can occur either by full fusion, when the vesicle collapses into the plasma membrane, or by a kiss-and-run mechanism that involves the formation of a transient contact, a pore, between a granule (for exemple of chromaffin cells) and the plasma membrane. The latter process most of the time leads to only partial secretion of the granule content. Exocytosis begins with steps that prepare vesicles for fusion with the membrane (tethering and docking) and ends when molecules are secreted from the cell. |
| glucose homeostasis | Any process involved in the maintenance of an internal steady state of glucose within an organism or cell. |
| negative regulation of insulin secretion | Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of insulin. |
| protein transport | The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. |
| regulation of exocytosis | Any process that modulates the frequency, rate or extent of exocytosis. |
| regulation of protein secretion | Any process that modulates the frequency, rate or extent of the controlled release of a protein from a cell. |
| regulation of synaptic vesicle exocytosis | Any process that modulates the frequency, rate or extent of synaptic vesicle exocytosis. |
10 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q15334 | LLGL1 | Lethal(2) giant larvae protein homolog 1 | Homo sapiens (Human) | PR |
| Q5T5C0 | STXBP5 | Syntaxin-binding protein 5 | Homo sapiens (Human) | PR |
| Q6P1M3 | LLGL2 | LLGL scribble cell polarity complex component 2 | Homo sapiens (Human) | PR |
| Q9Y2K9 | STXBP5L | Syntaxin-binding protein 5-like | Homo sapiens (Human) | PR |
| Q80Y17 | Llgl1 | Lethal(2) giant larvae protein homolog 1 | Mus musculus (Mouse) | PR |
| Q8K400 | Stxbp5 | Syntaxin-binding protein 5 | Mus musculus (Mouse) | PR |
| Q8K4K5 | Llgl1 | Lethal(2) giant larvae protein homolog 1 | Rattus norvegicus (Rat) | PR |
| Q9WU70 | Stxbp5 | Syntaxin-binding protein 5 | Rattus norvegicus (Rat) | PR |
| Q7SZE3 | llgl2 | LLGL scribble cell polarity complex component 2 | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| Q5SQE2 | stxbp5l | Syntaxin-binding protein 5-like | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MKKFNFRKVL | DGLTASSPGS | GSSSGSNSGG | AGSGSVHPGG | TAGLPREEIQ | ESLTSDYFQI |
| 70 | 80 | 90 | 100 | 110 | 120 |
| CKTVRHGFPY | QPTALAFDPV | QKILAIGTRT | GAIRILGRPG | VDCYCQHESG | AAVLQLQFLI |
| 130 | 140 | 150 | 160 | 170 | 180 |
| NEGALVSASS | DDTLHLWNLR | QKRPAILHSL | KFNRERITYC | HLPFQSKWLY | VGTERGNTHI |
| 190 | 200 | 210 | 220 | 230 | 240 |
| VNIESFILSG | YVIMWNKAIE | LSTKTHPGPV | VHLSDSPRDE | GKLLIGYENG | TVVFWDLKSK |
| 250 | 260 | 270 | 280 | 290 | 300 |
| RAELRVYYDE | AIHSIDWHHE | GKQFMCSHSD | GSLTLWNLKS | PSRPFQTTVP | HGKSQREGRK |
| 310 | 320 | 330 | 340 | 350 | 360 |
| SESCKPILKV | EYKTCRNSEP | FIIFSGGLSY | DKACRRPSLT | IMHGKAITVL | EMDHPIVEFL |
| 370 | 380 | 390 | 400 | 410 | 420 |
| TLCETPYPNE | FQEPYAVAVL | LEKDLIVVDL | TQTNFPIFEN | PYPMDIHESP | VTCTAYFADC |
| 430 | 440 | 450 | 460 | 470 | 480 |
| PPDLILVLYS | IGVKHKKQGY | SNKEWPVSGG | AWNLGAQTYP | EIIITGHADG | TIKFWDASAM |
| 490 | 500 | 510 | 520 | 530 | 540 |
| TLQMLYKLKT | SKVFEKQKAG | EGKQTCELVE | EDPFAVQMIY | WCPESRIFCV | SGVSAYVIIY |
| 550 | 560 | 570 | 580 | 590 | 600 |
| KFSRHEVTTE | IVSLEVRLQC | DVEDIITPEP | ETSPPFPDLS | SQLPPSRSLS | GSTNTVSSEG |
| 610 | 620 | 630 | 640 | 650 | 660 |
| VTKDSIPCLS | VKTRPVRMPP | GYQADLVIQL | VWVDGEPPQQ | ITSLSISSAY | GIVAFGNCTG |
| 670 | 680 | 690 | 700 | 710 | 720 |
| LVVVDFIQKT | VLLSMGTIDL | YRSSDLYQRQ | PRSPRKNRQF | IADNFCMRGL | SNFYPDLTKR |
| 730 | 740 | 750 | 760 | 770 | 780 |
| IRTSYQSLTE | LNDSPVPLEL | ERCKSPTSDH | VNGHCTSPTS | QSCSSGKRLS | SADVSKVNRW |
| 790 | 800 | 810 | 820 | 830 | 840 |
| GPGRPPFRKA | QSAACMEISL | PVTTEETREN | SYNRSRSSSI | SSIDKDSKEA | ITALYFMESF |
| 850 | 860 | 870 | 880 | 890 | 900 |
| ARKNDSTVSP | CLFVGTSLGM | VVLISLNLPS | SDEQRFTEPV | VVLPSGTFLS | LKGAVLTFSC |
| 910 | 920 | 930 | 940 | 950 | 960 |
| MDRTGSLMQP | PYEVWRDPNN | TDENEKTWKR | KLVMNYSSSS | QEMGDHQYTI | ICSEKQAKVF |
| 970 | 980 | 990 | 1000 | 1010 | 1020 |
| SLPSQTCLYV | HNITETSFIL | QADVVVMCNS | ACLACFCANG | HIMIMSLPSL | RPMLDVNYLP |
| 1030 | 1040 | 1050 | 1060 | 1070 | 1080 |
| LTDMRIARTF | CFTNEGQALY | LVSPTEIQRL | TYSQEMCDNI | QDMLGDLFTP | IETPEAQNRG |
| 1090 | 1100 | 1110 | 1120 | 1130 | 1140 |
| FLKGLFGGSG | QTFDREELFG | EASAGKASRS | LAQHIPGPGS | IEGMKGAAGG | VMGELTRARI |
| 1150 | 1160 | 1170 | 1180 | ||
| ALDERGQRLG | ELEEKTAGMM | TSAEAFSKHA | HELMLKYKDK | KWYQF |