Q5SQE2

PR
Gene name
stxbp5l (si:ch211-194d6.1)
Protein name
Syntaxin-binding protein 5-like
Names
Species
Danio rerio (Zebrafish) (Brachydanio rerio)
KEGG Pathway
dre:567605
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-72 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q5SQE2

Entry ID Method Resolution Chain Position Source
AF-Q5SQE2-F1 Predicted AlphaFoldDB

No variants for Q5SQE2

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q5SQE2

No associated diseases with Q5SQE2

8 regional properties for Q5SQE2

Type Name Position InterPro Accession
repeat WD40 repeat 51 - 91 IPR001680-1
repeat WD40 repeat 101 - 140 IPR001680-2
repeat WD40 repeat 199 - 238 IPR001680-3
repeat WD40 repeat 242 - 279 IPR001680-4
repeat WD40 repeat 399 - 478 IPR001680-5
repeat WD40 repeat 504 - 543 IPR001680-6
domain Lethal giant larvae homologue 2 290 - 398 IPR013577
domain v-SNARE, coiled-coil homology domain 1094 - 1154 IPR042855

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm
  • Cell membrane ; Peripheral membrane protein
  • Membrane ; Peripheral membrane protein
  • Cytoplasmic, and associated with vesicular membranes and the plasma membrane
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
SNARE complex A protein complex involved in membrane fusion; a stable ternary complex consisting of a four-helix bundle, usually formed from one R-SNARE and three Q-SNAREs with an ionic layer sandwiched between hydrophobic layers. One well-characterized example is the neuronal SNARE complex formed of synaptobrevin 2, syntaxin 1a, and SNAP-25.

3 GO annotations of molecular function

Name Definition
GTPase activator activity Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP.
myosin II binding Binding to a class II myosin, any member of the class of 'conventional' double-headed myosins that includes muscle myosin.
syntaxin binding Binding to a syntaxin, a SNAP receptor involved in the docking of synaptic vesicles at the presynaptic zone of a synapse.

4 GO annotations of biological process

Name Definition
exocytosis A process of secretion by a cell that results in the release of intracellular molecules (e.g. hormones, matrix proteins) contained within a membrane-bounded vesicle. Exocytosis can occur either by full fusion, when the vesicle collapses into the plasma membrane, or by a kiss-and-run mechanism that involves the formation of a transient contact, a pore, between a granule (for exemple of chromaffin cells) and the plasma membrane. The latter process most of the time leads to only partial secretion of the granule content. Exocytosis begins with steps that prepare vesicles for fusion with the membrane (tethering and docking) and ends when molecules are secreted from the cell.
protein transport The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
regulation of exocytosis Any process that modulates the frequency, rate or extent of exocytosis.
regulation of protein secretion Any process that modulates the frequency, rate or extent of the controlled release of a protein from a cell.

10 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q15334 LLGL1 Lethal(2) giant larvae protein homolog 1 Homo sapiens (Human) PR
Q5T5C0 STXBP5 Syntaxin-binding protein 5 Homo sapiens (Human) PR
Q6P1M3 LLGL2 LLGL scribble cell polarity complex component 2 Homo sapiens (Human) PR
Q9Y2K9 STXBP5L Syntaxin-binding protein 5-like Homo sapiens (Human) PR
Q80Y17 Llgl1 Lethal(2) giant larvae protein homolog 1 Mus musculus (Mouse) PR
Q8K400 Stxbp5 Syntaxin-binding protein 5 Mus musculus (Mouse) PR
Q5DQR4 Stxbp5l Syntaxin-binding protein 5-like Mus musculus (Mouse) PR
Q8K4K5 Llgl1 Lethal(2) giant larvae protein homolog 1 Rattus norvegicus (Rat) PR
Q9WU70 Stxbp5 Syntaxin-binding protein 5 Rattus norvegicus (Rat) PR
Q7SZE3 llgl2 LLGL scribble cell polarity complex component 2 Danio rerio (Zebrafish) (Brachydanio rerio) PR
10 20 30 40 50 60
MKKFRKVLDG LTTSSPVNPG GSPGCGSAAG TPSAAPTPRE LEIQETLMSE HFQICKTVRH
70 80 90 100 110 120
GFPYQPTALA FDPVQKILAI GSRSGGIRMY PFLSFPHLGR PGVDCHSQHE SGAAVLQMQF
130 140 150 160 170 180
LINEGALVTA CADDTLHLWS LRQRLPAILH SLKFNRERIT FCHLPFQSKW LYVGTERGNT
190 200 210 220 230 240
HIVNIESFIL SGYVIMWNKA IELSTKTHPG PVVHLSDSPK DEGKLLIGFE SGTIVMWDLR
250 260 270 280 290 300
AKRADFRIYY DEAIHSVSWH HEGRQFMCSH SDGSLSMWNM RNTAKPFQVT FPHGKTQRDG
310 320 330 340 350 360
RKESCKPILK VEYKTSRNSS EAFVIFSGGL SYDKAGRRPT LTIMHGKAIT VLEMDYPIVD
370 380 390 400 410 420
FMVLCETPYL NEVQEPYAVV VLLEKDFVVV DLTQSNFPIF ENPYPMDVHE SPVTCTAYFA
430 440 450 460 470 480
DCPPDIIPVL YSIGAKHKKT GYSHKEWPVS GGTWTVGSQT YPEIIITGHA DGSIKFWDAT
490 500 510 520 530 540
AITLQMLYKL KTSKVFEKPK TGDMGRSADL VEEDPYAVQM ISWCPQSRIF CVVGISAHVI
550 560 570 580 590 600
LYRFSKHDAN TIITSLELRL QCEMEDVISP SDTENTPCFS DPSGHSPQPQ PPSPRSNTPD
610 620 630 640 650 660
SVRDSIPCLK VKDRMIRMPP GYQAELVVQL LWVDGEPPQQ ITCLDLNSAY GLLALGNCNG
670 680 690 700 710 720
LAVVDYLQKT ILLCMSTLEL YGSADPFQRL TRSPRKNRQS TSGLTELSDN QVSLDLERSK
730 740 750 760 770 780
SPTSDHVNGH CTSPTSQPCP SGRARVPGGP EGPRLARRGP GRPPFRKAQS AACMEVSLPV
790 800 810 820 830 840
SSLTEENSFS RSRSSSVSSI DRETKEAVTT LQFAESYGRK SDSLPTPCLW VGTSLGLVLI
850 860 870 880 890 900
IPMSIPTDEQ ERQEDPVTVA PTGTVLMLKG SVLRFGFLDC GGALINSPYE VWRDQHAPDD
910 920 930 940 950 960
PDRPRKRKLV NFSPSSSQEA CGDGHLAVVC SERQAKVFYM PSQACLYVHN ITESSFVLRA
970 980 990 1000 1010 1020
DVVSVSNSVC LACFCANGHI MILSLPSLRP LLDVSYLPLT DMRIARTFCF TNGGQALYLC
1030 1040 1050 1060 1070 1080
SPTEIQRITY SQEMCETLGE LFTPIETPEA QNRGFLKGFF GGNAQTFDRE ELFGEASAGK
1090 1100 1110 1120 1130 1140
ASRSLAQHIP GQGGIEGMKA AAGGVVGDLA RARIALDERG QRLGELEERT ALMMTSAETF
1150
SKHAHELMLK CKDKKWYQF