Q12038
PR
Gene name |
SRO7 (SNI1, SOP1, YPR032W, YP9367.12) |
Protein name |
Lethal(2) giant larvae protein homolog SRO7 |
Names |
Polarity protein SRO7, Sodium protection protein 1, Suppressor of RHO3 protein 7 |
Species |
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
KEGG Pathway |
sce:YPR032W |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
2 structures for Q12038
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 2OAJ | X-ray | 240 A | A | 61-962 | PDB |
| AF-Q12038-F1 | Predicted | AlphaFoldDB |
16 variants for Q12038
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| s16-634222 | 35 | S>T | No | SGRP | |
| s16-634360 | 81 | I>L | No | SGRP | |
| s16-634449 | 110 | E>D | No | SGRP | |
| s16-634520 | 134 | V>A | No | SGRP | |
| s16-635075 | 319 | P>L | No | SGRP | |
| s16-635148 | 343 | N>K | No | SGRP | |
| s16-635528 | 470 | A>V | No | SGRP | |
| s16-635795 | 559 | E>G | No | SGRP | |
| s16-635809 | 564 | A>T | No | SGRP | |
| s16-635873 | 585 | V>A | No | SGRP | |
| s16-635907 | 596 | M>I | No | SGRP | |
| s16-635942 | 608 | G>D | No | SGRP | |
| s16-635977 | 620 | G>S | No | SGRP | |
| s16-636733 | 872 | I>V | No | SGRP | |
| s16-636739 | 874 | I>V | No | SGRP | |
| s16-636797 | 893 | L>Q | No | SGRP |
No associated diseases with Q12038
1 regional properties for Q12038
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Lethal giant larvae (Lgl)-like, C-terminal domain | 549 - 943 | IPR013905 |
4 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| mating projection tip | The apex of the mating projection in unicellular fungi exposed to mating pheromone; site of polarized growth. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
5 GO annotations of molecular function
| Name | Definition |
|---|---|
| GTPase activator activity | Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP. |
| myosin II binding | Binding to a class II myosin, any member of the class of 'conventional' double-headed myosins that includes muscle myosin. |
| small GTPase binding | Binding to a small monomeric GTPase. |
| SNARE binding | Binding to a SNARE (soluble N-ethylmaleimide-sensitive factor attached protein receptor) protein. |
| syntaxin binding | Binding to a syntaxin, a SNAP receptor involved in the docking of synaptic vesicles at the presynaptic zone of a synapse. |
6 GO annotations of biological process
| Name | Definition |
|---|---|
| establishment of cell polarity | The specification and formation of anisotropic intracellular organization or cell growth patterns. |
| exocytosis | A process of secretion by a cell that results in the release of intracellular molecules (e.g. hormones, matrix proteins) contained within a membrane-bounded vesicle. Exocytosis can occur either by full fusion, when the vesicle collapses into the plasma membrane, or by a kiss-and-run mechanism that involves the formation of a transient contact, a pore, between a granule (for exemple of chromaffin cells) and the plasma membrane. The latter process most of the time leads to only partial secretion of the granule content. Exocytosis begins with steps that prepare vesicles for fusion with the membrane (tethering and docking) and ends when molecules are secreted from the cell. |
| Golgi to plasma membrane transport | The directed movement of substances from the Golgi to the plasma membrane in transport vesicles that move from the trans-Golgi network to the plasma membrane, where they fuse and release their contents by exocytosis. |
| regulation of exocytosis | Any process that modulates the frequency, rate or extent of exocytosis. |
| regulation of protein secretion | Any process that modulates the frequency, rate or extent of the controlled release of a protein from a cell. |
| small GTPase mediated signal transduction | The series of molecular signals in which a small monomeric GTPase relays a signal. |
7 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P38163 | SRO77 | Lethal(2) giant larvae protein homolog SRO77 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| Q8MKF0 | LLGL1 | Lethal(2) giant larvae protein homolog 1 | Bos taurus (Bovine) | PR |
| Q6P1M3 | LLGL2 | LLGL scribble cell polarity complex component 2 | Homo sapiens (Human) | PR |
| Q15334 | LLGL1 | Lethal(2) giant larvae protein homolog 1 | Homo sapiens (Human) | PR |
| Q80Y17 | Llgl1 | Lethal(2) giant larvae protein homolog 1 | Mus musculus (Mouse) | PR |
| Q8K4K5 | Llgl1 | Lethal(2) giant larvae protein homolog 1 | Rattus norvegicus (Rat) | PR |
| Q7SZE3 | llgl2 | LLGL scribble cell polarity complex component 2 | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MFGSKRLKNV | KEAFKSLKGQ | NSETPIENSK | ASFKSKNSKT | STISKDAKSS | SSLKIPISSN |
| 70 | 80 | 90 | 100 | 110 | 120 |
| NKNKIFSLAE | TNKYGMSSKP | IAAAFDFTQN | LLAIATVTGE | VHIYGQQQVE | VVIKLEDRSA |
| 130 | 140 | 150 | 160 | 170 | 180 |
| IKEMRFVKGI | YLVVINAKDT | VYVLSLYSQK | VLTTVFVPGK | ITSIDTDASL | DWMLIGLQNG |
| 190 | 200 | 210 | 220 | 230 | 240 |
| SMIVYDIDRD | QLSSFKLDNL | QKSSFFPAAR | LSPIVSIQWN | PRDIGTVLIS | YEYVTLTYSL |
| 250 | 260 | 270 | 280 | 290 | 300 |
| VENEIKQSFI | YELPPFAPGG | DFSEKTNEKR | TPKVIQSLYH | PNSLHIITIH | EDNSLVFWDA |
| 310 | 320 | 330 | 340 | 350 | 360 |
| NSGHMIMART | VFETEINVPQ | PDYIRDSSTN | AAKISKVYWM | CENNPEYTSL | LISHKSISRG |
| 370 | 380 | 390 | 400 | 410 | 420 |
| DNQSLTMIDL | GYTPRYSITS | YEGMKNYYAN | PKQMKIFPLP | TNVPIVNILP | IPRQSPYFAG |
| 430 | 440 | 450 | 460 | 470 | 480 |
| CHNPGLILLI | LGNGEIETML | YPSGIFTDKA | SLFPQNLSWL | RPLATTSMAA | SVPNKLWLGA |
| 490 | 500 | 510 | 520 | 530 | 540 |
| LSAAQNKDYL | LKGGVRTKRQ | KLPAEYGTAF | ITGHSNGSVR | IYDASHGDIQ | DNASFEVNLS |
| 550 | 560 | 570 | 580 | 590 | 600 |
| RTLNKAKELA | VDKISFAAET | LELAVSIETG | DVVLFKYEVN | QFYSVENRPE | SGDLEMNFRR |
| 610 | 620 | 630 | 640 | 650 | 660 |
| FSLNNTNGVL | VDVRDRAPTG | VRQGFMPSTA | VHANKGKTSA | INNSNIGFVG | IAYAAGSLML |
| 670 | 680 | 690 | 700 | 710 | 720 |
| IDRRGPAIIY | MENIREISGA | QSACVTCIEF | VIMEYGDDGY | SSILMVCGTD | MGEVITYKIL |
| 730 | 740 | 750 | 760 | 770 | 780 |
| PASGGKFDVQ | LMDITNVTSK | GPIHKIDAFS | KETKSSCLAT | IPKMQNLSKG | LCIPGIVLIT |
| 790 | 800 | 810 | 820 | 830 | 840 |
| GFDDIRLITL | GKSKSTHKGF | KYPLAATGLS | YISTVEKNND | RKNLTVIITL | EINGHLRVFT |
| 850 | 860 | 870 | 880 | 890 | 900 |
| IPDFKEQMSE | HIPFPIAAKY | ITESSVLRNG | DIAIRVSEFQ | ASLFSTVKEQ | DTLAPVSDTL |
| 910 | 920 | 930 | 940 | 950 | 960 |
| YINGIRIPYR | PQVNSLQWAR | GTVYCTPAQL | NELLGGVNRP | ASKYKESIIA | EGSFSERSSD |
| 970 | 980 | 990 | 1000 | 1010 | 1020 |
| DNNANHPEHQ | YTKPTRKGRN | SSYGVLRNVS | RAVETRWDAV | EDRFNDYATA | MGETMNEAVE |
| 1030 | |||||
| QTGKDVMKGA | LGF |