AiPD: Autoinhibited Protein Database

Gene name	SRO77 (SNI2, SOP2, YBL106C, YBL0806)
Protein name	Lethal(2) giant larvae protein homolog SRO77
Names	Sodium protection protein 2, Suppressor of RHO3 protein 77
Species	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
KEGG Pathway	sce:YBL106C
EC number
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

1-49 (Predicted disordered autoinhibitory region) PR

1-49 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
AF-P38163-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
s02-13353	176	R>K	No	SGRP
s02-13261	207	I>F	No	SGRP
s02-13189	231	N>D	No	SGRP
s02-13184	232	I>M	No	SGRP
s02-13072	270	K>E	No	SGRP
s02-13061	273	H>Q	No	SGRP
s02-13006	292	C>G	No	SGRP
s02-12864	339	G>D	No	SGRP
s02-12359	507	K>N	No	SGRP
s02-12328	518	K>Q	No	SGRP
s02-12268	538	V>F	No	SGRP
s02-12133	583	T>A	No	SGRP
s02-11892	663	G>E	No	SGRP
s02-11803	693	V>I	No	SGRP
s02-11771	703	N>K	No	SGRP
s02-11749	711	N>D	No	SGRP
s02-11707	725	I>L	No	SGRP
s02-11545	779	I>V	No	SGRP
s02-11470	804	T>A	No	SGRP
s02-11361	840	T>R	No	SGRP
s02-11319	854	S>N	No	SGRP
s02-11052	943	E>G	No	SGRP
s02-11017	955	G>R	No	SGRP
s02-10873	1003	M>V	No	SGRP

Type	Name	Position	InterPro Accession
repeat	WD40 repeat	33 - 71	IPR001680-1
repeat	WD40 repeat	103 - 152	IPR001680-2
repeat	WD40 repeat	231 - 274	IPR001680-3
repeat	WD40 repeat	450 - 498	IPR001680-4
repeat	WD40 repeat	588 - 626	IPR001680-5
domain	Lethal giant larvae (Lgl)-like, C-terminal domain	514 - 916	IPR013905

		Description
EC Number
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
cellular bud neck	The constriction between the mother cell and daughter cell (bud) in an organism that reproduces by budding.
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
plasma membrane	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

Name	Definition
GTPase activator activity	Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP.
myosin II binding	Binding to a class II myosin, any member of the class of 'conventional' double-headed myosins that includes muscle myosin.
syntaxin binding	Binding to a syntaxin, a SNAP receptor involved in the docking of synaptic vesicles at the presynaptic zone of a synapse.

Name	Definition
establishment of cell polarity	The specification and formation of anisotropic intracellular organization or cell growth patterns.
exocytosis	A process of secretion by a cell that results in the release of intracellular molecules (e.g. hormones, matrix proteins) contained within a membrane-bounded vesicle. Exocytosis can occur either by full fusion, when the vesicle collapses into the plasma membrane, or by a kiss-and-run mechanism that involves the formation of a transient contact, a pore, between a granule (for exemple of chromaffin cells) and the plasma membrane. The latter process most of the time leads to only partial secretion of the granule content. Exocytosis begins with steps that prepare vesicles for fusion with the membrane (tethering and docking) and ends when molecules are secreted from the cell.
Golgi to plasma membrane transport	The directed movement of substances from the Golgi to the plasma membrane in transport vesicles that move from the trans-Golgi network to the plasma membrane, where they fuse and release their contents by exocytosis.
regulation of exocytosis	Any process that modulates the frequency, rate or extent of exocytosis.
regulation of protein secretion	Any process that modulates the frequency, rate or extent of the controlled release of a protein from a cell.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q12038	SRO7	Lethal(2) giant larvae protein homolog SRO7	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)	PR
Q8MKF0	LLGL1	Lethal(2) giant larvae protein homolog 1	Bos taurus (Bovine)	PR
Q6P1M3	LLGL2	LLGL scribble cell polarity complex component 2	Homo sapiens (Human)	PR
Q15334	LLGL1	Lethal(2) giant larvae protein homolog 1	Homo sapiens (Human)	PR
Q80Y17	Llgl1	Lethal(2) giant larvae protein homolog 1	Mus musculus (Mouse)	PR
Q8K4K5	Llgl1	Lethal(2) giant larvae protein homolog 1	Rattus norvegicus (Rat)	PR
Q7SZE3	llgl2	LLGL scribble cell polarity complex component 2	Danio rerio (Zebrafish) (Brachydanio rerio)	PR