Q61035

PR
Gene name
Hars1 (Hars)
Protein name
Histidine--tRNA ligase, cytoplasmic
Names
Histidyl-tRNA synthetase, HisRS
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:15115
EC number
6.1.1.21: Ligases forming aminoacyl-tRNA and related compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-89 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q61035

Entry ID Method Resolution Chain Position Source
AF-Q61035-F1 Predicted AlphaFoldDB

28 variants for Q61035

Variant ID(s) Position Change Description Diseaes Association Provenance
rs3407776784 52 Q>H No EVA
rs3389489385 73 R>W No EVA
rs3389510779 114 I>N No EVA
rs3389475938 116 D>E No EVA
rs3389452949 124 L>P No EVA
rs3389489418 149 R>H No EVA
rs3389453007 174 C>S No EVA
rs3408362515 210 K>N No EVA
rs3389495892 248 E>* No EVA
rs3389489302 248 E>G No EVA
rs3389497400 250 K>M No EVA
rs3389488591 251 N>D No EVA
rs3389488588 251 N>I No EVA
rs3389496209 253 M>I No EVA
rs3389499939 253 M>V No EVA
rs231988665 266 R>S No EVA
rs3389442651 269 D>G No EVA
rs3389462025 291 Q>L No EVA
rs218606592 296 V>L No EVA
rs3389475957 350 E>* No EVA
rs3389442714 351 P>A No EVA
rs3389510789 352 L>V No EVA
rs3389405538 385 G>R No EVA
rs3389475919 388 R>G No EVA
rs3389496243 391 S>P No EVA
rs31790952 490 R>Q No EVA
rs48146623 508 T>I No EVA
rs236041419 509 C>R No EVA

No associated diseases with Q61035

1 regional properties for Q61035

Type Name Position InterPro Accession
conserved_site Di-trans-poly-cis-decaprenylcistransferase-like, conserved site 212 - 229 IPR018520

Functions

Description
EC Number 6.1.1.21 Ligases forming aminoacyl-tRNA and related compounds
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.

4 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
histidine-tRNA ligase activity Catalysis of the reaction: ATP + L-histidine + tRNA(His) = AMP + diphosphate + L-histidyl-tRNA(His).
identical protein binding Binding to an identical protein or proteins.
protein homodimerization activity Binding to an identical protein to form a homodimer.

2 GO annotations of biological process

Name Definition
histidyl-tRNA aminoacylation The process of coupling histidine to histidyl-tRNA, catalyzed by histidyl-tRNA synthetase. The histidyl-tRNA synthetase is a class-II synthetase. The activated amino acid is transferred to the 3''-OH group of a histidine-accetping tRNA.
mitochondrial translation The chemical reactions and pathways resulting in the formation of a protein in a mitochondrion. This is a ribosome-mediated process in which the information in messenger RNA (mRNA) is used to specify the sequence of amino acids in the protein; the mitochondrion has its own ribosomes and transfer RNAs, and uses a genetic code that differs from the nuclear code.

9 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
A5D7V9 HARS2 Histidine--tRNA ligase, mitochondrial Bos taurus (Bovine) PR
Q2KI84 HARS1 Histidine--tRNA ligase, cytoplasmic Bos taurus (Bovine) PR
P49590 HARS2 Histidine--tRNA ligase, mitochondrial Homo sapiens (Human) PR
P12081 HARS1 Histidine--tRNA ligase, cytoplasmic Homo sapiens (Human) PR
Q99KK9 Hars2 Histidine--tRNA ligase, mitochondrial Mus musculus (Mouse) PR
P93422 Os09g0504400 Histidine--tRNA ligase, cytoplasmic Oryza sativa subsp japonica (Rice) PR
P34183 hars-1 Histidine--tRNA ligase Caenorhabditis elegans PR
F4IYF8 At3g02760 Histidine--tRNA ligase, cytoplasmic Arabidopsis thaliana (Mouse-ear cress) PR
O82413 At3g46100 Histidine--tRNA ligase, chloroplastic/mitochondrial Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MADRAALEEL VRLQGAHVRG LKEQKASAEQ IEEEVTKLLK LKAQLGQDEG KQKFVLKTPK
70 80 90 100 110 120
GTRDYSPRQM AVREKVFDVI IRCFKRHGAE VIDTPVFELK ETLTGKYGED SKLIYDLKDQ
130 140 150 160 170 180
GGELLSLRYD LTVPFARYLA MNKLTNIKRY HIAKVYRRDN PAMTRGRYRE FYQCDFDIAG
190 200 210 220 230 240
QFDPMIPDAE CLKIMCEILS SLQIGNFLVK VNDRRILDGM FAVCGVPDSK FRTICSSVDK
250 260 270 280 290 300
LDKVSWEEVK NEMVGEKGLA PEVADRIGDY VQQHGGVSLV EQLLQDPKLS QNKQAVEGLG
310 320 330 340 350 360
DLKLLFEYLI LFGIDDKISF DLSLARGLDY YTGVIYEAVL LQMPTQAGEE PLGVGSIAAG
370 380 390 400 410 420
GRYDGLVGMF DPKGRKVPCV GLSIGVERIF SIVEQRLEAS EEKVRTTETQ VLVASAQKKL
430 440 450 460 470 480
LEERLKLVSE LWDAGIKAEL LYKKNPKLLN QLQYCEEAGI PLVAIIGEQE LKDGVIKLRS
490 500
VASREEVDVR REDLVEEIRR RTNQPLSTC