F4IYF8

PR
Gene name
At3g02760 (F13E7.30)
Protein name
Histidine--tRNA ligase, cytoplasmic
Names
Histidyl-tRNA synthetase, HisRS
Species
Arabidopsis thaliana (Mouse-ear cress)
KEGG Pathway
ath:AT3G02760
EC number
6.1.1.21: Ligases forming aminoacyl-tRNA and related compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-131 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for F4IYF8

Entry ID Method Resolution Chain Position Source
AF-F4IYF8-F1 Predicted AlphaFoldDB

62 variants for F4IYF8

Variant ID(s) Position Change Description Diseaes Association Provenance
ENSVATH05759155 20 S>F No 1000Genomes
tmp_3_600586_A_G 22 V>A No 1000Genomes
ENSVATH13860319 55 F>V No 1000Genomes
ENSVATH05759154 66 T>N No 1000Genomes
tmp_3_600439_G_C 71 A>G No 1000Genomes
ENSVATH10461225 82 S>F No 1000Genomes
ENSVATH00302771 85 P>S No 1000Genomes
tmp_3_600394_G_A 86 S>F No 1000Genomes
tmp_3_600377_A_G 92 S>P No 1000Genomes
tmp_3_600362_T_C 97 K>E No 1000Genomes
tmp_3_600340_A_G 104 L>S No 1000Genomes
ENSVATH00302770 106 A>P No 1000Genomes
ENSVATH05759153 126 K>R No 1000Genomes
tmp_3_600193_G_A 153 A>V No 1000Genomes
tmp_3_600089_G_T 188 L>I No 1000Genomes
tmp_3_599984_C_G 223 V>L No 1000Genomes
tmp_3_599977_G_A 225 A>V No 1000Genomes
tmp_3_599932_G_T 240 T>N No 1000Genomes
ENSVATH02106049 278 E>G No 1000Genomes
tmp_3_599806_T_G 282 D>A No 1000Genomes
ENSVATH00302768 282 D>N No 1000Genomes
tmp_3_599794_T_C 286 K>R No 1000Genomes
tmp_3_599764_T_A 296 E>V No 1000Genomes
ENSVATH02106048 305 K>R No 1000Genomes
tmp_3_599674_C_T 326 C>Y No 1000Genomes
tmp_3_599638_G_C 338 A>G No 1000Genomes
ENSVATH00302766 340 A>D No 1000Genomes
tmp_3_599627_A_T 342 F>I No 1000Genomes
tmp_3_599578_G_A 358 A>V No 1000Genomes
tmp_3_599559_C_A 364 K>N No 1000Genomes
tmp_3_599557_G_C 365 T>S No 1000Genomes
tmp_3_599555_C_T 366 D>N No 1000Genomes
ENSVATH00302764 383 S>I No 1000Genomes
tmp_3_599487_A_T 388 F>L No 1000Genomes
ENSVATH02106047 395 S>G No 1000Genomes
ENSVATH02106046 397 D>Y No 1000Genomes
ENSVATH02106045 400 S>I No 1000Genomes
tmp_3_599444_C_G 403 D>H No 1000Genomes
tmp_3_599417_C_A 412 G>W No 1000Genomes
ENSVATH05759151 416 L>V No 1000Genomes
ENSVATH02106044 417 N>Y No 1000Genomes
tmp_3_599375_A_G 426 F>L No 1000Genomes
tmp_3_599348_C_G 435 E>Q No 1000Genomes
tmp_3_599337_T_A 438 E>D No 1000Genomes
ENSVATH05759149 439 S>T No 1000Genomes
tmp_3_598893_T_G 532 N>H No 1000Genomes
ENSVATH02106039 572 P>L No 1000Genomes
ENSVATH02106039 572 P>R No 1000Genomes
ENSVATH02106040 572 P>S No 1000Genomes
tmp_3_598725_C_T 588 D>N No 1000Genomes
ENSVATH02106038 660 K>R No 1000Genomes
tmp_3_598393_T_C 671 K>E No 1000Genomes
tmp_3_598335_T_G 690 D>A No 1000Genomes
tmp_3_598327_T_C 693 S>G No 1000Genomes
tmp_3_598305_T_G 700 K>T No 1000Genomes
ENSVATH05759138 724 V>L No 1000Genomes
tmp_3_597880_T_G 787 E>A No 1000Genomes
tmp_3_597849_A_C 797 D>E No 1000Genomes
ENSVATH00302751 849 S>R No 1000Genomes
tmp_3_597598_T_C 881 K>R No 1000Genomes
tmp_3_597589_CAG_C,CAAG 884 L>L No 1000Genomes
tmp_3_597589_CAG_C,CAAG 884 L>S No 1000Genomes

No associated diseases with F4IYF8

No regional properties for F4IYF8

Type Name Position InterPro Accession
No domain, repeats, and functional sites for F4IYF8

Functions

Description
EC Number 6.1.1.21 Ligases forming aminoacyl-tRNA and related compounds
Subcellular Localization
  • Cytoplasm, cytosol
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.

2 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
histidine-tRNA ligase activity Catalysis of the reaction: ATP + L-histidine + tRNA(His) = AMP + diphosphate + L-histidyl-tRNA(His).

2 GO annotations of biological process

Name Definition
histidyl-tRNA aminoacylation The process of coupling histidine to histidyl-tRNA, catalyzed by histidyl-tRNA synthetase. The histidyl-tRNA synthetase is a class-II synthetase. The activated amino acid is transferred to the 3''-OH group of a histidine-accetping tRNA.
mitochondrial translation The chemical reactions and pathways resulting in the formation of a protein in a mitochondrion. This is a ribosome-mediated process in which the information in messenger RNA (mRNA) is used to specify the sequence of amino acids in the protein; the mitochondrion has its own ribosomes and transfer RNAs, and uses a genetic code that differs from the nuclear code.

9 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q2KI84 HARS1 Histidine--tRNA ligase, cytoplasmic Bos taurus (Bovine) PR
A5D7V9 HARS2 Histidine--tRNA ligase, mitochondrial Bos taurus (Bovine) PR
P49590 HARS2 Histidine--tRNA ligase, mitochondrial Homo sapiens (Human) PR
P12081 HARS1 Histidine--tRNA ligase, cytoplasmic Homo sapiens (Human) PR
Q61035 Hars1 Histidine--tRNA ligase, cytoplasmic Mus musculus (Mouse) PR
Q99KK9 Hars2 Histidine--tRNA ligase, mitochondrial Mus musculus (Mouse) PR
P93422 Os09g0504400 Histidine--tRNA ligase, cytoplasmic Oryza sativa subsp japonica (Rice) PR
P34183 hars-1 Histidine--tRNA ligase Caenorhabditis elegans PR
O82413 At3g46100 Histidine--tRNA ligase, chloroplastic/mitochondrial Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MAAERSSITL GGKGSSLSSS SVYNVASGVA NVRIDSSAIE RFSTRNVPSI KRSSFGIPQG
70 80 90 100 110 120
LTNEETRASL AVLLNKLILS TSGPPSSSTA RSVLPLKIVE ILNLKAESLE LGEIDVTEGE
130 140 150 160 170 180
NIVLEKSCAS LIGICSIIDH KSTTLSQIVD SVAALSCEVT KADIASFSLL DSGDGNGDKD
190 200 210 220 230 240
VIGVAGDLKV LLNGYKGTGK LEIEEISKIP WIHGKFRYVV KSVHADARRE LNSGVKGGKT
250 260 270 280 290 300
GSGNTGIGEA LGTTLLPLLT AIKNLGVCSF LRAKLCFEKI VDENLKKCLS EKICVENENL
310 320 330 340 350 360
KNSYKLAYTA HLEEDYCRFA HKLNECLGIV WRIVGLEAVA AFFALAGGEL FVQKSGDADK
370 380 390 400 410 420
EESKTDKKKK KNEKKAVVGK GTSLVIQFIK DRLVSNDAAS DGDQMHSLMQ CGEQILNLFN
430 440 450 460 470 480
PEGRSFDSLL DKVKEIVESN ENRRLPKLPK GTRDFAKEQM AVREKAFSII QNVFKRHGAT
490 500 510 520 530 540
ALDTPVFELR ETLMGKYGED SKLVYDIADQ GGELCSLRYD LTVPFARYVA MNGITSFKRY
550 560 570 580 590 600
QIAKVYRRDN PSKGRYREFY QCDFDIAGLF EPMGPDFEIV KILTELLDEL EIGDYEVKLN
610 620 630 640 650 660
HRKLLDGMLE ICGVPPEKFR TICSSIDKLD KQSFEQVKKE MVEEKGLSSE IADRIGNFVK
670 680 690 700 710 720
EKGAPLELLS KLRQEGSEFL DNQSSREALD ELSIMFEALK RSKCSERIVF DLSLARGLDY
730 740 750 760 770 780
YTGVIFEAVC IGAEVGSIGA GGRYDNLIGM FGTKQVPAVG MSLGIERVFN IMEELNEKQK
790 800 810 820 830 840
QVIRPTETQV LVSIMVDNKL AEAAELVSQL WGAKINAEYL VSKRKEKHFN RAKESGIPWM
850 860 870 880
VMVGEKELSG SFVTLKKLEK GSEEKEDQTC TRDRFVEELK KLL