Q2KI84

PR
Gene name
HARS1 (HARS)
Protein name
Histidine--tRNA ligase, cytoplasmic
Names
Histidyl-tRNA synthetase, HisRS
Species
Bos taurus (Bovine)
KEGG Pathway
bta:510937
EC number
6.1.1.21: Ligases forming aminoacyl-tRNA and related compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-86 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q2KI84

Entry ID Method Resolution Chain Position Source
AF-Q2KI84-F1 Predicted AlphaFoldDB

109 variants for Q2KI84

Variant ID(s) Position Change Description Diseaes Association Provenance
rs438712425 3 D>G No EVA
rs458804633 3 D>H No EVA
rs472963831 4 R>S No EVA
rs435989610 5 A>G No EVA
rs473662216 6 A>G No EVA
rs469435556 9 D>E No EVA
rs438127369 9 D>G No EVA
rs456887323 9 D>H No EVA
rs452710462 11 V>A No EVA
rs432710453 12 R>P No EVA
rs446790666 13 V>F No EVA
rs481422705 14 Q>* No EVA
rs451041381 15 G>A No EVA
rs467837700 15 G>R No EVA
rs481996344 16 E>D No EVA
rs458788955 22 K>Q No EVA
rs438682327 23 Q>K No EVA
rs479709497 24 Q>R No EVA
rs459597206 25 K>T No EVA
rs473621488 27 S>G No EVA
rs456848819 29 E>V No EVA
rs443317405 30 Q>K No EVA
rs526052924 32 E>K No EVA
rs436723710 35 V>G No EVA
rs110158462 68 R>W No EVA
rs442111547 99 L>Q No EVA
rs448722437 132 T>A No EVA
rs483075093 132 T>N No EVA
rs458791741 159 D>E No EVA
rs482125650 159 D>G No EVA
rs438351133 160 N>K No EVA
rs452872347 162 A>P No EVA
rs442516148 163 M>L No EVA
rs475002231 163 M>T No EVA
rs454928577 165 R>P No EVA
rs432336328 170 E>G No EVA
rs467003541 173 Q>P No EVA
rs446955196 174 C>S No EVA
rs443620104 180 G>V No EVA
rs471842320 184 P>R No EVA
rs465834568 205 G>S No EVA
rs455465441 209 V>G No EVA
rs715581545 215 R>H No EVA
rs449562199 227 P>R No EVA
rs800030600 248 E>K No EVA
rs447416131 251 N>D No EVA
rs479998747 251 N>K No EVA
rs474365226 298 G>C No EVA
rs443567972 308 Y>D No EVA
rs464193218 321 D>V No EVA
rs447379307 343 P>H No EVA
rs468277660 345 A>D No EVA
rs449464093 349 E>V No EVA
rs433121611 355 G>S No EVA
rs450396526 362 R>P No EVA
rs478243573 363 Y>* No EVA
rs472465437 367 V>A No EVA
rs441767460 379 C>* No EVA
rs476475663 380 V>E No EVA
rs433115109 383 S>R No EVA
rs453683770 386 V>E No EVA
rs433573937 387 E>D No EVA
rs468240945 391 S>F No EVA
rs470442081 397 L>P No EVA
rs474731591 400 L>F No EVA
rs467041910 411 V>G No EVA
rs432362164 411 V>L No EVA
rs446993940 417 Q>L No EVA
rs446993940 417 Q>P No EVA
rs436176814 423 E>K No EVA
rs467585813 424 R>G No EVA
rs439167726 438 A>E No EVA
rs453187247 439 E>D No EVA
rs442824706 443 K>Q No EVA
rs457461604 444 K>N No EVA
rs474277002 444 K>R No EVA
rs436961612 445 N>H No EVA
rs465037321 445 N>T No EVA
rs436961612 445 N>Y No EVA
rs451491759 446 P>T No EVA
rs434600038 449 L>Q No EVA
rs465910265 456 E>K No EVA
rs469845299 475 V>G No EVA
rs449801186 480 S>T No EVA
rs482407452 482 A>G No EVA
rs455951358 487 V>A No EVA
rs468238032 487 V>M No EVA
rs470332417 493 D>A No EVA
rs450262230 495 V>E No EVA
rs450262230 495 V>G No EVA
rs478016613 496 E>* No EVA
rs447594250 496 E>D No EVA
rs464345173 496 E>G No EVA
rs478016613 496 E>K No EVA
rs478016613 496 E>Q No EVA
rs479196255 497 E>* No EVA
rs479196255 497 E>K No EVA
rs462202076 498 I>M No EVA
rs441832322 501 R>K No EVA
rs439482893 502 T>K No EVA
rs462864796 502 T>P No EVA
rs470881792 503 S>G No EVA
rs453767927 503 S>I No EVA
rs453767927 503 S>N No EVA
rs439978215 504 Q>E No EVA
rs474753278 504 Q>H No EVA
rs439978215 504 Q>K No EVA
rs435800827 507 C>* No EVA
rs454515362 507 C>Y No EVA

No associated diseases with Q2KI84

17 regional properties for Q2KI84

Type Name Position InterPro Accession
domain NGN domain 183 - 265 IPR005100
domain KOW 273 - 300 IPR005824-1
domain KOW 425 - 452 IPR005824-2
domain KOW 477 - 522 IPR005824-3
domain KOW 601 - 628 IPR005824-4
domain KOW 712 - 739 IPR005824-5
domain KOW 988 - 1015 IPR005824-6
conserved_site Ribosomal protein L24/L26, conserved site 429 - 446 IPR005825
domain NusG-like, N-terminal 181 - 268 IPR006645
domain Spt5 transcription elongation factor, N-terminal 90 - 177 IPR022581
domain NGN domain, eukaryotic 183 - 266 IPR039385
domain Spt5, KOW domain repeat 1 277 - 314 IPR041973
domain Spt5, KOW domain repeat 2 426 - 476 IPR041975
domain Spt5, KOW domain repeat 3 477 - 527 IPR041976
domain Spt5, KOW domain repeat 4 605 - 647 IPR041977
domain Spt5, KOW domain repeat 5 711 - 758 IPR041978
domain Spt5, KOW domain repeat 6 982 - 1039 IPR041980

Functions

Description
EC Number 6.1.1.21 Ligases forming aminoacyl-tRNA and related compounds
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.

4 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
histidine-tRNA ligase activity Catalysis of the reaction: ATP + L-histidine + tRNA(His) = AMP + diphosphate + L-histidyl-tRNA(His).
identical protein binding Binding to an identical protein or proteins.
protein homodimerization activity Binding to an identical protein to form a homodimer.

2 GO annotations of biological process

Name Definition
histidyl-tRNA aminoacylation The process of coupling histidine to histidyl-tRNA, catalyzed by histidyl-tRNA synthetase. The histidyl-tRNA synthetase is a class-II synthetase. The activated amino acid is transferred to the 3''-OH group of a histidine-accetping tRNA.
mitochondrial translation The chemical reactions and pathways resulting in the formation of a protein in a mitochondrion. This is a ribosome-mediated process in which the information in messenger RNA (mRNA) is used to specify the sequence of amino acids in the protein; the mitochondrion has its own ribosomes and transfer RNAs, and uses a genetic code that differs from the nuclear code.

9 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
A5D7V9 HARS2 Histidine--tRNA ligase, mitochondrial Bos taurus (Bovine) PR
P49590 HARS2 Histidine--tRNA ligase, mitochondrial Homo sapiens (Human) PR
P12081 HARS1 Histidine--tRNA ligase, cytoplasmic Homo sapiens (Human) PR
Q61035 Hars1 Histidine--tRNA ligase, cytoplasmic Mus musculus (Mouse) PR
Q99KK9 Hars2 Histidine--tRNA ligase, mitochondrial Mus musculus (Mouse) PR
P93422 Os09g0504400 Histidine--tRNA ligase, cytoplasmic Oryza sativa subsp japonica (Rice) PR
P34183 hars-1 Histidine--tRNA ligase Caenorhabditis elegans PR
F4IYF8 At3g02760 Histidine--tRNA ligase, cytoplasmic Arabidopsis thaliana (Mouse-ear cress) PR
O82413 At3g46100 Histidine--tRNA ligase, chloroplastic/mitochondrial Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MADRAALEDL VRVQGERVRG LKQQKASAEQ IEEEVAKLLK LKAQLGPDEG KPKFVLKTPK
70 80 90 100 110 120
GTRDYSPRQM AVREKVFDVI ISCFKRHGAE VIDTPVFELK ETLTGKYGED SKLIYDLKDQ
130 140 150 160 170 180
GGELLSLRYD LTVPFARYLA MNKLTNIKRY HIAKVYRRDN PAMTRGRYRE FYQCDFDIAG
190 200 210 220 230 240
QFDPMLPDAE CLKIMCEILS SLQIGDFLVK VNDRRILDGM FAICGVPDSK FRTICSSVDK
250 260 270 280 290 300
LDKVSWEEVK NEMVGEKGLA PEVADRIGDY VQQHGGVSLV EQLLQDPKLS QNKQALEGLG
310 320 330 340 350 360
DLKLLFEYLT LFGIADKISF DLSLARGLDY YTGVIYEAVL LQPPARAGEE PLGVGSVAAG
370 380 390 400 410 420
GRYDGLVGMF DPKGRKVPCV GLSIGVERIF SIVEQRLEAL EEKVRTTETQ VLVASAQKKL
430 440 450 460 470 480
LEERLKLISE LWDAGIKAEL LYKKNPKLLN QLQYCEETGI PLVAIIGEQE LKDGVIKLRS
490 500
VASREEVDVR REDLVEEIKR RTSQPLCIC