P93422

PR
Gene name
Os09g0504400 (LOC_Os09g32680)
Protein name
Histidine--tRNA ligase, cytoplasmic
Names
Histidyl-tRNA synthetase, HisRS
Species
Oryza sativa subsp japonica (Rice)
KEGG Pathway
EC number
6.1.1.21: Ligases forming aminoacyl-tRNA and related compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

22-106 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P93422

Entry ID Method Resolution Chain Position Source
AF-P93422-F1 Predicted AlphaFoldDB

No variants for P93422

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P93422

No associated diseases with P93422

4 regional properties for P93422

Type Name Position InterPro Accession
domain Anticodon-binding 708 - 783 IPR004154
domain Aminoacyl-tRNA synthetase, class II 327 - 680 IPR006195
domain Histidyl-anticodon-binding 694 - 782 IPR033656
domain Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain 358 - 681 IPR041715

Functions

Description
EC Number 6.1.1.21 Ligases forming aminoacyl-tRNA and related compounds
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.

2 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
histidine-tRNA ligase activity Catalysis of the reaction: ATP + L-histidine + tRNA(His) = AMP + diphosphate + L-histidyl-tRNA(His).

2 GO annotations of biological process

Name Definition
histidyl-tRNA aminoacylation The process of coupling histidine to histidyl-tRNA, catalyzed by histidyl-tRNA synthetase. The histidyl-tRNA synthetase is a class-II synthetase. The activated amino acid is transferred to the 3''-OH group of a histidine-accetping tRNA.
mitochondrial translation The chemical reactions and pathways resulting in the formation of a protein in a mitochondrion. This is a ribosome-mediated process in which the information in messenger RNA (mRNA) is used to specify the sequence of amino acids in the protein; the mitochondrion has its own ribosomes and transfer RNAs, and uses a genetic code that differs from the nuclear code.

9 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q2KI84 HARS1 Histidine--tRNA ligase, cytoplasmic Bos taurus (Bovine) PR
A5D7V9 HARS2 Histidine--tRNA ligase, mitochondrial Bos taurus (Bovine) PR
P49590 HARS2 Histidine--tRNA ligase, mitochondrial Homo sapiens (Human) PR
P12081 HARS1 Histidine--tRNA ligase, cytoplasmic Homo sapiens (Human) PR
Q61035 Hars1 Histidine--tRNA ligase, cytoplasmic Mus musculus (Mouse) PR
Q99KK9 Hars2 Histidine--tRNA ligase, mitochondrial Mus musculus (Mouse) PR
P34183 hars-1 Histidine--tRNA ligase Caenorhabditis elegans PR
O82413 At3g46100 Histidine--tRNA ligase, chloroplastic/mitochondrial Arabidopsis thaliana (Mouse-ear cress) PR
F4IYF8 At3g02760 Histidine--tRNA ligase, cytoplasmic Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MAPPAAAAAV TLGGKGAALT PAAVYALSHG LADPAIDCCA SPLVRVADAV AALSCEAARG
70 80 90 100 110 120
DVAAFDVPTS GDGLSAKDEA DVAADVKMLL FGSKLVGAAG GADAASFTKV PTVNGIFREA
130 140 150 160 170 180
VRALHARVRI ELNAPVKLGK RDAVQTGEGK EEALVALATQ LARPVQAMLK LSVARARLCV
190 200 210 220 230 240
ARIDDAELRK KLTDGVEIDD LKGMLGKVTI DSDAVSVLRG VYNSLLKFRD ILAWEAAVAM
250 260 270 280 290 300
AVIEMDSSIE KPQACEENEA GSSTENPHAS GEKPKGDKKS KKKKTLGKGT SAVLMLLRDL
310 320 330 340 350 360
VTNGKEVLSV NSALLAEWGT ELSLLFDPKC PRLVSLVDKV KEIVETNEVR RLPKIPKGTR
370 380 390 400 410 420
DFGKEQMAIR EHAFSIITGV FKMHGAVSLD TPVFELRETL MGKYGEDSKL IYDLADQGGE
430 440 450 460 470 480
LCSLRYDLTV PFARYVAMNN ISSLKRYQIA KVYRRDNPSK GRYREFYQCD FDIAGVYETM
490 500 510 520 530 540
EPDFEVIKVL TELLDQLDIG TYEIKLNHRK LLDGMLEICG VPPEKFRTVC SSIDKLDKQT
550 560 570 580 590 600
FEQVKKELVD EKGISNETAD KIGDLVKTRG PPLEVLLELR KEGSKFMGNA GSVTALNELE
610 620 630 640 650 660
ILFKALDKAN AIGKIVFDLS LARGLDYYTG VIYEAVFKGT TQVGSIAAGG RYDNLVGMFS
670 680 690 700 710 720
GKQVPAVGVS LGIERVFAIM EQQEMEKNQI RATETEVLVS IIGKDLILAA ELVSELWNAG
730 740 750 760 770 780
IKAEFKLTTR IQNHLKYATQ SGIPWMVLVG ESEISSGKVK LKNLAASQEE EVDRTEFAQV
LKQKLRNP