O82413

PR
Gene name
At3g46100 (F12M12_70)
Protein name
Histidine--tRNA ligase, chloroplastic/mitochondrial
Names
Histidyl-tRNA synthetase, HisRS, Histidyl-tRNA synthetase 1, AtHRS1
Species
Arabidopsis thaliana (Mouse-ear cress)
KEGG Pathway
ath:AT3G46100
EC number
6.1.1.21: Ligases forming aminoacyl-tRNA and related compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

22-99 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for O82413

Entry ID Method Resolution Chain Position Source
AF-O82413-F1 Predicted AlphaFoldDB

53 variants for O82413

Variant ID(s) Position Change Description Diseaes Association Provenance
tmp_3_16930980_C_A 2 R>L No 1000Genomes
tmp_3_16930971_T_C 5 H>R No 1000Genomes
tmp_3_16930941_A_C 15 F>C No 1000Genomes
ENSVATH02444923 21 L>F No 1000Genomes
ENSVATH02444922 21 L>H No 1000Genomes
ENSVATH06240749 23 L>M No 1000Genomes
tmp_3_16930905_C_T 27 C>Y No 1000Genomes
ENSVATH06240747 32 Q>H No 1000Genomes
ENSVATH06240748 32 Q>K No 1000Genomes
ENSVATH06240746 42 A>T No 1000Genomes
ENSVATH02444921 55 A>T No 1000Genomes
ENSVATH12551351 64 H>D No 1000Genomes
ENSVATH02444917 91 N>D No 1000Genomes
ENSVATH06240734 120 A>S No 1000Genomes
ENSVATH02444900 160 V>L No 1000Genomes
ENSVATH06240726 197 P>A No 1000Genomes
ENSVATH06240722 209 I>V No 1000Genomes
tmp_3_16929828_T_C 214 K>R No 1000Genomes
ENSVATH06240720 225 F>L No 1000Genomes
ENSVATH00401836 239 K>R No 1000Genomes
tmp_3_16929571_G_T 243 P>H No 1000Genomes
tmp_3_16929366_A_C 263 D>E No 1000Genomes
tmp_3_16929368_C_T 263 D>N No 1000Genomes
ENSVATH14377773 267 K>T No 1000Genomes
tmp_3_16929333_T_C 274 I>M No 1000Genomes
tmp_3_16929322_G_A 278 A>V No 1000Genomes
tmp_3_16929270_T_G 295 E>D No 1000Genomes
ENSVATH08140190 297 I>T No 1000Genomes
ENSVATH02444863 298 I>L No 1000Genomes
ENSVATH06240708 300 G>E No 1000Genomes
ENSVATH02444862 301 A>V No 1000Genomes
tmp_3_16929113_A_C 321 S>A No 1000Genomes
ENSVATH12551267 326 F>L No 1000Genomes
tmp_3_16928952_T_C 350 K>E No 1000Genomes
tmp_3_16928919_C_T 361 D>N No 1000Genomes
ENSVATH00401833 372 F>I No 1000Genomes
tmp_3_16928704_C_T 401 V>I No 1000Genomes
ENSVATH02444843 404 I>L No 1000Genomes
tmp_3_16928678_G_T 409 D>E No 1000Genomes
tmp_3_16928676_T_C 410 K>R No 1000Genomes
tmp_3_16928666_T_G 413 Q>H No 1000Genomes
ENSVATH14377767 422 A>T No 1000Genomes
tmp_3_16928640_G_A 422 A>V No 1000Genomes
tmp_3_16928632_C_A 425 D>Y No 1000Genomes
tmp_3_16928623_G_T 428 Q>K No 1000Genomes
tmp_3_16928599_T_C 436 S>G No 1000Genomes
ENSVATH06240692 438 P>T No 1000Genomes
ENSVATH02444840 439 L>M No 1000Genomes
tmp_3_16928560_C_T 449 V>I No 1000Genomes
ENSVATH12551220 452 R>K No 1000Genomes
ENSVATH12551218 466 S>A No 1000Genomes
ENSVATH12551217 483 S>T No 1000Genomes
ENSVATH06240691 484 D>E No 1000Genomes

No associated diseases with O82413

1 regional properties for O82413

Type Name Position InterPro Accession
repeat Pentatricopeptide repeat 411 - 445 IPR002885

Functions

Description
EC Number 6.1.1.21 Ligases forming aminoacyl-tRNA and related compounds
Subcellular Localization
  • Plastid, chloroplast
  • Mitochondrion
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
chloroplast A chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma.
mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.

2 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
histidine-tRNA ligase activity Catalysis of the reaction: ATP + L-histidine + tRNA(His) = AMP + diphosphate + L-histidyl-tRNA(His).

1 GO annotations of biological process

Name Definition
histidyl-tRNA aminoacylation The process of coupling histidine to histidyl-tRNA, catalyzed by histidyl-tRNA synthetase. The histidyl-tRNA synthetase is a class-II synthetase. The activated amino acid is transferred to the 3''-OH group of a histidine-accetping tRNA.

9 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
A5D7V9 HARS2 Histidine--tRNA ligase, mitochondrial Bos taurus (Bovine) PR
Q2KI84 HARS1 Histidine--tRNA ligase, cytoplasmic Bos taurus (Bovine) PR
P12081 HARS1 Histidine--tRNA ligase, cytoplasmic Homo sapiens (Human) PR
P49590 HARS2 Histidine--tRNA ligase, mitochondrial Homo sapiens (Human) PR
Q61035 Hars1 Histidine--tRNA ligase, cytoplasmic Mus musculus (Mouse) PR
Q99KK9 Hars2 Histidine--tRNA ligase, mitochondrial Mus musculus (Mouse) PR
P93422 Os09g0504400 Histidine--tRNA ligase, cytoplasmic Oryza sativa subsp japonica (Rice) PR
P34183 hars-1 Histidine--tRNA ligase Caenorhabditis elegans PR
F4IYF8 At3g02760 Histidine--tRNA ligase, cytoplasmic Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MRAIHIVTTR LSSSFRPILL LDLVSSCSPP RQFSIPRRLI CAAANGGGRS GSIVAPLVTE
70 80 90 100 110 120
EDFHKKIDVN PPKGTRDFPP EDMRLRNWLF NHFKEVSRLY GYEEVDYPVL ETEALFIRKA
130 140 150 160 170 180
GEEIRDQLYC FEDRGNRRVA LRPELTPSLA RLVIQKGKSV SLPLKWFAIG QCWRYERMTR
190 200 210 220 230 240
GRRREHYQWN MDIIGVPQVT AEAELISSIV TFFKRIGITA SDVGFKVSSR KVLQELLKKY
250 260 270 280 290 300
GVPEDLFGRV CIIIDKIEKI PIDEIKKELG FTGISEDAIE QLLQVLSVKS LDDLEDIIGG
310 320 330 340 350 360
AGEAIADLKQ LFSLAEKFGY SEWIQFDASV VRGLAYYTGI VFEGFDRKGK LRAICGGGRY
370 380 390 400 410 420
DRLLSTYGGD DFPACGFGFG DAVIVELLKE KDLLPELGQE VENIVCALDK DLQGAAATVA
430 440 450 460 470 480
TALRDKGQTV DLVLESKPLK WVFKRAARVN ARRLVLVGKT EWEDGSVSVK VLSSGEQFQV
KLSDLE