A5D7V9

PR
Gene name
HARS2
Protein name
Histidine--tRNA ligase, mitochondrial
Names
Histidyl-tRNA synthetase, HisRS
Species
Bos taurus (Bovine)
KEGG Pathway
bta:615182
EC number
6.1.1.21: Ligases forming aminoacyl-tRNA and related compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

3-84 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for A5D7V9

Entry ID Method Resolution Chain Position Source
AF-A5D7V9-F1 Predicted AlphaFoldDB

No variants for A5D7V9

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for A5D7V9

No associated diseases with A5D7V9

1 regional properties for A5D7V9

Type Name Position InterPro Accession
conserved_site Di-trans-poly-cis-decaprenylcistransferase-like, conserved site 245 - 262 IPR018520

Functions

Description
EC Number 6.1.1.21 Ligases forming aminoacyl-tRNA and related compounds
Subcellular Localization
  • Mitochondrion
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.

3 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
histidine-tRNA ligase activity Catalysis of the reaction: ATP + L-histidine + tRNA(His) = AMP + diphosphate + L-histidyl-tRNA(His).
identical protein binding Binding to an identical protein or proteins.

1 GO annotations of biological process

Name Definition
histidyl-tRNA aminoacylation The process of coupling histidine to histidyl-tRNA, catalyzed by histidyl-tRNA synthetase. The histidyl-tRNA synthetase is a class-II synthetase. The activated amino acid is transferred to the 3''-OH group of a histidine-accetping tRNA.

9 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q2KI84 HARS1 Histidine--tRNA ligase, cytoplasmic Bos taurus (Bovine) PR
P12081 HARS1 Histidine--tRNA ligase, cytoplasmic Homo sapiens (Human) PR
P49590 HARS2 Histidine--tRNA ligase, mitochondrial Homo sapiens (Human) PR
Q61035 Hars1 Histidine--tRNA ligase, cytoplasmic Mus musculus (Mouse) PR
Q99KK9 Hars2 Histidine--tRNA ligase, mitochondrial Mus musculus (Mouse) PR
P93422 Os09g0504400 Histidine--tRNA ligase, cytoplasmic Oryza sativa subsp japonica (Rice) PR
P34183 hars-1 Histidine--tRNA ligase Caenorhabditis elegans PR
O82413 At3g46100 Histidine--tRNA ligase, chloroplastic/mitochondrial Arabidopsis thaliana (Mouse-ear cress) PR
F4IYF8 At3g02760 Histidine--tRNA ligase, cytoplasmic Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MPQLGLLPGR AWTVLLGLLR PPPGALCIRA VRSHSQVAEA LFASQLKPHQ EKSNFTIKTP
70 80 90 100 110 120
KGTRDLSPQQ MVVREKILDV VVSCFKRHGA KGLDTPAFEL KEILTEKYGE DSGLIYDLKD
130 140 150 160 170 180
QGGELLSLRY DLTVPFARYL AMNKVKKMKR YHVGKVWRRE SPTIVQGRYR EFYQCDFDIA
190 200 210 220 230 240
GQFDPMIPDA ECLKIMCEIL SGLHLGDFLI KVSDRRILDG IFAVCGVPES KFHAICSSVD
250 260 270 280 290 300
KLDKISWKDV RHEMVVKKGL APEVADRIGD YVQCHGGISL VEQMFQDPRL SQNKQALEGL
310 320 330 340 350 360
GDLKLLFEYL TLFGVAEKVS FDLSLARGLD YYTGVIYEAV LLQTPVHAEE EPLNMGSVAA
370 380 390 400 410 420
GGRYDGLVGM FDPRGHKVPC VGLSIGVERI FSIVEQRIKT FGEKIRTTET QVFVATPQKN
430 440 450 460 470 480
FLQERLKLIA ELWDAGIKAE LMYKNNPKLL PQLHYCENMG IPLVVIIGEQ ELKEGVIKLR
490 500
SVASREEVAI KRENLVAEIQ KRLSES