Q5ZK10
Gene name |
NSFL1C (RCJMB04_13o20) |
Protein name |
NSFL1 cofactor p47 |
Names |
p97 cofactor p47 |
Species |
Gallus gallus (Chicken) |
KEGG Pathway |
gga:419268 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q5ZK10
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q5ZK10-F1 | Predicted | AlphaFoldDB |
5 variants for Q5ZK10
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs739734627 | 52 | L>P | No | Ensembl | |
| rs733005207 | 167 | V>G | No | Ensembl | |
| rs737006140 | 171 | R>G | No | Ensembl | |
| rs735717551 | 269 | T>P | No | Ensembl | |
| rs10729117 | 282 | A>V | No | Ensembl |
No associated diseases with Q5ZK10
Functions
5 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| Golgi stack | The set of thin, flattened membrane-bounded compartments, called cisternae, that form the central portion of the Golgi complex. The stack usually comprises cis, medial, and trans cisternae; the cis- and trans-Golgi networks are not considered part of the stack. |
| microtubule organizing center | An intracellular structure that can catalyze gamma-tubulin-dependent microtubule nucleation and that can anchor microtubules by interacting with their minus ends, plus ends or sides. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
| VCP-NSFL1C complex | A protein complex between the ATPase VCP (p97) and its cofactor p47 (NSFL1C). In human, the protein complex consists of one homotrimer of NSFL1C/p47 per homohexamer of VCP/p97. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| lipid binding | Binding to a lipid. |
| ubiquitin binding | Binding to ubiquitin, a protein that when covalently bound to other cellular proteins marks them for proteolytic degradation. |
8 GO annotations of biological process
| Name | Definition |
|---|---|
| autophagosome assembly | The formation of a double membrane-bounded structure, the autophagosome, that occurs when a specialized membrane sac, called the isolation membrane, starts to enclose a portion of the cytoplasm. |
| establishment of mitotic spindle orientation | A cell cycle process that sets the alignment of mitotic spindle relative to other cellular structures. |
| Golgi organization | A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the Golgi apparatus. |
| membrane fusion | The membrane organization process that joins two lipid bilayers to form a single membrane. |
| negative regulation of protein localization to centrosome | Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to centrosome. |
| nuclear membrane reassembly | The reformation of the nuclear membranes following their breakdown in the context of a normal process. |
| positive regulation of mitotic centrosome separation | Any process that activates or increases the frequency, rate or extent of centrosome separation. |
| proteasome-mediated ubiquitin-dependent protein catabolic process | The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome. |
12 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q3SZC4 | NSFL1C | NSFL1 cofactor p47 | Bos taurus (Bovine) | PR |
| Q5T124 | UBXN11 | UBX domain-containing protein 11 | Homo sapiens (Human) | PR |
| Q14CS0 | UBXN2B | UBX domain-containing protein 2B | Homo sapiens (Human) | PR |
| Q9UNZ2 | NSFL1C | NSFL1 cofactor p47 | Homo sapiens (Human) | PR |
| Q99KJ0 | Ubxn2a | UBX domain-containing protein 2A | Mus musculus (Mouse) | PR |
| Q0KL01 | Ubxn2b | UBX domain-containing protein 2B | Mus musculus (Mouse) | PR |
| Q9D572 | Ubxn11 | UBX domain-containing protein 11 | Mus musculus (Mouse) | PR |
| Q9CZ44 | Nsfl1c | NSFL1 cofactor p47 | Mus musculus (Mouse) | PR |
| P0C627 | Ubxn2b | UBX domain-containing protein 2B | Rattus norvegicus (Rat) | PR |
| Q8R512 | Ubxn11 | UBX domain-containing protein 11 | Rattus norvegicus (Rat) | PR |
| O35987 | Nsfl1c | NSFL1 cofactor p47 | Rattus norvegicus (Rat) | PR |
| F4IXN6 | PUX6 | Plant UBX domain-containing protein 6 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MADREEALRE | FVAVTGAEEE | RARFFLESAG | WDLQIALASF | YEDGGDEDIL | TLPQPTPSSV |
| 70 | 80 | 90 | 100 | 110 | 120 |
| SRGTAASDHR | VTSFRDLVHA | QEDDDEEEEG | QRFYAGGSER | SGQQIVGPPR | KKSPNELVED |
| 130 | 140 | 150 | 160 | 170 | 180 |
| LFKGAKEHGA | VAVDRTAKSS | GESSKPKPFA | GGGYRLGATP | EEESAYVAGE | RRHNSVQDVH |
| 190 | 200 | 210 | 220 | 230 | 240 |
| VVLKLWKTGF | SLDSGELRSY | QDPSNAQFLD | DIRRGEVPAE | LRRLARGGQV | NLDMEDHRDE |
| 250 | 260 | 270 | 280 | 290 | 300 |
| EYVKPKSVFK | AFTGEGQKLG | STAPQVLSTS | SPAQQAENEA | KASSAIAIDE | SEPVTNIQIR |
| 310 | 320 | 330 | 340 | 350 | 360 |
| LADGGRLVQK | FNHNHRIRDI | RLFIVDARPA | MAATSFVLMT | TFPNKELTDE | NQTLKEANLL |
| NAVIVQRLT |